San Francisco Holidays from £888

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Your San Francisco Holiday

When a fun city break is calling, answer it with a holiday package to San Francisco. The neighbourhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco holiday is just a few clicks away. Explore flights, accommodation and more on Expedia for an adventure that's tailored to suit your travel style.

Price found within the past 48 hours. Click for updated prices.
Arcadia Condo Suites

Arcadia Condo Suites

2.5 out of 5
Costa del Este
per person
4 Sept - 9 Sept
found 14 hours ago
Return flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (21 reviews)
Muy ordenado y limpio Bastante amplio y cómodo con todo lo necesario

Reviewed on 21 May 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
4 Sept - 9 Sept
found 14 hours ago
Return flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (918 reviews)
My room was spacious, clean and comfortable. The Hotel staff were very friendly and helpful and made my first visit to Panama a very memorable one.

Reviewed on 24 Jun 2025

Hotel Plaza Herrera

Hotel Plaza Herrera

3 out of 5
Casco Viejo
per person
4 Sept - 9 Sept
found 14 hours ago
Return flight included
London (LON) to Panama City (PTY)
10/10 Exceptional! (3 reviews)
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
per person
4 Sept - 9 Sept
found 14 hours ago
Return flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (4,025 reviews)
Location and customer service. Tastes Restaurant was outstanding. Excellent Food

Reviewed on 24 Jun 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
4 Sept - 9 Sept
found 14 hours ago
Return flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (920 reviews)
Dining options were limited. the nightclub and sky bar or lounge were all closed. the bell staff and security were amazingly helpful. will recommend

Reviewed on 21 Jun 2025

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
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Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in San Francisco

Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is £103 per night from 3 Jul to 4 Jul
£103
3 Jul - 4 Jul
includes taxes & fees
8.4/10 Very Good! (885 reviews)
"Cold AC in room 65F, 18C. Clean linen. Staff professional. Older hotel, starting to show wear around the edges, tiny bathrooms . Windows are dirty, missing a few towels."

Reviewed on 24 Jun 2025

Sheraton Grand Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is £157 per night from 18 Jul to 19 Jul
£157
18 Jul - 19 Jul
includes taxes & fees
8.8/10 Excellent! (1,003 reviews)
"Great staff."

Reviewed on 10 Jun 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is £82 per night from 1 Jul to 2 Jul
£82
1 Jul - 2 Jul
includes taxes & fees
9.4/10 Exceptional! (1,003 reviews)
"Amazing and clean"

Reviewed on 20 Jun 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
See all 1,463 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Holidays

All Inclusive Holidays

Beach Holidays

Beach Holidays

Family Friendly Holidays

Family Friendly Holidays

Frequently asked questions

Why should I book my San Francisco holiday with Expedia?
Choose Expedia to plan your next big adventure easily and all in the same place. Our top tip for bagging an unbeatable deal on a San Francisco getaway? Bundle your hotel, flights and/or hire car into a package holiday. Then add a couple of exciting tours and activities. Many bookings also have flexible cancellation policies, so there's no need to worry if you have to change your travel plans. Round-the-clock assistance with cancelling and amending your trip is on-hand via our Customer Service Portal link.
When is the best time of year to holiday in San Francisco?
Love sightseeing but don't like huge crowds? Lock in your San Francisco getaway for May, August and October. Typically, it's much quieter than in November, December and January. Organise your visit to San Francisco based on what style of adventure you want. November is the coolest time of year, when average daytime temperatures are 25ºC. In January, the warmest month, expect averages of 26ºC during the day.
What are the top hotels for my holiday in San Francisco?
If you're wanting to stay within easy reach of San Francisco, lock in a room at Home Suite Ocean View or Modern Apartment in a Luxurious Residential Unit in the heart of the city. Both will make you feel at home and are popular options with many travellers.
How do I get a cheap holiday to San Francisco?
Browse and book everything all in one place with our San Francisco holidays. You'll discover deals on hotels, flights, tours and more that'll keep your bank account happy and your adventurous spirit alive. And, with more than 400 partner airlines and 321,000 properties worldwide to choose from, you'll have endless opportunities to mix and match as you want. Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my San Francisco holiday?
Offering leading attractions such as Miraflores Locks and Metropolitan Cathedral of Panama, a holiday in San Francisco is packed with exciting places to visit. Albrook Shopping Mall and Multiplaza Pacific Mall are two other sights worth discovering.
What is the best area to stay in when on holiday in San Francisco?
There's so much to explore in San Francisco, so stay near its top attractions and spend more time sightseeing. Multiplaza Pacific Mall is one place to add to your to-do list.
Do I need a visa for my San Francisco holiday?
Official government websites are the best source of information on visa requirements, application procedures and any supporting documentation. Your nationality and the reason for your visit, whether it be for work or holidays, will determine if you need a visa for San Francisco. Also check that your passport is up to date and has a minimum of six months validity remaining after the date of your return. Do all your travel planning ahead of time to avoid any last-minute surprises.
What should I wear on my San Francisco holiday?
Do some research into the types of clothing people in San Francisco wear, and maybe even check out fashion pages on social media for inspiration. Try to create a versatile wardrobe full of pieces that work for your destination and show off your unique style.
What does an Expedia San Francisco holiday include?
Hotels, flights and hire cars --- we've got them all. With Expedia, you can shape your San Francisco package however you want. All you have to do is work out just what you need. Once you've made your booking, why not add extras like activities and experiences? The more you bundle, the bigger the savings! Explore a variety of styles on Expedia and find the right fit for you and your travel companions. From the most popular property types, like apartments and condos, to many other options, there are loads of holiday retreats in San Francisco to select from so you can personalise your stay just the way you like it.
Does Expedia offer Book Now, Pay Later San Francisco holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book your dream getaway without draining your savings. Klarna offers flexible payment options at checkout that take the worry out of budgeting for your trip. Check out these flexible payment options:
  • Pay monthly holidays: Klarna offers convenient monthly payment plans that suit all budgets, so you can have that well-deserved holiday now.
  • No-deposit holidays: If no upfront fee for your getaway makes hitting that "book now" button more stress-free, opt for a no-deposit holiday plan with Klarna so that you can Book Now, Pay Later!

Can I choose my airline with a San Francisco Expedia holiday?
With a holiday package, you're always in charge. Whether you're looking to fly to San Francisco in economy or business class, simply pick from the available airline options. Expedia has access to more than 400 partner airlines all over the world.

Popular places to visit

Pacific Center

You can browse for the perfect souvenirs at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

£110
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

£81
per adult
All included - Day tour in San Blas Islands - No extra fees
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

£106
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.