Title: The Best Hotels Closest to Sanctuary of Guadalupe in Piedras Negras - 2026 Updated Prices | Expedia.co.uk [Piedras Negras Travel Guide](https://expedia.co.uk/Piedras-Negras.dx6052600)[Holiday Rentals in Piedras Negras](https://expedia.co.uk/Piedras-Negras-Holiday-Rentals.d6052600.Travel-Guide-HolidayRentals)[Flights to Piedras Negras](https://expedia.co.uk/Cheap-Flights-To-Piedras-Negras.d6052600.Travel-Guide-Flights)[Sanctuary of Guadalupe Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sanctuary-Of-Guadalupe.d6276699.Car-Hire-Guide)[Sanctuary of Guadalupe Holidays](https://expedia.co.uk/Sanctuary-Of-Guadalupe-Piedras-Negras.d6276699.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [20 Jan - 21 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6276699&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Jan - 22 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6276699&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6276699&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6276699&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Sanctuary of Guadalupe hotels ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/b331987e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/50e27a3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/06527b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/b067eda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Autel Rio Inn Luxury Inns [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Autel-Rio-Inn-Luxury-Inns.h15490085.Hotel-Information) 0.2 mi from Sanctuary of Guadalupe 8.0/10 Very good (269 reviews) "Excellent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lizzette £66 includes taxes & fees 3 Feb - 4 Feb [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Autel-Rio-Inn-Luxury-Inns.h15490085.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/424db3e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/d0af41c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/078de1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/3a53d6b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Piedras Negras [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Days-Inn-By-Wyndham-Piedras-Negras.h35812618.Hotel-Information) 0.9 mi from Sanctuary of Guadalupe 8.4/10 Very good (405 reviews) "Everything for our stay was great! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rosa £75 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Days-Inn-By-Wyndham-Piedras-Negras.h35812618.Hotel-Information) ![Standard Room | Down duvets, free WiFi](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/bcc73c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/0a3f746b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/aae898dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/1e60a0d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Yolotl Sleep Experience [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Yolotl-Sleep-Experience.h98435861.Hotel-Information) 0.8 mi from Sanctuary of Guadalupe 7.2/10 Good (57 reviews) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Yolotl-Sleep-Experience.h98435861.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/cbdbc155.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/e21fc0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/08a921af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/9ceae354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Piedras Negras by IHG [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Holiday-Inn-Express-Piedras-Negras.h687851.Hotel-Information) 2 mi from Sanctuary of Guadalupe 9.0/10 Wonderful (377 reviews) "Really good breakfast and the staff was exceptional. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller £82 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Holiday-Inn-Express-Piedras-Negras.h687851.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/7ed133af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/1ecfb893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast ](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/0f23b784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/82a16b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Piedras Negras [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Quality-Inn-Piedras-Negras.h78138.Hotel-Information) 2.4 mi from Sanctuary of Guadalupe 8.6/10 Excellent (499 reviews) "All essentials were met and breakfast menu was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roberto £68 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Quality-Inn-Piedras-Negras.h78138.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/e42eea97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/adcebb2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/db6c7230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/602379a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express by Marriott Piedras Negras [](https://www.expedia.co.uk/Piedras-Negras-Hotels-City-Express-Piedras-Negras.h15380105.Hotel-Information) 2.5 mi from Sanctuary of Guadalupe 8.6/10 Excellent (787 reviews) "Room was spotless, good breakfast & staff very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) vivianne £69 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Piedras-Negras-Hotels-City-Express-Piedras-Negras.h15380105.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/e2db00af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/87e7ea2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/751f2d18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/46afe873.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn by Hilton Piedras Negras [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Hampton-Inn-By-Hilton-Piedras-Negras.h15431578.Hotel-Information) 3 mi from Sanctuary of Guadalupe 9.4/10 Exceptional (932 reviews) "Property is safe and breakfast was good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan £99 includes taxes & fees 14 Feb - 15 Feb [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Hampton-Inn-By-Hilton-Piedras-Negras.h15431578.Hotel-Information) ![Standard Room | Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/22fdeb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/9c387216.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/3af0637a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/b1bf2382.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Herederos Hotel Piedras Negras [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Hotel-Herederos.h44043969.Hotel-Information) 2.4 mi from Sanctuary of Guadalupe 7.2/10 Good (1,000 reviews) "There was always parking, the area and hotel was very safe, staff was super nice and place was very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) elizabeth [](https://www.expedia.co.uk/Piedras-Negras-Hotels-Hotel-Herederos.h44043969.Hotel-Information) ![Double Room | Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/cda33911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/b2b86aeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/0f62cb12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/6e37f786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### QUINTA SAN CARLOS INN [](https://www.expedia.co.uk/Piedras-Negras-Hotels-QUINTA-SAN-CARLOS-INN.h41980680.Hotel-Information) 2 mi from Sanctuary of Guadalupe £72 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Piedras-Negras-Hotels-QUINTA-SAN-CARLOS-INN.h41980680.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-03&endDate=2026-02-04®ionId=6276699&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Sanctuary of Guadalupe Hotel Reviews ![Spacious 3-bedroom house in serene Piedras Negras with AC and pool](https://images.trvl-media.com/lodging/122000000/121280000/121277000/121276963/bf6b74d5_y.jpg) ### Spacious 3-bedroom house in serene Piedras Negras with AC and pool 10/10 Excellent "our host was very responsive " [](https://expedia.co.uk/Piedras-Negras-Hotels-Spacious-3-Bedroom-House-In-Serene-Piedras-Negras-With-AC-And-Pool.h121276963.Hotel-Information) ## Hotels near other Sanctuary of Guadalupe attractions ### Gran Plaza 4.1/5 (110 reviews) Learn about the local history of Piedras Negras with a stop at Gran Plaza. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6276692) ### Museo de la Frontera Norte You can spend time exploring the galleries in Museo de la Frontera Norte during your travels in Piedras Negras. You can enjoy the restaurants while in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=956848376843145216) ### Eagle Pass International Bridge I Eagle Pass International Bridge I is just one of the places to see in Eagle Pass, so why not enjoy the other things to explore during your travels? Visit the casinos and top-notch restaurants in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=951034639462883328) ### Piedras Negras River Walk After visiting Piedras Negras River Walk, make a plan to see the other sights and activities in Piedras Negras. You can enjoy the restaurants while in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=956848816743837696) ### Eagle Pass Golf Course 3.7/5 (107 reviews) Enjoy a round of golf in Eagle Pass at Eagle Pass Golf Course. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6277120) ### Fort Duncan Museum 3.8/5 (98 reviews) You can spend time browsing the exhibits at Fort Duncan Museum in Eagle Pass. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6303588) ### Three Cultures Square 4.3/5 (63 reviews) Learn about the local history of Piedras Negras when you spend time at Three Cultures Square. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6276688) ### Macroplaza I Macroplaza I is just one of the places to see in Piedras Negras, so why not enjoy the other things to explore during your travels? You can enjoy the restaurants while in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=956848054622031872) ## Frequently asked questions ### What's the area like around Sanctuary of Guadalupe? ### What's the best place to stay close to Sanctuary of Guadalupe? ### How many hotels will I find near Sanctuary of Guadalupe? ### If I need to cancel the hotel reservation for my stay near Sanctuary of Guadalupe, will I receive a refund?