Title: The Best Hotels Closest to Mayo Clinic Florida in Jacksonville - 2026 Updated Prices | Expedia.co.uk [Jacksonville Travel Guide](https://expedia.co.uk/Jacksonville.dx602997)[Holiday Rentals in Jacksonville](https://expedia.co.uk/Jacksonville-Holiday-Rentals.d602997.Travel-Guide-HolidayRentals)[Flights to Jacksonville](https://expedia.co.uk/Cheap-Flights-To-Jacksonville.d602997.Travel-Guide-Flights)[Things to do in Jacksonville](https://expedia.co.uk/Things-To-Do-In-Jacksonville.d602997.Travel-Guide-Activities)[Mayo Clinic Florida Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mayo-Clinic-Florida.d6127706.Car-Hire-Guide)[Mayo Clinic Florida Holidays](https://expedia.co.uk/Mayo-Clinic-Florida-Jacksonville.d6127706.Attraction) ![Jacksonville_MayoClinicFlorida_6127706_04](https://images.trvl-media.com/place/6127706/6901ae4a-327b-40c7-92f0-e912ea036578.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6127706/6901ae4a-327b-40c7-92f0-e912ea036578.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [7 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6127706&startDate=2026-02-07&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [8 Feb - 9 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6127706&startDate=2026-02-08&endDate=2026-02-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6127706&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6127706&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Mayo Clinic Florida hotels ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/b2da11bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/c1792edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/d0436ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/b1b680e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Jacksonville At Mayo Clinic [](https://www.expedia.co.uk/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information) 0.5 mi from Mayo Clinic Florida 9.6/10 Exceptional (135 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Judy £155 includes taxes & fees 19 Feb - 20 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/b5b95b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/8626ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/c8f0b79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/3b4310c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn By Marriott Jacksonville - Mayo Clinic Area [](https://www.expedia.co.uk/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information) 0.7 mi from Mayo Clinic Florida 9.4/10 Exceptional (460 reviews) "Clean room, amazing staff great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darlene £161 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/3ebd8af1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/a0b6a0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/a7e8a27c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/bb7e3270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott Jacksonville East [](https://www.expedia.co.uk/Jacksonville-Hotels-TownePlace-Suites-By-Marriott-Jacksonville-East.h50557569.Hotel-Information) Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida 9.2/10 Wonderful (571 reviews) "Very good hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Careli £96 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-TownePlace-Suites-By-Marriott-Jacksonville-East.h50557569.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/9eef35fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/1bf84034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/92e09e6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/1ba0722a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-Suites-Jacksonville-Beach-BlvdMayo-Clinic.h2880174.Hotel-Information) Golden Glades - The Woods, 1.9 mi from Mayo Clinic Florida 9.0/10 Wonderful (1,002 reviews) "Enjoyed the complimentary breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew £96 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-Suites-Jacksonville-Beach-BlvdMayo-Clinic.h2880174.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/620f795f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0036a1dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8 AM to 10 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/e289e58e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information) 1.6 mi from Mayo Clinic Florida 8.6/10 Excellent (1,009 reviews) "Staff was nice and room was clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles £98 includes taxes & fees 21 Feb - 22 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/7dde0660.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/ae56473a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/36a2496a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/3cb87b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches [](https://www.expedia.co.uk/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information) 0.2 mi from Mayo Clinic Florida 8.4/10 Very good (760 reviews) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Josiah Christine £135 includes taxes & fees 28 Feb - 1 Mar [](https://www.expedia.co.uk/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/ace2c9f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch TV with cable channels](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/8364a654.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/03ea9367.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/311013a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Salt Air Inn & Suites [](https://www.expedia.co.uk/Jacksonville-Hotels-Salt-Air-Inn-Suites.h74603302.Hotel-Information) 4.8 mi from Mayo Clinic Florida 9.8/10 Exceptional (428 reviews) "The room was roomy and clean very close to the beach and lot's of food options within walking distance " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) abilio [](https://www.expedia.co.uk/Jacksonville-Hotels-Salt-Air-Inn-Suites.h74603302.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/322c81fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/5d3207b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/24802fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/w5565h3712x0y0-2f0fd935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Element Jacksonville Beach [](https://www.expedia.co.uk/Jacksonville-Hotels-Element-Jacksonville-Beach.h67391288.Hotel-Information) 3.4 mi from Mayo Clinic Florida 9.6/10 Exceptional (535 reviews) "Great place (and location)!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale £135 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jacksonville-Hotels-Element-Jacksonville-Beach.h67391288.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/3cc4947f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/a435d2ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/dffb8ae9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/36e9c181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Jacksonville - Town Center by IHG [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-Town-Center.h34413457.Hotel-Information) Southside, 4.8 mi from Mayo Clinic Florida 9.6/10 Exceptional (1,003 reviews) "Great location, friendly staff, nice rooms, great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle £110 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-Town-Center.h34413457.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/898b0a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/78bc0b87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/9b491ef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/c7b511f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-JacksonvillePonte-Vedra-Beach-Mayo-Clinic-Area.h570425.Hotel-Information) 2.6 mi from Mayo Clinic Florida 9.0/10 Wonderful (1,027 reviews) "Clean room, good breakfast and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jesus £103 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-JacksonvillePonte-Vedra-Beach-Mayo-Clinic-Area.h570425.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking | Down duvets, minibar, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/b9cd2404.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking | Bathroom | Shower, rainfall showerhead, designer toiletries, hair dryer](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/fcfa2192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/c2598c1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/fe355a4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Hotel Palms [](https://www.expedia.co.uk/Jacksonville-Hotels-The-Hotel-Palms.h15784631.Hotel-Information) 4.8 mi from Mayo Clinic Florida 9.6/10 Exceptional (293 reviews) "stayed here for an event and it was awesome" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) clayton £149 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-The-Hotel-Palms.h15784631.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/2f9db172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/d12dee4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/2ef5c205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/714d9afd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott® Jacksonville Mayport [](https://www.expedia.co.uk/Jacksonville-Hotels-Towneplace-Suites-By-Marriott-Atlantic-Beach.h111923614.Hotel-Information) 6.7 mi from Mayo Clinic Florida 9.8/10 Exceptional (74 reviews) "New, clean room and nice breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory £105 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Towneplace-Suites-By-Marriott-Atlantic-Beach.h111923614.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/d30ef697.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/0eb8f75d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/04850bd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/512c8fad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Jacksonville Beach [](https://www.expedia.co.uk/Jacksonville-Hotels-Margaritaville-Jacksonville-Beach.h51266293.Hotel-Information) 3.7 mi from Mayo Clinic Florida 9.0/10 Wonderful (3,606 reviews) "Yes room was spotless and staff was amazing!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martina £112 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Margaritaville-Jacksonville-Beach.h51266293.Hotel-Information) ![Sports facility](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/130353e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/6ba7ab47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/dfe7c0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/0dae47f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Jacksonville / St. Johns Town Center [](https://www.expedia.co.uk/Jacksonville-Hotels-Hyatt-Place-Jacksonville-St-Johns-Town-Center.h29846486.Hotel-Information) Southside, 5.4 mi from Mayo Clinic Florida 9.2/10 Wonderful (1,001 reviews) "very friendly staff!! i love staying here!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evani £121 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Hyatt-Place-Jacksonville-St-Johns-Town-Center.h29846486.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/975500/975423/7989c84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/975500/975423/7977b403.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Irish cuisine, al fresco dining ](https://images.trvl-media.com/lodging/1000000/980000/975500/975423/b011ad1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/980000/975500/975423/4914098f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass [](https://www.expedia.co.uk/Jacksonville-Hotels-Hilton-Garden-Inn-Jacksonville-Ponte-Vedra-Sawgrass.h975423.Hotel-Information) 5.3 mi from Mayo Clinic Florida 9.2/10 Wonderful (1,004 reviews) "Very friendly staff, good restaurants in hotel and in the complex " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard £134 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jacksonville-Hotels-Hilton-Garden-Inn-Jacksonville-Ponte-Vedra-Sawgrass.h975423.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/8cf3943d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 2 Queen Beds, Balcony, Oceanfront | Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/b29f7074.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/c103e93e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 8:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/76bd5c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites By Marriott Jacksonville Beach Oceanfront [](https://www.expedia.co.uk/Jacksonville-Hotels-Springhill-Suites-By-Marriott-Jacksonville-Beach-Oceanfront.h90175988.Hotel-Information) 3.6 mi from Mayo Clinic Florida 9.0/10 Wonderful (634 reviews) "The hotel was great! Very clean room and staff were very courteous and professional" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike £156 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jacksonville-Hotels-Springhill-Suites-By-Marriott-Jacksonville-Beach-Oceanfront.h90175988.Hotel-Information) ![On the beach](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/cd4b0791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/105ea82f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/b0d3d74f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/3260d371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Oceanfront [](https://www.expedia.co.uk/Jacksonville-Hotels-Best-Western-Oceanfront.h119095.Hotel-Information) 3.6 mi from Mayo Clinic Florida 9.0/10 Wonderful (1,007 reviews) "Great location, breakfast was delicious " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul £109 includes taxes & fees 9 Feb - 10 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Best-Western-Oceanfront.h119095.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/100000000/99780000/99777200/99777110/335b1fee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99780000/99777200/99777110/5740568d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99780000/99777200/99777110/fba2ad11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/100000000/99780000/99777200/99777110/be234916.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel Jacksonville St Johns Town Center [](https://www.expedia.co.uk/Jacksonville-Hotels-AC-Hotel-Jacksonville-ST-Johns-Town-CTR.h99777110.Hotel-Information) Southside, 5 mi from Mayo Clinic Florida 9.4/10 Exceptional (176 reviews) "Staff was excellent...highly recommend this Hotel" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Robert £141 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-AC-Hotel-Jacksonville-ST-Johns-Town-CTR.h99777110.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/ac80791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/2040edc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/10ecbce2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/c5d5c944.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Jacksonville Beach by IHG [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information) 2.9 mi from Mayo Clinic Florida 9.2/10 Wonderful (1,000 reviews) "Hotel was clean, breakfast was perfect." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kurt £107 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information) ![2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/26800/26716/c86000c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26800/26716/e91db574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/30000/26800/26716/551a0744.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/30000/26800/26716/74f88633.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Jacksonville Beach/Oceanfront [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-Jacksonville-BeachOceanfront.h26716.Hotel-Information) 3.9 mi from Mayo Clinic Florida 9.2/10 Wonderful (2,633 reviews) "Great location, hot hot tub, courteous and proactive staff. Would definitely stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £130 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-Jacksonville-BeachOceanfront.h26716.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-21&endDate=2026-02-22®ionId=6127706&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to Mayo Clinic Florida | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | ------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/b2da11bc.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hilton Jacksonville At Mayo Clinic | 4.5 star property | 9.6Exceptional135 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/b5b95b3d.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Residence Inn By Marriott Jacksonville - Mayo Clinic Area | 3.0 star property | 9.4Exceptional460 reviews | View | | | | | | | ![Terrace/patio](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/3ebd8af1.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)TownePlace Suites by Marriott Jacksonville East | 3.0 star property | 9.2Wonderful571 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/9eef35fb.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic | 2.5 star property | 9.0Wonderful1,002 reviews | View | | | | | | | ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG | 2.5 star property | 8.6Excellent1,009 reviews | View | | | | | | ## Top Mayo Clinic Florida Hotel Reviews ![Hilton Jacksonville At Mayo Clinic](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/a30920c9_y.jpg) ### Hilton Jacksonville At Mayo Clinic 10/10 Excellent "Wonderful!" [](https://expedia.co.uk/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information) ![Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763_y.jpg) ### Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG 10/10 Excellent "Enjoyed our time." [](https://expedia.co.uk/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information) ![Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/7227c750_y.jpg) ### Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic 10/10 Excellent "Staff clean rooms" [](https://expedia.co.uk/Jacksonville-Hotels-Hampton-Inn-Suites-Jacksonville-Beach-BlvdMayo-Clinic.h2880174.Hotel-Information) ![Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/7dde0660_y.jpg) ### Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches 10/10 Excellent "Staff were very courteous; room, very clean and comfortable. The only problem was the a/c was noisy and interrupted our sleeping. Otherwise, great visit." [](https://expedia.co.uk/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information) ![Comfy Mayo Retreat; Heated Pool, Close to Beach](https://images.trvl-media.com/lodging/68000000/67200000/67195700/67195679/5cb6747d_y.jpg) ### Comfy Mayo Retreat; Heated Pool, Close to Beach 10/10 Excellent "The house was fully stocked with everything you could need. " [](https://expedia.co.uk/Jacksonville-Hotels-32-Home.h67195679.Hotel-Information) ![Modern Coastal Retreat w/ Private Pool](https://images.trvl-media.com/lodging/120000000/119750000/119746000/119745989/8544d748_y.jpg) ### Modern Coastal Retreat w/ Private Pool 10/10 Excellent "We would definitely stay here again. The host is fabulous, very quick to respond. The home had everything that we needed and more. Thanks for a great stay! " [](https://expedia.co.uk/Jacksonville-Hotels-Modern-Coastal-Retreat-W-Private-Pool.h119745989.Hotel-Information) ![Amazing Centrally Located Home in Peaceful Area](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608360/32fbbd37_y.jpg) ### Amazing Centrally Located Home in Peaceful Area 10/10 Excellent "The home was clean, and had enough space for our family." [](https://expedia.co.uk/Jacksonville-Hotels-Amazing-Centrally-Located-Home-In-Peaceful-Area.h100608360.Hotel-Information) ![5/2 Pool Cottage, Walk to Beach close to Mayo](https://images.trvl-media.com/lodging/97000000/96680000/96678600/96678592/451d0d91_y.jpg) ### 5/2 Pool Cottage, Walk to Beach close to Mayo 10/10 Excellent "Great property and a great location" [](https://expedia.co.uk/Jacksonville-Hotels-Shiplap-Pool-Cottage-Beach-52.h96678592.Hotel-Information) ![Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard](https://images.trvl-media.com/lodging/89000000/88400000/88398100/88398052/db3a0da5_y.jpg) ### Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard 10/10 Excellent "Great location to visit family being treated at the Mayo Clinic. Accomodated wheelchairs wonderfully." [](https://expedia.co.uk/Jacksonville-Hotels-Big-Wheelchair-Accessible-Home-Close-To-BeachMayo-With-Zen-Den-And-Fenced-Yard.h88398052.Hotel-Information) ## Hotels near other Mayo Clinic Florida attractions ### Adventure Landing 4.1/5 (157 reviews) This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6128080) ### Windsor Parke Golf Club Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6068663) ### Windsor Commons Shopping Center You can find the perfect gifts to bring home at Windsor Commons Shopping Center during your trip to Jacksonville. Experience the area's great live music and acclaimed theatre scene. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621558033805) ### Harbor City Municipal Golf Course Enjoy a round of golf in Jacksonville at Harbor City Municipal Golf Course. Amble around the area's beautiful beaches or attend a sporting event. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621563220206) ### Cradle Creek Preserve Explore the great outdoors at Cradle Creek Preserve, a lovely green space in Jacksonville Beach. Amble around this family-friendly area's beautiful beaches and enjoy its top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561766841) ### Jacksonville Beach Golf Club 3.9/5 (58 reviews) Enjoy a round of golf in Jacksonville Beach at Jacksonville Beach Golf Club. Wander through the beautiful beaches and seaside in this romantic area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561766896) ### South Beach Park and Sunshine Playground 4.3/5 (44 reviews) South Beach Park and Sunshine Playground is just one of the places to see in Jacksonville Beach, so why not enjoy the other things to explore during your travels? Stroll along the beautiful beaches or experience the acclaimed theatre scene in this family-friendly area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561892262) ### Gonzales Park 4.1/5 (31 reviews) Gonzales Park is just one of the places to see in Jacksonville Beach, so why not enjoy the other things to explore during your travels? Stroll along the seaside or experience the acclaimed theatre scene in this romantic area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621558033757) ## Frequently asked questions ### What's the area like around Mayo Clinic Florida? ### Where is the best place to stay close to Mayo Clinic Florida? ### How many hotels are there near Mayo Clinic Florida? ### If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund? ### What can I see and do near Mayo Clinic Florida?