Beginning of main content

Florida Keys Hotel Guide - 4 stars Hotels in Florida Keys, United States of America

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florida Keys Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 265 Hotels in Florida Keys
Southernmost Beach Resort
Southernmost Beach Resort
508 South St, Key West
4.0 out of 5.0
4.5 out of 5 (1,358 reviews)
Hide review
Absolutely Beautiful Hotel !!! Amazing experience here. The room, the grounds and the service is top notch. One of the nicest spots you can stay on Key West.
  20 May 2017

£208

£208
Pier House Resort & Spa
Pier House Resort & Spa
1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (612 reviews)
Hide review
Fantastic resort. We will for sure stay there again
  19 May 2017

£250

£250
Ocean Key Resort - A Noble House Resort
Ocean Key Resort - A Noble House Resort
Zero Duval St., Key West
4.0 out of 5.0
4.6 out of 5 (711 reviews)
Hide review
Room booked was not what we received The first time we stayed at the Ocean Key we would have rated it 5 stars, this time, not so much. We paid a lot extra for what was described as an island view, what we got was a view of Duvall Street! When ask about it, we were told, Key West is an island so you did get an island view!!! That's pretty ...
  16 May 2017

£249

£249
The Gardens Hotel
The Gardens Hotel
526 Angela Street, Key West
4.0 out of 5.0
4.8 out of 5 (111 reviews)
Hide review
Small boutique hotel with the best beds! Elegant small boutique hotel. Close enough to Duvall but far enough to be quiet and relaxing. Absolutely the best beds ever.
  7 May 2017

£131

£131
Little Palm Island Resort & Spa - A Noble House Resort
Little Palm Island Resort & Spa - A Noble House Resort
28500 Overseas Hwy, Little Torch Key
4.5 out of 5.0
4.9 out of 5 (21 reviews)
Hide review
Incredible experience from start to finish; the staff was terrific and the experience was everything I thought it would be
  2 Mar 2017

£763

£763
Hyatt Centric Key West Resort and Spa
Hyatt Centric Key West Resort and Spa
601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (657 reviews)
Hide review
Great place.... Great view ! The Hyatt is by far one of the best places to stay in Key West. The service was outstanding, the food was great and the view is worth every penny.
  4 May 2017

£201

£201
Cheeca Lodge & Spa
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (634 reviews)
Hide review
Very elegant resort When we arrive, we were nicely greeted by the valet and then went to check in, we were greeted with glasses of champagne - NICE!
  19 May 2017

£206

£206
Santa Maria Suites
Santa Maria Suites
1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (355 reviews)
Hide review
Santa Maria Suites was a wonderful hotel! We enjoyed everything about this hotel, from the front desk staff of Ken and Matilda, to the pool bartender and room service people. Everyone was so friendly. The modern accommodations were clean and comfortable. The amenities (wine, Dove bars, Ghiardelli chocolates , muffins and bottled water in ...
  28 Apr 2017

£242

£242
Parrot Key Hotel & Resort
Parrot Key Hotel & Resort
2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,108 reviews)
Hide review
What a wonderful hotel. We arrived and were quickly checked in. The hotel is incredible. The staff were excellent. The staff who helped us get our stuff to our room were amazing. Especially wonderful were the cats that roamed the facility. They were very well taken care of. They kept the chickens away. The four swimming ...
  15 May 2017

£188

£188
Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (451 reviews)
Hide review
Very beautiful resort. Wonderful experience. Tranquility is the perfect word to describe this beautiful resort. The cottages have more than enough room to accommodate a family. The pool was wonderful. Our kids loved it. The beach was peaceful and relaxing. Not the kind of beach you find along the Atlantic. Loved the experience at Tranquility ...
  13 May 2017

£180

£180
Map

Pocket Guide: 4 stars Hotels in Florida Keys

4 Star Luxury in the Florida Keys

You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.

Where Are Florida Keys’ 4 Star Hotels?

Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.

You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.

Enjoy the Florida Keys in Style

Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.

If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.

Recently booked Florida Keys hotels

Southernmost Beach Resort
4.0 out of 5.0
Last booking: 29 minutes ago