Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 Star Hotels

See all 508 Hotels in Florida Keys
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.2 out of 5 (2,361 reviews)
Nice hotel. Nice breakfast. Poor beach. Rooms good but need bathroom remodelation. Excellent worker.
  6 Sep 2017

£173

£173
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.0 out of 5.0
4.1 out of 5 (1,037 reviews)
Hotel has a great shuttle to Mallory Square! The hotel was nice. The shuttle was fantastic because we did not have to use our rental car the whole time we were there. The only complaint I have is it is very noisy in the mornings on the Gulf side. Next time I will get a room on the pool side.
  9 Nov 2017

£117

£117
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.0 out of 5.0
4.1 out of 5 (1,861 reviews)
Top notch StaffThe hotel common areas and staff are very good and helpful. I stopped to ask a question or two several times and always received accurate information. While coming and going they front desk staff always had a hello and a smile which makes me feel like a valued customer. The remodeled lobby/bar is ...
  5 Nov 2017

£147

£147
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (1,063 reviews)
great experience...loved the complimentary rum punch 😁
  21 Nov 2017

£127

£127
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.0 out of 5.0
4.3 out of 5 (149 reviews)
Margaritaville at Its BestWe had a great time. Very nice to be on the water with sunset views yet close to all the restaurants and Duvall St. Food was great. The mojito at Bistro 245 was awesome. We loved our Marina/Ocean view to watch the cruise ships from our balcony. For this trip we had a vehicle so also nice to have ...
  20 Nov 2017

£166

£166
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (1,288 reviews)
Overall, great property.Treated ourselves to a nice hotel for a last minute trip to Key West. The property was beautiful, room was very nice and even though we didn’t pay for a water front room, we still had a partial view from our balcony. The only complaint I have is that multiple staff members had us a on a search for ...
  10 Nov 2017

£183

£183
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (1,421 reviews)
Nice Key West spotThis was a very nice hotel and friendly hotel staff. The ‘beach’ is very small, but nice, and excellent music in the bar/restaurant next to it close to Duvall street stuff and Mallory square.
  20 Nov 2017

£205

£205
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.5 out of 5 (294 reviews)
Beautiful hotelMy husband and I had a wonderful time staying at this beautiful hotel. Will definitely be back.
  19 Nov 2017

£122

£122
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (3,084 reviews)
Great HotelGreat Hotel! Has a lot of options for everyone. 2 Beach options, 3 pools, restaurant on/near site and right on Duval street. The rooms had character and were some of the nicest we've been in. Staff was friendly and helpful. Our only negative was the extra fees not included in room rate - (parking, ...
  20 Nov 2017

£157

£157
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (1,033 reviews)
Nice room close to waterVery nice! Happy about the hotel. Plan to stay next time with friends. Hope can get a good deal, so we can stay a little longer. Thanks. Nice seafood restaurant close by. Hope we can get more fish tomorrow.
  19 Nov 2017

£137

£137
Map

Pocket Guide: 4 stars Hotels in Florida Keys

4 Star Luxury in the Florida Keys

You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.

Where Are Florida Keys’ 4 Star Hotels?

Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.

You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.

Enjoy the Florida Keys in Style

Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.

If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.