Title: £28 Cheap Flights from Santiago to La Serena (SCL to LSC) - Expedia.co.uk ![Lighthouse at La Serena, Chile](https://images.trvl-media.com/place/2139/d4916bcd-6a4a-4c25-b665-93e13c32c0c5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/2139/d4916bcd-6a4a-4c25-b665-93e13c32c0c5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £28 Cheap Flights from Santiago (SCL) to La Serena (LSC) [View £28 flight on Wed, 10 Dec 2025](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:SCL,to:LSC,departure:10/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:27.30&airProductToken=AQovCi0IyGQSBDE3MTIY0lggyxQosKr_AjD3qv8COEFAAFgBagJaT3IIQVpPMTAwMDASCggBEAEYASoCSFIYASIECAEQASgCKAMoBDAB) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Santiago Intl. Airport (SCL) to La Serena (LSC-La Florida) - ![LATAM Airlines Group](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group [](https://www.expedia.co.uk/Flights-Search?leg1=from:SCL,to:LSC,departure:04/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"LA"}}]) - ![Sky Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_H2.svg) Sky Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:SCL,to:LSC,departure:04/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"H2"}}]) - ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Santiago (SCL) to La Serena (LSC) Prices were available within the past 7 days and start at £28 for one-way flights and £55 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Wed, 10 Dec - Thu, 11 Dec SCL Santiago LSC La Serena £55 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:10/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:54.60&airProductToken=AQovCi0IyGQSBDE3MTIY0lggyxQosKr_AjD3qv8COEFAAFgBagJaT3IIQVpPMTAwMDAKLgosCMhkEgMyMDkYyxQg0lgojLv_AjDMu_8COEFAAFgBagJaT3IIQVpPMTAwMDASCggBEAEYASoCSFIYASIECAEQASgCKAMoBDAB) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, 26 Apr - Tue, 28 Apr SCL Santiago LSC La Serena £57 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:26/04/2026TANYT&leg2=from:LSC,to:SCL,departure:28/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:56.60&airProductToken=AQovCi0IzIIBEgMxMDAY0lggyxQooLCLAzDmsIsDOEdAAFgBagJRUHIIRzAwUVA1WkoKLwotCMyCARIDMTAxGMsUINJYKLrHiwMw8seLAzhHQABYAWoCUVByCEcwMFFQNVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Wed, 10 Dec - Thu, 11 Dec SCL Santiago LSC La Serena £59 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:10/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:58.60&airProductToken=AQovCi0IyGQSBDE3MTIY0lggyxQosKr_AjD3qv8COEFAAFgBagJaT3IIQVpPMTAwMDAKLwotCMhkEgQxNzI3GMsUINJYKJO3_wIw07f_AjhYQABYAWoCWk9yCFhaTzEwMDAwEgoIARABGAEqAkhSGAEiBAgBEAEoAigDKAQwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, 30 Nov - Thu, 4 Dec SCL Santiago LSC La Serena £61 Return found 11 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:30/11/2025TANYT&leg2=from:LSC,to:SCL,departure:04/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:60.60&airProductToken=AQovCi0IzIIBEgMxMDAY0lggyxQo6Ln-AjCquv4COEdAAFgBagJRUHIIRzAwUVA1WkoKLwotCMyCARIDMTAzGMsUINJYKNro_gIwlOn-AjhPQABYAWoCUVByCE8wMFFQNVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Thu, 12 Feb - Thu, 19 Feb SCL Santiago LSC La Serena £65 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:12/02/2026TANYT&leg2=from:LSC,to:SCL,departure:19/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:64.20&airProductToken=AQouCiwIyGQSAzIwOBjSWCDLFCjc-4QDMKP8hAM4WkAAWAFqAlpPcghaWk8xMDAwMBIKCAEQARgBKgJIUhgBIgQIARABKAIoAygEMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, 30 Nov - Thu, 4 Dec SCL Santiago LSC La Serena £65 Return found 11 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:30/11/2025TANYT&leg2=from:LSC,to:SCL,departure:04/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:64.60&airProductToken=AQovCi0IzIIBEgMxMDAY0lggyxQo6Ln-AjCquv4COEdAAFgBagJRUHIIRzAwUVA1WkoKLwotCMyCARIDMTAxGMsUINJYKNjn_gIwkuj-AjhRQABYAWoCUVByCFEwMFFQNVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Wed, 10 Dec - Thu, 11 Dec SCL Santiago LSC La Serena £67 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:10/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:66.60&airProductToken=AQovCi0IyGQSBDE3NDIY0lggyxQo_ar_AjDEq_8COFFAAFgBagJaT3IIUVpPMTAwMDAKLgosCMhkEgMyMDkYyxQg0lgojLv_AjDMu_8COEFAAFgBagJaT3IIQVpPMTAwMDASCggBEAEYASoCSFIYASIECAEQASgCKAMoBDAB) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, 26 Apr - Tue, 28 Apr SCL Santiago LSC La Serena £68 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:26/04/2026TANYT&leg2=from:LSC,to:SCL,departure:28/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:67.60&airProductToken=AQovCi0IzIIBEgMxMDQY0lggyxQozLKLAzCSs4sDOE9AAFgBagJRUHIITzAwUVA1WkoKLwotCMyCARIDMTA1GMsUINJYKIjKiwMwwMqLAzhRQABYAWoCUVByCFEwMFFQNVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sat, 6 Dec - Sun, 21 Dec SCL Santiago LSC La Serena £69 Return found 4 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:06/12/2025TANYT&leg2=from:LSC,to:SCL,departure:21/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:68.60&airProductToken=AQovCi0IzIIBEgMxMDQY0lggyxQosID_AjD0gP8COE5AAFgBagJRUHIITjAwUVA1WkoKLwotCMyCARIDMTAxGMsUINJYKPimgAMwsqeAAzhHQABYAWoCUVByCEcwMFFQNVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![SKY AIRLINE](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/H2.gif) Wed, 10 Dec - Thu, 11 Dec SCL Santiago LSC La Serena £70 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SCL,to:LSC,departure:10/12/2025TANYT&leg2=from:LSC,to:SCL,departure:11/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:69.60&airProductToken=AQovCi0IyGQSBDE3NDIY0lggyxQo_ar_AjDEq_8COFFAAFgBagJaT3IIUVpPMTAwMDAKLwotCMhkEgQxNzI3GMsUINJYKJO3_wIw07f_AjhYQABYAWoCWk9yCFhaTzEwMDAwEgoIARABGAEqAkhSGAEiBAgBEAEoAigDKAQwAQ) ## Find the cheapest month to fly from Santiago (SCL) to La Serena (LSC) ### May is typically the cheapest month to fly From £27 - £65 per traveller. Flight from Santiago to La Serena route information | Origin airport | Arturo Merino Benitez | | --- | --- | | Destination airport | La Florida | | Airlines serving | LATAM Airlines Group, SKY AIRLINE | | Return price | £55 | | Distance | 386 km | | Average flight time | 1 hour 5 mins | ## Compare flights from Santiago to La Serena easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Santiago to La Serena. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to La Florida in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Arturo Merino Benitez to La Florida.   To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights.  Grab a great deal on your flight from Arturo Merino Benitez (SCL) to La Florida (LSC) The easiest way to view the best deals on flights from Santiago to La Serena today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Arturo Merino Benitez to La Florida start at just £55 and range up to £70.   To find an even better deal, try   - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Santiago and La Serena - booking your flight during December, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper  Why you should book your Santiago to La Serena flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Arturo Merino Benitez to La Florida for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.   Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.   ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other ### Accommodation - [Alcoguaz Hotels](https://www.expedia.co.uk/Alcoguaz-Hotels.d3000006451.Travel-Guide-Hotels) - [Coquimbo Hotels](https://www.expedia.co.uk/Coquimbo-Hotels.d6024027.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Coquimbo Region](https://www.expedia.co.uk/Destinations-In-Coquimbo-Region-Gay-Friendly-Hotel.0-0-d6236544-tGayFriendlyHotel.Hotel-Filter-Destinations) - [Coquimbo Region Hotels](https://www.expedia.co.uk/Destinations-In-Coquimbo-Region.d6236544.Hotel-Destinations) - [Hotels near Elqui Valley](https://www.expedia.co.uk/Elqui-Valley-Hotels.0-l6293291-0.Travel-Guide-Filter-Hotels) - [Horcón Hotels](https://www.expedia.co.uk/Horcon-Hotels.d3000006399.Travel-Guide-Hotels) - [La Herradura Hotels](https://www.expedia.co.uk/La-Herradura-Hotels.d6293292.Travel-Guide-Hotels) - [La Higuera Hotels](https://www.expedia.co.uk/La-Higuera-Hotels.d6203805.Travel-Guide-Hotels) - [Casino Hotels in La Serena](https://www.expedia.co.uk/La-Serena-Hotels-Casino-Hotel.0-0-d2139-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in La Serena](https://www.expedia.co.uk/La-Serena-Hotels-Gay-Friendly-Hotel.0-0-d2139-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [La Serena Hotels](https://www.expedia.co.uk/La-Serena-Hotels.d2139.Travel-Guide-Hotels) - [Hotels near La Silla Observatory](https://www.expedia.co.uk/La-Silla-Observatory-Hotels.0-l6098444-0.Travel-Guide-Filter-Hotels) - [Las Mollacas Hotels](https://www.expedia.co.uk/Las-Mollacas-Hotels.d553248635946399536.Travel-Guide-Hotels) - [Monte Grande Hotels](https://www.expedia.co.uk/Monte-Grande-Hotels.d3000470723.Travel-Guide-Hotels) - [Monte Patria Hotels](https://www.expedia.co.uk/Monte-Patria-Hotels.d6141337.Travel-Guide-Hotels) - [Ovalle Hotels](https://www.expedia.co.uk/Ovalle-Hotels.d6143185.Travel-Guide-Hotels) - [Pisco Elqui Hotels](https://www.expedia.co.uk/Pisco-Elqui-Hotels.d3000006314.Travel-Guide-Hotels) - [Punta de Choros Hotels](https://www.expedia.co.uk/Punta-De-Choros-Hotels.d6293308.Travel-Guide-Hotels) - [Rapel Hotels](https://www.expedia.co.uk/Rapel-Hotels.d3000384148.Travel-Guide-Hotels) - [Rio Hurtado Hotels](https://www.expedia.co.uk/Rio-Hurtado-Hotels.d6140331.Travel-Guide-Hotels) - [Totoralillo Hotels](https://www.expedia.co.uk/Totoralillo-Hotels.d6293298.Travel-Guide-Hotels) - [Vicuña Hotels](https://www.expedia.co.uk/Vicuna-Hotels.d6203808.Travel-Guide-Hotels) ### Flights - [Flights to Coquimbo](https://www.expedia.co.uk/Cheap-Flights-To-Coquimbo.d6024027.Travel-Guide-Flights) - [Flights to La Serena](https://www.expedia.co.uk/Cheap-Flights-To-La-Serena.d2139.Travel-Guide-Flights) ### Packages - [Cerro Tololo Observatory](https://www.expedia.co.uk/Cerro-Tololo-Observatory-Vicuna.d6098438.Attraction) - [Visit Coquimbo](https://www.expedia.co.uk/Coquimbo.dx6024027) - [Cruz del Tercer Milenio Monument](https://www.expedia.co.uk/Cruz-Del-Tercer-Milenio-Monument-Coquimbo.d6293445.Attraction) - [Kokoro No Niwa Japanese Garden](https://www.expedia.co.uk/Kokoro-No-Niwa-Japanese-Garden-La-Serena.d6098428.Attraction) - [Visit La Higuera](https://www.expedia.co.uk/La-Higuera.dx6203805) - [La Serena Holidays](https://www.expedia.co.uk/La-Serena.d2139.Holidays-City-Breaks) - [Visit Monte Patria](https://www.expedia.co.uk/Monte-Patria.dx6141337) - [Visit Ovalle](https://www.expedia.co.uk/Ovalle.dx6143185) ### Cars - [Car hire La Serena](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-La-Serena.d2139.Car-Hire-Guide) ### Holiday Homes - [La Herradura Holiday Rentals](https://www.expedia.co.uk/La-Herradura-Holiday-Rentals.d6293292.Travel-Guide-HolidayRentals) ### Other - [Things to do in La Serena](https://www.expedia.co.uk/Things-To-Do-In-La-Serena.d2139.Travel-Guide-Activities) \*Available to Expedia members.