Skip to main content

Zapotillo Holidays from £601

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Top Zapotillo flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • Front of property
    9 Sept - 15 Sept

    Decapolis Hotel Panama City + Flight

    San Francisco
    6 nights
    4.0 star property
    8.6/10 - Excellent (1,711 reviews)
    Return • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Direct PTY - KIN • Direct
    £916
    £601
    per traveller
    found 15 hours ago
    Decapolis Hotel Panama City
  • Front of property
    9 Sept - 14 Sept

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    4 nights
    4.0 star property
    9.2/10 - Wonderful (1,001 reviews)
    "Rooms were very clean and staff respectful and helpful at all times, views from the pool rooftop are stunning and can see the city, breakfast was great with several options to chose from. Will definetely come back it was a great place to stay in the City for me and my family."
    Reviewed July 19, 2026
    Return • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Direct PTY - KIN • Direct
    £1,179
    £653
    per traveller
    found 15 hours ago
    Central Hotel Panama Casco Viejo
  • Front of property
    9 Sept - 14 Sept

    Megapolis Hotel Panamá + Flight

    San Francisco
    4 nights
    4.5 star property
    8.4/10 - Very good (1,600 reviews)
    "I highly recommend this hotel….. from the buffet breakfast straight to the cleanliness 9.5/10"
    Reviewed July 19, 2026
    Return • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Direct PTY - KIN • Direct
    £1,087
    £676
    per traveller
    found 15 hours ago
    Megapolis Hotel Panamá
  • Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
    9 Sept - 14 Sept

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen
    4 nights
    4.0 star property
    8.4/10 - Very good (1,808 reviews)
    "si tienes que hacer escala en panama. este lugar es perfecto. super cerca. te da transporte de aeropuerto hotel y viceversa. Y me toco comer ahi y todo rico. Dormi bien y volveria para ir de compras a panama"
    Reviewed July 19, 2026
    Return • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Direct PTY - KIN • Direct
    £818
    £612
    per traveller
    found 15 hours ago
    Riande Aeropuerto Hotel & Casino
  • View from property
    9 Sept - 14 Sept

    Las Americas Golden Tower Panama + Flight

    San Francisco
    4 nights
    4.0 star property
    9.0/10 - Wonderful (1,054 reviews)
    "Clean room"
    Reviewed July 14, 2026
    Return • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Direct PTY - KIN • Direct
    £779
    £616
    per traveller
    found 15 hours ago
    Las Americas Golden Tower Panama
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.