£509 Cheap Flights from Panama City (PTY) to Lisbon (LIS)

View £509 flight on Sun, 31 Jan 2027Opens in a new window

Flight 1

Popular airlines from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)

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Cheap Flights from Panama City (PTY) to Lisbon (LIS)

Prices were available within the past 7 days and start at £509 for one-way flights and £715 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Iberia
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£715 Return, found 14 hours ago
£715
Return
found 14 hours ago
Select Iberia flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £715 found 14 hours ago
Iberia
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£748 Return, found 14 hours ago
£748
Return
found 14 hours ago
Select Iberia flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £748 found 14 hours ago
Air Europa
Tue, 21 Jul - Tue, 11 Aug
PTY
Panama City
LIS
Lisbon
£751 Return, found 4 days ago
£751
Return
found 4 days ago
Select Air Europa flight, departing Tue, 21 Jul from Panama City to Lisbon, returning Tue, 11 Aug, priced at £751 found 4 days ago
Air Europa
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£753 Return, found 14 hours ago
£753
Return
found 14 hours ago
Select Air Europa flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £753 found 14 hours ago
Iberia
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£755 Return, found 14 hours ago
£755
Return
found 14 hours ago
Select Iberia flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £755 found 14 hours ago
Air Europa
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£761 Return, found 14 hours ago
£761
Return
found 14 hours ago
Select Air Europa flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £761 found 14 hours ago
Air Europa
Wed, 3 Jun - Sun, 7 Jun
PTY
Panama City
LIS
Lisbon
£769 Return, found 5 days ago
£769
Return
found 5 days ago
Select Air Europa flight, departing Wed, 3 Jun from Panama City to Lisbon, returning Sun, 7 Jun, priced at £769 found 5 days ago
British Airways
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£795 Return, found 14 hours ago
£795
Return
found 14 hours ago
Select British Airways flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £795 found 14 hours ago
Turkish Airlines
Tue, 28 Jul - Tue, 11 Aug
PTY
Panama City
LIS
Lisbon
£810 Return, found 4 days ago
£810
Return
found 4 days ago
Select Turkish Airlines flight, departing Tue, 28 Jul from Panama City to Lisbon, returning Tue, 11 Aug, priced at £810 found 4 days ago
KLM
Mon, 5 Oct - Wed, 28 Oct
PTY
Panama City
LIS
Lisbon
£891 Return, found 14 hours ago
£891
Return
found 14 hours ago
Select KLM flight, departing Mon, 5 Oct from Panama City to Lisbon, returning Wed, 28 Oct, priced at £891 found 14 hours ago

Frequently asked questions

How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
There are approximately 30 connecting flights per day from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado). Some common connection points include El Dorado Intl. (BOG), Miami Intl. (MIA), and Liberty Intl. (EWR).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) typically departs at approximately 3:00 AM local time. This service is seasonal, active only in March, and involves connecting flights operated by Avianca and Iberia. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
If you're flying from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado), you'll typically find the most flights on a Monday, with around 38 flight options available. This gives you a good selection to choose from. Major airlines on this route include Copa Airlines, Avianca, and American Airlines. Looking at the overall week, Mondays offer notably more flight options compared to other days, with about 50% more flights than on Saturdays, for example.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) are in the late evening, from 9pm to midnight. About 36% of passengers prefer this time. Many major carriers, including Air Europa and Iberia, offer flights during this window. This timing works well because you can make the most of your day before your flight and arrive refreshed at your destination.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
Flights from PTY to LIS with one stop typically take around 16 hours 30 minutes, covering approximately 4,766 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
Select the "Business class" and "First class" filters when looking for PTY to LIS flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Lisbon from Tocumen Intl. (PTY)?
From Tocumen Intl. (PTY), you can fly directly into Humberto Delgado (LIS) to reach Lisbon. Some flights may connect through major hubs like El Dorado Intl. (BOG), Miami Intl. (MIA), Liberty Intl. (EWR) before reaching Lisbon. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado)?
If you booked your Panama City (PTY-Tocumen Intl.) to Lisbon (LIS-Humberto Delgado) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Humberto Delgado
Airlines serving
Air Europa, Air France, American Airlines, Iberia, KLM, Turkish Airlines, United
Return price
£715
Distance
7624 km

Book with confidence

Compare flights from Panama City to Lisbon easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to Lisbon. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Humberto Delgado in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to Humberto Delgado.  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to Humberto Delgado (LIS)

The easiest way to view the best deals on flights from Panama City to Lisbon today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to Humberto Delgado start at just £715 and range up to £891.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and Lisbon
  • booking your flight during October, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to Lisbon flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to Humberto Delgado for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to Lisbon easily and book with confidence

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*Available to Expedia members.