Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Save up to 17% by booking Flight + Hotel.

Search 321,000 hotels and 550 airlines worldwide.


Cairo

Welcome! Cairo in Southwest Illinois is part of a pretty region where rural landscapes, rolling hills and prairies feature in the scenery.

Packages in Cairo

Save now with your Expedia package deal. We help savvy travelers buy their flight and hotel deals. What are you and your significant other going to find in Cairo with all that extra cash?

Receive savings of up to 17% with a package deal.

With just a few minutes you can arrange everything you and your family will need for your next vacation via our comprehensive global database. Search through some 400 partner airlines and 321,000 hotels from all around the world.

The super discounts at Expedia make planning your Cairo getaway so much fun. What are you waiting for?

If you change your travel plans we will certainly honor your cancellation request with no extra charges from us, on almost all bookings.

Cairo Vacation Packages

About 120 miles northwest of Cairo is where you'll find the major city of St. Louis.

Lovers of nature gravitate towards this part of the country to explore its splendid natural landscapes. Discover the magic for yourself at Fort Massac State Park and Columbus-Belmont State Park, 30 miles and 19 miles away from Cairo, respectively.

This region has a fascinating past. You'll be able to find out all about it at Fort Defiance.

Like the sound of Ballard Wildlife Management Area and Mound City National Cemetery? They're located in Mound City, some 4 miles out of Cairo. Alternatively, Ullin is 16 miles away. When you get there, go to Ullin City Hall and White Crane Canoes.

Cape Girardeau is approximately 30 miles to the northwest of Cairo. This regional hub features a whole host of things to do and see, including Cape Rock Park, Isle Casino Cape Girardeau and eDen Spa & Salon. Southeast Missouri State University and Fort D Historic Site are a couple more choices that await you here.

Enjoy the sunshine and see how the locals spend their free moments at the region's popular farms.

What's a vacation without indulging in some delicious cuisine? Southwest Illinois is a fantastic place to treat your taste buds!

If you're here for the 4th of July, you can throw yourself into the festive fun of Independence Day, a national day of celebration.

Cape Girardeau Municipal Airport is the most convenient airport at 25 miles to the northwest, so make sure you give yourself enough time.


Top Hotel Deals

See all 6 Hotels in Cairo
£39
Quality Inn

Quality Inn

13201 Kessler Road, Cairo
3.7
of 5, from 65 reviews
3.0 out of 5.0

Situated in Cairo, this hotel is 18.6 mi (30 km) from Ullin City Hall and within 32 miles (52 km) of The Book Bug and Columbus-Belmont State Park. Central Park and Sikeston Depot Museum are also within 32 miles (52 km).

£37
Super 8 Charleston MO

Super 8 Charleston MO

310 S Story St, Charleston
3.5
of 5, from 145 reviews
2.5 out of 5.0

Located in the heart of Charleston, this motel is within 20 miles (32 km) of Fort Defiance, The Book Bug and Central Park. Sikeston Depot Museum and Boot Heel Golf Club are also within 20 miles (32 km).

£45
Quality Inn Charleston

Quality Inn Charleston

102 Drake St, Charleston
3.9
of 5, from 76 reviews
3.0 out of 5.0

Situated in Charleston, this hotel is within 16 miles (25 km) of The Book Bug, Central Park and Fort Defiance. Sikeston Depot Museum and Boot Heel Golf Club are also within 20 miles (32 km).

£30
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street, Charleston
3.0
of 5, from 24 reviews
2.5 out of 5.0

Situated in a rural location, this motel is within 20 miles (32 km) of The Book Bug, Central Park and Sikeston Depot Museum. Boot Heel Golf Club and Ullin City Hall are also within 32 miles (52 km).

£45
Americas Best Value Inn Ullin / Mounds

Americas Best Value Inn Ullin / Mounds

128 Cheekwood Lane, Ullin
4.2
of 5, from 18 reviews
2.5 out of 5.0

Situated in a rural location, this motel is 1.7 mi (2.8 km) from Ullin City Hall.

2017 Eclipse Rooms For Rent!

2017 Eclipse Rooms For Rent!

276 Margaret St, East Prairie
0.0 out of 5.0