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£305 Cheap Flights from Panama City (PTY) to San Francisco (SFO)

View £305 flight on Thu, 10 Sept 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to San Francisco International Airport (SFO)

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Cheap Flights from Panama City (PTY) to San Francisco (SFO)

Prices were available within the past 7 days and start at £305 for one-way flights and £569 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Thu, 17 Sept - Tue, 12 Jan
PTY
Panama City
SFO
San Francisco
£569 Return, found 5 days ago
£569
Return
found 5 days ago
Select avianca flight, departing Thu, 17 Sept from Panama City to San Francisco, returning Tue, 12 Jan, priced at £569 found 5 days ago
avianca
Mon, 7 Sept - Sun, 13 Sept
PTY
Panama City
SFO
San Francisco
£571 Return, found 6 days ago
£571
Return
found 6 days ago
Select avianca flight, departing Mon, 7 Sept from Panama City to San Francisco, returning Sun, 13 Sept, priced at £571 found 6 days ago
avianca
Wed, 20 Jan - Wed, 27 Jan
PTY
Panama City
SFO
San Francisco
£573 Return, found 4 days ago
£573
Return
found 4 days ago
Select avianca flight, departing Wed, 20 Jan from Panama City to San Francisco, returning Wed, 27 Jan, priced at £573 found 4 days ago
avianca
Thu, 17 Sept - Tue, 12 Jan
PTY
Panama City
SFO
San Francisco
£576 Return, found 5 days ago
£576
Return
found 5 days ago
Select avianca flight, departing Thu, 17 Sept from Panama City to San Francisco, returning Tue, 12 Jan, priced at £576 found 5 days ago
avianca
Wed, 20 Jan - Wed, 27 Jan
PTY
Panama City
SFO
San Francisco
£579 Return, found 4 days ago
£579
Return
found 4 days ago
Select avianca flight, departing Wed, 20 Jan from Panama City to San Francisco, returning Wed, 27 Jan, priced at £579 found 4 days ago
avianca
Wed, 20 Jan - Wed, 27 Jan
PTY
Panama City
SFO
San Francisco
£581 Return, found 4 days ago
£581
Return
found 4 days ago
Select avianca flight, departing Wed, 20 Jan from Panama City to San Francisco, returning Wed, 27 Jan, priced at £581 found 4 days ago
avianca
Thu, 17 Sept - Tue, 12 Jan
PTY
Panama City
SFO
San Francisco
£581 Return, found 5 days ago
£581
Return
found 5 days ago
Select avianca flight, departing Thu, 17 Sept from Panama City to San Francisco, returning Tue, 12 Jan, priced at £581 found 5 days ago
avianca
Thu, 17 Sept - Tue, 12 Jan
PTY
Panama City
SFO
San Francisco
£583 Return, found 5 days ago
£583
Return
found 5 days ago
Select avianca flight, departing Thu, 17 Sept from Panama City to San Francisco, returning Tue, 12 Jan, priced at £583 found 5 days ago
Copa
Mon, 7 Sept - Sun, 13 Sept
PTY
Panama City
SFO
San Francisco
£650 Return, found 6 days ago
£650
Return
found 6 days ago
Select Copa flight, departing Mon, 7 Sept from Panama City to San Francisco, returning Sun, 13 Sept, priced at £650 found 6 days ago
Aeromexico
Thu, 14 Jan - Thu, 21 Jan
PTY
Panama City
SFO
San Francisco
£979 Return, found 4 days ago
£979
Return
found 4 days ago
Select Aeromexico flight, departing Thu, 14 Jan from Panama City to San Francisco, returning Thu, 21 Jan, priced at £979 found 4 days ago

Find the cheapest month to fly from Panama City (PTY) to San Francisco (SFO)

February is typically the cheapest month to fly

From £337 - £529 per traveller.

Frequently asked questions

How much does a flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) cost?
You can find cheap one-way flights from £305 and cheap return flights from £569 PTY to SFO with Expedia. One-way flights typically cost between £269 and £1029. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when PTY to SFO ticket fares go up or down.
What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The cheapest months to fly from PTY to SFO are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Only one airline offers direct flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.). Copa operates 11 direct flights from PTY to SFO every week.
What is the cheapest airline that flies from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Aeromexico offers one of the cheapest connecting return flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) with a layover in Mexico City Intl. (MEX), starting from around £428. United is one of the cheapest airlines offering nonstop return flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.), with tickets starting from around £865 for flights that can be booked for departure within the next year. These prices are per adult, for economy/coach class. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The best airline to fly with from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) will differ from traveler to traveler. If you like to fly early, United offers early morning flights. If price is the most important factor, United typically offers the lowest fares. Copa offers the most daily flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
There is 1 nonstop flight per day from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.). For even more choices, look at flights that include layovers, as there are around 43 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), Miami Intl. (MIA), and George Bush Intercontinental (IAH).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) typically departs around 2:55 AM. This service is seasonal, active in January, March, and December, and is operated by airlines such as Avianca and Alaska Airlines. An early departure like this can be great for maximising your time in San Francisco. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
You'll find the most flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) on a Monday, with around 30 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include Copa, Avianca, and United. Looking at the week, Monday has notably more flight options compared to other days, which typically see around 22 to 29 flights.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) are in the afternoon, from 3pm to 6pm. Many major carriers, including United, Avianca and Copa, offer flights during this window. Many travellers prefer this time as it allows for a full day of activities before heading to the airport, and you'll arrive in San Francisco in the evening.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
A non-stop flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) typically takes around 7 hours 48 minutes. This journey covers a distance of approximately 5,345 kilometers. If you opt for a flight with one stop, your travel time will be significantly longer, usually around 18 hours. Flights with two or more stops can take even longer, often around 22 hours 18 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some flexibility in your travel plans.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
Yes, you can fly business class between PTY and SFO. Airlines that offer business class service on this route include:
  • Avianca
  • Copa
  • Delta
  • Aeromexico
  • United
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Francisco, CA (SFO) from Panama City (PTY)?
If you're planning to travel to San Francisco from Tocumen Intl. (PTY), you can fly directly into San Francisco Intl. (SFO). Some flights may connect through major hubs like El Dorado Intl. (BOG), Miami Intl. (MIA), or Juan Santamaria Intl. (SJO) before reaching San Francisco. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to San Francisco, CA (SFO-San Francisco Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
San Francisco Intl.
Return price
£568
Distance
5313 km
Average flight time
5 hours 34 mins

Book with confidence

Compare flights from Panama City to San Francisco easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to San Francisco. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to San Francisco Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to San Francisco Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to San Francisco Intl. (SFO)

The easiest way to view the best deals on flights from Panama City to San Francisco today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to San Francisco Intl. start at just £569 and range up to £979.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and San Francisco
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to San Francisco flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to San Francisco Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to San Francisco easily and book with confidence

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*Available to Expedia members.