Nombre de Dios Holidays from £454

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Top Nombre de Dios flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • 8 Oct - 13 Oct

    Decapolis Hotel Panama City + Flight

    San Francisco
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,712 reviews)
    Return Medellín (MDE) - Panama City (PTY)
    MDE - PTY1 stop PTY - MDE1 stop
    Save 100% on your flight
    £728
    £454
    per traveller
    found 9 hours ago
    Decapolis Hotel Panama City
  • 8 Oct - 13 Oct

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    5 nights
    4.0 star property
    9.2/10 - Wonderful (1,014 reviews)
    "The bathrooms and plumbing is poor. Leaking sink, water in the bath doesn’t drain The thermostat can’t be adjusted easily No bedroom slippers Breakfast was packed but ok. Not 5 star at all. Good location."
    Reviewed August 7, 2026
    Return Medellín (MDE) - Panama City (PTY)
    MDE - PTY1 stop PTY - MDE1 stop
    £1,190
    £463
    per traveller
    found 9 hours ago
    Central Hotel Panama Casco Viejo
  • 8 Oct - 13 Oct

    Megapolis Hotel Panamá + Flight

    San Francisco
    5 nights
    4.5 star property
    8.4/10 - Very good (1,639 reviews)
    Return Medellín (MDE) - Panama City (PTY)
    MDE - PTY1 stop PTY - MDE1 stop
    £1,253
    £505
    per traveller
    found 9 hours ago
    Megapolis Hotel Panamá
  • 8 Oct - 13 Oct

    Hyatt Regency Panama City + Flight

    Bella Vista
    5 nights
    5.0 star property
    9.6/10 - Exceptional (400 reviews)
    "Great atmosphere. Staff was very helpful when asking for directions and information, some more than others. Everything was clean. I really liked this hotel and my stay."
    Reviewed August 4, 2026
    Return Medellín (MDE) - Panama City (PTY)
    MDE - PTY1 stop PTY - MDE1 stop
    Save 100% on your flight
    £758
    £488
    per traveller
    found 9 hours ago
    Hyatt Regency Panama City
  • 8 Oct - 13 Oct

    Las Americas Golden Tower Panama + Flight

    San Francisco
    5 nights
    4.0 star property
    9.0/10 - Wonderful (1,061 reviews)
    Return Medellín (MDE) - Panama City (PTY)
    MDE - PTY1 stop PTY - MDE1 stop
    £680
    £469
    per traveller
    found 9 hours ago
    Las Americas Golden Tower Panama

Nombre de Dios Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my Nombre de Dios holiday with Expedia?

Choose Expedia to plan your next big adventure simply and all in one place. Our insider tip for landing a fabulous deal on a Nombre de Dios getaway? Bundle your flights, hotel and/or car hire into a package holiday. Then throw in some exciting tours and activities. Many bookings also include flexible cancellation policies, so there's no need to stress if you have to switch up your itinerary. Round-the-clock help with changing and cancelling your trip is available via our Customer Service Portal link.

When is the best time of year to holiday in Nombre de Dios?

To enjoy the atmosphere of peak season, pack your bags for January, February and October. August, November and December are typically quieter and a good idea if you want to get away from the crowds. To get an idea of what type of weather you can experience, the daytime average temperature in January, the coolest month in Nombre de Dios, is 26ºC. The warmest time here is May, when temperatures reach around 27ºC.

What is the top hotel for my holiday in Nombre de Dios?

Relax in comfort in Nombre de Dios by choosing Melia Panama Canal as your home-away-from-home and gateway to exploration and adventure.

How do I get a cheap holiday to Nombre de Dios?

Combining your flight and hotel with Expedia won't just save valuable time — it'll save you pounds too. A Nombre de Dios holiday makes it a breeze to create the perfect trip. With more than 400 airlines around the world to select from, finding convenient flights that suit your busy schedule won't be a challenge. In addition to that, we have over 321,000 hotel options globally to pick from. Now that's what you call choice. Whatever your budget, Expedia can show you the world. Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.

What should I do on my Nombre de Dios holiday?

Every great holiday in Nombre de Dios has to include a stop at Portobelo National Park. But that's not the only thing to see and do in this area, so do some research into other cool attractions.

Do I need a visa for my Nombre de Dios holiday?

Visa requirements for Nombre de Dios vary depending on your nationality and reason for your visit. Be sure to check official government websites to determine if you need a visa for your trip. This is also a good place to find the most up-to-date information, including details about application procedures or any supporting documentation you may need. Enquire about your visa requirements in advance to ensure a hassle-free travel experience. Finally, check to see that your passport is valid for a further six months from your planned date of return.

What should I wear on my Nombre de Dios holiday?

Though everyone's style is different, it can be useful to have a few guidelines for what type of clothes to bring during your holiday in Nombre de Dios. Think about looking up social media before you go for inspiration on fashion trends or dress codes. Daytime temperatures during January, Nombre de Dios's coolest month, are around 26ºC. May marks this destination's warmest month when the average reaches 27ºC. Our suggestion? Take the guesswork out of packing and check the weather forecast.

What does an Expedia Nombre de Dios holiday include?

Choose from any combination of hire cars, flights and hotels. Once you've made your booking, add the fun stuff like experiences and tours. Want to pick your fare class? That's easily done too. The choice is yours when it comes to putting together your perfect Nombre de Dios trip. Expedia has different types of properties, with the most well known in Nombre de Dios being private holiday homes. With Expedia, you can expect the freedom and flexibility to personalise your holiday however you like.

Does Expedia offer Book Now, Pay Later Nombre de Dios holidays?

Good news! We do. Expedia has teamed up with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan that works for you during checkout and take away the stress of budgeting for your trip. Don't forget to bundle your accommodation, flights and activities with Expedia to get the biggest bang for your holiday buck. Consider these flexible payment options below:

  • Pay monthly holidays: Klarna offers the ability to pay in multiple transactions that work for all budget sizes, so you can lock in that well-deserved holiday sooner.
  • No-deposit holidays: If not paying upfront for your getaway makes pressing that "book now" button more stress-free, opt for a no-deposit holiday plan with Klarna so that you can Book Now, Pay Later!

Can I choose my airline with a Nombre de Dios Expedia holiday?

Expedia offers access to more than 400 partner airlines globally, so you definitely can. Simply select the airline you want and craft your ideal Nombre de Dios getaway.