£250 Cheap Flights from Des Moines (DSM) to Manchester (MAN)

View £250 flight on Mon, 9 Nov 2026Opens in a new window

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Popular airlines from Des Moines International Airport (DSM) to Manchester Airport (MAN)

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Cheap Flights from Des Moines (DSM) to Manchester (MAN)

Prices were available within the past 7 days and start at £250 for one-way flights and £746 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£746 Return, found 6 days ago
£746
Return
found 6 days ago
Select British Airways flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £746 found 6 days ago
British Airways
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£760 Return, found 6 days ago
£760
Return
found 6 days ago
Select British Airways flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £760 found 6 days ago
Air Canada
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£765 Return, found 6 days ago
£765
Return
found 6 days ago
Select Air Canada flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £765 found 6 days ago
KLM
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£781 Return, found 6 days ago
£781
Return
found 6 days ago
Select KLM flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £781 found 6 days ago
Virgin Atlantic
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£781 Return, found 6 days ago
£781
Return
found 6 days ago
Select Virgin Atlantic flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £781 found 6 days ago
Air France
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£781 Return, found 6 days ago
£781
Return
found 6 days ago
Select Air France flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £781 found 6 days ago
British Airways
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£793 Return, found 6 days ago
£793
Return
found 6 days ago
Select British Airways flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £793 found 6 days ago
British Airways
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£801 Return, found 6 days ago
£801
Return
found 6 days ago
Select British Airways flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £801 found 6 days ago
Virgin Atlantic
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£802 Return, found 6 days ago
£802
Return
found 6 days ago
Select Virgin Atlantic flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £802 found 6 days ago
Virgin Atlantic
Sun, 20 Sept - Sun, 27 Sept
DSM
Des Moines
MAN
Manchester
£803 Return, found 6 days ago
£803
Return
found 6 days ago
Select Virgin Atlantic flight, departing Sun, 20 Sept from Des Moines to Manchester, returning Sun, 27 Sept, priced at £803 found 6 days ago

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) cost?
One-way flights typically cost between £391 and £2,453 and return flights often range between £391 and £2,453. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
There are approximately 25 connecting flights per day from Des Moines Intl. (DSM) to Manchester (MAN). Some common connection points include O'Hare Intl. (ORD), Minneapolis - St. Paul Intl. (MSP), and Hartsfield-Jackson Atlanta Intl. (ATL).
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from DSM to MAN. To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
You'll find the most flights from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) on a Wednesday, with around 36 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Delta Air Lines, American Airlines, and United Airlines. Flight schedules are fairly consistent throughout the week, with only a slight variation in the number of flights.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
The most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) are in the afternoon, from 3pm to 6pm. About 55% of passengers prefer this time. Many major carriers, including American Airlines, British Airways and Aer Lingus, offer flights during this window. This timing works well for many travellers as it allows for a productive morning before heading to the airport.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
A flight from DSM to MAN with a layover takes around 12 hours 20 minutes, with the route covering approximately 4,048 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
Select the "Business class" and "First class" filters when looking for DSM to MAN flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Manchester from Des Moines Intl. (DSM)?
If you're planning to travel to Manchester from Des Moines Intl. (DSM), you can fly into Manchester-Boston Regional (MHT) Some flights may connect through major hubs like Denver Intl. (DEN), O'Hare Intl. (ORD), Lambert-St. Louis Intl. (STL) before reaching Manchester. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Manchester (MAN) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Manchester
Return price
£745
Distance
6475 km

Book with confidence

Compare flights from Des Moines to Manchester easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Des Moines to Manchester. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Manchester in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Des Moines Intl. to Manchester.  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Des Moines Intl. (DSM) to Manchester (MAN)

The easiest way to view the best deals on flights from Des Moines to Manchester today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Des Moines Intl. to Manchester start at just £746 and range up to £803.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Des Moines and Manchester
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Des Moines to Manchester flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Des Moines Intl. to Manchester for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Des Moines to Manchester easily and book with confidence

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*Available to Expedia members.