
San Francisco Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your San Francisco Holiday
When a fun city break is calling, answer it with a holiday package to San Francisco. The neighbourhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco holiday is just a few clicks away. Explore flights, accommodation and more on Expedia for an adventure that's tailored to suit your travel style.
Where to stay in San Francisco

Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Top hotels in San Francisco

Megapolis Hotel Panamá
"The room was clean and well stocked. The breakfast was excellent with lots of variety."
Reviewed on 9 Jul 2026

JW Marriott Panama
"Súper tranquilo y muy limpio todo y el trato de los trabajadores muy cordial"
Reviewed on 7 Jul 2026

Las Americas Golden Tower Panama
"Great location! Breakfast was good Overall nice stay"
Reviewed on 4 Jul 2026
Frequently asked questions
Stay near popular San Francisco attractions
Things to do

Half day of Panama city and canal tour: shared and private

Panama City: POIN Swing Experience
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.














