Beginning of main content

Florida Keys Hotel Guide - 4 stars Hotels in Florida Keys, Florida

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florida Keys Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 266 Hotels in Florida Keys
Hyatt Centric Key West Resort and Spa
Hyatt Centric Key West Resort and Spa
601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (659 reviews)
Hide review
Luxury Loved the Dauphin show. Beautiful room and grounds. Food was great but pricey $$
  25 May 2017

£225

£225
Southernmost Beach Resort
Southernmost Beach Resort
508 South St, Key West
4.0 out of 5.0
4.5 out of 5 (1,361 reviews)
Hide review
Best location Concierge helped us book a seadoo tour. Even let us use bikes for free that they keep on the property. Got us a discount rate. Three pools, one next to the beach with drink service. Had a great time.
  27 May 2017

£199

£199
Pier House Resort & Spa
Pier House Resort & Spa
1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (615 reviews)
Hide review
Great stay in Key West. Would come back to this place again.
  24 May 2017

£250

£250
Ocean Key Resort - A Noble House Resort
Ocean Key Resort - A Noble House Resort
Zero Duval St., Key West
4.0 out of 5.0
4.6 out of 5 (712 reviews)
Hide review
Wonderful stay, excellent location to restaurants and shops. Waterfront hotel with pool by the ocean.
  24 May 2017

£249

£249
Little Palm Island Resort & Spa - A Noble House Resort
Little Palm Island Resort & Spa - A Noble House Resort
28500 Overseas Hwy, Little Torch Key
4.5 out of 5.0
4.9 out of 5 (21 reviews)
Hide review
Incredible experience from start to finish; the staff was terrific and the experience was everything I thought it would be
  2 Mar 2017

£763

£763
The Gardens Hotel
The Gardens Hotel
526 Angela Street, Key West
4.0 out of 5.0
4.8 out of 5 (111 reviews)
Hide review
Small boutique hotel with the best beds! Elegant small boutique hotel. Close enough to Duvall but far enough to be quiet and relaxing. Absolutely the best beds ever.
  7 May 2017

£163

£163
Santa Maria Suites
Santa Maria Suites
1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (356 reviews)
Hide review
Nice hotel , great location Hotel staff were great, excellent services and great amenities.
  24 May 2017

£242

£242
Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (453 reviews)
Hide review
Best Resort in Keys We were overly impressed with the resort and staff. Beautifully landscaped with everything in one spot, makes this the perfect getaway.
  24 May 2017

£180

£180
Parrot Key Hotel & Resort
Parrot Key Hotel & Resort
2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,109 reviews)
Hide review
serenity Extremely peaceful, beautiful surroundings, staff very friendly, walking convenience to Walgreens, Denny's, Dominos Pizza, but you wouldn't even know these stores are around..shuttle service to Duvall Street/ Mallory Center, Smathers Beach, 4 different pools..great place to relax after a full day ...
  24 May 2017

£176

£176
Cheeca Lodge & Spa
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (636 reviews)
Hide review
Really beautiful place. Nice spacious rooms. The beach is not for swimming, but the pools were lovely and not at all crowded. The food was good and the staff really nice and helpful. They gave us a glass of champagne while we were first got there. The gardening was really beautiful. The weather couldn't ...
  25 May 2017

£206

£206
Map

Pocket Guide: 4 stars Hotels in Florida Keys

4 Star Luxury in the Florida Keys

You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.

Where Are Florida Keys’ 4 Star Hotels?

Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.

You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.

Enjoy the Florida Keys in Style

Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.

If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.

Recently booked Florida Keys hotels

Parrot Key Hotel & Resort
4.0 out of 5.0
Last booking: 2 hours ago