Mission Bay Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Mission Bay Holiday

Organising your next adventure just got easier with a holiday package to Mission Bay. Enjoy all this neighbourhood has to offer while creating beautiful memories that'll stay with you for years. When it's time to explore the sights, you'll find a lot of big-name attractions nearby including Pier 39, Lombard Street and Oracle Park. Tick off one, two or all during your trip to Mission Bay. No matter your travel plans or budget, booking a perfect Mission Bay holiday is easy with Expedia.

Price found within the past 48 hours. Click for updated prices.
  • Deluxe Room, 2 Double Beds | Premium bedding, blackout curtains, free WiFi, bed sheets
    Aug 17 - Aug 27

    The Grove Inn + Flight

    Western Addition
    10 nights
    3.0 star property
    9.2/10 - Wonderful (714 reviews)
    "The Grove Inn was great for a quick trip into San Francisco. Close enough to the area. Be mindful it is San Francisco and the streets are definitely full of hilss. If you can walk, everything is close enough. If you can't, Ubers are always available. The hotel itself was clean and secure with the charm of the Victorian Homes that are known for the area. Will definitely return to stay again. Thank you Azizza!"
    Reviewed May 20, 2026
    Return • Manchester (MAN) - San Francisco (SFO)
    MAN - SFO • 1 stop SFO - MAN • 1 stop
    £2,193
    £1,488
    per traveller
    found 1 day ago
    The Grove Inn
  • Terrace/patio
    Aug 17 - Aug 27

    Claremont Resort & Club + Flight

    Claremont Hills
    10 nights
    5.0 star property
    9.0/10 - Wonderful (1,000 reviews)
    "Friendly bar in the restaurant"
    Reviewed May 24, 2026
    Return • Manchester (MAN) - San Francisco (SFO)
    MAN - SFO • 1 stop SFO - MAN • 1 stop
    Save 100% on your flight
    £2,833
    £1,704
    per traveller
    found 1 day ago
    Claremont Resort & Club
  • Meeting facility
    Aug 17 - Aug 27

    The Huntington Hotel + Flight

    Downtown San Francisco
    10 nights
    5.0 star property
    9.0/10 - Wonderful (18 reviews)
    Return • Manchester (MAN) - San Francisco (SFO)
    MAN - SFO • 1 stop SFO - MAN • 1 stop
    Save 100% on your flight
    £4,260
    £2,752
    per traveller
    found 1 day ago
    The Huntington Hotel
  • Breakfast, lunch and dinner served
    Jul 31 - Aug 7

    1 Hotel San Francisco + Flight

    Downtown San Francisco
    7 nights
    5.0 star property
    9.2/10 - Wonderful (555 reviews)
    "top-notch could notask for anything better, love the bikes! If they could add a infinity pool, that would be awesome"
    Reviewed May 25, 2026
    Return • London (LGW) - San Francisco (SFO)
    LGW - SFO • 2 stops SFO - LGW • 2 stops
    Save 100% on your flight
    £2,838
    £1,851
    per traveller
    found 1 day ago
    1 Hotel San Francisco
  • Lunch, dinner and brunch served
    Jul 31 - Aug 7

    Treehouse Hotel Silicon Valley + Flight

    Sunnyvale
    7 nights
    5.0 star property
    9.6/10 - Exceptional (98 reviews)
    "Amazing property ! Highly recommend . No ice Machine which was different, but overall the stay was nice"
    Reviewed May 26, 2026
    Return • London (LGW) - San Francisco (SFO)
    LGW - SFO • 2 stops SFO - LGW • 2 stops
    Save 100% on your flight
    £3,187
    £2,249
    per traveller
    found 1 day ago
    Treehouse Hotel Silicon Valley

Where to stay in Mission Bay

Find the best Mission Bay areas and neighborhoods for the activities you enjoy most. Learn more about Mission Bay
Union Square

Union Square

4/5(289 area reviews)

Fashion puts on its finest face in one of the country’s largest shopping plazas.

Find hotels in Union Square

Top hotels in Mission Bay

LUMA Hotel San Francisco

LUMA Hotel San Francisco

4 out of 5
100 Channel Street San Francisco CA
The price is £200 per night from 7 Jun to 8 Jun
£200
7 Jun - 8 Jun
includes taxes & fees
9.6/10 Exceptional! (2,500 reviews)
"Really like the automation, the rooms and the robots.... and the coffee shop is nice too. Will go back."

Reviewed on 28 May 2026

LUMA Hotel San Francisco
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £184 per night from 8 Jun to 9 Jun
£184
8 Jun - 9 Jun
includes taxes & fees
9/10 Wonderful! (7,478 reviews)
"very comfortable to stay in hte hotel"

Reviewed on 29 May 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £132 per night from 5 Jun to 6 Jun
£132
5 Jun - 6 Jun
includes taxes & fees
8.8/10 Excellent! (2,824 reviews)
"The beds were a little hard and very squeaky but over all it was nice"

Reviewed on 28 May 2026

Hilton San Francisco Financial District
See all 4,463 properties in Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Mission Bay travel package cost?
Say yes to new adventures with our Mission Bay travel packages, which start from a low . Choose the flights and hotels that match your travel style. Then, add on one or two tours or experiences for an unforgettable escape.
If I'm not able to travel, can I cancel my Mission Bay travel package?
It is possible to cancel your Mission Bay booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to cancel or change free of charge if you booked in the last 24 hours. Head to our Customer Service Portal for more information.
How do I get a cheap travel package to Mission Bay?
It's easy. Just bundle everything together. Flights, rental cars and hotels — combine whatever you need into a Mission Bay travel package to save loads of cash. Score even more discounts when you add extras such as experiences or tours to your booking. But that's not the only impressive part. You have the freedom to customize your holiday your way. We offer over 550 air carriers and 1,000,000 hotels across the world, so that everyone has a chance to travel and fulfil those holiday fantasies.
Does Expedia offer Book Now, Pay Later Mission Bay holidays?
Expedia has teamed up with online lender Klarna to make booking your next getaway easier on your bank balance. Paying by instalment means you can spread the costs of your dream holiday, leaving you with more cash to splash while you're away. Klarna has several payment plans to choose from, so you're sure to find one that suits your budget. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that work for all budget sizes, so you can have that well-earned holiday now.
  • Pay in instalments holidays: If you want to pay off your getaway in multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: If paying a small percentage of your trip (rather than all of it upfront) makes it easier to hit that "book now" button, opt for a low deposit holiday payment plan with Klarna.

Where should I stay in Mission Bay?
Urban explorers come from every corner of the globe to experience Golden Gate Bridge and Pier 39 in Mission Bay. Book yourself a room near these top attractions and visit them at your leisure.
What are the top hotels in Mission Bay?
If this will be your first visit to Mission Bay, book a room at Hilton San Francisco Financial District or San Francisco Marriott Marquis. Both have good amenities and are popular options with many savvy travellers.
How far in advance should I book my Mission Bay holiday?
Search Expedia to compare international airfares ASAP. You can usually purchase a seat up to a year in advance. If you don't see your preferred carrier, or you've left things to the last moment, don't worry. Cheap tickets to Mission Bay sometimes emerge a few weeks before the date of departure.
What does an Expedia Mission Bay travel package include?
Expedia has all you need to book your Mission Bay trip, but what your package looks like is totally up to you. Pick from a combination of rental cars, flights and hotels. Searching for some tours or activities to keep you busy? Once you've made your booking, you can add them on too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Mission Bay travel package?
An Expedia travel package can be customized for your circumstances and is a simple way to make your money go further. What you include is your call. Rental cars, hotels and flights — come up with a combination that suits your plans.
Can I choose my airline with a Mission Bay Expedia travel package?
Yes, and with over 550 airlines to pick from throughout the world, you have loads of choice. Look through the available options and find out which airline best suits your budget and needs.

Popular places to visit

Chase Center San Francisco Skyline Aerial Photography

Chase Center

Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices.

Chase Center

Things to do

Alcatraz Visit with Night Option and SF Bay Cruise

Alcatraz Visit with Night Option and SF Bay Cruise

£92
per adult
94% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat

San Francisco Bay Sightseeing Cruise International Narration

£29
per adult
92% of travellers recommend
San Francisco Bay Sightseeing Cruise International Narration
San Francisco City Lights Cruise

California Sunset Cruise (2-hours)

£43
per adult
94% of travellers recommend
California Sunset Cruise (2-hours)
See all activities in San Francisco

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.