Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Save up to 17% by booking Flight + Hotel.

Search 321,000 hotels and 400 airlines worldwide.

Get the price Guarantee available for your trip.


Main Street Hyannis Vacation Packages

Check out the sights in Main Street Hyannis, located 3 miles (5 kilometers) to the southeast of Cape Cod. A popular spot for visitors, Main Street Hyannis is about less than 1 mile (1.6 kilometers) from Barnstable Municipal Airport.

Main Street Hyannis is a great place to base yourself in Cape Cod as many of the city’s main attractions are close. Two sights that should be on every visitor’s list is the fabulous John F Kennedy Hyannis Museum and the much-loved Hyannis Harbor. Two other interesting attractions that are close by Main Street Hyannis are Kalmus Beach and the Hyannis Port Beach.

If you are looking for family fun, head to the various child-friendly attractions. Both kids and adults will appreciate the chance to relax and burn off some steam at the Pirate's Cove Mini Golf in South Yarmouth.

If the weather is good, follow the locals and appreciate the local natural destinations. Explore the coastal destinations nearby such as Seagull Beach in West Yarmouth.

If you have a passion for golf, visit the Bayberry Hills Golf Course in West Yarmouth and the Hyannis Golf Course in Barnstable. It’s a great way to enjoy the outdoors.

When you’re ready to rest your weary head after a day spent exploring the charming streets of Main Street Hyannis, check in to one of the area’s numerous accommodation options. Whether you’re staying for a night or a few weeks check out the amenities at the Bayside Resort Hotel, West Yarmouth, the International Inn Cape Cod, and the popular Heritage House Hotel.


Top Hotel Deals

See all 406 Hotels in Main Street Hyannis
£44
Americas Best Value Inn and Suites Hyannis/Cape Cod

Americas Best Value Inn and Suites Hyannis/Cape Cod

206 Main St, Hyannis
3.2
of 5, from 203 reviews
2.0 out of 5.0

Located in Main Street Hyannis, this hotel is within a 10-minute walk of John F. Kennedy Hyannis Museum, Cape Cod Baseball Hall of Fame, and Hyannis Harbor. Cape Cod Carousel and Wild Animal Lagoon are also within 15 minutes.

£51
Heritage House Hotel

Heritage House Hotel

259 Main Street, Hyannis
3.4
of 5, from 465 reviews
2.5 out of 5.0
£54
International Inn

International Inn

662 Main Street, Hyannis
3.0
of 5, from 616 reviews
2.5 out of 5.0

Located in Main Street Hyannis, this luxury hotel is within a 10-minute walk of Cape Cod Carousel, St. Francis Xavier Church, and Twin Brooks Golf Course. Cape Cod Melody Tent and Cape Cod Baseball Hall of Fame are also within 10 minutes.

£55
Cape Cod Inn

Cape Cod Inn

447 Main St, Hyannis
3.4
of 5, from 106 reviews
2.0 out of 5.0

Located in Main Street Hyannis, this motel is steps from Cape Cod Baseball Hall of Fame and John F. Kennedy Hyannis Museum. Cape Cod Carousel and St. Francis Xavier Church are also within 5 minutes.

£73
Bayside Resort Hotel

Bayside Resort Hotel

225 Route 28, West Yarmouth
4.0
of 5, from 806 reviews
3.0 out of 5.0

Bayside Resort Hotel is in West Yarmouth, less than 10 minutes’ drive from the airport in Hyannis, and within easy reach of Cape Cod. Guests have a great choice of beaches, and there are 20 golf courses within a 20-minute drive. Nantucket and Martha’s Vineyard are both a ferry ride away.

£96
Cape Codder Resort and Spa

Cape Codder Resort and Spa

1225 Iyannough Rd, Hyannis
3.7
of 5, from 203 reviews
3.0 out of 5.0

Situated near the airport, this spa resort is 1.2 mi (2 km) from Hyannis Golf Course and within 3 mi (5 km) of Coast Guard Heritage Museum and Barnstable Old Gaol. Barnstable Performing Arts Center and Cape Cod Carousel are also within 3 mi (5 km).

£69
Falmouth Inn

Falmouth Inn

824 Main Street, Falmouth
3.4
of 5, from 25 reviews
2.0 out of 5.0

Situated in Falmouth, this hotel is within 1 mi (2 km) of Island Queen Ferry, Falmouth Heights Beach, and Falmouth Museums on the Green. Menauhant Beach and College Light Opera Company are also within 2 mi (3 km).

£85
Hyannis Harbor Hotel

Hyannis Harbor Hotel

213 Ocean St, Hyannis
3.4
of 5, from 470 reviews
3.0 out of 5.0

Located on Hyannis Harbor, this hotel overlooks the Nantucket and Martha's Vineyard ferries; the JFK Memorial is 1 block away.

Top Flight + Hotel Deals