Beginning of main content

4 Star Hotels in Florida Keys, Florida

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florida Keys Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 Star Hotels

See all 344 Hotels in Florida Keys
Parrot Key Hotel & Resort

Parrot Key Hotel & Resort

2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,133 reviews)
Great Hotel!The resort really has customer service down to a fine art. They're professional, courteous and friendly. The pools are in great condition, the rooms are beautifully appointed, oh and those bath products are 10/10. Food selection at the cafe could be better, but its clean so no complaints. Very family ...
  23 Aug 2017

£101

£101
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
3.5 out of 5.0
3.9 out of 5 (332 reviews)
Nice. Lots of neighboring construction Hurt the experience a little. Hot tub would be nice.
  23 Aug 2017

£87

£87
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (652 reviews)
Excellent staff with amazing service!! Great locatI have stayed at Cheeca many times & it has been excellent always. All Of the staff & there services are amazing!
  23 Aug 2017

£154

£154
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,137 reviews)
Wonderful staff, very clean great service.When we got there at 4 p.m. my room wasn't ready. It took an hour for us to go to our room. They gave us a late check out to make up for the time we lost. The staff is very friendly and nice. The room and hotel itself was very clean. The bars were great. I enjoyed the pools and the beach. I would ...
  22 Aug 2017

£154

£154
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
3.5 out of 5.0
4.0 out of 5 (595 reviews)
Need better house cleaning The room was not cleaning while we were gone all day. Had to ask for clean towels.
  23 Aug 2017

£137

£137
Casa Marina Resort - A Waldorf Astoria Resort

Casa Marina Resort - A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.1 out of 5 (978 reviews)
Nice place, warm waters, small beaches, good foodThis seems to be one of the better hotels on Key West. The rooms are nice and the service was quite good. The whole atmosphere is elegant and understated. I would stay there again. One disadvantage was the small beach areas: more coral than sand.
  21 Aug 2017

£196

£196
Southernmost Beach Resort

Southernmost Beach Resort

508 South St, Key West
4.0 out of 5.0
4.5 out of 5 (1,456 reviews)
Great hotel and private beachGreat place to stay. Private beach with a nice hotel beach cafe. The food was great and the staff was very friendly. The pools had pool bars with outdoor tv's and they were amazing. The rooms were nice and clean. I recommend this place to everyone!
  23 Aug 2017

£151

£151
Oceans Edge Key West Hotel & Marina

Oceans Edge Key West Hotel & Marina

5950 Peninsular Avenue, Key West
3.5 out of 5.0
4.4 out of 5 (89 reviews)
OutstandingThe hotel is beautiful and right by the ocean. Customer service was top notch and everyone was extremely polite. You could probably spend your entire trip at the hotel because it is just that nice and relaxing. About a ten minute drive from the hotel to the main attractions; there is a parking garage ...
  23 Aug 2017

£117

£117
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (305 reviews)
Very goodVery good, clean and friendly. The hotel was everything that the pictures show and the staff was very courteous. It was very clean and very much to our expectations.
  17 Aug 2017

£96

£96
Map

Pocket Guide: 4 stars Hotels in Florida Keys

4 Star Luxury in the Florida Keys

You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.

Where Are Florida Keys’ 4 Star Hotels?

Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.

You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.

Enjoy the Florida Keys in Style

Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.

If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.

Recently booked Florida Keys hotels

Cheeca Lodge & Spa
4.0 out of 5.0
Last booking: 19 minutes ago