The Best Hotels Closest to Mayo Clinic Florida in Jacksonville - 2026 Updated Prices

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A modern kitchen with a bar area, seating, and a view of the outdoors.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

0.7 mi from Mayo Clinic Florida

Michaelanne

£115

includes taxes & fees

11 Sept - 12 Sept

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

0.5 mi from Mayo Clinic Florida

Mercedes

£126

includes taxes & fees

7 Sept - 8 Sept

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

An outdoor patio with a pool, wooden pergola, and seating area.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida

Tiffany

£100

includes taxes & fees

6 Sept - 7 Sept

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida

Patsy

£107

includes taxes & fees

23 Aug - 24 Aug

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A Holiday Inn Express & Suites building with a modern facade, a prominent entrance, and a well-maintained outdoor area with palm trees and a landscaped garden.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

1.6 mi from Mayo Clinic Florida

Jorge

£89

includes taxes & fees

20 Sept - 21 Sept

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.2 mi from Mayo Clinic Florida

Troy

£127

includes taxes & fees

29 Aug - 30 Aug

A wooden deck leading to a picnic area with a table and benches, surrounded by a wooden fence and palm trees.

A living room with a grey sofa, wicker armchairs, a glass coffee table, a potted plant, and a wall art piece.

A bedroom with a bed, a nightstand, a lamp, a wicker chair, a coffee table, and a potted plant.

A backyard with a swimming pool, wooden deck, lounge chairs, and palm trees.

7. The Hotel Palms Poolside

4.8 mi from Mayo Clinic Florida

Vinny

£142

includes taxes & fees

23 Aug - 24 Aug

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A pathway leading to a sunset over a beach with sand and grass.

A modern building entrance with a sign reading "element by Westin".

A modern conference room with a long table, several chairs, and pendant lighting.

8. Element by Marriott Jacksonville Beach

3.4 mi from Mayo Clinic Florida

Tablo

£134

includes taxes & fees

27 Aug - 28 Aug

A hotel entrance with a covered walkway, palm trees, and a clear sign indicating a handicap-accessible entrance.

A modern reception area with a reception desk, seating area, and a view of the outdoor space.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

A modern dining area with wooden tables and red chairs, a coffee station, and a seating area with a blue accent wall.

9. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 4.8 mi from Mayo Clinic Florida

Satish

£107

includes taxes & fees

23 Aug - 24 Aug

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

A modern living room with sofas, a coffee table, and a dining area.

10. TownePlace Suites by Marriott® Jacksonville Mayport

6.7 mi from Mayo Clinic Florida

Paul

£119

includes taxes & fees

26 Aug - 27 Aug

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

11. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 4.8 mi from Mayo Clinic Florida

Alicia

£92

includes taxes & fees

28 Aug - 29 Aug

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A modern building with multiple balconies overlooking a beach.

A cafe with a tropical mural, a coffee menu, and a variety of seating options.

A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

12. Margaritaville Jacksonville Beach

3.7 mi from Mayo Clinic Florida

Noelia

£125

includes taxes & fees

9 Sept - 10 Sept

A spacious lobby with a reception desk, seating area, and large windows.

A bar area with wooden chairs, a round table, and a brick wall.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

13. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

5.3 mi from Mayo Clinic Florida

Brooke

£104

includes taxes & fees

31 Aug - 1 Sept

A spacious lobby with a central seating area, large windows, and a fountain.

A hotel room with two beds, a desk, a chair, a TV, and a view of the ocean.

A beach umbrella with two chairs underneath, a sandy beach, and the ocean in the background.

14. Ponte Vedra Inn & Club

3.9 mi from Mayo Clinic Florida

Michael

£392

includes taxes & fees

31 Aug - 1 Sept

A pool with a waterfall feature, surrounded by large rock formations.

A balcony with a view of the ocean, a chair, and a railing.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A hotel with a pool, a parking lot, and a view of the ocean.

15. Hampton Inn Jacksonville Beach/Oceanfront

3.9 mi from Mayo Clinic Florida

Kevin

£141

includes taxes & fees

7 Sept - 8 Sept

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern bar area with seating, a bar counter, and a view of the city through large windows.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

A modern hotel with a pool, palm trees, and a clear blue sky.

16. AC Hotel Jacksonville St Johns Town Center

Southside, 5 mi from Mayo Clinic Florida

Alysha

£149

includes taxes & fees

22 Aug - 23 Aug

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

A hotel with a central tower, a parking area, and a lake view.

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 6.7 mi from Mayo Clinic Florida

stacy

£106

includes taxes & fees

7 Sept - 8 Sept

An outdoor patio with seating, a fire pit, and string lights.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

18. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 5.4 mi from Mayo Clinic Florida

David

£113

includes taxes & fees

3 Sept - 4 Sept

A buffet with labeled containers of omelets and other dishes.

A modern office space with two desks, each with a computer monitor, keyboard, and chair.

A golf course with a water hazard and a bridge.

A hotel lobby with a reception desk, seating area, and a wall with a mountain mural.

19. Holiday Inn Express Jacksonville Beach by IHG

2.9 mi from Mayo Clinic Florida

Salvador

£96

includes taxes & fees

30 Aug - 31 Aug

A self-service beverage station with a refrigerated display and a coffee machine.

A snack display in a store with various chips and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

20. Tru By Hilton Jacksonville St Johns Town Center

Southside, 5.4 mi from Mayo Clinic Florida

Janet

£92

includes taxes & fees

23 Aug - 24 Aug

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 585 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 324 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 650 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,005 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,019 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent

"Really nice! The room was lovely, the staff was great and it was the best breakfast spread we’ve seen on our 2 week road trip!"

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Nice breakfast very satisfying"

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"This is one of the best-run hotels we have ever stayed in. They obviously have fantastic management. It’s reflected in the state of the rooms, the housekeeping staff, the common areas…all are excellent. As a result, we had a great stay. Can’t say enough about the staff. Everyone we encountered at the front desk was friendly, kind, and so helpful. We’ll be returning to Jacksonville in the future and won’t be staying anywhere else!"

Comfy Mayo Retreat: Pool & Close to Beach

10/10 Excellent

"Great location with a really nice park close by to walk the dogs. The pool was perfect!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

10/10 Excellent

"Cute, nicely decorated house in a quiet neighborhood but close to grocery and restaurants. Not far from the beach. Host was extremely helpful and responsive. Hope to stay here again soon."

Private Pool Getaway • 5min Beach • Sleeps 9

10/10 Excellent

"We had a wonder time ! Very clean and close to beaches and shopping ! Highly recommend!"

Beach Retreat in Jacksonville: Pet/Family-Friendly

10/10 Excellent

"Our stay was great there was plenty of room for our group of 12. The house was clean and the pool was a huge hit."

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Wonderful property! My family loved the pool table and darts. So much fun. Thanks for a great weekend."

Quiet Coastal Home w/ Patio Near Beaches

8/10 Good

"It was a pleasure staying here, the house was exactly as pictured showed. We were close to shopping areas and was only 10 min from the beach, which was a plus. I enjoyed the enclosed porch and the large yard( please just make sure the grass is cut before guest arrives) I love that the host communicated quickly. I would definitely book again. Thank you!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 45 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 45 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at Players by the Sea, SeaWalk Pavillion and Wilson Center For the Arts. Spend some time exploring the the natural beauty of Cradle Creek Preserve, Huguenot Park and Oceanfront Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Search Hotels Near Mayo Clinic Florida, Jacksonville

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. TownePlace Suites by Marriott Jacksonville East

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. The Hotel Palms Poolside

8. Element by Marriott Jacksonville Beach

9. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

10. TownePlace Suites by Marriott® Jacksonville Mayport

11. Hyatt Studios Jacksonville/St Johns Town Center

12. Margaritaville Jacksonville Beach

13. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

14. Ponte Vedra Inn & Club

15. Hampton Inn Jacksonville Beach/Oceanfront

16. AC Hotel Jacksonville St Johns Town Center

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

18. Hyatt Place Jacksonville / St. Johns Town Center

19. Holiday Inn Express Jacksonville Beach by IHG

20. Tru By Hilton Jacksonville St Johns Town Center

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

TownePlace Suites by Marriott Jacksonville East

Comfy Mayo Retreat: Pool & Close to Beach

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Private Pool Getaway • 5min Beach • Sleeps 9

Beach Retreat in Jacksonville: Pet/Family-Friendly

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Quiet Coastal Home w/ Patio Near Beaches

Frequently asked questions