The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious living room with a fireplace, large windows, and modern furniture.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

1. Highpoint Hotel

University Heights, 0.1 mi from Sioux Empire Medical Museum

Randell J

£94

includes taxes & fees

11 Oct - 12 Oct

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

A spacious lobby with a central seating area, a staircase, and a fireplace.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 1.7 mi from Sioux Empire Medical Museum

Jordyn

£121

includes taxes & fees

13 Oct - 14 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

3. Hotel On Phillips

Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum

Frank

£125

includes taxes & fees

4 Oct - 5 Oct

A patio with wicker chairs and a round table with a fire pit.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.1 mi from Sioux Empire Medical Museum

Ross

£103

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A hotel lobby with a bar area, seating, and a television.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

5. Hampton Inn Sioux Falls

Mall District, 1.9 mi from Sioux Empire Medical Museum

Tami

£90

includes taxes & fees

18 Oct - 19 Oct

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 1.5 mi from Sioux Empire Medical Museum

Frankie

£175

includes taxes & fees

11 Oct - 12 Oct

A buffet with labeled containers of omelets and other dishes.

A snack and beverage display with various brands and products.

A reception area with a glass door entrance, a reception desk, and a computer station.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 1.9 mi from Sioux Empire Medical Museum

John

£88

includes taxes & fees

18 Oct - 19 Oct

A covered outdoor area with a wooden railing, chairs, and tables.

A traditional room with wooden paneling, a sofa, armchairs, a patterned rug, and stained glass windows.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

A small pond with a waterfall, surrounded by rocks and plants.

8. Historic Victorian Inn

Cathedral, 0.9 mi from Sioux Empire Medical Museum

Jackie

£111

includes taxes & fees

15 Oct - 16 Oct

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A modern lobby with seating areas, a large pillar, and a wall mural.

9. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum

Todd

£111

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum

Rachael

£104

includes taxes & fees

11 Oct - 12 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum

Joan

£89

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum

Hayley

£84

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with a computer, a television, and a couch.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A sign for Center Inn with a parking lot and buildings in the background.

A black leather chair, a floor lamp, and a window with a view of parked cars.

13. The Center Inn

All Saints, 1.5 mi from Sioux Empire Medical Museum

Marissa

£80

includes taxes & fees

2 Oct - 3 Oct

An indoor pool area with a slide, seating, and tropical decor.

A living room with a fireplace, a television, and a dining area with a table and chairs.

A lobby with a stone fire feature, seating area, and a reception desk.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum

Sami

£53

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

15. Valley Inn

University Heights, 0.1 mi from Sioux Empire Medical Museum

Darrel

£69

includes taxes & fees

1 Oct - 2 Oct

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A dining room with a wooden table, six chairs, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

16. Historic Twin Tudors Inn

0.9 mi from Sioux Empire Medical Museum

Anonymous traveller

£215

includes taxes & fees

30 Oct - 31 Oct

17. Sioux Falls Inn

Northwest Sioux Falls, 2 mi from Sioux Empire Medical Museum

Stephanie

£40

includes taxes & fees

5 Oct - 6 Oct

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

Two vending machines in a hallway with a sign that reads "VENDORS".

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

18. WoodSpring Suites Sioux Falls

1.7 mi from Sioux Empire Medical Museum

Catherine

£67

includes taxes & fees

1 Oct - 2 Oct

A reception area with a counter, a food mart sign, and a security camera.

A hotel room with two beds, a desk, a chair, and a TV.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

19. Ramada by Wyndham Sioux Falls

1.6 mi from Sioux Empire Medical Museum

Tiffany

£49

includes taxes & fees

11 Oct - 12 Oct

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

A conference room with a long table, chairs, water bottles, a flat-screen TV, and a window with curtains.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

20. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 3.2 mi from Sioux Empire Medical Museum

Bailey

£108

includes taxes & fees

18 Oct - 19 Oct

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 342 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,225 reviews	View
Hotel On Phillips	9.6 Exceptional 1,604 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 675 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,009 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

10/10 Excellent

"I absolutely love this hotel. It has a great vibe and is in a great location. I also really enjoy The Treasury on site. My favorite place to stay in Sioux Falls!"

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"It was a very nice place"

Valley Inn

10/10 Excellent

"Everything was great"

Highpoint Hotel

10/10 Excellent

"The hotel was a great place to stay. It was super clean."

Country Inn & Suites by Radisson, Sioux Falls

8/10 Good

"Stayed here before and it’s a good place for a reasonable rate. Clean, updated furniture. Comfortable bed. Really good Continental breakfast. The pool and hot tub are nice, although very disappointed the hot tub was out of order as we were looking forward to that after being in the road a lot. It would’ve been nice if the reception would’ve informed us of that upon check in so we didn’t get our suits on and go all the way down there in anticipation - only to find out it was out of order once we were a foot from getting in. We dined at the restaurant in the hotel this time, Ode, and it was very good, great service."

The Warm & Inviting Place

10/10 Excellent

"All the comforts of home. Thank you for providing such a great place to stay we had a very memorable time visiting our daughter in Sioux Falls. Would stay again in the future."

Upper West Villa-by Sanford,MidcoAqu.&CountryClub

10/10 Excellent

"Nice place"

Stylish & Modern •Sleeps 10• Cornhole+PingPong • Minutes to Most!

10/10 Excellent

"Very cute and trendy house. Older on the outside but updated on the inside. Nice TV’s for watching football, ping ping, foos ball and a fun electronic game table with tons of games. Perfect for three couples. One bathroom on main floor and one in the basement. Very clean."

Stylish, comfort-first 2BR/1BA

10/10 Excellent

"Great property blocks from Sanford Hospital and hosts were fantastic when I needed to extend my stay. Great wi-fi, well furnished and super comfortable."

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Treat yourself

Be picky

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

8. Historic Victorian Inn

9. Hilton Garden Inn Sioux Falls Downtown

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. The Center Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Valley Inn

16. Historic Twin Tudors Inn

17. Sioux Falls Inn

18. WoodSpring Suites Sioux Falls

19. Ramada by Wyndham Sioux Falls

20. Staybridge Suites Sioux Falls Southwest by IHG

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

Clubhouse Hotel Suites Sioux Falls

Valley Inn

Highpoint Hotel

Country Inn & Suites by Radisson, Sioux Falls

The Warm & Inviting Place

Upper West Villa-by Sanford,MidcoAqu.&CountryClub

Stylish & Modern •Sleeps 10• Cornhole+PingPong • Minutes to Most!

Stylish, comfort-first 2BR/1BA

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions