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Check prices for these dates

Tonight
29 Sept - 30 Sept
Tomorrow
30 Sept - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for Fort Defiance State Park hotels

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

1. The Riverview

The Riverview
30.6 mi from Fort Defiance State Park
United States
Alyssa
£90
includes taxes & fees
29 Oct - 30 Oct
The Riverview
A large hotel with a prominent sign reading "Harriss" and a decorative archway with lights.
A casino bar with multiple gaming machines, a central bar area with stools, and a patterned carpet.
A lobby with leather seating, a reception desk, and a patterned carpet.
A Harrah's Metropolis casino bar area with multiple gaming tables, a well-stocked liquor shelf, and bar stools.

2. Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
25.2 mi from Fort Defiance State Park
United States
Jason
£89
includes taxes & fees
28 Oct - 29 Oct
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.
An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

3. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
22.6 mi from Fort Defiance State Park
United States
Scott
£82
includes taxes & fees
29 Oct - 30 Oct
Drury Inn & Suites Sikeston, MO
A hotel lobby with a reception desk, seating area, and a large window.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
4.8 mi from Fort Defiance State Park
United States
Santiago
£57
includes taxes & fees
16 Oct - 17 Oct
Quality Inn Cairo I-57
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.
A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

5. Hampton Inn Sikeston

Hampton Inn Sikeston
26 mi from Fort Defiance State Park
United States
John
£87
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Sikeston
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A spacious living room with a sofa set, a coffee table, and a dining area.

6. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
30.5 mi from Fort Defiance State Park
United States
Kristin
£107
includes taxes & fees
8 Oct - 9 Oct
Courtyard by Marriott Cape Girardeau Downtown
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.
An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.
Room

7. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
22.3 mi from Fort Defiance State Park
United States
Shelley
£72
includes taxes & fees
1 Oct - 2 Oct
Best Western Plus Sikeston I-55
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

8. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
26.1 mi from Fort Defiance State Park
United States
Allen
£86
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites by Marriott Sikeston
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.
A spacious lobby with a central atrium, a piano, and a reception desk.
A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
22.4 mi from Fort Defiance State Park
United States
David
£57
includes taxes & fees
5 Oct - 6 Oct
Days Inn and Suites by Wyndham Sikeston
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.
A breakfast buffet area with a display of cinnamon sweet rolls, a sign indicating the roll selection, and a patterned wall in the background.
A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

10. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
25.7 mi from Fort Defiance State Park
United States
Melissa
£86
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.
A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.
A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

11. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
22.6 mi from Fort Defiance State Park
United States
Craig
£55
includes taxes & fees
30 Sept - 1 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

12. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
26.1 mi from Fort Defiance State Park
United States
Stacy
£93
includes taxes & fees
8 Oct - 9 Oct
TownePlace Suites by Marriott Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.
A motel with a covered entrance, multiple rooms, and a parking lot.
A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.
A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

13. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
22.8 mi from Fort Defiance State Park
United States
William
£49
includes taxes & fees
6 Oct - 7 Oct
Super 8 by Wyndham Sikeston/Miner Area
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.

14. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
10.9 mi from Fort Defiance State Park
United States
William
£50
includes taxes & fees
12 Oct - 13 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

15. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
12.6 mi from Fort Defiance State Park
United States
Kathleen
£56
includes taxes & fees
1 Oct - 2 Oct
The Riverstone Hotel Charleston-Sikeston
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.
A living room with two sofas, a coffee table, a TV, and a cabinet.
A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.
A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

16. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
22.6 mi from Fort Defiance State Park
United States
Starlette
£74
includes taxes & fees
29 Oct - 30 Oct
Comfort Inn & Suites Sikeston I-55
A hotel room with two beds, a desk, a chair, a TV, and a mirror.
A bathroom with a bathtub, toilet, and shower curtain.
A reception area with a counter, a coffee machine, and seating.
A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

17. Country Yard Inn and Suite

Country Yard Inn and Suite
22.3 mi from Fort Defiance State Park
United States
William
£51
includes taxes & fees
7 Oct - 8 Oct
Country Yard Inn and Suite
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
A reception desk with a computer, a framed picture on the wall, and a vase with flowers.
A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.
A motel with a red roof and beige walls, a parking lot, and a signboard.

18. La Center Motel

La Center Motel
10.9 mi from Fort Defiance State Park
United States
Carrie
£43
includes taxes & fees
2 Oct - 3 Oct
La Center Motel
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A bathroom with a sink, mirror, towel rack, shower, and toilet.

19. Eagle Inn Charleston

Eagle Inn Charleston
10 mi from Fort Defiance State Park
United States
Jackson
£55
includes taxes & fees
12 Oct - 13 Oct
Eagle Inn Charleston
An indoor swimming pool with wooden walls and stone accents, surrounded by seating areas and a balcony.
A reception desk with a wooden finish and granite top, a sign above it reading "Baymont Inn & Suites," and a stone wall in the background.
A hotel room with a large bed, a chair, a desk, a desk lamp, a lamp, a window with curtains, a picture on the wall, and a bathroom with a bathtub and a mirror.
A gym with treadmills, ellipticals, and a stationary bike.

20. Baymont by Wyndham Metropolis

Baymont by Wyndham Metropolis
25.3 mi from Fort Defiance State Park
United States
Julee
Baymont by Wyndham Metropolis
View all properties

Compare popular hotels close to Fort Defiance State Park

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
La Center Motel
7.6
Good
22 reviews
View
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
Super 8 by Wyndham Charleston/Sikeston East MO
6.8
671 reviews
View
A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57
6.4
295 reviews
View
A building with a fountain and flower beds in front.
The Riverstone Hotel Charleston-Sikeston
6.8
438 reviews
View
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
Eagle Inn Charleston
6.6
107 reviews
View

Top Fort Defiance State Park Hotel Reviews

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

10/10 Excellent
"We were competing in a dog field trial located at the WKWMA and this rental was a perfect location just minutes from the various sites where competitions were taking place. It has a great airing area for the dogs. Dianna was very responsive and checked in a couple of times over the week to make sure everything was OK. The house was clean and had a full kitchen with basic appliances. Overall the place had everything we needed including a good, strong air conditioner and lots of hot water for showers. Would stay here again!"
Karen N. 6-night trip
Posted 12 hours ago
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Drury Inn Paducah

Drury Inn Paducah

10/10 Excellent
"The staff were very friendly & made sure our stay was good."
Karen 1-night trip
Posted 13 hours ago
Drury Inn Paducah
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

8/10 Good
"I have stayed there annually for 4 straight years to attend an event in nearby Sikeston. This year, for the first time, there was no couch or coffee table in my room, only a small computer desk and chair. I used to enjoy the small couch and table when watching TV and eating or using my laptop. I did not enjoy the extra empty space with no furniture. The receptionist said their removal was an "upgrade" and commented "We're doing it 'right' now..." whatever that means? Otherwise, I enjoyed my stay as usual. RB"
Rodney 3-night trip
Posted 20 hours ago
Super 8 by Wyndham Charleston/Sikeston East MO
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

10/10 Excellent
"not full and quiet for a casino environment."
Sophie 1-night trip
Posted 3 days ago
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"perfect"
Sandra D. 5-night trip
Posted 4 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 8 days ago
Days Inn and Suites by Wyndham Sikeston
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 12 days ago
Cozy cabins on beautiful Horseshoe Lake
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"This is the 2nd time staying here and location is perfect for exploring Cache River. Brent and Wendy are amazing hosts and excellent at communicating. Already booked in November to come back for a week of relaxing with friends and doing some hunting. I highly recommend staying here if you want something clean, good communication and great location."
David P. 3-night trip
Posted 3 weeks ago
Wandering the wineries or hitting the hills? We got you! Come stay!

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

7.4/10 (23 reviews)
You can learn about the history of Columbus when you stop by Columbus-Belmont State Park.
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Ullin City Hall

6.6/10 (4 reviews)
After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums.
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Limekin Springs Trail Trailhead

You can take time to visit Limekin Springs Trail Trailhead during your travels to Ullin. Make some time to visit the shops while you're in the area.
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Front Street Studio & Art Gallery

8.6/10 (15 reviews)
You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savour the top-notch restaurants.
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Lower Cache River Access Area

You can take time to visit Lower Cache River Access Area during your travels to Cypress.
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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.
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Henry N Barkhausen Cache River Wetlands Center

8.0/10 (1 review)
You can spend time studying the exhibits at Henry N Barkhausen Cache River Wetlands Center during your travels in Cypress. Amble around the area's parks or experience its museums.
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Frequently asked questions

What's the area like around Fort Defiance State Park?
Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best place to stay close to Fort Defiance State Park?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.
If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If your reservation is non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best deals available near Fort Defiance State Park.