Mediterranean Region Holidays from £295

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Top Mediterranean Region Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

Nomentano
£295
per person
14 Nov - 18 Nov
found 1 day ago
Return flight included
London (LGW) to Rome (FCO)
9.6/10 Exceptional! (318 reviews)
Hotiday Roma Trevi

Hotiday Roma Trevi

Rome City Centre
£605
per person
31 Oct - 3 Nov
found 21 hours ago
Return flight included
London (LHR) to Rome (FCO)
No reviews
SIRTAJ - Beverly Hills

SIRTAJ - Beverly Hills

South of Wilshire
£766
per person
19 Oct - 24 Oct
found 1 day ago
Return flight included
London (LHR) to Los Angeles (LAX)
8.2/10 Very good! (1,006 reviews)
Apollo Boutique Hotel

Apollo Boutique Hotel

Prati
£569
per person
18 Oct - 22 Oct
found 22 hours ago
Return flight included
London (LHR) to Rome (FCO)
9.2/10 Wonderful! (142 reviews)
Nice establishment. Didn’t receive the complimentary sparkling wine thou.

Reviewed on 11 Sept 2026

Relais de la Poste

Relais de la Poste

Rome City Centre
Save 100% on your flight
£650
per person
24 Oct - 28 Oct
found 1 day ago
Return direct flight included
London (LGW) to Rome (FCO)
9.2/10 Wonderful! (720 reviews)
We really enjoyed our stay at this hotel. The location was excellent, and everything was very clean and smelled fresh. They had water, sparkling water, ice, and coffee available for guests. This was our second trip to Italy, and we in total stayed in 8 boutique hotels during our trip. This one was definitely the best. On our last day, which was raining they even had umbrellas ready for guests. We would definitely stay here again!

Reviewed on 12 Sept 2026

Where to stay in Mediterranean Region

Find the best Mediterranean Region areas and neighborhoods for the activities you enjoy most. Learn more about Mediterranean Region
A historic building with a dome and columns, surrounded by pedestrians and parked vehicles.

Rome City Centre

Trevi Fountain and Piazza Navona are a few top attractions in Rome City Centre. Hop around the city on the metro at Venezia Tram Stop or Arenula-Cairoli Tram Station and check out the area's fascinating museums, stunning cathedral and stunning river views.

Find hotels in Rome City Centre
A busy urban street with historic buildings, a clock tower, and a bus.

Madrid Centro

Known for its fascinating museums and acclaimed art galleries, there's plenty to explore in Madrid Centro. Check out top attractions like Gran Via and Puerta del Sol, and jump on the metro at Sol Station or Gran Via Station to see more of the city.

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A cityscape with a prominent stone wall and a view of the city below.

Lisbon City Center

Avenida da Liberdade and Rossio Square are top sights in Lisbon City Center, and you should be sure to explore the popular shops. Hop aboard the metro at Saldanha Station or Sao Sebastiao Station to see more sights in the area.

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A classical building with columns and statues, surrounded by well-maintained hedges and a clear blue sky.

Athens City Centre

Known for its fascinating museums, charming cafes and popular shops, there's plenty to explore in Athens City Centre. Top attractions like Syntagma Square and Acropolis are major draws. Catch the metro at Panepistimio Station or Syntagma Station to see more of the city.

Find hotels in Athens City Centre
A classical fountain with multiple statues, including a prominent figure holding a staff, surrounded by water.

Rome Historic Centre

Visit the center of Italy’s capital and enjoy traditional Italian food. Relax in old bars and see some of the city’s famous historic sites.

Find hotels in Rome Historic Centre

Top hotels in Mediterranean Region

Hotel101- Madrid

Hotel101- Madrid

Av. de las Fuerzas Armadas, 328 Madrid
Fully refundableReserve now, pay when you stay
£77
20 Sept - 21 Sept
includes taxes & fees
Hotel101- Madrid
Barcelona Airport Hotel

Barcelona Airport Hotel

Plaza de la Volateria, 3 El Prat de Llobregat
Fully refundableReserve now, pay when you stay
£143
27 Sept - 28 Sept
includes taxes & fees
8.6/10 Excellent! (5,199 reviews)
"Great place to stay while heading to the airport. Good food, wine and shuttle."

Reviewed on 14 Sept 2026

Barcelona Airport Hotel
Swandor Hotels & Resort Topkapi Palace - All Inclusive

Swandor Hotels & Resort Topkapi Palace - All Inclusive

Kundu Aksu Antalya Antalya
Fully refundableReserve now, pay when you stay
£171
3 Oct - 4 Oct
includes taxes & fees
9/10 Wonderful! (2,317 reviews)
"I have been in more than 10 luxury hotels in Antalya and I can tell you that Swandor Topkapi is something different, it is an experience not just a hotel. Here, everything is perfect and well thought out even in the smallest details. The cleanliness, staff, food, rooms, entertainment, restaurant, ..."

Reviewed on 14 Sept 2026

Swandor Hotels & Resort Topkapi Palace - All Inclusive
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Where to go when
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Stay near popular Mediterranean Region attractions

The Colosseum in Rome with tourists around.

Colosseum

9.4/10 (44,408 reviews)
One of Rome's most famous landmarks, and one of the world's most notable monuments, no visitor to Rome should miss the opportunity to visit this iconic structure.
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The Sagrada Familia with a construction crane in the foreground.

Sagrada Familia

9.4/10 (32,723 reviews)
Gaudí’s basilica in the center of Barcelona is an architectural marvel and offers views across the city from eight towering spires.
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The Trevi Fountain with sculptures and a large archway.

Trevi Fountain

9.2/10 (43,482 reviews)
Rome is a city abundant in world-class water features, but none more stunning, or more famous, than the Trevi Fountain.
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A cityscape at dusk with historic buildings, a prominent Rolex store, and a busy street.
Photo by National Tourist Office of Spain

Gran Via

9.4/10 (23,455 reviews)
Madrid’s famous shopping strip has boutiques and international brands, an exciting nightlife and an impressive display of early 20th-century architecture.
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A coastal cityscape at dusk with illuminated buildings, a marina, and a prominent fortress-like structure.

Port of Civitavecchia

8.6/10 (754 reviews)
Explore the waterfront in Civitavecchia with a trip to Port of Civitavecchia. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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A bustling urban square with historic buildings, a central mosaic, and pedestrians.

La Rambla

8.8/10 (31,278 reviews)
These lively pedestrian streets in the heart of Barcelona are filled with flower stalls, tapas restaurants and street performers.
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A large neoclassical building with columns and the inscription "MAGRIPPA COSTERTIVI".

Pantheon

9.4/10 (37,189 reviews)
One of ancient Rome’s greatest achievements combines momentous history and inspired architecture.
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A clear turquoise sea, a sandy beach, and a resort with white buildings and palm trees.

Playa de Muro

8.8/10 (1,444 reviews)
A holiday in Platja de Muro, on the island of Mallorca, is the ideal way to spend your next summer. Find out everything it has to offer!
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.