Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Boutique Hotels

See all 304 Hotels in Florida Keys
Azul del Mar

Azul del Mar

104300 Overseas Highway, Key Largo
3.5 out of 5.0
4.4 out of 5 (73 reviews)
Relaxing RetreatMy husband and I stayed 2 nights after driving the Keys and spending 3 nights in Key West. We were greeted warmly, our room was perfect. Loved the adult only atmosphere. The only disappointment was no swimming pool. I didn't notice it when I booked . We enjoyed the small private beach area. Would ...
  23 Aug 2017
Artist House Key West

Artist House Key West

534 Eaton Street, Key West
3.5 out of 5.0
4.5 out of 5 (22 reviews)
Great place and location! Loved breakfast and happy hour. Convenient and pleasant service.
  25 Jul 2017

£110

£110
The Cabana Inn Key West - Adult Exclusive

The Cabana Inn Key West - Adult Exclusive

413 Applerouth Lane, Key West
3.0 out of 5.0
4.6 out of 5 (272 reviews)
Nice hotelVery nice hotel, with a central location right next to duval street.
  29 Aug 2017

£114

£114
Almond Tree Inn

Almond Tree Inn

512 Truman Ave, Key West
3.5 out of 5.0
4.8 out of 5 (301 reviews)
Clean, quiet, comfortableClose to Duval on the quieter side. Park your car and don't use it till you leave. Nice breakfast included. Clean, modern rooms. The pool area is well maintained. Friendly staff. No complaints on my stay.
  5 Sep 2017

£202

£202
Silver Palms Inn

Silver Palms Inn

830 Truman Ave, Key West
3.5 out of 5.0
4.4 out of 5 (698 reviews)
IRMA!!!!!This hotel is spotless. Close to Duval Street although far from Mallory Square. Excellent parking. We evacuated before having breakfast so cannot comment. Helpful staff. I only stayed one night but I recommend. We got an early check in around 1pm which was great. Then at 6pm we received a letter ...
  12 Sep 2017

£102

£102
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.0 out of 5.0
4.5 out of 5 (329 reviews)
Wonderful hotel! To bad we had to evacuate......We loved this hotel. I was with my husband and 2 daughters (24 and 26 years old) and we were celebrating my husband's 60th birthday. The hotel was in the best location. It was so clean and friendly. The staff was fabulous and we were just getting comfortable when on September 5th (my husbands birthday) ...
  13 Sep 2017

£121

£121
The Saint Hotel Key West, Autograph Collection

The Saint Hotel Key West, Autograph Collection

417 Eaton Street, Key West
3.5 out of 5.0
4.4 out of 5 (86 reviews)
Great Location to Duval and all the activitiesWe really enjoyed The Saint and the fact we could walk about everywhere we wanted. The people were super nice and the hotel had a fun new vibe about it. Beautiful pool. And somehow tucked right in the middle of everything. Our room was super small but that was all that was available. Was prices but ...
  11 May 2017

£155

£155
Weatherstation Inn

Weatherstation Inn

57 Front St, Key West
2.5 out of 5.0
4.8 out of 5 (112 reviews)
Excellent place to stay in awesome location!We absolutely loved everything about Weatherstation Inn! Check in was smooth and easy. Rooms were very clean and large. Bottled water was very nice since it was so hot outside. Location was fantastic. Definitely will return for another stay in the future!
  17 Aug 2017

£136

£136
Albury Court Hotel - Key West

Albury Court Hotel - Key West

1030 Eaton St, Key West
3.0 out of 5.0
3.9 out of 5 (462 reviews)
Anniversary tripWas not there long. Very small house like bedroom with bath. All a big mass unit close to Duval Street. No parking available
  24 Aug 2017

£105

£105
Artist House on Fleming

Artist House on Fleming

1016 Fleming St., Key West
3.5 out of 5.0
4.6 out of 5 (25 reviews)
Lots of character and quaint. Breakfast was awesome with pastries from look places in town. I would defiantly go back. Close enough to walk yet far enough away from the busy Duvall st
  31 Aug 2017

£117

£117
Map

Recently booked Florida Keys hotels

Lime Tree Bay Resort
3.5 out of 5.0
Last booking: 57 minutes ago
Pegasus International Hotel
2.5 out of 5.0
Last booking: 1 hour ago
Parrot Key Hotel & Resort
4.0 out of 5.0
Last booking: 2 hours ago
Ocean Pointe Suites at Key Largo
3.5 out of 5.0
Last booking: 3 hours ago
Ibis Bay Beach Resort
2.5 out of 5.0
Last booking: 4 hours ago
Key Lime Inn - Key West
3.0 out of 5.0
Last booking: 6 hours ago
Southernmost Beach Resort
4.0 out of 5.0
Last booking: 7 hours ago
Key West Harbour Oceanfront Suites
3.5 out of 5.0
Last booking: 10 hours ago
Travelers Palm
2.5 out of 5.0
Last booking: 14 hours ago

Pocket Guide: Boutique Hotels Hotels in Florida Keys

Find a Boutique Hotel in Florida Keys

Sometimes the sprawling chain resorts of the Florida Keys can feel a little overwhelming. For something smaller and more individual, stay in a Florida Keys boutique hotel. The local architecture of the area, often with the porches and pillars typical of the Queen Anne style, has led to many unique and beautifully designed smaller boutique hotels.

Stay in stylishly appointed rooms in smaller, more personalised accommodation all across the keys. The majority of Florida Keys’ boutique hotels are in Key West, but there are also options on Islamorada and Key Largo.

Artistic Attractions in Florida Keys

People rushing to the beach in Florida Keys often miss the region’s lively arts scene. Visit the three Key West Art and Historical Society sites to survey artwork by local painters and sculptors. Fort East Martello, one of the society’s three buildings, features sculptures of repurposed junk turned into art by Stanley Papio. The society’s base, in Customs House, also hosts galleries of paintings by Florida Keys residents.

One way to see other art galleries in Florida Keys is to join an art walk. Groups in both Islamorada and Key West go for regular strolls around the neighbourhoods, visiting galleries and sharing ideas.

Stay in a Boutique Hotel during a Florida Keys Festival

Florida Keys has a seemingly constant cycle of arts events across the region. Key Largo, for instance, has an annual film festival dedicated to the work of one of Hollywood’s greatest actors, Humphrey Bogart.

Every November, Key West also holds its own film festival, which welcomes world-famous actors and directors. Most of the islands, from the bigger ones to the tiny Pigeon Key, will host at least one music and art festival at some point during the year. For family fun, don’t miss the Key Largo Pirates’ Fest, when buccaneers invade the island for three days.

The Florida Keys brim with cultural events and boast a vibrant arts scene. Choose a beautiful boutique hotel in Florida Keys and get out about experience its artistic side.