Compare and book 5 Star hotels in Florida Keys, United States of America

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Check availability on Florida Keys 5 Star Hotels

Top Florida Keys 5 Star Hotels

Cheeca Lodge & Spa
Private beach, sun-loungers, beach umbrellas, beach towels

Cheeca Lodge & Spa

5.0 star property
9.0 out of 10, Wonderful, (1158)
"amazing stay"
The price is £170
includes taxes & fees
24 Aug - 25 Aug
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.2 out of 10, Wonderful, (1034)
"Beautiful hotel with fantastic facilities and stunning views. Great spot for some family downtime - the kids loved the pools and the linked fishing charters were awesome "
The price is £238
includes taxes & fees
25 Aug - 26 Aug
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy, Key Largo, FL
The price is £252 per night from 2 Sept to 3 Sept
£252
2 Sept - 3 Sept
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Discover the seaside area of Florida Keys—live music, beaches and top sights like Duval Street.

See all hotels in Florida Keys
Higgs Beach showing tropical scenes and a beach as well as a large group of people

Top Florida Keys Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Beautiful hotel with fantastic facilities and stunning views. Great spot for some family downtime - the kids loved the pools and the linked fishing charters were awesome "
Matthew 5-night trip
Posted 2 days ago
Isla Bella Beach Resort & Spa
Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent
"An amazing hidden gem. From the staff to the hotel you feel like you’re on an island. Everyone is sooo friendly and kind!!! Most amazing stay ever !!"
Indira 2-night trip
Posted 3 days ago
Cheeca Lodge & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
How much you pay for a 5-star hotel in Florida Keys depends on factors like when you plan to go and the length of your stay. A top tip for bagging an awesome deal? Use our pricing filters to check out the available accommodation for your chosen dates.

  • Search for the lowest price per night from £189

What makes a hotel 5 stars in Florida Keys?
Impeccable guest service is integral to every 5-star hotel in Florida Keys. From the second you arrive, staff ensure your every need is met, whether recommending activities or providing a turn-down service. What's more, hotels must feature superior conveniences to meet the standard for a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gastronomic restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find a luxurious retreat that includes your room, meals, drinks and entertainment in Florida Keys with the help of our filters. Search for hotels with a 5-star rating and select the "All inclusive" filter. Have a look at what's included in the price. This way, you can take full advantage of all the perks on offer from the moment you arrive.