Title: The 10 Best 5 Star Hotels in Florida Keys - 2025 Updated Prices | Expedia.co.uk [Florida Keys Travel Guide](https://expedia.co.uk/Florida-Keys.dx6023765)[Hotels in Florida Keys](https://expedia.co.uk/Florida-Keys-Hotels.d6023765.Travel-Guide-Hotels)[Holiday Rentals in Florida Keys](https://expedia.co.uk/Florida-Keys-Holiday-Rentals.d6023765.Travel-Guide-HolidayRentals)[Flights to Florida Keys](https://expedia.co.uk/Cheap-Flights-To-Florida-Keys.d6023765.Travel-Guide-Flights)[Things to do in Florida Keys](https://expedia.co.uk/Things-To-Do-In-Florida-Keys.d6023765.Travel-Guide-Activities)[Florida Keys Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Florida-Keys.d6023765.Car-Hire-Guide)[Florida Keys Holidays](https://expedia.co.uk/Florida-Keys.d6023765.Holidays-City-Breaks) ![Higgs Beach showing tropical scenes and a beach as well as a large group of people](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Florida Keys, United States of America - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Florida Keys 5 Star Hotels Tonight [23 Nov - 24 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6023765&startDate=2025-11-23&endDate=2025-11-24&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [24 Nov - 25 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6023765&startDate=2025-11-24&endDate=2025-11-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6023765&startDate=2025-11-28&endDate=2025-11-30&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6023765&startDate=2025-12-05&endDate=2025-12-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Florida Keys 5 Star Hotels ![Private beach, sun-loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/981feca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/79d31a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/9b929f51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cheeca Lodge & Spa Matecumbe 9.2/10 Wonderful (1275) "It was absolutely beautiful and the staff was always super nice!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary £241 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f4f56036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/9f64224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/02a3a50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/046d7acc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isla Bella Beach Resort & Spa Marathon 9.2/10 Wonderful (1058) "Rooms and property were very clean . " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica £255 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Florida-Keys-Hotels.s50-0-d6023765.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Florida-Keys-Hotels.s50-0-d6023765.Travel-Guide-Filter-Hotels) ## Learn more about Florida Keys Snorkel crystal-clear waters teeming with colourful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures. [See all hotels in Florida Keys](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-07&endDate=2025-12-08&adults=2®ionId=6023765) ![Higgs Beach showing tropical scenes and a beach as well as a large group of people](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Florida Keys Hotel Reviews ![Cheeca Lodge & Spa](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723_y.jpg) ### Cheeca Lodge & Spa 10/10 Excellent "Nice place " [](https://expedia.co.uk/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Isla Bella Beach Resort & Spa](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f4f56036_y.jpg) ### Isla Bella Beach Resort & Spa 10/10 Excellent "views" [](https://expedia.co.uk/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ## Find out more about Florida Keys ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Florida Keys? > How much you pay for a 5-star hotel in Florida Keys depends on factors like when you plan to go and the length of your stay. A top tip for bagging an awesome deal? Use our pricing filters to check out the available accommodation for your chosen dates. > > > > - Search for the lowest price per night ### What makes a hotel 5 stars in Florida Keys? > Impeccable guest service is integral to every 5-star hotel in Florida Keys. From the second you arrive, staff ensure your every need is met, whether recommending activities or providing a turn-down service. What's more, hotels must feature superior conveniences to meet the standard for a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gastronomic restaurants and knowledgeable concierge. ### Are there any 5-star all-inclusive resorts in Florida Keys? > Find a luxurious retreat that includes your room, meals, drinks and entertainment in Florida Keys with the help of our filters. Search for hotels with a 5-star rating and select the "All inclusive" filter. Have a look at what's included in the price. This way, you can take full advantage of all the perks on offer from the moment you arrive. ## Explore a world of travel with Expedia - Accommodation - Packages - More ways to book - [Hotels near John Pennekamp Coral Reef State Park](https://www.expedia.co.uk/John-Pennekamp-Coral-Reef-State-Park-Hotels.0-l6068611-0.Travel-Guide-Filter-Hotels) - [John Pennekamp Coral Reef State Park](https://www.expedia.co.uk/John-Pennekamp-Coral-Reef-State-Park-United-States-of-America.d6068611.Attraction) - [Book 5 Star Hotels in Florida Keys on Expedia.com](https://www.expedia.com/5Star-Florida-Keys-Hotels.s50-0-d6023765.Travel-Guide-Filter-Hotels)