Title: Hotels in San Cosme y Damian - Best San Cosme y Damian Hotels from £42 - Fully Refundable Options - Expedia.co.uk [San Cosme y Damian Travel Guide](https://expedia.co.uk/San-Cosme-Y-Damian.dx6348319)[Holiday Rentals in San Cosme y Damian](https://expedia.co.uk/San-Cosme-Y-Damian-Holiday-Rentals.d6348319.Travel-Guide-HolidayRentals)[San Cosme y Damian Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Cosme-Y-Damian.d6348319.Car-Hire-Guide)[San Cosme y Damian Holidays](https://expedia.co.uk/San-Cosme-Y-Damian.d6348319.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [30 Jan - 31 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6348319&startDate=2026-01-30&endDate=2026-01-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [31 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6348319&startDate=2026-01-31&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6348319&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6348319&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels) ## Stay near popular San Cosme y Damian attractions ### Buenaventura Suarez Planetarium You can spend time exploring the galleries in Buenaventura Suarez Planetarium in San Cosme y Damian. Take in the museums while you're in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463875) ### Guarani Jesuit Ruins of San Cosme and San Damián Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=812269535561961472) ## Top San Cosme y Damian Hotel Reviews ## More cheap stays in San Cosme y Damian ![Puesta del Sol by Nobile](https://images.trvl-media.com/lodging/16000000/15240000/15237500/15237430/560dc4db_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Puesta del Sol by Nobile 14 de Mayo 44 Esq. Av. Francia Encarnacion Itapua £42 1 Mar - 2 Mar includes taxes & fees 8.6/10 Excellent! (48 reviews) [](https://expedia.co.uk/Encarnacion-Hotels-Hotel-Puesta-Del-Sol.h15237430.Hotel-Information) ![Apartament central with river views pool](https://images.trvl-media.com/lodging/104000000/103160000/103150100/103150003/ea823cad_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Apartament central with river views pool Paraguayan Railways Encarnacion Itapúa Department [Get rates](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=103150003&PinnedHotelID=103150003&HadPinnedHotel=true®ionId=6348319) [](https://expedia.co.uk/Encarnacion-Hotels-Apartament-Central-With-River-Views-Pool.h103150003.Hotel-Information) ![Hermosa Casa de 3 Dormitorios 🤩](https://images.trvl-media.com/lodging/106000000/105890000/105886800/105886780/c6b64097_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hermosa Casa de 3 Dormitorios 🤩 Encarnación Itapúa [Get rates](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=105886780&PinnedHotelID=105886780&HadPinnedHotel=true®ionId=6348319) [](https://expedia.co.uk/Encarnacion-Hotels-Hermosa-Casa-De-3-Dormitorios.h105886780.Hotel-Information) ![Terwindt Hotel](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059377/1100e8de_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Terwindt Hotel Lomas Valentinas 1152 e Wissen y corá Encarnacion [Get rates](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=29059377&PinnedHotelID=29059377&HadPinnedHotel=true®ionId=6348319) [](https://expedia.co.uk/Encarnacion-Hotels-Terwindt-Hotel.h29059377.Hotel-Information) ![Casa de la Y, b&b, your place in Encarnación, close to everything.](https://images.trvl-media.com/lodging/122000000/121120000/121110200/121110117/c96014ea_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Casa de la Y, b&b, your place in Encarnación, close to everything. Encarnación Itapúa [Get rates](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=121110117&PinnedHotelID=121110117&HadPinnedHotel=true®ionId=6348319) [](https://expedia.co.uk/Encarnacion-Hotels-Vrbo-Property.h121110117.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in San Cosme Y Damian? > This area is the heart of visitor activity. It's relatively compact, with accommodations often found within a short walk or drive of the historic Jesuit mission site. You'll find a few local eateries and shops primarily suiting tourists here. > > > For couples and anyone interested in history and astronomy, staying near the Jesuit Ruins is ideal. The mission itself is a UNESCO World Heritage site, and its astronomical observatory is a unique feature. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a San Cosme y Damian hotel booking with Expedia? ### How much is the nightly rate at a San Cosme y Damian hotel? ## Explore a world of travel with Expedia - Accommodation - Packages - Other - [Bella Vista Hotels ](https://www.expedia.co.uk/Bella-Vista-Hotels.d6141312.Travel-Guide-Hotels) - [Hotels near Carnival Sambadrome ](https://www.expedia.co.uk/Carnival-Sambadrome-Hotels.0-l553248621532374355-0.Travel-Guide-Filter-Hotels) - [Encarnacion Hotels ](https://www.expedia.co.uk/Encarnacion-Hotels.d6141802.Travel-Guide-Hotels) - [Jesús Hotels ](https://www.expedia.co.uk/Jesus-Hotels.d6353265.Travel-Guide-Hotels) - [Santa María Hotels ](https://www.expedia.co.uk/Santa-Maria-Hotels.d553248635975867967.Travel-Guide-Hotels) - [Trinidad Hotels ](https://www.expedia.co.uk/Trinidad-Hotels.d6141611.Travel-Guide-Hotels) - [Encarnacion Holidays ](https://www.expedia.co.uk/Encarnacion.d6141802.Holidays-City-Breaks) - [Visit Encarnacion ](https://www.expedia.co.uk/Encarnacion.dx6141802) - [Jesús Holidays ](https://www.expedia.co.uk/Jesus.d6353265.Holidays-City-Breaks) - [Things to do in Encarnacion ](https://www.expedia.co.uk/Things-To-Do-In-Encarnacion.d6141802.Travel-Guide-Activities) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app