Title: Lewis and Clark Trail Trailhead in St. Louis | Expedia.co.uk [Lewis and Clark Trail Trailhead Hotels](https://expedia.co.uk/Lewis-And-Clark-Trail-Trailhead-Hotels.0-l641530008594042880-0.Travel-Guide-Filter-Hotels)[Flights to St. Louis](https://expedia.co.uk/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.co.uk/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Lewis and Clark Trail Trailhead Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Lewis-And-Clark-Trail-Trailhead.d641530008594042880.Car-Hire-Guide)[St. Louis Holidays](https://expedia.co.uk/St-Louis.d178309.Holidays-City-Breaks) # Lewis and Clark Trail Trailhead ## Visit Lewis and Clark Trail Trailhead Activities [St. Louis travel guide](https://expedia.co.uk/St-Louis.dx178309) --- --- ### Popular places to visit ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### August A. Busch Memorial Conservation Area Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/August-A-Busch-Memorial-Conservation-Area-St-Louis.d6160337.Attraction) ![9-11 memorial in New York ](https://images.trvl-media.com/place/6268196/1e2df18b-5a0c-4e2a-9bc0-6956a83c47d9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### 9-11 Memorial Learn about the local history of O'Fallon when you spend time at 9-11 Memorial. While in this family-friendly area, you can savour the top-notch restaurants. [](https://expedia.co.uk/9-11-Memorial-St-Louis.d6268196.Attraction) ![Chandler Hill Vineyards](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Chandler Hill Vineyards You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savour the top-notch restaurants. [](https://expedia.co.uk/Chandler-Hill-Vineyards-Defiance.d553248621532648567.Attraction) #### Weldon Spring Site Interpretive Center You can spend time studying the exhibits at Weldon Spring Site Interpretive Center during your trip to Weldon Spring Heights. Attend a sporting event while in this family-friendly area or simply enjoy the top-notch restaurants. [](https://expedia.co.uk/Weldon-Spring-Site-Interpretive-Center-St-Louis.d553248621532648611.Attraction) #### Hamburg Trail Trailhead You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg. [](https://expedia.co.uk/Hamburg-Trail-Trailhead-St-Louis.d641529175733194752.Attraction) #### Missouri Bluffs Golf Course Enjoy a round of golf in Weldon Spring Heights at Missouri Bluffs Golf Course. Experience the great live music or attend a sporting event in this family-friendly area. [](https://expedia.co.uk/Missouri-Bluffs-Golf-Course-St-Louis.d553248621532648614.Attraction) --- ## Top Hotel Deals ## Check availability on hotels close to Lewis and Clark Trail Trailhead [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-03-31&endDate=2026-04-01)[31 Mar - 1 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-03-31&endDate=2026-04-01) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-04-01&endDate=2026-03-02)[1 Apr - 2 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-04-01&endDate=2026-03-02) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[3 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026)[10 Apr - 12 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Wildwood Hotel 2801 Fountain Pl Wildwood MO [](https://expedia.co.uk/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/69d580ec_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel St. Louis Chesterfield 355 Chesterfield Ctr Chesterfield MO [](https://expedia.co.uk/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![Drury Inn & Suites St. Louis St. Peters](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/68bc6d17_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites St. Louis St. Peters 170 Mid Rivers Mall Circle St. Peters MO [](https://expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information) ![Fairfield Inn & Suites by Marriott St. Louis Chesterfield](https://images.trvl-media.com/lodging/1000000/130000/126800/126794/f06ceba4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott St. Louis Chesterfield 1065 Chesterfield Pkwy E Chesterfield MO [](https://expedia.co.uk/St-Louis-Hotels-SpringHill-Suites-By-Marriott-St-Louis-Chesterfield.h126794.Hotel-Information) ![Sonesta ES Suites St. Louis - Chesterfield](https://images.trvl-media.com/lodging/1000000/10000/500/422/6f160867_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sonesta ES Suites St. Louis - Chesterfield 15431 Conway Rd Chesterfield MO [](https://expedia.co.uk/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hollywood Casino & Hotel St. Louis 777 Casino Center Drive Maryland Heights MO [](https://expedia.co.uk/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/70b128db_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ameristar Casino Resort and Spa 1 Ameristar Blvd St. Charles MO [](https://expedia.co.uk/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![Embassy Suites by Hilton St. Louis St. Charles](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/ac68aac2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Embassy Suites by Hilton St. Louis St. Charles 2 Convention Center Plz St. Charles MO [](https://expedia.co.uk/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information) ![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Suites St Charles - St Louis 1400 S 5th St St. Charles MO [](https://expedia.co.uk/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) [See all 2,399 properties in Lewis and Clark Trail Trailhead](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=641530008594042880) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. 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