Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Gay-Friendly Hotels

See all 368 Hotels in Florida Keys
Casa Morada

Casa Morada

136 Madeira Road, Islamorada
3.5 out of 5.0
4.5 out of 5 (23 reviews)
I got a room with a nice Bathtub but was not working... very dissapointed. Manager gave me a discount but of course kind of ruined my night. Great service and beautiful place to relax. They gave me a complementary welcome drink and a piece of cake for my bday. That was nice!
  23 Aug 2017

£246

£246
Hilton Key Largo Resort

Hilton Key Largo Resort

97000 Overseas Hwy, Key Largo
3.5 out of 5.0
3.7 out of 5 (821 reviews)
Small beach but lots to do and hotel grounds were beautiful
  16 Sep 2017

£129

£129
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (683 reviews)
Great location near Duval Street. The hotel has beautiful rooms with great views. The staff could not have been any nicer. The service was great. The swimming pool is nice size with comfortable chairs and umbrellas. The Shor Restaurant at the hotel has an amazing breakfast.
  7 Sep 2017

£168

£168
New Orleans House - Gay Men Adult Resort

New Orleans House - Gay Men Adult Resort

724 Duval Street, Key West
2.5 out of 5.0
3.8 out of 5 (16 reviews)
We had a wonderful time at this hotel. It is centrally located on Duval Street within walking distance of any attraction. Parking is across the street which is very convenient since Key West is very limited in parking spaces. The bar area in the rear of the building is great with a clean pool and ...
  6 Jan 2017

£78

£78
Santa Maria Suites

Santa Maria Suites

1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (373 reviews)
Had to evacuate due to Irma. Staff handled it wonderfully! They explained everything perfectly and made sure we were credited for all of the unused days.
  15 Sep 2017

£194

£194
Map

Recently booked Florida Keys hotels

Harbor Lights
2.0 out of 5.0
Last booking: 5 hours ago
Chelsea House Hotel - Key West
3.0 out of 5.0
Last booking: 5 hours ago
Coconut Mallory Resort And Marina By Kees Vacations
3.0 out of 5.0
Last booking: 7 hours ago
Key Largo Bay Marriott Beach Resort
3.5 out of 5.0
Last booking: 7 hours ago
Coconut Cay Resort & Marina
2.0 out of 5.0
Last booking: 9 hours ago
Ed & Ellens Lodging Key largo
3.0 out of 5.0
Last booking: 9 hours ago
Hyatt Centric Key West Resort and Spa
4.0 out of 5.0
Last booking: 9 hours ago
The Pelican Key Largo Cottages
2.0 out of 5.0
Last booking: 10 hours ago
Captain Pips Marina & Hideaway
3.0 out of 5.0
Last booking: 10 hours ago

Gay-Friendly Hotels in Florida Keys

Florida Keys has a long legacy of being one of the most progressive and open-minded parts of America. Today it retains its reputation as one of the most gay-friendly destinations in the country.

LGBTQ+ travellers are welcomed across Florida Keys, but some hotels in the region make this welcome part of their raison d’être. Stay in gay-friendly guesthouses, lodges and resorts in Florida Keys to enjoy the sights of the region and the company of like-minded guests.

The gay-friendly hotels in Florida Keys come in a range of prices and with different amenities. Find a cosy guesthouse accommodation that comes with fitness facilities and a nightclub, or stay in an elegant lodge hotel complete with a beachside tiki bar, outdoor spa tubs and childcare services.

LGBTQ+ History of Florida Keys

The Florida Keys have long marched to the leisurely beat of their own drum, once even seceding from the rest of the US. The region takes pride in its progressive attitudes and in less tolerant times, LGBTQ+ citizens would flock to the welcoming atmosphere of the Keys. It’s been at the forefront of gay-rights campaigning and was the home of writer and gay icon Tennessee Williams.

Key West even has the motto “One Human Family” as a declaration of its tolerant spirit. Look around the city centre and you’ll find a crosswalk covered in the colours of the rainbow flag, painted there in 2015 to celebrate the city’s annual Pride celebrations.

Partying and Pride in Florida Keys

Stay in a Key West hotel for the Pride parade, one of the best celebrations of its kind in Florida. Come to the city in June and join revellers from around the world celebrating diversity and love with a big, colourful party. Even if you can’t make it at this busy time of year, there are plenty of popular gay-friendly night clubs and bars around the region where you can always have a good time. Look around Key West city centre to find some of the best and most popular gay bars in the city.