Title: Holiday Rentals Isla Santa María from £59: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Hotels in Isla Santa María](https://expedia.co.uk/Isla-Santa-Maria-Hotels.d739209696364867584.Travel-Guide-Hotels)[Isla Santa María Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Isla-Santa-Maria.d739209696364867584.Car-Hire-Guide)[Isla Santa María Holidays](https://expedia.co.uk/Isla-Santa-Maria.d739209696364867584.Holidays-City-Breaks) ![Sea lions soaking in some rays on the island of espanola in the Galapagos. Unfortunately no mai tai's on this beach. #LifeAtExpedia #nature](https://images.trvl-media.com/place/739209696364867584/329f8833-28e7-41c2-a4af-1e9e3462ce94.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Delen Wong ![](https://images.trvl-media.com/place/739209696364867584/329f8833-28e7-41c2-a4af-1e9e3462ce94.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-02-20&endDate=2026-02-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [1 May - 3 May](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [29 May - 31 May](https://www.expedia.co.uk/Hotel-Search?regionId=739209696364867584&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Isla Santa María holiday rentals ![Family Duplex, 2 Bedrooms, Private Bathroom, Garden View (Courtyard ) | Terrace/patio](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/ffb9bce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Ensuite (One bedroom King) | Premium bedding, pillow-top beds, in-room safe, individually decorated](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/34c553bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/392aa62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/aabb8b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Torre Mar Galapagos Boutique Suites [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Boutique-Suites.h16786878.Hotel-Information) Puerto Ayora 9.2/10 Wonderful (19 reviews) "Very nice suite, clean, quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Masoud [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Boutique-Suites.h16786878.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/9468ea94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Suite | 1 bedroom, down duvets, individually furnished, blackout curtains](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/48fd3b45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Quadruple Room, 1 Bedroom | Private kitchen | Fridge, oven, rice cooker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/7ebdf614.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Quadruple Room, 1 Bedroom | 1 bedroom, down duvets, individually furnished, blackout curtains](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/95d1d08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suites [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Suites.h34937768.Hotel-Information) Puerto Ayora 9.4/10 Exceptional (24 reviews) "Check was early and friendly staff Room was super clean and comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Judy £67 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Suites.h34937768.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711113/a8eb4c6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711113/1ea32b4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![8 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711113/32a60550.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711113/141f97bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Torre Mar Galapagos Villa [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Villa.h121711113.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (1 review) "We had a very nice time staying at Torre Mar. It was very conveniently located. We were 5 families...me (the mom) and my 4 kids, their spouses and 6 grandkids. Everyone had their own "suite". The advertising is a little confusing. I thought we were renting a "home", and then realized it was an apartment/hotel....but as I said, it was very nice for each family to have private space. The owner John was very friendly, although we did have some miscommunication issues, which is interesting... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betty A. £1,293 10 Feb - 11 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Villa.h121711113.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/a58537c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/9e01f48f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/d98281b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/d3c64b45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Queen Bedroom Suite ON THE Second High Floor AT Ariana\`s Galapagos Hostal [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Queen-Bedroom-Suite-ON-THE-Second-High-Floor-AT-Arianas-Galapagos-Hostal.h102780548.Hotel-Information) Puerto Ayora £59 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Queen-Bedroom-Suite-ON-THE-Second-High-Floor-AT-Arianas-Galapagos-Hostal.h102780548.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/e9b7ef2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/8b0d2620.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/4776976b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/c74f8717.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### GALAPAGOS DIVER ESTUDIO. [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h110134025.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "Perfect start to finish. Very clean! Drinking water provided. The host helped us with a small hiccup regarding our transfer so we were able to catch the ferry to San Cristóbal with no problem. Highly recommend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shannyn Z. £69 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h110134025.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/1cd8189f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/80e1d3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/c544ac54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/bf0a5a6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### KING-SIZE BED OR TWO TWIN BEDS SUITE ON SECOND FLOOR WITH CITY VIEW BALCONY [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h103192998.Hotel-Information) Puerto Ayora £43 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h103192998.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/9465b582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/daa6d638.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, stovetop, coffee/tea maker, blender](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/a87cb59a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/5328eb63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TWO Bedrooms Apartment ON THE Ground Floor IN Ariana\`s Galapagos Hostal [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h102721840.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "We enjoyed our 6-night stay at Ariana's. The apartment was large and comfortable. Bedroom air conditioners were whisper quiet. We especially enjoyed the rooftop terrace with its soft breezes. It’s a 20 minute walk to the big tortoise statue and a few minutes more to the Mlecon, or a 2 taxi ride." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Dean P. £76 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h102721840.Hotel-Information) ![6 bedrooms, WiFi](https://images.trvl-media.com/lodging/125000000/124600000/124595200/124595164/9cc38edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/125000000/124600000/124595200/124595164/e0550d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/125000000/124600000/124595200/124595164/w1277h900x0y0-d7e197ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 bedrooms, WiFi](https://images.trvl-media.com/lodging/125000000/124600000/124595200/124595164/ed6ecff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 6-bedroom building in superb Puerto Ayora with AC [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Spacious-6-Bedroom-Building-In-Superb-Puerto-Ayora-With-AC.h124595164.Hotel-Information) Puerto Ayora £45 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Spacious-6-Bedroom-Building-In-Superb-Puerto-Ayora-With-AC.h124595164.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/784c1849.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/6359bb06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/98c3994e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/bea60ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### KING SIZE BED & TWIN SIZE BED WITH PRIVATE BATHROOM ON SECOND FLOOR [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h103424658.Hotel-Information) Puerto Ayora £51 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h103424658.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/40000000/39990000/39987500/39987421/ebf60a8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/40000000/39990000/39987500/39987421/b574e039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/40000000/39990000/39987500/39987421/753f38a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/40000000/39990000/39987500/39987421/46b3f49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Two Bedroom house - The Galapagos Pearl Hotel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Two-Bedroom-House-The-Galapagos-Pearl-Hotel.h39987421.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "We stayed 3 nights in the "casa grande" associated with the Galapagos Pearl Hotel and could not have been more pleased. The casa has 2 bedrooms, a small kitchen, one bathroom, and is conveniently located right next to the pool and the outdoor dining area where Yolanda serves breakfast. Your room is cleaned every day. The garden surrounding the pool and casa is lush and full of geckos, cats, and beautiful plantings. Yolanda is from the Galapagos, she is a wonderful host and her daughter helped us... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura E. £187 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Two-Bedroom-House-The-Galapagos-Pearl-Hotel.h39987421.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/101000000/100650000/100640300/100640217/910a26ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/101000000/100650000/100640300/100640217/e5fb900f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven](https://images.trvl-media.com/lodging/101000000/100650000/100640300/100640217/6cb34f61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100650000/100640300/100640217/59b60aa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Jardin de Galápagos. [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Jardin-De-Galapagos.h100640217.Hotel-Information) Galápagos Islands £92 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Jardin-De-Galapagos.h100640217.Hotel-Information) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/f0249e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/2475343d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/f1c0fb19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, coffee/tea maker, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/6f52aa05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Casa-Vacacional-En-Puerto-Ayora.h94862210.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "Nice and beautiful house to stay very impressed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £92 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Casa-Vacacional-En-Puerto-Ayora.h94862210.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/6e3cf51a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/247eabf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/f20e4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, books](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/9f903199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Island Life Two-Bedroom Galapagos Casita [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Island-Life-Two-Bedroom-Galapagos-Casita.h37756447.Hotel-Information) Puerto Ayora 10/10 Exceptional (3 reviews) "We had a great time and are grateful to John and Donna for hosting us. The casita was very comfortable and quiet. Great wifi and air conditioning for when we needed to relax. Thank you again!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Victoria K. £149 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Island-Life-Two-Bedroom-Galapagos-Casita.h37756447.Hotel-Information) ![Luxury Apartment, Balcony | Living area | LCD TV, Netflix, pay films, streaming services](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/39eae50b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/987560e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment, Balcony | Balcony](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/992ac688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, Balcony, City View | Balcony](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/5efe3e57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galapagos Coliving Ecuador Casa Tuna [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Coliving-Ecuador-Casa-Tuna.h106882041.Hotel-Information) Puerto Ayora [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Coliving-Ecuador-Casa-Tuna.h106882041.Hotel-Information) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/0d93ae7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/0f077b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/4548d4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/63983c7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### This two-bedroom is a perfect island getaway. [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-This-Two-Bedroom-Is-A-Perfect-Island-Getaway.h22869358.Hotel-Information) Puerto Ayora, Santa Cruz Island 8.8/10 Excellent (5 reviews) "Donna communicated with us before our trip to provide information about arrival and to offer transportation assistance from the airport. Once we were there she offered to arrange tours, suggest dining places and made reservations for us. She did everything she could to make our stay easy and enjoyable. On one of the tours she was our guide. That was so helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia H. £149 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-This-Two-Bedroom-Is-A-Perfect-Island-Getaway.h22869358.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/83000000/82560000/82555500/82555432/aa67740e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/83000000/82560000/82555500/82555432/77881106.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/83000000/82560000/82555500/82555432/2ebaba6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/83000000/82560000/82555500/82555432/f2ba9c8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### FAMILY SUITE in Puerto Ayora [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-FAMILY-SUITE-In-Puerto-Ayora.h82555432.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "Great lodging with effective space for multiple groups of travelers. Location is perfect, off the tourist path, and easy to access by any taxis in Puerto Arroyo (just say you want to go to Parque Cascada). Groceries are available anywhere near the house, better produce quality found in the shops on Baltra Ave. Property manager is easy to communicate with and responds instantly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nathan M. £169 11 Feb - 12 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-FAMILY-SUITE-In-Puerto-Ayora.h82555432.Hotel-Information) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/22b8a278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/12fe5d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/df21dec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/70b97955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Oceanview two-bedroom with balcony [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Balcony-Two-Bedroom-Suite.h32591880.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (25 reviews) "Comfortable stay for a family of 4 with the 2 bedrooms. Well equipped kitchen although we did not use much. Easy walk to the port for ferries and tours. Several dining options with 10 min walk. 4 th floor stay was nice with lots of natural breeze " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Visweswaren £181 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Balcony-Two-Bedroom-Suite.h32591880.Hotel-Information) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/1707fdb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/62a59e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/cd828067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/4113332d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ocean view Penthouse [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Penthouse.h121711108.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (1 review) "We enjoyed our stay. The air conditioning was a welcome retreat after a day spent exploring. The views are amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greta S. £154 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Penthouse.h121711108.Hotel-Information) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711104/fa293fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711104/4aa376a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711104/6b16da4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711104/87bf7fb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious two-bedroom suite with a balcony [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Spacious-Two-Bedroom-Suite-With-A-Balcony.h121711104.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (22 reviews) "Great place to stay with great hosts who were very accommodating. Very walkable to all the places or a short taxi anywhere for 1.50\. Would highly recommend." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jon g. £181 9 Feb - 10 Feb [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Spacious-Two-Bedroom-Suite-With-A-Balcony.h121711104.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23®ionId=739209696364867584&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find holiday rentals that suit your style Aparthotels [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=APART_HOTEL) Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=APARTMENT) Villas [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=VILLA) Condos [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=CONDO) Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=VACATION_HOME) Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Isla+Santa+Mar%C3%ADa%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=739209696364867584&latLong=-1.290182%2C-90.42823&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=CABIN) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Holiday-Rentals.d739209696364867584.Travel-Guide-HolidayRentals)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Holiday-Rentals.d739209696364867584.Travel-Guide-HolidayRentals) ## Top Isla Santa María Hotel Reviews ![Capitan Max B&B](https://images.trvl-media.com/lodging/15000000/14720000/14716700/14716616/7e3fbe48_y.jpg) ### Capitan Max B&B 10/10 Excellent "I wish I could rate 10 stars to Captain Max. The bedroom comfort, quietness, cleanliness, and location made our stay extremely enjoyable. But Max attentions were over the top every day. The best stay out of the 3 islands we stayed in the Galapagos " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Capitan-Max-BB.h14716616.Hotel-Information) ![Hotel el descanso del Guia](https://images.trvl-media.com/lodging/18000000/17530000/17525300/17525206/b6171efd_y.jpg) ### Hotel el descanso del Guia 10/10 Excellent "Beautiful room. Comfortable balcony. Wonderful staff. Fresh breakfast. Very clean hotel. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-El-Descanso-Del-Guia.h17525206.Hotel-Information) ![Hotel Ninfa](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e_y.jpg) ### Hotel Ninfa 10/10 Excellent "Clean room, great staff. Would be nice if there was an airport shuttle instead of putting us all on separate $30 taxis. Myself and five other guests all had separate taxis to get to the same ferry. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Fernandina Hotel & Spa Galápagos](https://images.trvl-media.com/lodging/91000000/90030000/90029600/90029511/27a5429e_y.jpg) ### Fernandina Hotel & Spa Galápagos 10/10 Excellent "Great staff! Cute room and pool/hot tub" [](https://expedia.co.uk/Puerto-Ayora-Hotels-HOTEL-FERNANDINA.h90029511.Hotel-Information) ![Blu Galapagos Sustainable Waterfront Lodge](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/92acdc7e_y.jpg) ### Blu Galapagos Sustainable Waterfront Lodge 10/10 Excellent "Great room with amazing view. Incredible service " [](https://expedia.co.uk/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Hotel Cucuve](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/733c9cb5_y.jpg) ### Hotel Cucuve 10/10 Excellent "Very, very clean. The staff was exceptional. Great amenities- left water bottles for guests, one free drink per day, had a patio for guests to use by the water. Breakfast was a lot of variety. Would give a 10 pot of 10!!" [](https://expedia.co.uk/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) ![Galapagos Dreams](https://images.trvl-media.com/lodging/12000000/11700000/11698100/11698055/6897639d_y.jpg) ### Galapagos Dreams 10/10 Excellent "The entire staff was very friendly and helpful. Breakfast was good with hot coffee always on. The location was walking distance to tourist spots in town from the pier to Darwin’s research center. I booked my tours through Galapagos Dreams and Joatan worked up a personalized tour for me. This made my stay easier as the staff kept me informed of pick up times and activities. Overall it really made my stay very enjoyable. " [](https://expedia.co.uk/Puerto-Ayora-Hotels-GALAPAGOS-DREAMS.h11698055.Hotel-Information) ![Ikala Galapagos Hotel](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/ecbf00ed_y.jpg) ### Ikala Galapagos Hotel 10/10 Excellent "Gorgeous property and wonderful staff!" [](https://expedia.co.uk/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) ![Posada del Mar](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/e7fb3ff1_y.jpg) ### Posada del Mar 10/10 Excellent "Fantastic room - spacious and all the amenities. Amazing staff, very friendly and helped with bags. Great location, very close to main shops, and quiet at night. Would definitely stay here again." [](https://expedia.co.uk/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) ## Find out more about Isla Santa María **Everything you need to know about** **Isla Santa María** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Isla Santa María holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Isla Santa María holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Isla Santa María holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Isla Santa María. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Isla Santa María holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Isla Santa María holiday rentals we have selected for you start as low as £59 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Isla Santa María rentals** At Expedia, we put the best Isla Santa María holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Isla Santa María rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Isla Santa María holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Isla Santa María. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.co.uk ### Trending destinations on Expedia.co.uk - [Holiday Rentals in the Cotswold ](https://www.expedia.co.uk/lp/b/vr/cotswold) - [Holiday Rentals in Lake District ](https://www.expedia.co.uk/lp/b/vr/lake-district) - [Devon Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) - [Norfolk Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Norfolk.d6046223.Holiday-Rental-Destinations) - [Bedfordshire Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Bedfordshire.d6046189.Holiday-Rental-Destinations) - [Dorset Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Dorset.d6046198.Holiday-Rental-Destinations) - [Northumberland Holiday Rentals ](https://www.expedia.com/Destinations-In-Northumberland.d6046225.Vacation-Rental-Destinations) - [Herefordshire Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Herefordshire.d6046203.Holiday-Rental-Destinations) - [Essex Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Essex.d6046201.Holiday-Rental-Destinations) - [Cumbria Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Cumbria.d6046194.Holiday-Rental-Destinations) - [Yorkshire Holiday Rentals ](https://www.expedia.co.uk/Yorkshire-Holiday-Rentals.d6342462.Travel-Guide-HolidayRentals) - [South Wales Holiday Rentals ](https://www.expedia.co.uk/South-Wales-Holiday-Rentals.d6054274.Travel-Guide-HolidayRentals) - [North Wales Holiday Rentals ](https://www.expedia.co.uk/North-Wales-Holiday-Rentals.d6054276.Travel-Guide-HolidayRentals) - [London Holiday Rentals ](https://www.expedia.co.uk/London-Holiday-Rentals.d178279.Travel-Guide-HolidayRentals) - [York Holiday Rentals ](https://www.expedia.co.uk/York-Holiday-Rentals.d5489.Travel-Guide-HolidayRentals) - [Blackpool Holiday Rentals ](https://www.expedia.co.uk/Blackpool-Holiday-Rentals.d619.Travel-Guide-HolidayRentals) - [Isle of Wight Holiday Rentals ](https://www.expedia.com/Destinations-In-Isle-Of-Wight.d6046218.Vacation-Rental-Destinations) - [Scarborough Holiday Rentals ](https://www.expedia.co.uk/Scarborough-Holiday-Rentals.d5680.Travel-Guide-HolidayRentals) - [Edinburgh Holiday Rentals ](https://www.expedia.co.uk/Edinburgh-Holiday-Rentals.d6069845.Travel-Guide-HolidayRentals) - [Bath Holiday Rentals ](https://www.expedia.co.uk/Bath-Holiday-Rentals.d6084496.Travel-Guide-HolidayRentals) - [Bournemouth Holiday Rentals ](https://www.expedia.co.uk/Bournemouth-Holiday-Rentals.d654.Travel-Guide-HolidayRentals) - [England Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-England.d11218.Holiday-Rental-Destinations) - [Scotland Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Scotland.d11219.Holiday-Rental-Destinations) - [Cornwall Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Cornwall.d6046193.Holiday-Rental-Destinations) - [Wales Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Wales.d11220.Holiday-Rental-Destinations) - [Northern Ireland Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Northern-Ireland.d11221.Holiday-Rental-Destinations) ## Frequently asked questions ### Can I find holiday rentals in Isla Santa María? ### What are some of the best holiday rentals that Isla Santa María has to offer? ### What’s there to see and do in Isla Santa María? ### What’s a holiday rental in Isla Santa María like? ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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