San Francisco Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your San Francisco Holiday

When a fun city break is calling, answer it with a holiday package to San Francisco. The neighbourhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco holiday is just a few clicks away. Explore flights, accommodation and more on Expedia for an adventure that's tailored to suit your travel style.

Price found within the past 48 hours. Click for updated prices.
  • Interior detail
    Aug 11 - Aug 20

    Hotel Casa Panamá + Flight

    Casco Viejo
    9 nights
    4.0 star property
    7.6/10 - Good (687 reviews)
    "Todo muy cerca , muy buena ubicación"
    Reviewed May 22, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,035
    £748
    per traveller
    found 6 hours ago
    Hotel Casa Panamá
  • Front of property
    Aug 11 - Aug 20

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    9 nights
    4.0 star property
    9.2/10 - Wonderful (1,003 reviews)
    "Central to everything "
    Reviewed May 20, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    Save 100% on your flight
    £2,117
    £1,238
    per traveller
    found 6 hours ago
    Central Hotel Panama Casco Viejo
  • Front of property
    Aug 11 - Aug 20

    Megapolis Hotel Panamá + Flight

    San Francisco
    9 nights
    4.5 star property
    8.4/10 - Very good (1,533 reviews)
    "Great hotel ! Pool, gym and restaurant great !"
    Reviewed May 25, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    Save 100% on your flight
    £1,744
    £1,070
    per traveller
    found 6 hours ago
    Megapolis Hotel Panamá
  • Apartment, 3 Bedrooms (CM5) | Living room | 55-inch Smart TV with digital channels
    Aug 2 - Aug 15

    Casa Mallet by Wynwood House + Flight

    Casco Viejo
    12 nights
    4.0 star property
    9.8/10 - Exceptional (27 reviews)
    "In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions. "
    Reviewed March 12, 2026
    Return • London (LHR) - Panama City (PTY)
    LHR - PTY • 1 stop PTY - LHR • 1 stop
    £2,616
    £1,853
    per traveller
    found 1 day ago
    Casa Mallet by Wynwood House
  • View from property
    Aug 11 - Aug 20

    Las Americas Golden Tower Panama + Flight

    San Francisco
    9 nights
    4.0 star property
    9.0/10 - Wonderful (1,016 reviews)
    "The room was great with the view of the downtown.. will book it again when in Panama"
    Reviewed May 25, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,268
    £921
    per traveller
    found 6 hours ago
    Las Americas Golden Tower Panama

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in San Francisco

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
The price is £104 per night from 19 Jun to 20 Jun
£104
19 Jun - 20 Jun
includes taxes & fees
9/10 Wonderful! (1,008 reviews)
"Staff at front desk was most helpful and friendly. Kudos to Francisco. He was very welcoming and accommodating."

Reviewed on 21 May 2026

Courtyard by Marriott Panama Multiplaza Mall
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £120 per night from 29 May to 30 May
£120
29 May - 30 May
includes taxes & fees
9/10 Wonderful! (1,016 reviews)
"The room was great with the view of the downtown.. will book it again when in Panama"

Reviewed on 25 May 2026

Las Americas Golden Tower Panama
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
The price is £84 per night from 29 May to 30 May
£84
29 May - 30 May
includes taxes & fees
9.6/10 Exceptional! (1,211 reviews)
"Good"

Reviewed on 24 May 2026

Ramada Plaza by Wyndham Panama Punta Pacifica
See all 1,765 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

Why should I book my San Francisco holiday with Expedia?
Choose Expedia to plan your next big adventure easily and all in the same place. Our top tip for bagging an unbeatable deal on a San Francisco getaway? Bundle your hotel, flights and/or hire car into a package holiday. Then add a couple of exciting tours and activities. Many bookings also have flexible cancellation policies, so there's no need to worry if you have to change your travel plans. Round-the-clock assistance with cancelling and amending your trip is on-hand via our Customer Service Portal link.
When is the best time of year to holiday in San Francisco?
Love sightseeing but don't like huge crowds? Lock in your San Francisco getaway for May, August and October. Typically, it's much quieter than in November, December and January. Organise your visit to San Francisco based on what style of adventure you want. November is the coolest time of year, when average daytime temperatures are 25ºC. In January, the warmest month, expect averages of 26ºC during the day.
What are the top hotels for my holiday in San Francisco?
If you're wanting to stay within easy reach of San Francisco, lock in a room at Home Suite Ocean View or Modern Apartment in a Luxurious Residential Unit in the heart of the city. Both will make you feel at home and are popular options with many travellers.
How do I get a cheap holiday to San Francisco?
Browse and book everything all in one place with our San Francisco holidays. You'll discover deals on hotels, flights, tours and more that'll keep your bank account happy and your adventurous spirit alive. And, with more than 400 partner airlines and 321,000 properties worldwide to choose from, you'll have endless opportunities to mix and match as you want. Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my San Francisco holiday?
Offering leading attractions such as Miraflores Locks and Metropolitan Cathedral of Panama, a holiday in San Francisco is packed with exciting places to visit. Albrook Shopping Mall and Multiplaza Pacific Mall are two other sights worth discovering.
What is the best area to stay in when on holiday in San Francisco?
There's so much to explore in San Francisco, so stay near its top attractions and spend more time sightseeing. Multiplaza Pacific Mall is one place to add to your to-do list.
Do I need a visa for my San Francisco holiday?
Official government websites are the best source of information on visa requirements, application procedures and any supporting documentation. Your nationality and the reason for your visit, whether it be for work or holidays, will determine if you need a visa for San Francisco. Also check that your passport is up to date and has a minimum of six months validity remaining after the date of your return. Do all your travel planning ahead of time to avoid any last-minute surprises.
What should I wear on my San Francisco holiday?
Do some research into the types of clothing people in San Francisco wear, and maybe even check out fashion pages on social media for inspiration. Try to create a versatile wardrobe full of pieces that work for your destination and show off your unique style.
What does an Expedia San Francisco holiday include?
Hotels, flights and hire cars — we've got them all. With Expedia, you can shape your San Francisco package however you want. All you have to do is work out just what you need. Once you've made your booking, why not add extras like activities and experiences? The more you bundle, the bigger the savings! Explore a variety of styles on Expedia and find the right fit for you and your travel companions. From the most popular property types, like apartments and condos, to many other options, there are loads of holiday retreats in San Francisco to select from so you can personalise your stay just the way you like it.
Does Expedia offer Book Now, Pay Later San Francisco holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book your dream getaway without draining your savings. Klarna offers flexible payment options at checkout that take the worry out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna offers convenient monthly payment plans that suit all budgets, so you can have that well-deserved holiday now.
  • No-deposit holidays: If no upfront fee for your getaway makes hitting that "book now" button more stress-free, opt for a no-deposit holiday plan with Klarna so that you can Book Now, Pay Later!

Can I choose my airline with a San Francisco Expedia holiday?
With a holiday package, you're always in charge. Whether you're looking to fly to San Francisco in economy or business class, simply pick from the available airline options. Expedia has access to more than 400 partner airlines all over the world.

Popular places to visit

Pacific Center

You can browse for the perfect souvenirs at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

£110
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

£31
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

£21
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.