Title: Hotels in Wykoff, MN - Best Wykoff Hotels from £45 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Wykoff](https://expedia.co.uk/Wykoff-Holiday-Rentals.d3000443967.Travel-Guide-HolidayRentals)[Wykoff Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Wykoff.d3000443967.Car-Hire-Guide)[Wykoff Holidays](https://expedia.co.uk/Wykoff.d3000443967.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Wykoff, MN from £45 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Wykoff Hot tub [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&amenities=HOT_TUB) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&travelerType=family_friendly) Cabin [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&lodging=CABIN) Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&amenities=POOL) Apart­ment [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&lodging=APARTMENT) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Wykoff%2C+Minnesota%2C+United+States+of+America®ionId=3000443967&latLong=43.707188%2C-92.268219&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&amenities=PETS) ## Check prices for these dates Tonight [24 Nov - 25 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000443967&startDate=2025-11-24&endDate=2025-11-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [25 Nov - 26 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000443967&startDate=2025-11-25&endDate=2025-11-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000443967&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=3000443967&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Wykoff hotels and places to stay ![Front of property](https://images.trvl-media.com/lodging/105000000/104020000/104013000/104012904/78958ccb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Room | 1 bedroom, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104020000/104013000/104012904/w1712h1283x2y0-ed421a47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/105000000/104020000/104013000/104012904/76c01c5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104020000/104013000/104012904/a69b6a55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Lodge inn Harmony 9.0/10 Wonderful (38) "Old motel but clean, with friendly owners." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fred £121 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Harmony-Hotels-Country-Lodge-Inn.h104012904.Hotel-Information) ![Indoor pool, open 7:00 AM to 11:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/101000000/100370000/100366400/100366373/f1672741.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/101000000/100370000/100366400/100366373/ce55c3ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room | 1 bedroom, down duvets, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/101000000/100370000/100366400/100366373/7a5a17fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/101000000/100370000/100366400/100366373/a0dd0f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Trails Inn & Suites Preston 9.4/10 Exceptional (101) "Great desk host, nice property, comfortable rooms, nice breakfast & dining room within walking from Casey’s gas & market. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £107 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Preston-Hotels-Country-Trails-Inn-Suites.h100366373.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/ecda08e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area | TV, pay films](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/45535621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/86c17899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Grand Hotel Downtown Rochester 8.2/10 Very good (1770) "Really enjoyed staying at this hotel. Very convenient to Mayo, dining, and shopping. Cozy room and nice people." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer £102 includes taxes & fees 12 Dec - 13 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Serves lunch, dinner and happy hour](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/8d7f7147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/3b0f1e42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/3bd995bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Rochester Near Mayo Clinic Rochester 8.2/10 Very good (1118) "Was great for a stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) eric £64 includes taxes & fees 28 Nov - 29 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/90000/84800/84723/5b8e813f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/90000/84800/84723/055a808d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/90000/84800/84723/37e2c033.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/90000/84800/84723/231bcb83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Mayo Clinic Area Rochester 9.0/10 Wonderful (884) "Good breakfast..shuttle service is excellent..super nice staff.." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) DALE K £55 includes taxes & fees 12 Dec - 13 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Econo-Lodge-Mayo-Clinic-Area.h84723.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s pool](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/f69df08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/dd818bd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/daff149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S Rochester 7.2/10 Good (1022) "Clean room and very courteous staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harlan £60 includes taxes & fees 28 Nov - 29 Nov [](https://www.expedia.co.uk/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/21638bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/b1805314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/bac0b2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/3613a59b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EVEN Hotel Rochester - Mayo Clinic Area by IHG Kutzky Park 9.4/10 Exceptional (943) "Hotel was spotless, excellent staff and the breakfast was excellent. Late night eats at the restaurant and the food served was fantastic." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carmino £78 includes taxes & fees 28 Nov - 29 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/7b237c12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/8b35b717.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/13abbe0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aspen Suites Rochester 9.0/10 Wonderful (680) "Excellent service excellent accommodations. I will stay here again when I come next time." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan [](https://www.expedia.co.uk/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed | 1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/290eee76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/42f521a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/f4426c19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG Downtown Rochester 8.8/10 Excellent (872) "Great room and stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trevor £66 includes taxes & fees 26 Dec - 27 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/34563649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/c7dc0b32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/00ce891c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Rochester South Rochester 9.4/10 Exceptional (284) "Staff was nice and rooms are nice!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly £60 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/460000/455600/455558/c3584a83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/460000/455600/455558/569ab236.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/460000/455600/455558/28d8dcf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/460000/455600/455558/937e22b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites Rochester South Mayo Clinic Rochester 8.4/10 Very good (1004) "Clean room, fun staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £74 includes taxes & fees 15 Dec - 16 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Country-Inn-Suites-By-Radisson.h455558.Hotel-Information) ![Suite (Buffalo Bill Suite) | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/2000000/1190000/1186500/1186426/80518cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1190000/1186500/1186426/e0e6ae12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Crate Whirlpool Suite | Jetted bathtub](https://images.trvl-media.com/lodging/2000000/1190000/1186500/1186426/f5dc5199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Buffalo Bill Suite) | Individually decorated, individually furnished, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1190000/1186500/1186426/8239cfbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stone Mill Hotel & Suites Lanesboro 9.2/10 Wonderful (658) "Great service, location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric £86 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Stone-Mill-Hotel-Suites.h1186426.Hotel-Information) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/0647340c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/4b144b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/w2998h3997x0y0-693a0036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area Historic Southwest 8.6/10 Excellent (1012) "If you are going to Mayo Clinic, this is a great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eileen £108 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25200/25164/6da96ba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/30000/25200/25164/bab1f0e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking (Ground Floor) | Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/25200/25164/46eaeea1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/25200/25164/dd4123a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Rochester Mayo Clinic Area Rochester 7.8/10 Good (1008) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aweng £45 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Super-8-By-Wyndham-Rochester-Mayo-Clinic-Area.h25164.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/39da8a7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/02cd0879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/222c4dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/bdf57892.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys Kutzky Park 8.6/10 Excellent (926) "This is a convenient place to stay when visiting Mayo." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Faith £80 includes taxes & fees 29 Nov - 30 Nov [](https://www.expedia.co.uk/Rochester-Hotels-SpringHill-Suites-By-Marriott-Rochester-Mayo-ClinicSt-Marys.h101902.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/1000000/850000/846600/846574/5f8bd693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/846600/846574/03c26c35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/850000/846600/846574/c5b39a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/850000/846600/846574/8cbdee80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MainStay Suites Rochester South Mayo Clinic Rochester 7.0/10 Good (86) "Staff is friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Merry £50 includes taxes & fees 12 Dec - 13 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Extended-Stay-America-Suites-Rochester-South.h846574.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/b1555778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/f4c0d6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/86063f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/1213b471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Rochester Mayo Clinic Area Downtown Rochester 9.6/10 Exceptional (538) "Had a great stay. Room was very clean and staff was very courteous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bonita £151 includes taxes & fees 5 Dec - 6 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/ae2efa7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/0e013528.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/63c05d38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed | Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/967fe3e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Rochester Mayo Clinic Downtown Rochester 8.2/10 Very good (520) "All staff were very nice and friendly and willing to help with whatever we needed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky £149 includes taxes & fees 28 Nov - 29 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Marriott-Rochester-Mayo-Clinic.h3948.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/92dc90b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/25e32575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/c5c5f3cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/31690353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aspen Select Rochester 8.4/10 Very good (1007) "Safe parking very clean and breakfast had options for anyone" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy [](https://www.expedia.co.uk/Rochester-Hotels-Aspen-Select.h12245240.Hotel-Information) ![Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout curtains, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2559x4y0-f5ee734c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (Living Room) | Blackout curtains, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/ec5f8616.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2555x4y4-921fa2b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout curtains, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/d609b8e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's Rochester 8.2/10 Very good (776) "Great place to stay. Freindly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joel £83 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-09&endDate=2025-12-10®ionId=3000443967&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_BF_PROMO_3000443967) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FWykoff-Hotels.d3000443967.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FWykoff-Hotels.d3000443967.Travel-Guide-Hotels) ## Stay near popular Wykoff attractions [](https://www.expedia.co.uk/Eds-Museum-Hotels.0-l553248621532649595-0.Travel-Guide-Filter-Hotels) ### Ed's Museum You can spend time browsing the exhibits at Ed's Museum during your travels in Wykoff. Discover the countryside while you're in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532649595) ## Top Wykoff Hotel Reviews ![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Had a great stay at the Spark Hotel. Friendly people and clean comfortable rooms, great service. Will definitely stay there again. " [](https://expedia.co.uk/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Room was fine and clean. The water pressure from the sink was horrible." [](https://expedia.co.uk/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Hyatt House Rochester/Mayo Clinic Area](https://images.trvl-media.com/lodging/57000000/56840000/56833100/56833067/369065b1_y.jpg) ### Hyatt House Rochester/Mayo Clinic Area 10/10 Excellent "Breakfast menu was large and good. One day i couldnt cut the breakfast sausage...dry and hard. Soups were delicious." [](https://expedia.co.uk/Rochester-Hotels-Hyatt-House-RochesterMayo-Clinic.h56833067.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "Very nice." [](https://expedia.co.uk/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "Excellent facility. Wonderful people!" [](https://expedia.co.uk/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "nice and quiet, no problems" [](https://expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Because Expedia's calendars indicates days rather than nights, what I thought was a reservation for 3 nights was a reservation for 2 nights and three days, so I had to book a room for an additional night. The staff was very helpful in letting us stay in the same room for that third night." [](https://expedia.co.uk/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Aspen Suites](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658_y.jpg) ### Aspen Suites 10/10 Excellent "Love this place! Very friendly and helpful staff. Located in a perfect spot for Mayo" [](https://expedia.co.uk/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Everything was as expected . Nice tidy unit" [](https://expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ## More cheap stays in Wykoff ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Rochester-South 1755 S Broadway Rochester MN £72 22 Dec - 23 Dec includes taxes & fees 9/10 Wonderful! (1,004 reviews) [](https://expedia.co.uk/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Brentwood Inn & Suites 123 Fourth Ave. NW Rochester MN £99 26 Nov - 27 Nov includes taxes & fees 8.6/10 Excellent! (1,009 reviews) [](https://expedia.co.uk/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Med City Inn & Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/821fc05d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Med City Inn & Suites - Mayo Clinic Area 435 16th Ave Nw Rochester MN £70 26 Nov - 27 Nov includes taxes & fees 7.8/10 Good! (1,005 reviews) [](https://expedia.co.uk/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Econo Lodge Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/90000/84800/84723/5b8e813f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Econo Lodge Mayo Clinic Area 1850 S Broadway Rochester MN £55 12 Dec - 13 Dec includes taxes & fees 9/10 Wonderful! (880 reviews) [](https://expedia.co.uk/Rochester-Hotels-Econo-Lodge-Mayo-Clinic-Area.h84723.Hotel-Information) ![Best Western Rochester Hotel Mayo Clinic Area/St. Mary's](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2559x4y0-f5ee734c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's 1517 16th St Sw Rochester MN £83 30 Nov - 1 Dec includes taxes & fees 8.2/10 Very Good! (776 reviews) [](https://expedia.co.uk/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information) ![Super 8 by Wyndham Rochester Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/30000/25200/25164/6da96ba9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Rochester Mayo Clinic Area 106 SE 21st Street Rochester MN £45 7 Dec - 8 Dec includes taxes & fees 7.6/10 Good! (1,006 reviews) [](https://expedia.co.uk/Rochester-Hotels-Super-8-By-Wyndham-Rochester-Mayo-Clinic-Area.h25164.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Wykoff hotel for you. ### How can I save on a Wykoff hotel booking with Expedia? > Before booking your Wykoff hotel, remember to join Expedia's free travel rewards program. Just sign up and sign in to access our lowest Member Prices as well as members-only perks. You could also enjoy savings by bundling together your hotel and flights on Expedia. ### How much is the nightly rate at a Wykoff hotel? > Prices for hotels in Wykoff often vary, but you can find a great deal from £45 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [5 Star Hotels in Rochester](https://www.expedia.co.uk/5Star-Rochester-Hotels.s50-0-d3041.Travel-Guide-Filter-Hotels) - [Altura Hotels](https://www.expedia.co.uk/Altura-Hotels.d553248634983344337.Travel-Guide-Hotels) - [Brownsdale Hotels](https://www.expedia.co.uk/Brownsdale-Hotels.d3000348812.Travel-Guide-Hotels) - [Byron Hotels](https://www.expedia.co.uk/Byron-Hotels.d553248623858895563.Travel-Guide-Hotels) - [Canton Hotels](https://www.expedia.co.uk/Canton-Hotels.d3000443033.Travel-Guide-Hotels) - [Dexter Hotels](https://www.expedia.co.uk/Dexter-Hotels.d3000443146.Travel-Guide-Hotels) - [Downtown Rochester Hotels](https://www.expedia.co.uk/Downtown-Rochester-Rochester-Hotels.0-n553248635976481217-0.Travel-Guide-Filter-Hotels) - [Eyota Hotels](https://www.expedia.co.uk/Eyota-Hotels.d3000348857.Travel-Guide-Hotels) - 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[Rose Creek Hotels](https://www.expedia.co.uk/Rose-Creek-Hotels.d3000348971.Travel-Guide-Hotels) - [Rushford Hotels](https://www.expedia.co.uk/Rushford-Hotels.d6298243.Travel-Guide-Hotels) - [Spring Valley Hotels](https://www.expedia.co.uk/Spring-Valley-Hotels.d602773.Travel-Guide-Hotels) - [St. Charles Hotels](https://www.expedia.co.uk/St-Charles-Hotels.d183431.Travel-Guide-Hotels) - [Stewartville Hotels](https://www.expedia.co.uk/Stewartville-Hotels.d183438.Travel-Guide-Hotels) - [Taopi Hotels](https://www.expedia.co.uk/Taopi-Hotels.d553248634983477966.Travel-Guide-Hotels) - [Flights to Rochester](https://www.expedia.co.uk/Cheap-Flights-To-Rochester.d3041.Travel-Guide-Flights) - [Flights from Rochester Intl.](https://www.expedia.co.uk/lp/airports/rst/flights-from-rochester-intl-airport) - [Flights from Harmony](https://www.expedia.co.uk/lp/flights/183425/flights-from-harmony) - [Flights from Stewartville](https://www.expedia.co.uk/lp/flights/183438/flights-from-stewartville) - [Flights from Le Roy](https://www.expedia.co.uk/lp/flights/3000443387/flights-from-le-roy) - 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