The Best Hotels Closest to Mayo Clinic Florida in Jacksonville - 2026 Updated Prices

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Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

1. Hilton Jacksonville at Mayo Clinic near Beaches

0.5 mi from Mayo Clinic Florida

Patricia

£145

includes taxes & fees

17 Oct - 18 Oct

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

A modern kitchen with a bar area, seating, and a view of the outdoors.

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

0.7 mi from Mayo Clinic Florida

Michaelanne

£117

includes taxes & fees

24 Oct - 25 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

An outdoor patio with a pool, wooden pergola, and seating area.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida

gregory

£105

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida

Patsy

£94

includes taxes & fees

11 Oct - 12 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

1.6 mi from Mayo Clinic Florida

frances

£82

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.2 mi from Mayo Clinic Florida

Patricia

£130

includes taxes & fees

24 Oct - 25 Oct

A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.

A compact kitchen with a refrigerator, microwave, and a dining area with a table and chairs.

A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

7. Hotel Palms

4.8 mi from Mayo Clinic Florida

Vinny

£136

includes taxes & fees

7 Oct - 8 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A gym with treadmills, elliptical machines, and free weights.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 4.8 mi from Mayo Clinic Florida

Ian

£102

includes taxes & fees

11 Oct - 12 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern hotel lobby with a long reception desk, seating area, and large windows.

A modern conference room with a long table, several chairs, and pendant lighting.

A modern building entrance with a sign reading "element by Westin".

9. Element by Marriott Jacksonville Beach

3.4 mi from Mayo Clinic Florida

Nick

£130

includes taxes & fees

25 Oct - 26 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 4.8 mi from Mayo Clinic Florida

Corey

£99

includes taxes & fees

30 Oct - 31 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A hotel with a pool, a parking lot, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

11. Hampton Inn Jacksonville Beach/Oceanfront

3.9 mi from Mayo Clinic Florida

Hope

£145

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

A bar area with wooden chairs, a round table, and a brick wall.

12. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

5.3 mi from Mayo Clinic Florida

William

£99

includes taxes & fees

19 Oct - 20 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

13. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 8.2 mi from Mayo Clinic Florida

Chloie Marie

£83

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A modern bar area with a counter, bar stools, and a television screen.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

14. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 6.7 mi from Mayo Clinic Florida

Carol

£112

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio with seating, a fire pit, and string lights.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern living room with a dining area, a flat-screen TV, and a bookshelf.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

15. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 5.4 mi from Mayo Clinic Florida

Becky

£109

includes taxes & fees

11 Oct - 12 Oct

A beach with a sandy shore, waves, and buildings in the background.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

16. Best Western Oceanfront

3.6 mi from Mayo Clinic Florida

Stephanie

£112

includes taxes & fees

8 Oct - 9 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

A snack display in a store with various chips and snacks.

17. Tru By Hilton Jacksonville St Johns Town Center

Southside, 5.4 mi from Mayo Clinic Florida

Mary

£94

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

A coffee station with two espresso machines and a display of coffee products.

A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

2.9 mi from Mayo Clinic Florida

Bobby

£94

includes taxes & fees

18 Oct - 19 Oct

A terrace with wooden tables and chairs, overlooking a beach and a pier.

A beach with a wooden boardwalk leading to a pier.

A modern living room with a sectional sofa, two round coffee tables, wicker chairs, and large windows with sheer curtains.

A spacious outdoor dining area with wooden tables and chairs, a bar with stools, and large windows offering a view of the ocean.

19. Springhill Suites By Marriott Jacksonville Beach Oceanfront

3.6 mi from Mayo Clinic Florida

MELISSA

£149

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

A modern building with multiple balconies overlooking a beach.

20. Margaritaville Jacksonville Beach

3.7 mi from Mayo Clinic Florida

Keisha

£118

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 367 reviews	View
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 604 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 661 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,002 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,002 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"The room was very clean and the staff was great. I truly enjoyed my stay!!"

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

10/10 Excellent

"The manager was VERY helpful. We use this hotel when we go to Mayo spots. L. Bush."

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Place was exactly as pictured and perfect for our stay. Spacious, great amenities, and convenient location. Our family loved the putting green and pool table for some friendly competition. Top of our list as a place to stay the next time we're in JAX!"

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent

"Wonderful property! My family loved the pool table and darts. So much fun. Thanks for a great weekend."

Cozy & Comfy 3 bedroom residential home

10/10 Excellent

"Clean, close to Mayo Clinic, and host was very kind and quick to respond"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Search Hotels Near Mayo Clinic Florida, Jacksonville

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Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3. TownePlace Suites by Marriott Jacksonville East

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. Hyatt Studios Jacksonville/St Johns Town Center

11. Hampton Inn Jacksonville Beach/Oceanfront

12. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

13. Courtyard by Marriott Jacksonville I-295/East Beltway

14. Hotel Indigo Jacksonville-Deerwood Park by IHG

15. Hyatt Place Jacksonville / St. Johns Town Center

16. Best Western Oceanfront

17. Tru By Hilton Jacksonville St Johns Town Center

18. Holiday Inn Express Jacksonville Beach by IHG

19. Springhill Suites By Marriott Jacksonville Beach Oceanfront

20. Margaritaville Jacksonville Beach

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Hilton Jacksonville at Mayo Clinic near Beaches

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Cozy & Comfy 3 bedroom residential home

Frequently asked questions