Title: Hotels in Isla Santa María - Best Isla Santa María Hotels from £34 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Isla Santa María](https://expedia.co.uk/Isla-Santa-Maria-Holiday-Rentals.d739209696364867584.Travel-Guide-HolidayRentals)[Isla Santa María Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Isla-Santa-Maria.d739209696364867584.Car-Hire-Guide)[Isla Santa María Holidays](https://expedia.co.uk/Isla-Santa-Maria.d739209696364867584.Holidays-City-Breaks) ![Sea lions soaking in some rays on the island of espanola in the Galapagos. Unfortunately no mai tai's on this beach. #LifeAtExpedia #nature](https://images.trvl-media.com/place/739209696364867584/329f8833-28e7-41c2-a4af-1e9e3462ce94.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Delen Wong ![](https://images.trvl-media.com/place/739209696364867584/329f8833-28e7-41c2-a4af-1e9e3462ce94.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Isla Santa María Spa [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&amenities=SPA_ON_SITE) Apart hotel [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&lodging=APART_HOTEL) Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&amenities=POOL) Sea view [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&amenities=OCEAN_VIEW) Apart­ment [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&lodging=APARTMENT) Hot tub [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&amenities=HOT_TUB) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&amenities=PETS) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-02-21&d1=2026-02-21&endDate=2026-02-23&d2=2026-02-23&travelerType=family_friendly) ## Check prices for these dates Tonight [7 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-02-07&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [8 Feb - 9 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-02-08&endDate=2026-02-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Isla Santa María hotels ![Interior](https://images.trvl-media.com/lodging/123000000/122700000/122698200/122698173/37ab94a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/123000000/122700000/122698200/122698173/e38fa236_edited_95c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Triple Room | Down duvets, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/123000000/122700000/122698200/122698173/232b41ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Double or Twin Room | Down duvets, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/123000000/122700000/122698200/122698173/c7251e4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### PENGUIN HOSTEL [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Penguin.h122698173.Hotel-Information) Puerto Ayora 10/10 Exceptional (2 reviews) "Love the stay, very welcoming atmosphere, wonderful owners, I recommend this to everyone" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LEO £36 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Penguin.h122698173.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119080000/119077900/119077847/1d8b2799.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Single Room | Laptop workspace, free WiFi](https://images.trvl-media.com/lodging/120000000/119080000/119077900/119077847/480813f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119080000/119077900/119077847/33a00204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119080000/119077900/119077847/4794a244.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ECO HOSTAL ISLA AZUL [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-ECO-HOSTAL-ISLA-AZUL.h119077847.Hotel-Information) Puerto Ayora 10/10 Exceptional (2 reviews) - Experience island comfort just steps from Galápagos National Park. "Loved that they had purified water to refill your water bottle instead of buying plastic! Staff were incredibly kind. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Jaclyn £132 11 Mar - 12 Mar [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-ECO-HOSTAL-ISLA-AZUL.h119077847.Hotel-Information) ![Breakfast, dinner served; local and international cuisine, sea views ](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/f2307f3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double or Twin Room | View from room](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/f92aa86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/2f16a828.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Duplex | View from room](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/5dea777b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ikala Galapagos Hotel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) Puerto Ayora 9.6/10 Exceptional (131 reviews) - Experience Galapagos steps from the national park with rooftop pool and terrace. "Gorgeous property and wonderful staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robyn £179 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/0a441130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, Terrace | View from room](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/62a98993.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/3b7f0639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food court](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/3a29c8f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cucuve [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) Puerto Ayora 9.8/10 Exceptional (274 reviews) - Explore the Galapagos from a B&B steps from the national park. "Wonderful staff, beautiful room, delicious breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley £178 23 Feb - 24 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/92acdc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine, sea views ](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/1d2d0c5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature | In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/f83773fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature | In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/d5ba3cfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blu Galapagos Sustainable Waterfront Lodge [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) Puerto Ayora 8.8/10 Excellent (125 reviews) - Stay on scenic waterfront in Galapagos with complimentary bike rentals. "Beautiful property " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) David £202 12 Feb - 13 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/2f892016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room, 1 Queen Bed, Ocean View | Premium bedding, in-room safe, individually decorated, desk](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/4c34b960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/102ca9ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily cooked-to-order breakfast ](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/1313257d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Angermeyer Waterfront Inn [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Angermeyer-Waterfront-Inn.h4884897.Hotel-Information) Puerto Ayora 9.4/10 Exceptional (129 reviews) - Explore Galápagos from a marina hotel with daily breakfast and adventure sports. "Very clean room, great staff and excellent location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tomasz £197 13 Feb - 14 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Angermeyer-Waterfront-Inn.h4884897.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/15000000/14660000/14658100/14658017/9110f771.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/15000000/14660000/14658100/14658017/f181106b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/15000000/14660000/14658100/14658017/4e8a4e60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/15000000/14660000/14658100/14658017/6bab7837.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel La Casa de Judy [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-La-Casa-De-Judy.h14658017.Hotel-Information) Puerto Ayora 9.0/10 Wonderful (165 reviews) - Explore Galápagos National Park from this peaceful hotel with outdoor pool. "We received an upgrade on the room with an ocean view. The room was clean, the staff friendly, breakfast was good, and the place is convenient to a laundry place and the downtown as well as the Darwin research center. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heidi £80 9 Mar - 10 Mar [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-La-Casa-De-Judy.h14658017.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/926c680e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/9ffdbf3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/75f9c54d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Finch Bay Galapagos Hotel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) Puerto Ayora 9.2/10 Wonderful (93 reviews) - Experience the Galapagos with direct beach access and on-site snorkelling adventures. "Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan £399 28 Feb - 1 Mar [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) ![Standard Triple Room | In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/2ca19af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/7e3fbe48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/64e7ee10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Bathroom | Shower, free toiletries, hair dryer, slippers](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/e94fe441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Capitan Max B&B [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Capitan-Max-BB.h14716616.Hotel-Information) Puerto Ayora 9.8/10 Exceptional (211 reviews) - Enjoy Galápagos Park from a welcoming B&B with complimentary breakfast. "Clean , friendly staff, accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anna [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Capitan-Max-BB.h14716616.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/112000000/111510000/111508100/111508035/9ff6c70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, Bay View | Exterior](https://images.trvl-media.com/lodging/112000000/111510000/111508100/111508035/3d626fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111510000/111508100/111508035/b352825f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111510000/111508100/111508035/9a095d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Barranco Galapagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Barranco-Galapagos.h111508035.Hotel-Information) Puerto Ayora 9.6/10 Exceptional (41 reviews) - Serene Galapagos retreat with Mediterranean style and poolside relaxation awaits. "Very comfortable hotel with good service and nice staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jairo £135 21 Feb - 22 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Barranco-Galapagos.h111508035.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/39000000/38820000/38819900/38819899/f1f7ec0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/39000000/38820000/38819900/38819899/c2bf4bc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/39000000/38820000/38819900/38819899/ee8ad519.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38820000/38819900/38819899/9c613ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mainao [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Mainao.h38819899.Hotel-Information) Puerto Ayora 9.6/10 Exceptional (34 reviews) - Experience Puerto Ayora's wonders steps from Galápagos National Park. "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pavel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Mainao.h38819899.Hotel-Information) ![Water view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/e0f99a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/fa27162b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/bb82add7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/9f35d995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Twin Hotel Galapagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Twin-Hotel-Galapagos-By-Rotamundos.h14842408.Hotel-Information) Bella Vista 8.4/10 Very good (45 reviews) - Discover panoramic Galápagos views from a family-friendly retreat with rooftop terrace. "This hotle is fantastic lovely people that work here Very helpful with booking tours ect . To rooms are so fantastic, comfortable bed can’t get any better and good breakfast." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chelsea £84 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Twin-Hotel-Galapagos-By-Rotamundos.h14842408.Hotel-Information) ![Jetted bathtub](https://images.trvl-media.com/lodging/10000000/9700000/9690700/9690626/19a51296.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9700000/9690700/9690626/bb93ee14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9700000/9690700/9690626/d6476f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/10000000/9700000/9690700/9690626/c4595842.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Fiesta [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Fiesta.h9690626.Hotel-Information) Puerto Ayora 9.0/10 Wonderful (390 reviews) - Escape to Galápagos National Park, with poolside amenities and nature at your doorstep. "Perfect place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carol £114 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Fiesta.h9690626.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/96c0ae07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/7136b5de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pingüinos | Premium bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/f685f5c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/f0b03fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Maidith Galapagos Inn [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Maidith-Galapagos-Inn.h88474681.Hotel-Information) Puerto Ayora 10/10 Exceptional (110 reviews) - Relax in Mediterranean comfort near Galápagos National Park with dual pools. "Overall excellent choice for a family stay in Puerto Ayora. Rooms are very clean and spacious and short walk to main ferry pier and lots of restaurants and shopping. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aaron £93 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Maidith-Galapagos-Inn.h88474681.Hotel-Information) ![Family Suite | Balcony view](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/e7fb3ff1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/da8f2af7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/e6b70681.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/70b1e5e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Posada del Mar [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) Puerto Ayora 9.8/10 Exceptional (217 reviews) - Relax in a pristine getaway just moments from Galápagos National Park. "This place is amazing, I only came across the lounge and kitchen on the higher floor on my second day but by far the best room during my trip" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharath £52 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) ![Beach nearby, white sand](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/bf30a401.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room, 2 Double Beds | Premium bedding, minibar, individually furnished, bed sheets](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/21a46bf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/c6391920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/a4592fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Ninfa [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) Puerto Ayora 8.4/10 Very good (223 reviews) - Relax in tropical beauty near Galápagos National Park with pool and spa services. "Great, clean, and convenient place. Good location close to docks. Walkable to the Main Street. Hotel rooms clean with good service and breakfast. We stayed here two seperate times during Galapagos and would stay again. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Aly £116 10 Feb - 11 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/27a5429e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/8283dd29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/c8e59971.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exclusive Double Room | In-room safe, blackout curtains, bed sheets](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/ba2b8217.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fernandina Hotel & Spa Galápagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-HOTEL-FERNANDINA.h90029511.Hotel-Information) Puerto Ayora 9.4/10 Exceptional (32 reviews) - Unwind at this oceanside retreat with pool, spa services, and Galápagos adventure. "Great staff! Cute room and pool/hot tub" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew £108 19 Feb - 20 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-HOTEL-FERNANDINA.h90029511.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/55000000/54130000/54122700/54122610/6b409832.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathroom sink](https://images.trvl-media.com/lodging/55000000/54130000/54122700/54122610/5b689e55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, bed sheets](https://images.trvl-media.com/lodging/55000000/54130000/54122700/54122610/7ca801a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/55000000/54130000/54122700/54122610/0a225066.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Leon Marino Galapagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Grand-Hotel-Lobo-Marino-Galapagos.h54122610.Hotel-Information) Puerto Ayora 8.8/10 Excellent (16 reviews) - Discover beachfront charm and adventure at this oceanside Puerto Ayora retreat. "Staff was very friendly and location convenient. Modern interior." ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Marc £68 10 Feb - 11 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Grand-Hotel-Lobo-Marino-Galapagos.h54122610.Hotel-Information) ![Standard Double or Twin Room, 1 Bedroom | Free minibar, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/10000000/9800000/9794800/9794727/faf80253.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/10000000/9800000/9794800/9794727/f4f162b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | Free minibar, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/10000000/9800000/9794800/9794727/a21927f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/10000000/9800000/9794800/9794727/f34c4f73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Santa Fe [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Santa-Fe.h9794727.Hotel-Information) Puerto Ayora 9.6/10 Exceptional (14 reviews) - Walking distance to Galápagos National Park with inviting outdoor pool. "Beautiful hotel, with amazing staff, and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven £156 10 Feb - 11 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Santa-Fe.h9794727.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/92000000/91760000/91753200/91753116/b9fd0c52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/92000000/91760000/91753200/91753116/0e46886e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91760000/91753200/91753116/8c7674f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living room](https://images.trvl-media.com/lodging/92000000/91760000/91753200/91753116/3e5d5308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Acacia Galapagos Boutique Hotel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Acacia-Galapagos-Boutique-Hotel.h91753116.Hotel-Information) Puerto Ayora 9.8/10 Exceptional (27 reviews) - Enjoy breathtaking nature steps from Galápagos National Park at this boutique retreat. "Beautiful boutique hotel with wonderful staff who attended to our every need. Breakfast was made fresh to order every morning- yogurt, fruit, granola, and then the main dish which was always eggs, a breakfast meat and some side dishes which changed daily. The entire hotel was spotless. Daily housekeeping kept our room spotless as well. Mini split air conditioning in our room kept us cool and comfortable. Many thanks for a wonderful stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £178 14 Feb - 15 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Acacia-Galapagos-Boutique-Hotel.h91753116.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23®ionId=739209696364867584&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Hotels.d739209696364867584.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Hotels.d739209696364867584.Travel-Guide-Hotels) ## Stay near popular Isla Santa María attractions ![Swimming with sea turtles was one of the many amazing moments of my Galapagos adventure. Like most of the other animals, they went about their business without seeming to even notice the people around. ](https://images.trvl-media.com/place/553248621554455070/325aa0d2-97cf-4c55-9857-ef170ef86bb3.jpg) Photo by Tove Martin ### Post Office Bay Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621554455070) ![Bedtime in the Galapagos #golden](https://images.trvl-media.com/place/553248621554455077/3a418a9c-4b02-498b-ba03-95c819b8b8f2.jpg) Photo by Delen Wong ### Punta Suarez Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621554455077) ## Learn more about Isla Santa María Explore attractions like Galápagos National Park and Post Office Bay as you discover things to see and do in Isla Santa María. [See all hotels in Isla Santa María](https://www.expedia.co.uk/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23&adults=2®ionId=739209696364867584) ![Sea lions soaking in some rays on the island of espanola in the Galapagos. Unfortunately no mai tai's on this beach. #LifeAtExpedia #nature](https://images.trvl-media.com/place/739209696364867584/329f8833-28e7-41c2-a4af-1e9e3462ce94.jpg?impolicy=fcrop&w=900&h=437&p=1&q=high) Photo by Delen Wong ## Top Isla Santa María Hotel Reviews ![Capitan Max B&B](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/7e3fbe48_y.jpg) ### Capitan Max B&B 10/10 Excellent "I wish I could rate 10 stars to Captain Max. The bedroom comfort, quietness, cleanliness, and location made our stay extremely enjoyable. But Max attentions were over the top every day. The best stay out of the 3 islands we stayed in the Galapagos " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Capitan-Max-BB.h14716616.Hotel-Information) ![Hotel el descanso del Guia](https://images.trvl-media.com/lodging/18000000/17530000/17525300/17525206/b6171efd_y.jpg) ### Hotel el descanso del Guia 10/10 Excellent "Beautiful room. Comfortable balcony. Wonderful staff. Fresh breakfast. Very clean hotel. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-El-Descanso-Del-Guia.h17525206.Hotel-Information) ![Hotel Ninfa](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e_y.jpg) ### Hotel Ninfa 10/10 Excellent "Clean room, great staff. Would be nice if there was an airport shuttle instead of putting us all on separate $30 taxis. Myself and five other guests all had separate taxis to get to the same ferry. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Fernandina Hotel & Spa Galápagos](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/27a5429e_y.jpg) ### Fernandina Hotel & Spa Galápagos 10/10 Excellent "Great staff! Cute room and pool/hot tub" [](https://expedia.co.uk/Puerto-Ayora-Hotels-HOTEL-FERNANDINA.h90029511.Hotel-Information) ![Blu Galapagos Sustainable Waterfront Lodge](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/92acdc7e_y.jpg) ### Blu Galapagos Sustainable Waterfront Lodge 10/10 Excellent "Great room with amazing view. Incredible service " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Hotel Cucuve](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/733c9cb5_y.jpg) ### Hotel Cucuve 10/10 Excellent "Very, very clean. The staff was exceptional. Great amenities- left water bottles for guests, one free drink per day, had a patio for guests to use by the water. Breakfast was a lot of variety. Would give a 10 pot of 10!!" [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) ![Galapagos Dreams](https://images.trvl-media.com/lodging/12000000/11700000/11698100/11698055/6897639d_y.jpg) ### Galapagos Dreams 10/10 Excellent "The entire staff was very friendly and helpful. Breakfast was good with hot coffee always on. The location was walking distance to tourist spots in town from the pier to Darwin’s research center. I booked my tours through Galapagos Dreams and Joatan worked up a personalized tour for me. This made my stay easier as the staff kept me informed of pick up times and activities. Overall it really made my stay very enjoyable. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-GALAPAGOS-DREAMS.h11698055.Hotel-Information) ![Ikala Galapagos Hotel](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/ecbf00ed_y.jpg) ### Ikala Galapagos Hotel 10/10 Excellent "Gorgeous property and wonderful staff!" [](https://expedia.co.uk/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) ![Posada del Mar](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/e7fb3ff1_y.jpg) ### Posada del Mar 10/10 Excellent "Fantastic room - spacious and all the amenities. Amazing staff, very friendly and helped with bags. Great location, very close to main shops, and quiet at night. Would definitely stay here again." [](https://expedia.co.uk/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) ## More cheap stays in Isla Santa María ![Hostal Casa Cascada](https://images.trvl-media.com/lodging/117000000/116770000/116762700/116762676/fccb146c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hostal Casa Cascada Pje. 1 Puerto Ayora Galápagos Islands £34 24 Feb - 25 Feb 9.6/10 Exceptional! (4 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hostal-Casa-Cascada.h116762676.Hotel-Information) ![Hostal Sir Francis Drake](https://images.trvl-media.com/lodging/17000000/16170000/16164100/16164081/b9484033_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hostal Sir Francis Drake Av. Baltra y Charles Binford Puerto Ayora Galapagos £51 23 Feb - 24 Feb 7.4/10 Good! (74 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hostal-Sir-Francis-Drake.h16164081.Hotel-Information) ![El Barranco Galapagos](https://images.trvl-media.com/lodging/112000000/111510000/111508100/111508035/910f927d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### El Barranco Galapagos Los colonos Puerto Ayora Galapagos £135 21 Feb - 22 Feb 9.6/10 Exceptional! (39 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Barranco-Galapagos.h111508035.Hotel-Information) ![Acacia Galapagos Boutique Hotel](https://images.trvl-media.com/lodging/92000000/91760000/91753200/91753116/8c7674f6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Acacia Galapagos Boutique Hotel C/ Floreana Y Matazarnos Puerto Ayora Islas Galápagos £178 14 Feb - 15 Feb 9.8/10 Exceptional! (27 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-Acacia-Galapagos-Boutique-Hotel.h91753116.Hotel-Information) ![Hotel Brisas Del Pacifico](https://images.trvl-media.com/lodging/17000000/16390000/16387800/16387791/f2a55546_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Brisas Del Pacifico General Rodriguez Puerto Ayora [Get rates](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=16387791&PinnedHotelID=16387791&HadPinnedHotel=true®ionId=739209696364867584) 7.4/10 Good! (80 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-HOTEL-BRISAS-DEL-PACIFICO.h16387791.Hotel-Information) ![White House Galapagos](https://images.trvl-media.com/lodging/16000000/15570000/15568900/15568830/c16ecd66_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### White House Galapagos Calle Roberto Schiess e Isla Duncan Puerto Ayora Santa Cruz [Get rates](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=15568830&PinnedHotelID=15568830&HadPinnedHotel=true®ionId=739209696364867584) 8.8/10 Excellent! (99 reviews) [](https://expedia.co.uk/Puerto-Ayora-Hotels-WHITE-HOUSE-GALAPAGOS.h15568830.Hotel-Information) ## Frequently asked questions ### Where is the best place for a stay in Isla Santa María? ### What are some of the best holiday rentals that Isla Santa María has to offer? ### If I need to cancel my hotel reservation in Isla Santa María, will I receive a refund? ### What is staying in Isla Santa María like? ### What is there to see in Isla Santa María? ### What's the seasonal weather in Isla Santa María? ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app