Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5
Nectar
Collect Nectar points
Nectar
Collect Nectar points
Nectar
Collect Nectar points

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 Star Hotels

See all 880 Hotels in Florida Keys
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
    4.0 out of 5.0
     
     
    4.5 out of 5 (3,325 reviews)
    Outstanding Service...The Best Hotel on Key WestMy wife and I stayed at Southernmost two years ago and loved it. We thought it would be nice to try another hotel for a change and booked the Hyatt Centric. It had great pictures and the reviews were good but it was a disappointment. I called Southernmost and they were able to get us into an Ocean ...
    18 Apr 2018

    Southernmost Beach Resort£192

    Southernmost Beach Resort£192
    Oceans Edge Key West Resort, Hotel & Marina

    Oceans Edge Key West Resort, Hotel & Marina

    5950 Peninsular Avenue, Key West
      4.0 out of 5.0
       
       
      4.5 out of 5 (481 reviews)
      Nice but a bit out of the way. Hours of operation of the bar and restaurant were confusing.
      21 Apr 2018

      Oceans Edge Key West Resort, Hotel & Marina£115

      Oceans Edge Key West Resort, Hotel & Marina£115
      The Gates Hotel Key West

      The Gates Hotel Key West

      3824 N Roosevelt Blvd, Key West
        4.0 out of 5.0
         
         
        4.3 out of 5 (1,191 reviews)
        Good hot, nice renovations!I really enjoyed my two night stay. They had a nice bar, a great lobby and two pretty good pools. The gym was comfortable with nice equipment. Staff was nice and on point. Shuttle back and forth to town was included as well as internet!
        21 Apr 2018
        24 North Hotel Key West

        24 North Hotel Key West

        3820 North Roosevelt Boulevard, Key West
          4.0 out of 5.0
           
           
          4.1 out of 5 (1,167 reviews)
          We had a great vacation! Staff was friendly and helpful. No complaints.
          20 Apr 2018
          The Marker Waterfront Resort Key West

          The Marker Waterfront Resort Key West

          200 William Street, Key West
            4.0 out of 5.0
             
             
            4.5 out of 5 (944 reviews)
            We had an excellent stay. Beautiful facility and great location. The staff was fantastic including the "conch"cierge. We will be back.
            18 Apr 2018

            The Marker Waterfront Resort Key West£162

            The Marker Waterfront Resort Key West£162
            Margaritaville Key West Resort & Marina

            Margaritaville Key West Resort & Marina

            245 Front Street, Key West
              4.0 out of 5.0
               
               
              4.3 out of 5 (268 reviews)
              Nice hotel close to everything Loved staying here at this hotel. Could have stayed much longer. Great location, beautiful view, food was good, staff friendly. Would recommend this to anyone.
              20 Apr 2018

              Margaritaville Key West Resort & Marina£182

              Margaritaville Key West Resort & Marina£182
              Hyatt Centric Key West Resort and Spa

              Hyatt Centric Key West Resort and Spa

              601 Front St, Key West
                4.0 out of 5.0
                 
                 
                4.4 out of 5 (1,348 reviews)
                Can’t wait to go back!The Hyatt centric in Key West is amazing! We loved our recent stay! Most of the staff was top notch a, courteous, helpful and there! Our restaurant experience was great bc the waitress was super ... food super! Sent from my iPad
                15 Apr 2018

                Hyatt Centric Key West Resort and Spa£240

                Hyatt Centric Key West Resort and Spa£240
                La Concha Hotel & Spa

                La Concha Hotel & Spa

                430 Duval St, Key West
                  4.0 out of 5.0
                   
                   
                  4.1 out of 5 (1,835 reviews)
                  Nice hotelGreat stay. Shower leaks. The lobby bathroom was kind of dirty during our stay. The balcony room is the best.
                  20 Apr 2018

                  La Concha Hotel & Spa£175

                  La Concha Hotel & Spa£175
                  The Perry Hotel Key West

                  The Perry Hotel Key West

                  7001 Shrimp Road, Key West
                    4.0 out of 5.0
                     
                     
                    4.6 out of 5 (151 reviews)
                    It was a nice hotel. Thought the pet fee was a little steep
                    20 Apr 2018

                    The Perry Hotel Key West£127

                    The Perry Hotel Key West£127
                    Tranquility Bay Beachfront Hotel and Resort

                    Tranquility Bay Beachfront Hotel and Resort

                    2600 Overseas Hwy, Marathon
                      4.0 out of 5.0
                       
                       
                      4.5 out of 5 (1,095 reviews)
                      Peaceful and serene destination.An outstanding resort for peace and serenity. Absolutely beautiful!
                      18 Apr 2018

                      Pocket Guide: 4 Stars Hotels in Florida Keys

                      4 Star Luxury in the Florida Keys

                      You’ll find a great selection of four-star hotels in Florida Keys, each reflecting its very own character, charm and ethos. Whatever the style, whether it’s an elegant resort and spa, contemporary seaside hotel or plush cottage, most four-star accommodation in the Florida Keys are close to the water, and you wouldn’t want it any other way. For the true magic of the Florida Keys is in its beaches, coral reefs and Gulf of Mexico views.

                      Where Are Florida Keys’ 4 Star Hotels?

                      Key West is home to most of Florida Keys’ four-star resorts. With Mallory Square Plaza, beautiful beaches, its historic old town and a world-class golf course, Key West is one of the most idyllic places to stay.

                      You’ll also find luxury accommodation on Islamorada, as well as the lesser-visited islands of Little Torch Key and the romantic Marathon Island. With swimming pools, sea views and palm trees (not to mention the spas and fine-dining restaurants) it will be hard to drag yourself away from your four-star hotel to explore.

                      Enjoy the Florida Keys in Style

                      Looking out to sea is one thing, but for an experience you won’t quickly forget, get out on to the water in comfort aboard your very own yacht for the day and explore hidden beaches and clear coves. You can charter catamarans, sail or motorboats from many of the islands’ marinas or through your hotel concierge. Anglers, whether novices or long-time enthusiasts, will find the waters teeming with big-game fish. Or why not learn a new water sport? Scuba-diving courses are a wonderful experience and will introduce you to a whole new world beneath the waves.

                      If you’re more of a land-lubber than a budding mariner, hunker down by one of the oasis-like pools in your hotel with a fruit rum cocktail in hand and ease in to your stay. Museums such as the Ernest Hemingway House, art galleries and cigar rooms are local institutions and give you an insight into the culture and history of the Florida Keys.

                      Recently booked Florida Keys hotels

                      Gilbert's Resort
                      2.0 out of 5.0
                      Last booking: 16 minutes ago
                      Skipjack Resort & Marina
                      3.0 out of 5.0
                      Last booking: 22 minutes ago
                      Best Western Hibiscus Motel
                      2.5 out of 5.0
                      Last booking: 26 minutes ago
                      Lime Tree Bay Resort
                      3.5 out of 5.0
                      Last booking: 1 hour ago
                      Orchid Key Inn
                      3.5 out of 5.0
                      Last booking: 1 hour ago
                      Postcard Inn Beach Resort & Marina
                      3.0 out of 5.0
                      Last booking: 1 hour ago
                      Hampton Inn Key Largo Manatee Bay
                      2.5 out of 5.0
                      Last booking: 1 hour ago
                      Ibis Bay Beach Resort
                      2.5 out of 5.0
                      Last booking: 1 hour ago
                      Hyatt Place Marathon Florida Keys
                      3.0 out of 5.0
                      Last booking: 2 hours ago