Title: £592 Cheap Flights from Madrid to São Tomé Island (MAD to TMS) - Expedia.co.uk ![Newton's sunbird, male, beautiful bird singing on a palm tree, in Sao Tome and Principe, Anabathmis newtonii ](https://images.trvl-media.com/place/3486/5eee3996-3014-4835-bbeb-ffea36d9d490.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3486/5eee3996-3014-4835-bbeb-ffea36d9d490.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £592 Cheap Flights from Madrid (MAD) to São Tomé Island (TMS) [View £592 flight on Tue, 12 May 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:MAD,to:TMS,departure:12/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:591.50&airProductToken=AQpvCjUI1KABEgQxMDE3GIwYIIuSASiA5owDMNXmjAM4QUAAWAFqCERJU0NPVU5UcghBTDBEU0kwNQo2CNSgARIEMTUyNxiLkgEgk5MBKPftjAMwifKMAzhBQAFYAWoIRElTQ09VTlRyCEFMMERTSTA1EgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Adolfo Suarez Madrid-Barajas Airport (MAD) to São Tomé Island (TMS-São Tomé Intl.) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_TP.svg) TAP Portugal [](https://www.expedia.co.uk/Flights-Search?leg1=from:MAD,to:TMS,departure:02/03/2026TANYT&leg2=from:TMS,to:MAD,departure:09/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"TP"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_ET.svg) Ethiopian Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:MAD,to:TMS,departure:02/03/2026TANYT&leg2=from:TMS,to:MAD,departure:09/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"ET"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Madrid (MAD) to São Tomé Island (TMS) Prices were available within the past 7 days and start at £592 for one-way flights and £1,212 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,212 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1211.10&airProductToken=AQp3Cj8I1KABEgQxMDE3GIwYIIuSASiA6pMDMNXqkwM4VkAAWAFqBkJBU0lOVHIIVkgwQlNJMDF6CgjOkgESBDEwMTcKNAjUoAESBDE1MzEYi5IBIJOTASjg8pMDMPX1kwM4VkAAWAFqBkJBU0lOVHIIVkgwQlNJMDEKdwo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQkFTSU5UcghWSDBCU0kwMQo_CNSgARIEMTAxOBiLkgEgjBgo9sOUAzDGxJQDOFZAAFgBagZCQVNJTlRyCFZIMEJTSTAxegoIzpIBEgQxMDE4EgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,217 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1216.50&airProductToken=AQp3Cj8I1KABEgQxMDE1GIwYIIuSASic6ZMDMPHpkwM4VkAAWAFqBkJBU0lOVHIIVkgwQlNJMDF6CgjOkgESBDEwMTUKNAjUoAESBDE1MzEYi5IBIJOTASjg8pMDMPX1kwM4VkAAWAFqBkJBU0lOVHIIVkgwQlNJMDEKawo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQkFTSU5UcghWSDBCU0kwMQozCNSgARIEMTAxNBiLkgEgjBgokMKUAzDgwpQDOFZAAFgBagZCQVNJTlRyCFZIMEJTSTAxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,274 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1273.30&airProductToken=AQprCjMI1KABEgQxMDIzGIwYIIuSASiU5ZMDMOnlkwM4UUAAWAFqBkJBU0lOVHIIUUgwQlNJMDEKNAjUoAESBDE1MjcYi5IBIJOTASjX5pMDMOnqkwM4UUAAWAFqBkJBU0lOVHIIUUgwQlNJMDEKawo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQkFTSU5UcghWSDBCU0kwMQozCNSgARIEMTAxMBiLkgEgjBgo1b-UAzClwJQDOFZAAFgBagZCQVNJTlRyCFZIMEJTSTAxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,283 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1282.50&airProductToken=AQp3Cj8I1KABEgQxMDE3GIwYIIuSASiA6pMDMNXqkwM4VkAAWAFqBkNMQUlOVHIIVkgwQ0xJMDF6CgjOkgESBDEwMTcKNAjUoAESBDE1MzEYi5IBIJOTASjg8pMDMPX1kwM4VkAAWAFqBkNMQUlOVHIIVkgwQ0xJMDEKdwo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQ0xBSU5UcghWSDBDTEkwMQo_CNSgARIEMTAxOBiLkgEgjBgo9sOUAzDGxJQDOFZAAFgBagZDTEFJTlRyCFZIMENMSTAxegoIzpIBEgQxMDE4EgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,288 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1287.90&airProductToken=AQp3Cj8I1KABEgQxMDE1GIwYIIuSASic6ZMDMPHpkwM4VkAAWAFqBkNMQUlOVHIIVkgwQ0xJMDF6CgjOkgESBDEwMTUKNAjUoAESBDE1MzEYi5IBIJOTASjg8pMDMPX1kwM4VkAAWAFqBkNMQUlOVHIIVkgwQ0xJMDEKawo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQ0xBSU5UcghWSDBDTEkwMQozCNSgARIEMTAxNBiLkgEgjBgokMKUAzDgwpQDOFZAAFgBagZDTEFJTlRyCFZIMENMSTAxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,336 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1335.50&airProductToken=AQp1Cj4I1KABEgQxMDIxGIwYIIuSASiJ7JMDMN7skwM4UUAAWAFqBUJBU0lDcghRSDBCU0kwMXoKCM6SARIEMTAyMQozCNSgARIEMTUzMRiLkgEgk5MBKODykwMw9fWTAzhRQAFYAWoFQkFTSUNyCFFIMEJTSTAxCmkKMwjUoAESBDE1MjgYk5MBIIuSASi8upQDMMS-lAM4UUAAWAFqBUJBU0lDcghRSDBCU0kwMQoyCNSgARIEMTAxNBiLkgEgjBgokMKUAzDgwpQDOFFAAVgBagVCQVNJQ3IIUUgwQlNJMDESCggBEAEYASoCVFAYASIECAEQASgCKAMoBDAB) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,341 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1340.90&airProductToken=AQp1Cj4I1KABEgQxMDE1GIwYIIuSASic6ZMDMPHpkwM4UUAAWAFqBUJBU0lDcghRSDBCU0kwMXoKCM6SARIEMTAxNQozCNSgARIEMTUzMRiLkgEgk5MBKODykwMw9fWTAzhRQAFYAWoFQkFTSUNyCFFIMEJTSTAxCmkKMwjUoAESBDE1MjgYk5MBIIuSASi8upQDMMS-lAM4UUAAWAFqBUJBU0lDcghRSDBCU0kwMQoyCNSgARIEMTAxMhiLkgEgjBgo8MCUAzDAwZQDOFFAAVgBagVCQVNJQ3IIUUgwQlNJMDESCggBEAEYASoCVFAYASIECAEQASgCKAMoBDAB) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,345 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1344.70&airProductToken=AQprCjMI1KABEgQxMDIzGIwYIIuSASiU5ZMDMOnlkwM4UUAAWAFqBkNMQUlOVHIIUUgwQ0xJMDEKNAjUoAESBDE1MjcYi5IBIJOTASjX5pMDMOnqkwM4UUAAWAFqBkNMQUlOVHIIUUgwQ0xJMDEKawo0CNSgARIEMTUyOBiTkwEgi5IBKLy6lAMwxL6UAzhWQABYAWoGQ0xBSU5UcghWSDBDTEkwMQozCNSgARIEMTAxMBiLkgEgjBgo1b-UAzClwJQDOFZAAFgBagZDTEFJTlRyCFZIMENMSTAxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 31 Jul - Fri, 7 Aug MAD Madrid TMS São Tomé Island £1,354 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/07/2026TANYT&leg2=from:TMS,to:MAD,departure:07/08/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1353.90&airProductToken=AQp5CkAI1KABEgQxMDE3GIwYIIuSASiA6pMDMNXqkwM4VkAAWAFqB1BMVVNJTlRyCFZIMFBVSTAxegoIzpIBEgQxMDE3CjUI1KABEgQxNTMxGIuSASCTkwEo4PKTAzD19ZMDOFZAAFgBagdQTFVTSU5UcghWSDBQVUkwMQp5CjUI1KABEgQxNTI4GJOTASCLkgEovLqUAzDEvpQDOFZAAFgBagdQTFVTSU5UcghWSDBQVUkwMQpACNSgARIEMTAxOBiLkgEgjBgo9sOUAzDGxJQDOFZAAFgBagdQTFVTSU5UcghWSDBQVUkwMXoKCM6SARIEMTAxOBIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) ![Ethiopian Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/ET.gif) Mon, 31 Aug - Sun, 13 Sept MAD Madrid TMS São Tomé Island £1,593 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MAD,to:TMS,departure:31/08/2026TANYT&leg2=from:TMS,to:MAD,departure:13/09/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1592.70&airProductToken=AQqLAQonCMWoARIDNzQxGIwYIOAYKJbJlgMwycyWAzhTQABYAXIGU1hSVEVTCigIxagBEgM5NTUY4Bggq6gBKK3NlgMwmtCWAzhTQAFYAXIGU1hSVEVTCjYIxagBEgQxMDIwGKuoASCTkwEoqNKWAzDk0pYDOFNAAVgBcgZTWFJURVN6CgjLoAESBDEwMjAKgAEKKQjLoAESAjYxGJOTASCrqAEo5NSXAzCg1ZcDOFFAAFgBcgdMTFdFU0VTCikIxagBEgM5MjUYq6gBIOAYKIbXlwMw89mXAzhMQAFYAXIHTExXRVNFUwooCMWoARIDNzQwGOAYIIwYKPralwMwy96XAzhMQAFYAXIHTExXRVNFUxIKCAEQARgBKgJFVBgBIgQIARABKAIoBCgGMAE) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=FTG_SPRING_PROMO_) __Flight from Madrid to São Tomé Island route information__ | Origin airport | Adolfo Suárez Madrid-Barajas | | ------------------- | ---------------------------- | | Destination airport | São Tomé Intl. | | Return price | £1,211 | | Distance | 4550 km | ## Compare flights from Madrid to São Tomé Island easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Madrid to São Tomé Island. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Adolfo Suárez Madrid-Barajas to São Tomé Intl.. To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. Grab a great deal on your flight from Adolfo Suárez Madrid-Barajas (MAD) to São Tomé Intl. (TMS) The easiest way to view the best deals on flights from Madrid to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Adolfo Suárez Madrid-Barajas to São Tomé Intl. start at just £1,212 and range up to £1,593\. To find an even better deal, try - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Madrid and São Tomé Island - booking your flight during July, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper Why you should book your Madrid to São Tomé Island flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Adolfo Suárez Madrid-Barajas to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you. Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight. ## Explore a world of travel with Expedia - Accommodation - [Água Grande Hotels ](https://www.expedia.co.uk/Destinations-In-Agua-Grande.d553248635976006815.Hotel-Destinations) - [Hotels near Estadio Nacional 12 de Julho ](https://www.expedia.co.uk/Estadio-Nacional-12-De-Julho-Hotels.0-l6118168-0.Travel-Guide-Filter-Hotels) - [São Tomé Hotels ](https://www.expedia.co.uk/Sao-Tome-Hotels.d553248635975177343.Travel-Guide-Hotels) \*Available to Expedia members.