Compare and book 4 Star hotels in Florida Keys, United States of America
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Top Florida Keys 4 Star Hotels

Hawks Cay Resort
Hawks Cay Resort

Amara Cay Resort
Amara Cay Resort

Islander Resort
Islander Resort

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection

Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort

La Siesta Resort & Villas
La Siesta Resort & Villas

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Explore similar 5-star hotels

Isla Bella Beach Resort & Spa
Learn more about Florida Keys
Jogging trails, fishing spots and popular sights from Duval Street to Everglades National Park—explore Florida Keys, a seaside destination also known for its live music scene.

Find out more about Florida Keys
Find out more about Florida Keys
Pocket Guide: 4 Stars Hotels in Florida Keys
4 Star Luxury in the Florida Keys
You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.
Where Are Florida Keys’ 4 Star Hotels?
Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.
You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.
Enjoy the Florida Keys in Style
Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.
If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.
Florida Keys Hotel Reviews
Florida Keys Hotel Reviews

Islander Resort
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Explore a world of travel with Expedia
Hotels in Florida Keys by Star Rating
Accommodation near Florida Keys attractions
- Hotels near Duval Street
- Hotels near Southernmost Point
- Hotels near Mallory Square
- Hotels near Smathers Beach
- Hotels near Sombrero Beach
- Hotels near John Pennekamp Coral Reef State Park
- Hotels near South Beach
- Hotels near Jimmy Johnson's Big Chill
- Hotels near Biscayne National Park
- Hotels near Stock Island Yacht Club & Marina
- Hotels near Clarence S. Higgs Memorial Beach Park
Choose Your Florida Keys Hotel Style
- Beach Resorts & Hotels in Florida Keys
- Business Hotels in Florida Keys
- Cheap Hotels in Florida Keys
- Family-Friendly Hotels in Florida Keys
- Golf Hotels in Florida Keys
- Historic Hotels in Florida Keys
- Hotels near Museums in Florida Keys
- Hotels with Air Conditioning in Florida Keys
- Hotels with Balcony in Florida Keys
- Hotels with Breakfast in Florida Keys
- Hotels with Connecting Rooms in Florida Keys
- Hotels with Entertainment in Florida Keys
- Hotels with Gym in Florida Keys
- Hotels with Hot Tubs in Florida Keys
- Hotels with Laundry Service in Florida Keys
- Hotels with Parking in Florida Keys
- Hotels with Parking in Florida Keys
- Hotels with Pool in Florida Keys
- Hotels with Restaurant in Florida Keys
- Hotels with Room Service in Florida Keys
- Hotels with Wifi in Florida Keys
- Hotels with a Bar in Florida Keys
- Hotels with a View in Florida Keys
- Hotels with smoking rooms in Florida Keys
- Luxury Hotels in Florida Keys
- Marina Hotels in Florida Keys
- Pet-Friendly Hotels in Florida Keys
- Romantic Hotels in Florida Keys
- Shopping Hotels in Florida Keys
- Spa Hotels in Florida Keys
- Sports Hotels in Florida Keys
- Wedding Hotels in Florida Keys
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- Holiday Homes in Florida Keys
- Condo Rentals in Florida Keys
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Explore more hotels
- Reefhouse Resort & Marina
- Playa Largo Resort & Spa, Autograph Collection
- Waterside Suites & Marina
- Lime Tree Bay Resort
- La Siesta Resort & Villas
- Marina Del Mar Resort and Marina
- Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
- Courtyard by Marriott Faro Blanco Resort
- Holiday Inn Key Largo by IHG
- Rock Reef Resort
- Creekside Inn Islamorada
- Tranquility Bay Beachfront Hotel and Resort
- The Pelican Key Largo Cottages
- Coconut Cay Resort & Marina
- Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
- Hadley Resort and Marina
- Drift Hotel
- Fisher Inn Resort & Marina
- Dove Creek Resort & Marina, Trademark Collection by Wyndham
- Sunset Cove Beach Resort