San Cosme y Damian Holidays from £428

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Top San Cosme y Damian Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Euro House Inn Airport

Euro House Inn Airport

4 out of 5
Isola Sacra
Save 100% on your flight
Price was £896, price is now £428 per person
£428
per person
31 Aug - 7 Sept
found 10 hours ago
Return direct flight included
London (LGW) to Rome (FCO)
7.8/10 Good! (947 reviews)
This is very clean but dated. The beds do not sleep well. It was a great value for the number of travelers. Be reminded, the restaurant is not on site.

Reviewed on 19 Jul 2026

Hotiday Roma Trevi

Hotiday Roma Trevi

4 out of 5
Rome City Centre
Price was £1,274, price is now £442 per person
£442
per person
12 Sept - 15 Sept
found 9 hours ago
Return flight included
London (LON) to Rome (FCO)
No reviews

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Price was £2,400, price is now £945 per person
£945
per person
12 Sept - 19 Sept
found 18 hours ago
Return flight included
London (LGW) to Rome (FCO)
9.6/10 Exceptional! (314 reviews)
Big room, nice breakfast, friendly staff. Close to Metro stop. This hotel is a hidden gem in Rome.

Reviewed on 28 Jul 2026

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Price was £928, price is now £432 per person
£432
per person
7 Sept - 10 Sept
found 1 day ago
Return flight included
London (LGW) to Rome (FCO)
9.2/10 Wonderful! (701 reviews)

Boutique Hotel Trevi

Boutique Hotel Trevi

4 out of 5
Rome City Centre
Price was £908, price is now £465 per person
£465
per person
3 Oct - 7 Oct
found 1 day ago
Return flight included
London (LON) to Rome (FCO)
8/10 Very good! (1,000 reviews)
All perfect, meter from the Fontana de Trevi!

Reviewed on 20 Jul 2026

San Cosme y Damian Essential Information

Language
Spanish
Currency
Paraguayan guaranís
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Libertador General Jose de San Martin Airport (PSS)
Population
2,200
Max Temp Winter
21ºC
Max Temp Summer
32ºC

Top hotels in San Cosme y Damian

Sun Hotel

Sun Hotel

3.5 out of 5
Encarnacion Itapúa
The price is £48 per night from 1 Aug to 2 Aug
£48
1 Aug - 2 Aug
includes taxes & fees
9/10 Wonderful! (130 reviews)
"Great stay!"

Reviewed on 8 Jul 2026

Sun Hotel
Alula Hotel Encarnacion

Alula Hotel Encarnacion

4.5 out of 5
1848 Gral Aquino Encarnación Itapúa
Fully refundableReserve now, pay when you stay
The price is £75 per night from 2 Aug to 3 Aug
£75
2 Aug - 3 Aug
includes taxes & fees
9.6/10 Exceptional! (37 reviews)
"_________________________"

Reviewed on 26 Jul 2026

Alula Hotel Encarnacion
Carnaval Hotel Casino

Carnaval Hotel Casino

3.5 out of 5
Av. Irrazabal, 750 Encarnacion
Fully refundableReserve now, pay when you stay
The price is £55 per night from 2 Aug to 3 Aug
£55
2 Aug - 3 Aug
includes taxes & fees
9.4/10 Exceptional! (204 reviews)
"Muuuuy recomendado. Buenos amenities y buenisisima ubicación. Desayuno completisimo."

Reviewed on 19 Jul 2026

Carnaval Hotel Casino
See all 35 properties in Itapúa Department
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular San Cosme y Damian attractions

Guarani Jesuit Ruins of San Cosme and San Damián

Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area.
See properties

Frequently asked questions

How much does a San Cosme y Damian travel package cost?
Starting from an incredible £428, you can create your own San Cosme y Damian package. Simply combine flights, hotels and car rentals and be rewarded with discounts.
If I'm not able to travel, can I cancel my San Cosme y Damian travel package?
You can cancel your San Cosme y Damian booking if your plans have changed. Whether you'll be charged a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.
How do I get a cheap travel package to San Cosme y Damian?
Booking a San Cosme y Damian travel package with Expedia is one of the best ways to save. We offer access to over 550 airlines and 1,000,000 properties spread across the globe. With such an amazing range to select from, you'll have no worries putting together your perfect escape.
Does Expedia offer Book Now, Pay Later San Cosme y Damian holidays?
We certainly do. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply pick the payment plan best suited to your needs during checkout and take the stress out of budgeting for your next trip. Make sure you bundle your accommodation, car hire and flights with Expedia to get the biggest bang for your holiday buck. Browse our flexible payment options below:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that work for all budget sizes, so you can lock in that well-earned holiday sooner.
  • Pay in instalments holidays: If you'd like to pay for your escape across multiple transactions, holidays paid in instalments might be the right choice for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: When you want to jump on an incredible deal but don't have the full amount yet, Klarna's low deposit holiday plan will help you lock in your escape.

Where should I stay in San Cosme y Damian?
San Cosme y Damian is home to numerous terrific places to explore, like Buenaventura Suarez Planetarium. Book a hotel close by and make sightseeing a breeze.
What are the top hotels in San Cosme y Damian?
Awa Resort Hotel and Hotel Luxsur are a couple of the most popular hotels in San Cosme y Damian. Why not take a look at the facilities and amenities at each and then make up your mind?
How far in advance should I book my San Cosme y Damian holiday?
Smart travellers will likely want to book early. You can normally browse through international fares on Expedia up to 12 months before your flight. If you're late to book, don't despair. Discounted prices sometimes occur in the last weeks before departure dates.
What does an Expedia San Cosme y Damian travel package include?
Hotels, flights and car rentals — we bring you the best deals. All you have to do is pick and choose your ideal combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to customize an exciting San Cosme y Damian holiday.
What should I know before booking a San Cosme y Damian travel package?
When you book your flights, hotels and car rentals together, you'll walk away with incredible discounts. Whether you're organising a mountain getaway in a cabin or want to stay in a comfortable hotel in the city, Expedia can make it happen for less.
Can I choose my airline with a San Cosme y Damian Expedia travel package?
Most definitely. We offer more than 550 airlines throughout the world, so you can customize your San Cosme y Damian getaway according to your budget and style.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.