Amenities are important when you plan a holiday, so we make it easy to get what you want to make your stay special. If you want an upscale hotel that has fine dining, a spa or several swimming pools, Expedia can help you find the best luxury hotel experience that Cayo Guillermo has to offer. Cayo Guillermo has some interesting things to see and do including Cayo Guillermo Beach, so you might want to take in the local sights during your visit.