Title: The 10 Best 5 Star Hotels in Panama City - 2025 Updated Prices | Expedia.co.uk [Panama City Travel Guide](https://expedia.co.uk/Panama-City.dx6023330)[Hotels in Panama City](https://expedia.co.uk/Panama-City-Hotels.d6023330.Travel-Guide-Hotels)[Holiday Rentals in Panama City](https://expedia.co.uk/Panama-City-Holiday-Rentals.d6023330.Travel-Guide-HolidayRentals)[Flights to Panama City](https://expedia.co.uk/Cheap-Flights-To-Panama-City.d6023330.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.co.uk/Things-To-Do-In-Panama-City.d6023330.Travel-Guide-Activities)[Panama City Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Panama-City.d6023330.Car-Hire-Guide)[Panama City Holidays](https://expedia.co.uk/Panama-City.d6023330.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/497000/497861-florida-panhandle.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Panama City, Florida ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Panama City 5 Star Hotels Tonight [18 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6023330&startDate=2025-10-18&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [19 Oct - 20 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6023330&startDate=2025-10-19&endDate=2025-10-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6023330&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6023330&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Panama City 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Panama-City-Hotels.s50-0-d6023330.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Panama-City-Hotels.s50-0-d6023330.Travel-Guide-Filter-Hotels) ## Panama City and related destinations - Panama City - Fort Walton Beach - Destin - Gulf Shores - Vero Beach - Wilmington White-sand beaches stretch for miles along the emerald Gulf waters, perfect for swimming and sunset walks. Venture to St. Andrews State Park where you can snorkel near the jetties or take a boat to Shell Island's unspoiled shores. [See all hotels in Panama City](https://www.expedia.co.uk/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02&adults=2®ionId=6023330) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/497000/497861-florida-panhandle.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Panama City Hotel Reviews ## Find out more about Panama City ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Panama City? > How much you pay for a 5-star hotel in Panama City can vary according to when you want to travel and how long you plan to be away, among several factors. Take advantage of our price per night filter and other search tools to find the best rate on a high-end stay. > > > > - Search for the lowest price per night ### What makes a hotel 5 stars in Panama City? > From high-end dining venues and 24-hour fitness centres to swimming pools and superior bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just upscale conveniences to receive a 5-star rating. Stays must also deliver outstanding services like in-room massages, on-site dry cleaning and laundry and 24-hour room service. ### Are there any 5-star all-inclusive resorts in Panama City? > Our filter tool is the easiest way to find exactly what you want. Check the "All inclusive" and "5-star" boxes to show the most luxurious properties in Panama City where your meals, lodging, entertainment and activities are included in the upfront price. 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