
San Marco Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your San Marco Holiday
From its bars and pubs to its cafes and culture, there are tons of great reasons to book a holiday package to San Marco. When you need to get away from it all, this leafy neighbourhood is calling. Your trip to San Marco wouldn't be complete without a stop at leading attractions nearby such as Cummer Museum of Art and Gardens, Jacksonville Museum of Modern Art and TIAA Bank Field. Don't just wish for it — turn it into a reality! Book your ultimate San Marco holiday with Expedia and travel your way.
Where to stay in San Marco

Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Top hotels in San Marco

Scottish Inn Jacksonville Downtown
"It's the most rundown horrid dumpster I ever stayed at. The lobby was locked, they made people stand in a long line outside at 4 pm in scorching heat to check in. The rep forgot to give me a parking tag, without it my car would have been towed. The room reeked of smoke. I booked a non-smoking room ..."
Reviewed on 26 Jun 2026

Hilton Garden Inn Jacksonville Downtown Southbank
"Excellent"
Reviewed on 25 Jun 2026

Homewood Suites by Hilton Jacksonville Downtown-Southbank
"Great stay Customer service"
Reviewed on 23 Jun 2026
Frequently asked questions
Stay near popular San Marco attractions
Things to do

The Escape Game at St. John's Town Center in Jacksonville

Electric Bike Tour with Free Application for Navigation
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.














