Title: Hotels in Clarksdale, MO - Best Clarksdale Hotels from £37 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Clarksdale](https://expedia.co.uk/Clarksdale-Holiday-Rentals.d553248634983445286.Travel-Guide-HolidayRentals)[Clarksdale Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Clarksdale.d553248634983445286.Car-Hire-Guide)[Clarksdale Holidays](https://expedia.co.uk/Clarksdale.d553248634983445286.Holidays-City-Breaks) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Clarksdale, MO from £37 ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Clarksdale Apart­ment [](https://www.expedia.co.uk/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2025-10-02&d1=2025-10-02&endDate=2025-10-04&d2=2025-10-04&lodging=APARTMENT) Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2025-10-02&d1=2025-10-02&endDate=2025-10-04&d2=2025-10-04&amenities=POOL) Cabin [](https://www.expedia.co.uk/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2025-10-02&d1=2025-10-02&endDate=2025-10-04&d2=2025-10-04&lodging=CABIN) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2025-10-02&d1=2025-10-02&endDate=2025-10-04&d2=2025-10-04&amenities=PETS) ## Check prices for these dates Tonight [18 Sept - 19 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983445286&startDate=2025-09-18&endDate=2025-09-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [19 Sept - 20 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983445286&startDate=2025-09-19&endDate=2025-09-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983445286&startDate=2025-09-19&endDate=2025-09-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983445286&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Clarksdale hotels and places to stay ## Our top choices for Clarksdale hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/2dd83c29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/ce15b185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/d2b9e218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/2753811d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St Joseph St. Joseph 9.2/10 Wonderful (1003) "Beautiful view, excellent rooms and very affordable " £76 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Free WiFi](https://images.trvl-media.com/lodging/115000000/114260000/114252400/114252394/30b33635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton St. Joseph St. Joseph 9.2/10 Wonderful (42) "Great, clean hotel! Will definitely stay again next time in area. " £111 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Home2-Suites-By-Hilton-St-Joseph.h114252394.Hotel-Information) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/da4c15cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, laptop workspace](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/29a35617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, laptop workspace](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/594d24e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### My Place Hotel St Joseph MO St. Joseph 9.2/10 Wonderful (134) "Property was clean & staff was great. " £65 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/35d22ebd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/6001dbbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/3ffb20d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/857c804e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Cameron, MO Cameron 7.2/10 Good (251) "Sketchy area. Door didn’t lock. No hot water. TV didn’t work. Never again. " £37 includes taxes & fees 19 Sept - 20 Sept [](https://www.expedia.co.uk/Cameron-Hotels-Motel-6-Cameron.h9992788.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, Accessible (Smoke Free) | Desk, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/65cb8e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/ebf14a58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/8d767806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Cameron Cameron 8.8/10 Excellent (1005) "Convenient, quiet, clean, try nearby McCorkles restaurant for food food!" £69 includes taxes & fees 29 Sept - 30 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![Free breakfast ](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/b317db33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/33a59e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/a2399256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/80e80506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Cameron Cameron 8.4/10 Very good (1002) "Good location off interstate. Room was clean & found bed comfortable. Breakfast was good with scrambled eggs & sausage along with cereal, muffins, & juice. Rooms were quiet & stay was restful." £63 includes taxes & fees 24 Sept - 25 Sept [](https://www.expedia.co.uk/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/602776a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/cdd2480a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/w3000h2001x0y1-908111e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/15262450.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Cameron Cameron 7.6/10 Good (781) "The artwork above the beds was nice" £60 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Days-Inn-By-Wyndham-Cameron.h42165.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8e39c5c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/b90af532.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/334d9a3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/cebd5503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn St. Joseph St. Joseph 8.2/10 Very good (619) "Great place to stay " £86 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/86578d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/aaaeda9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/c08809f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/9ec7263b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vineyard Mansion & Carriage House Bed & Breakfast St. Joseph 9.0/10 Wonderful (191) "Enjoyed our stay" £115 includes taxes & fees 19 Sept - 20 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/342fa799.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/f14c672a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/f4de68bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/9fe8eb65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stoney Creek Hotel St. Joseph St. Joseph 9.0/10 Wonderful (1525) "Cute hotel, really liked the Location." [](https://www.expedia.co.uk/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108200000/108195800/108195771/0938fa17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free valet parking](https://images.trvl-media.com/lodging/109000000/108200000/108195800/108195771/e7560bd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108200000/108195800/108195771/c67791cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108200000/108195800/108195771/aedc9baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Capri Motel By OYO Elwood, Wathena Wathena £59 includes taxes & fees 30 Sept - 1 Oct [](https://www.expedia.co.uk/Wathena-Hotels-Capri-Motel-By-OYO-Elwood.h108195771.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/81b46103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room, Ensuite (Single Queen ) | Bathroom | Combined shower/bathtub, hair dryer, towels, soap](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/3259f00c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/w1000h963x0y0-b16dd7a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/cffb314f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Whiskey Mansion St. Joseph 9.2/10 Wonderful (579) "The mansion was beautiful and staff was friendly and helpful and welcoming. " £111 includes taxes & fees 27 Sept - 28 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) ![Room, 1 King Bed, Hot Tub | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fbe988e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Hot Tub | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/9c85d31a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fd3d7861.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/52e087b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Cameron Cameron 8.4/10 Very good (627) "Very friendly check in. " £68 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/5baaa282.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/bb5c8240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/8fb5321b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/44ee6160.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cameron Cameron 8.4/10 Very good (594) "Great place to stay. Staff so nice and great breakfast!" £92 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/f5217c79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/7977062c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/2dbfeb6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/b42a1684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott St. Joseph St. Joseph 9.6/10 Exceptional (450) "Great stay!" £97 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/c6dc4154.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/71deeec7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/8955ad72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG St. Joseph 9.2/10 Wonderful (765) "Updated, clean and tidy. Very helpful staff. " £108 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/683baa8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/d13708b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/23b052a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/7ac0c126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Cameron Cameron 6.2/10 (153) "Quiet." £64 includes taxes & fees 20 Sept - 21 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Econo-Lodge-Cameron.h171630.Hotel-Information) ![Premium bedding, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/8f84e3de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/b3fa2b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/66883004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/6328c1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmeriStay Inn St. Joseph 5.4/10 (684) "Roaches where every where. I didn't stay there slept in my car in the parking lot. " [](https://www.expedia.co.uk/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/771cfdad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/183e59b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/d3111fa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/57ce8583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Saint Joseph, MO St. Joseph 4.6/10 (1005) "Gina love here need more staff like her " £53 includes taxes & fees 25 Sept - 26 Sept [](https://www.expedia.co.uk/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-02&endDate=2025-10-03®ionId=553248634983445286&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels) ## Top Clarksdale Hotel Reviews ![My Place Hotel St Joseph MO](//images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0_y.jpg) ### My Place Hotel St Joseph MO 10/10 Excellent "Property was clean & staff was great. " [](https://expedia.co.uk/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Stoney Creek Hotel St. Joseph](//images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/342fa799_y.jpg) ### Stoney Creek Hotel St. Joseph 10/10 Excellent "The property is beautiful! The room is wonderful! It was an unexpected upgrade to one of their themed rooms. It was a nice surprise after being on the road all day! I would stay here again if ever in the area." [](https://expedia.co.uk/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Whiskey Mansion](//images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/81b46103_y.jpg) ### Whiskey Mansion 10/10 Excellent "The accomodations were excellent, breakfast was wonderful. 10/10 would stay again." [](https://expedia.co.uk/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) ![Drury Inn & Suites St Joseph](//images.trvl-media.com/lodging/1000000/10000/4200/4180/2dd83c29_y.jpg) ### Drury Inn & Suites St Joseph 10/10 Excellent "This hotel is well managed. The staff was attentive and helpful. The rooms were spacious and quiet. The thing that blew me away was an evening meal that was free. They called it a snack, but much more than that. And it gets even better. They give coupons allowing each guest to have three drinks on the house. Amazing. What I cannot understand is that of the eighteen hotels we stayed at during our motorcycle trip out west, this was both the nicest and least expensive." [](https://expedia.co.uk/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Waterfront Cabin w/ Sunset View, WiFi, HUGE yard, and Fire-pit!](//images.trvl-media.com/lodging/112000000/111900000/111891200/111891118/b97970c0_y.jpg) ### Waterfront Cabin w/ Sunset View, WiFi, HUGE yard, and Fire-pit! 10/10 Excellent "Beautiful place, breath taking view. So peaceful. " [](https://expedia.co.uk/St-Joseph-Hotels-Ants-Waterfront-2-Bdrm-Cabin-W-Best-Sunset-View.h111891118.Hotel-Information) ![Vineyard Mansion & Carriage House Bed & Breakfast](//images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/86578d4d_y.jpg) ### Vineyard Mansion & Carriage House Bed & Breakfast 10/10 Excellent "Enjoyed our stay" [](https://expedia.co.uk/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) ![SureStay Hotel by Best Western Cameron](//images.trvl-media.com/lodging/1000000/20000/10500/10417/b317db33_y.jpg) ### SureStay Hotel by Best Western Cameron 10/10 Excellent "Cute" [](https://expedia.co.uk/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![AmeriStay Inn](//images.trvl-media.com/lodging/1000000/50000/41500/41477/8f84e3de_y.jpg) ### AmeriStay Inn 10/10 Excellent "My wife and I had a great experience at Ameristay Inn. Check in was fast. The room was clean and comfortable. The breakfast was perfect..cereal, fruit, muffins, juice, milk, and coffee. Pet Friendly. A/C works great. Right by the highway. Gas stations and places to eat close by. We will stay again." [](https://expedia.co.uk/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Penthouse Cabin BOHO Loft, 3 balconies & Jetted Jacuzzi tub w/ Sunset VIEW!](//images.trvl-media.com/lodging/113000000/112250000/112245800/112245712/15db6c23_y.jpg) ### Penthouse Cabin BOHO Loft, 3 balconies & Jetted Jacuzzi tub w/ Sunset VIEW! 10/10 Excellent "Its really a beautiful rental and the host was quick to reply with any questions we had. Ultra clean and easy to acces with a great sunset view of the river. Only issue we had was that we stayed during a muggy heatwave (96 degrees), and the upper boho loft was to warm for us to sleep in comfortably so we skept in the lower level bedroom. " [](https://expedia.co.uk/St-Joseph-Hotels-Penthouse-W-Boho-Loft.h112245712.Hotel-Information) ## More cheap stays in Clarksdale ![My Place Hotel St Joseph MO](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### My Place Hotel St Joseph MO 3621 N Village Dr, St. Joseph, MO £65 28 Sept - 29 Sept includes taxes & fees 9/10 Wonderful! (134 reviews) [](https://expedia.co.uk/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Red Roof Inn Cameron](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Red Roof Inn Cameron 501 Northland Drive, Cameron, MO £69 29 Sept - 30 Sept includes taxes & fees 8.6/10 Excellent! (1,005 reviews) [](https://expedia.co.uk/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![SureStay Hotel by Best Western Cameron](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/b317db33_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### SureStay Hotel by Best Western Cameron 2210 US Highway 36, Cameron, MO £63 24 Sept - 25 Sept includes taxes & fees 8.2/10 Very Good! (1,000 reviews) [](https://expedia.co.uk/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![AmeriStay Inn](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/8f84e3de_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### AmeriStay Inn 4502 SE US HWY 169, St. Joseph, MO [Get rates](https://expedia.co.uk/Hotel-Search?startDate=02%2F10%2F2025&endDate=03%2F10%2F2025&selected=41477&PinnedHotelID=41477&HadPinnedHotel=true®ionId=553248634983445286) 5.2/10 (684 reviews) [](https://expedia.co.uk/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Motel 6 Saint Joseph, MO](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/771cfdad_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Saint Joseph, MO 4021 Frederick Ave, St. Joseph, MO £53 25 Sept - 26 Sept includes taxes & fees 4.6/10 (1,005 reviews) [](https://expedia.co.uk/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![Holiday Inn Express Hotel & Suites St. Joseph by IHG](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG 3600 N. Village Dr., St. Joseph, MO £108 28 Sept - 29 Sept includes taxes & fees 9/10 Wonderful! 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