Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Featured Florida Keys Best Western Hotels

See all 511 Hotels in Florida Keys
Best Western Hibiscus Motel

Best Western Hibiscus Motel

1313 Simonton St, Key West
2.5 out of 5.0
4.3 out of 5 (453 reviews)
Pleasantly surprised - good value Key West accommodation is expensive, and this hotel was relatively inexpensive and set up like a mo … - 

Recently booked Florida Keys hotels

24 North Hotel Key West
3.5 out of 5.0
Last booking: 6 minutes ago
Conch On Inn Motel
2.0 out of 5.0
Last booking: 19 minutes ago
Sheraton Suites Key West
3.5 out of 5.0
Last booking: 49 minutes ago
Artist House on Fleming
3.5 out of 5.0
Last booking: 59 minutes ago
Bayside Inn Key Largo
2.5 out of 5.0
Last booking: 1 hour ago
The Cabana Inn Key West - Adult Exclusive
3.0 out of 5.0
Last booking: 1 hour ago
Ocean Pointe Suites at Key Largo
3.5 out of 5.0
Last booking: 1 hour ago
The Gates Hotel Key West
4.0 out of 5.0
Last booking: 1 hour ago
Ibis Bay Beach Resort
2.5 out of 5.0
Last booking: 1 hour ago

Pocket Guide: Best Western Hotels in Florida Keys

Mid-Range Best Western Hotels for Everyone

With more than 4,000 properties in 100 countries around the globe, Best Western is a world-leading hotel chain. It’s grown considerably from humble beginnings in 1946, when the company owned a cluster of hotels west of the Mississippi River, hence the Best Western name. Fast-forward 70 years and the brand is now one of the best known in the world, with an average of 400,000 guests every night.

Best Western’s Great Customer Service

The Best Western Hotels group is committed to making sure all its hotels deliver the brand’s high standards of service and hospitality, while retaining their individual personalities, which means no two Best Western Hotels are the same.

The collection of Best Western hotels in the Florida Keys is no exception to this rule. Mid-range hotels are what the company does best on these islands, which means good quality three-star accommodation with friendly staff.

Pools with sun terraces, breakfast restaurants and pool bars serving drinks are a few of the facilities found at three-star Best Western hotels. In the Florida Keys, they range from cosy laid-back motels to large sea-view hotels, but they all promise to deliver the same high levels of customer service.

Best Western Hotels in the Florida Keys

The Florida Keys is a vibrant destination made up of islands perfect for both relaxing getaways and all-action adventure. So whether you want to kick back and enjoy the idyllic beaches and famous sunsets, or you’ve got your sights set on the water sports and lively nightlife, you’ll find the perfect holiday on this sun-kissed archipelago.

Exploring the Florida Keys

Best Western hotels in the Florida Keys put the best of the islands in easy reach. You can dive and fish in beautiful clear blue waters, explore deep green mangroves and eco trails, and dine out in fresh seafood restaurants. If you’re travelling with family, enjoy kid-friendly hotels with in-room facilities such as fridges and microwaves, all just a stone’s throw from the beaches and main attractions of the Florida Keys.