Beginning of main content

Search Cairo Hotels, Illinois

Nectar
Collect Nectar points

Book on the go and pay later.

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Check Prices on Hotels in Cairo

Tonight Tonight 20 Jun - 21 Jun
This weekend This weekend 22 Jun - 24 Jun
Next weekend Next weekend 29 Jun - 1 Jul

Top 10 Hotels in Cairo

See all 6 properties in Cairo

Get 200 Nectar points when you book your hotel

Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.

Quality Inn

Quality Inn

13201 Kessler Road, Cairo
  • Free cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in Cairo, this hotel is 9.7 mi (15.7 km) from Fort Defiance and within 25 miles (40 km) of Ullin City Hall and Shawnee Community College. Columbus-Belmont ...

Quality Inn£43

Quality Inn£43
Americas Best Value Inn Ullin / Mounds

Americas Best Value Inn Ullin / Mounds

128 Cheekwood Lane, Ullin
  • Free cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in a rural location, this motel is 1.7 mi (2.8 km) from Ullin City Hall.

Americas Best Value Inn Ullin / Mounds£48

Americas Best Value Inn Ullin / Mounds£48
Quality Inn Charleston

Quality Inn Charleston

102 Drake St, Charleston
  • Free cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in Charleston, this hotel is within 16 miles (25 km) of Central Park, Fort Defiance and Sikeston Depot Museum. Boot Heel Golf Club and Kentucky Bend ...

Quality Inn Charleston£50

Quality Inn Charleston£50
Super 8 by Wyndham Charleston MO

Super 8 by Wyndham Charleston MO

310 S Story St, Charleston
  • Free cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Located in the heart of Charleston, this motel is within 20 miles (32 km) of Fort Defiance, Central Park and Sikeston Depot Museum. Boot Heel Golf Club and Ullin ...

Super 8 by Wyndham Charleston MO£37

Super 8 by Wyndham Charleston MO£37
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street, Charleston
  • Free cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in a rural location, this motel is 12 mi (19.4 km) from Fort Defiance and within 20 miles (32 km) of Central Park and Sikeston Depot Museum. Boot Heel ...

Eagle Inn Charleston£41

Eagle Inn Charleston£41
2017 Eclipse Rooms For Rent!

2017 Eclipse Rooms For Rent!

, East Prairie
     
     

    Situated in East Prairie, this holiday home is within 20 miles (32 km) of Central Park, Hunter-Dawson State Historic Site and Sikeston Depot Museum. Boot Heel ...

    2017 Eclipse Rooms For Rent!Get Rates

    2017 Eclipse Rooms For Rent!Get Rates
    See all 6 properties in Cairo
    Map

    Cairo Hotel Reviews

    Not too bad
    4 out of 5
    Front desk person was super nice and helpful. The room wasn't bad. Satisfactory for a one nighter.

    A verified traveller stayed at Super 8 by Wyndham Charleston MO

    Posted 16 hours ago
    Open Super 8 by Wyndham Charleston MO hotel guest reviews
    Nice hotel
    5 out of 5
    Easy check -in. Staff was very friendly and accommodating. Rooms were clean and comfortable. Nice quiet, scenic area. Definitely works for those short trips up and back.

    A verified traveller from Illinois stayed at Americas Best Value Inn Ullin / Mounds

    Posted 1 month ago
    Open Americas Best Value Inn Ullin / Mounds hotel guest reviews

    Travel to Cairo & Explore

    Explore Cairo with Expedia's Travel Guides to find the best flights, cars, holiday packages and more!