A large suspension bridge, industrial cranes, and a calm river.

Compare and book 4 Star hotels in Panama Canal Zone, Panama

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone 4 Star Hotels

Tonight
9 Oct - 10 Oct
Tomorrow
10 Oct - 11 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Panama Canal Zone 4-star hotels

A spacious lobby with a high ceiling, modern lighting fixtures, and a glass entrance leading to a lower level.
A modern bar area with a central island, bar stools, and a television mounted on the ceiling.
A modern restaurant with checkered flooring, wooden chairs, and large windows offering a view of greenery.
A modern dining area with a wooden table and chairs, a built-in bookshelf, and a decorative hanging light fixture.

1. Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
Tocumen Airport
United States
Duran
£116
includes taxes & fees
6 Nov - 7 Nov
Crowne Plaza Panama Airport by IHG
A multi-story building with balconies, arched windows, and decorative railings.
A multi-level atrium with wooden staircases, seating areas, and a decorative ceiling.
A spacious lobby with a wooden staircase, multiple seating areas, and a reception desk.
A building with a balcony and a street view.

2. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
Casco Viejo
United States
Olga
£152
includes taxes & fees
8 Nov - 9 Nov
Central Hotel Panama Casco Viejo
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
An escalator in a hotel lobby with a patterned wall and framed artwork.
A modern spa area with a hot tub, seating, and a city view.
A rooftop lounge with modern seating and a panoramic city view.

3. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
benjamin
£113
includes taxes & fees
31 Oct - 1 Nov
Megapolis Hotel Panamá
Pool
A reception area with marble reception desks and a sign indicating the reception desk.
A hotel room with a large bed, a smaller bed, a sofa, a TV mounted on the wall, and a dining area with a table and chairs.
A balcony with a view of a swimming pool, palm trees, and city buildings.

4. Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Bella Vista
United States
Althea
£92
includes taxes & fees
9 Nov - 10 Nov
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
A balcony with wicker chairs and a view of the cityscape.
A hotel room with a large bed, a desk with a lamp, a chair, and a view of a cityscape through a window.
A rooftop pool area with a view of high-rise buildings in the background.
A reception area with a marble wall, a 'Free Wireless Internet' sign, and a floral arrangement.

5. Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
San Francisco
United States
Luis
£87
includes taxes & fees
9 Nov - 10 Nov
Ramada Plaza by Wyndham Panama Punta Pacifica
A resort with a large swimming pool, thatched-roof structures, and palm trees.
A hotel room with a large bed, a chair, a desk, and a view of the ocean.
An outdoor dining area with tables and chairs, overlooking a body of water and a forested island.
A resort with a pool, palm trees, and a building with a red roof.

6. Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive
Veracruz
£210
includes taxes & fees
10 Oct - 11 Oct
Dreams Playa Bonita Panama - All Inclusive
A modern living room with a sofa, a coffee table, a flat-screen TV, and a view of greenery through large windows.
A hotel room with two beds, a desk, a television, and an air conditioning unit.
A conference room with a long table, chairs, and a carpeted floor.
A swimming pool with a wooden bridge, surrounded by palm trees and lounge chairs.

7. Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
Tocumen Airport
United States
Lucas
£90
includes taxes & fees
9 Nov - 10 Nov
Riande Aeropuerto Hotel & Casino
A modern building with a glass facade, a curved structure, and a flat roof.
A modern hotel room with a large bed, a TV, a desk, and a view of the city.
A rooftop lounge area with clear glass tables and chairs, a pool, and potted plants.
A modern hotel room with a large bed, a desk with a flat-screen TV, a city view, and a large painting on the wall.

8. Decapolis Hotel Panama City

Decapolis Hotel Panama City
San Francisco
United States
Jorge Luis
£72
includes taxes & fees
31 Oct - 1 Nov
Decapolis Hotel Panama City
A buffet with various food items including fruits, juices, and cheeses.
An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.
A modern hotel lobby with a sectional sofa, a glass coffee table, and a vibrant green wall mural.
A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.

9. Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
San Antonio
United States
Chaloma
£84
includes taxes & fees
6 Nov - 7 Nov
Courtyard by Marriott Panama Metromall
A multi-story hotel with a Marriott sign, surrounded by high-rise buildings and a busy street with cars.
A coastal building complex with multiple structures, a prominent tower, and a beach in the foreground.
A modern lounge area with a wooden partition, a bar with a variety of bottles, and a seating area with chairs.
A modern reception area with a wooden panel wall, a sign indicating 'Marriott Bonvoy', and three reception desks with digital displays.

10. Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
San Francisco
£94
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Panama Multiplaza Mall
A modern lobby with a glass railing, a central staircase, and a view of the cityscape through large windows.
A modern living area with a sofa, chairs, and a coffee table. There is a view of the city through large windows.
An indoor swimming pool with lounge chairs and a modern interior design.
A modern hotel room with a large window offering a city view, a chandelier, and a cozy seating area.

11. Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
San Francisco
£126
includes taxes & fees
18 Oct - 19 Oct
Las Americas Golden Tower Panama
A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.
A spacious lobby with high ceilings, large windows, and modern lighting fixtures.
A rooftop terrace with outdoor seating, potted plants, and a view of a hill with buildings in the distance.
A buffet setup with various dishes and utensils.

12. Marriott Panama Hotel

Marriott Panama Hotel
Panama City
£148
includes taxes & fees
17 Oct - 18 Oct
Marriott Panama Hotel
A hotel room with a sofa, a coffee table, a TV, and a cabinet.
A rooftop swimming pool with lounge chairs and a city skyline in the background.
A cityscape with modern high-rise buildings, including a prominent tower labeled 'TOWERBANK.'
A hotel room with a bed, bedside tables, a nightstand, a lamp, a digital clock, a bathroom with a toilet, a sink, and a mirror.

13. Studio Coliving

Studio Coliving
Bella Vista
United States
Phillip
Studio Coliving
A rooftop pool with sun loungers and a city skyline in the background.
A modern hotel room with a large bed, a desk, a chair, and a wardrobe.
A long, narrow hallway with a wooden floor and light-colored walls.
A bar area with a curved counter, multiple screens, and a patterned carpet.

14. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
Bella Vista
United States
Bruno
£108
includes taxes & fees
18 Oct - 19 Oct
Waymore Hotel Spa & Casino
A modern hotel entrance with a prominent 'NOVOTEL' sign, large glass windows, and geometric light patterns on the facade.
A bar area with a variety of liquor bottles, a counter, and seating with tables and chairs.
A hotel room with a bed and a view of a cityscape through sheer curtains.
A spacious lobby with large windows, a curved ceiling, and a seating area with a patterned rug.

15. Novotel Panama City

Novotel Panama City
Bella Vista
£97
includes taxes & fees
18 Oct - 19 Oct
Novotel Panama City
A resort with a pool area, lounge chairs, and a view of a bridge at night.
A reception desk with three staff members, a green patterned wall, a wooden reception area, and a large plant.
A formal dining area with round tables, white tablecloths, and blue lace borders.
A hotel room with a bed, a TV on a wooden cabinet, a nightstand with a lamp, and a view of the outdoors through a glass door.

16. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
Amador
United States
Jose
£70
includes taxes & fees
16 Oct - 17 Oct
Radisson Hotel Panama Canal
A buffet with various food items and a decorative plant.
A spa area with a hot tub, candles, and a curved bench.
A gym with treadmills, weight machines, and a red carpet.
A hotel with a swimming pool, outdoor seating, and a modern architectural design.

17. Sheraton Grand Panama

Sheraton Grand Panama
San Francisco
United States
Nicole
£145
includes taxes & fees
1 Nov - 2 Nov
Sheraton Grand Panama
A poolside area with covered seating and palm trees.
A modern reception area with a large window, a geometric patterned floor, and two potted plants.
A modern living room with a city view, a flat-screen TV, and a dining area with white chairs and a table.
A modern interior with a large abstract sculpture, a staircase, a sofa with orange cushions, and a patterned rug.

18. Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Bella Vista
£216
includes taxes & fees
12 Oct - 13 Oct
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
A spacious indoor area with high ceilings, large windows, and multiple dining tables.
A spacious lobby with a tiled floor, large windows, and potted plants.
A white building with multiple balconies, large windows, and decorative railings.
A multi-story hotel with a central courtyard, balconies, and a view of the city skyline.

19. American Trade Hotel

American Trade Hotel
Casco Viejo
£166
includes taxes & fees
13 Oct - 14 Oct
American Trade Hotel
A wooden door with a number plate, a black and white striped bag, and a lantern on the ground.
A bedroom with a large bed, a stone wall, a wooden bench, and a hanging light fixture.
A restaurant with a wine display and a table set for two.
A rooftop terrace with a city skyline view, a pool, and outdoor seating.

20. Hotel Casa Panamá

Hotel Casa Panamá
Casco Viejo
United States
Naveera Jyoti
£55
includes taxes & fees
8 Nov - 9 Nov
Hotel Casa Panamá
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Panama Canal Zone.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
£110
25 Oct - 26 Oct
includes taxes & fees
Hotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama
£218
2 Nov - 3 Nov
includes taxes & fees
Waldorf Astoria Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama
£292
3 Nov - 4 Nov
includes taxes & fees
Sofitel Legend Casco Viejo, Panama City
Still don't see what you're looking for?
See all properties in Panama Canal Zone.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—rainforests, golf courses and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
A large suspension bridge, industrial cranes, and a calm river.

Top Panama Canal Zone Hotel Reviews

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

10/10 Excellent
"I thought it was also close to multiple restaurants and a AmPm type shop. Very convenient. Good food in their in-house restaurant."
Leonel 2-night trip
Posted 9 hours ago
Ramada Plaza by Wyndham Panama Punta Pacifica
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

10/10 Excellent
"I recommend"
Tejishwar 5-night trip
Posted 12 hours ago
Dreams Playa Bonita Panama - All Inclusive
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

10/10 Excellent
"N/A"
WINIFER TORIBIO 3-night trip
Posted 21 hours ago
Waymore Hotel Spa & Casino
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

8/10 Good
"Good hotel conveniently located in the mall but not directly connected inside it. It’s by the parking lot. My only other complaint is that they don’t have AC or at least don’t turn it on for the hallways and elevators so it can get very hot on your way to the lobby. Otherwise decent hotel, good breakfast and friendly staff."
Luis 3-night trip
Posted 1 day ago
Courtyard by Marriott Panama Multiplaza Mall
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

10/10 Excellent
"Muy cerca al aeropuerto y buena comida buffet..aparte el shutter muy puntual solo falto pantuflas para el baño para no pasar el piso descalso sea transporte excelente"
Ruth Mercedes 1-night trip
Posted 1 day ago
Crowne Plaza Panama Airport by IHG
Marriott Panama Hotel

Marriott Panama Hotel

10/10 Excellent
"Smooth check-in, clean rooms, good breakfast, smooth checkout."
Calvin 4-night trip
Posted 4 days ago
Marriott Panama Hotel

Find out more about Panama Canal Zone

Frequently asked questions

What are the best 4-star hotels in Panama Canal Zone?
Melia Panama Canal is a 4-star hotel in Panama Canal Zone that's popular among Expedia guests. Concierge services and a terrace are just a couple of its amenities. Travellers also recommend Radisson Colon 2,000 Hotel & Casino. From a swimming pool to spa facilities, it comes with conveniences that cater to every aspect of your relaxation and enjoyment.
How much does it cost to stay in a 4-star hotel in Panama Canal Zone?
To lock in a 4-star hotel in Panama Canal Zone that fits your budget, use Expedia's search and sort filters. Take a look at the availability during your holiday dates and use our pricing filter to set your limit. You can also sort your results by the most economical property first.
  • Search for the lowest price from £110
What's the difference between 5-star and 4-star hotels in Panama Canal Zone?
Treat yourself to luxury living during your Panama Canal Zone escape by choosing a 4-star hotel. As well as featuring upscale accommodation, these properties are usually filled with amenities, including complimentary bathrobes, large beds and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and unforgettable one. Concierge assistance, elegant furnishings and world-class dining are a few of the superior conveniences and services you'll likely get access to.