£164 Cheap Flights from St. Louis (STL) to San Francisco (SFO)

View £164 flight on Tue, 13 Oct 2026Opens in a new window

Popular airlines from Lambert-St. Louis International Airport (STL) to San Francisco International Airport (SFO)

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Cheap Flights from St. Louis (STL) to San Francisco (SFO)

Prices were available within the past 7 days and start at £164 for one-way flights and £330 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£330 Return, found 6 days ago
£330
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £330 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£368 Return, found 6 days ago
£368
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £368 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£370 Return, found 6 days ago
£370
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £370 found 6 days ago
Alaska Airlines
Wed, 3 Jun - Tue, 9 Jun
STL
St. Louis
SFO
San Francisco
£403 Return, found 4 days ago
£403
Return
found 4 days ago
Select Alaska Airlines flight, departing Wed, 3 Jun from St. Louis to San Francisco, returning Tue, 9 Jun, priced at £403 found 4 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£405 Return, found 6 days ago
£405
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £405 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£406 Return, found 6 days ago
£406
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £406 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£407 Return, found 6 days ago
£407
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £407 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
STL
St. Louis
SFO
San Francisco
£416 Return, found 6 days ago
£416
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from St. Louis to San Francisco, returning Wed, 27 May, priced at £416 found 6 days ago
Alaska Airlines
Wed, 3 Jun - Tue, 9 Jun
STL
St. Louis
SFO
San Francisco
£418 Return, found 4 days ago
£418
Return
found 4 days ago
Select Alaska Airlines flight, departing Wed, 3 Jun from St. Louis to San Francisco, returning Tue, 9 Jun, priced at £418 found 4 days ago
Alaska Airlines
Wed, 3 Jun - Tue, 9 Jun
STL
St. Louis
SFO
San Francisco
£419 Return, found 4 days ago
£419
Return
found 4 days ago
Select Alaska Airlines flight, departing Wed, 3 Jun from St. Louis to San Francisco, returning Tue, 9 Jun, priced at £419 found 4 days ago

Alternative airports near San Francisco

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to San Francisco Intl. SFO. Cheapest and Closest option available. Average driving time to city centre is 19 minutes. Flights from £521
SFO
San Francisco Intl.
CheapestClosest
Average driving time to city centre19 min
Flights from £521

Frequently asked questions

How much does a flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) cost?
One-way flights typically cost between £290 and £1,064 and return flights often range between £290 and £1,064. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.
What is the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
September is typically the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.), with average return fares of approximately £524. This is about 13% lower than the average price throughout the year. September often sees lower prices as the summer travel rush ends and before the holiday season begins. Other cheap months to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) include August and October.
Which airlines fly direct from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Enter STL to SFO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
To find a cheap flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) (STL) to San Francisco, CA (SFO-San Francisco Intl.) (SFO) will differ from traveller to traveller. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. WN offers the most daily flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) (STL) to San Francisco, CA (SFO-San Francisco Intl.) (SFO), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Based on booking data from the past year, the cheapest months to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) are typically September and October, with average return flights around £524. While these months offer great value, the most popular times to travel are August and March, which means you'll find plenty of flight options during those periods. If you're looking for the best balance of price and availability, focusing on September or October could be a good strategy, as you'll likely find more affordable fares.
How many flights per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
When flying from Lambert-St. Louis Intl. (STL) to San Francisco Intl. (SFO), you'll find approximately 2 nonstop flights per day. For even more choice, look at flights that include layovers, as there are around 94 connecting flights per day. Some common connection points include O'Hare Intl. (ORD), Seattle - Tacoma Intl. (SEA), and Denver Intl. (DEN).
What is the earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in January, November, and December. An early departure like this can help you maximise your time in San Francisco. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
You'll typically find the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) on a Friday, with around 76 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Southwest Airlines, United Airlines, and American Airlines. Flight schedules are consistent throughout the week, with Friday offering only slightly more options.
What are the most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The most popular departure times for flights from Lambert-St. Louis Intl. (STL) to San Francisco Intl. (SFO) are in the early morning, from 6am to 9am. About 35% of passengers prefer this time. Many major carriers, including American Airlines, Southwest Airlines and Delta Air Lines, offer flights during this window. This timing works well because you can get an early start to your travel day and arrive in San Francisco with plenty of time to settle in.
How long does it take to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Flying nonstop from STL to SFO takes around 4 hours 30 minutes, with the route covering approximately 1,732 miles. Flights with a layover typically take 3 hours 30 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Select the "Business class" and "First class" filters when looking for STL to SFO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight with Expedia?
It's easy to earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Francisco from Lambert-St. Louis Intl. (STL)?
From Lambert-St. Louis Intl. (STL), you can fly directly into San Francisco Intl. (SFO) to reach San Francisco. Some flights may connect through major hubs like Seattle - Tacoma Intl. (SEA), Love Field (DAL), Wichita Dwight D. Eisenhower National (ICT) before reaching San Francisco. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) at the last minute?
Typically, booking a last minute flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight and hotel package?
Securing a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
If you booked your St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
San Francisco Intl.
Return price
£330
Distance
2771 km
Average flight time
4 hours 18 mins

Book with confidence

Compare flights from St. Louis to San Francisco easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from St. Louis to San Francisco. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to San Francisco Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Lambert-St. Louis Intl. to San Francisco Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Lambert-St. Louis Intl. (STL) to San Francisco Intl. (SFO)

The easiest way to view the best deals on flights from St. Louis to San Francisco today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Lambert-St. Louis Intl. to San Francisco Intl. start at just £330 and range up to £419.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near St. Louis and San Francisco
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your St. Louis to San Francisco flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Lambert-St. Louis Intl. to San Francisco Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from St. Louis to San Francisco easily and book with confidence

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