Title: The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices | Expedia.co.uk [Sioux Empire Medical Museum Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sioux-Empire-Medical-Museum.d553248621532648850.Car-Hire-Guide)[Sioux Empire Medical Museum Holidays](https://expedia.co.uk/Sioux-Empire-Medical-Museum-University-Heights.d553248621532648850.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [10 Feb - 11 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-02-10&endDate=2026-02-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [11 Feb - 12 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-02-11&endDate=2026-02-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Sioux Empire Medical Museum hotels ![Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/41b578f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/82416cbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/8b0ea35c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Highpoint Hotel [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 9.6/10 Exceptional (9 reviews) "We were the first people to stay in this room. Great front desk people. Will absolutely stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Caden £110 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/93b8eb51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/31b10812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, River View (Blarney Stone King) | 1 bedroom, premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/19a1b775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel On Phillips [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information) Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum 9.6/10 Exceptional (1,358 reviews) "Nice place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andy [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/7ff68e14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking | Living area | LCD TV](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/w3837h2557x3y3-a3ae36e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/f0fde50d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton Sioux Falls/Sanford Medical Center [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (604 reviews) "Clean room | Breakfast Great | Wonderful and Helpful Staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Natalie £88 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/3e8532be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/e6f72405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e8d1af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clubhouse Hotel Suites Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) Mall District, 1.7 mi from Sioux Empire Medical Museum 9.6/10 Exceptional (1,017 reviews) "The stay was fantastic!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cleo £124 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/282817a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/a6a97a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/4a36c889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/9d38e9aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy By Hilton Sioux Falls Downtown [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information) Downtown Sioux Falls, 1.5 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (178 reviews) "Amazing place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marius £117 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/e471ae53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/566cc0a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/07efade6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/2fcb2d1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Victorian Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information) Cathedral, 0.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (56 reviews) "It was a great place to stay and super interesting." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy £93 includes taxes & fees 21 Feb - 22 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3837h2557x3y3-da1cbf43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/8fd379c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3836h2560x4y0-5db521c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/f7df70ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Sioux Falls Downtown [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information) Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum 8.8/10 Excellent (899 reviews) "Nice hotel! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £96 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/c76521c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/1920c746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed with Sofa bed, City View | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/815973f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/a50b7486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Sioux Falls-City Centre by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information) Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum 8.6/10 Excellent (1,009 reviews) "The staff was super friendly and helpful. Our room was clean and beds were comfy. The noise from the bar area kept us up, but overall it was a great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather £71 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/96cc4a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/553fc343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/59d8aa71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information) Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum 8.4/10 Very good (1,190 reviews) "Staff was awesome and the room was nice and clean beds were comfortable. The breakfast was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra £74 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/4e8f652b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible Bathtub, Non Smoking (Communications, Mobility) | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/edd7efef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/835a882c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/c4b07f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information) Mall District, 1.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (1,000 reviews) "The breakfast was amazing and plenty of options with cold food and hot. The staff were great too and so was our room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JACKIE £102 includes taxes & fees 24 Feb - 25 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information) ![Suite 2 Queens, Recliner, Pullout Sofa | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/ea709935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handi 1 queen, MF, Recliner | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/3c5850aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2f94c1d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2e93ca6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Center Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information) All Saints, 1.5 mi from Sioux Empire Medical Museum 8.4/10 Very good (721 reviews) "Friendly front staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan [](https://www.expedia.co.uk/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/c06c9122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/880f9dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/bd8a3927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/247f7239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Sioux Falls Hotel & Convention Center [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information) Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum 8.6/10 Excellent (1,000 reviews) "Clean and friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eddie £79 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information) ![Basic Studio, 1 King Bed | Desk, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/38fc7edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/92752fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/24e9ff66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/05067e34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valley Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 7.8/10 Good (1,001 reviews) "Clean room Friendliness Great location for us " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rhonda or doug [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) ![3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/fe163ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking (1 King Bed and 2 Queen Beds) | Living room | LCD TV](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/6f285d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/7248bace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/8735dc1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum 7.8/10 Good (1,506 reviews) "Great pool! And lifeguards that let your kids be kids!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan £53 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) ![50-inch flat-screen TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/cc5b60f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/c8a90a6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![50-inch flat-screen TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/cf922b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining room](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/5fb9fa52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Twin Tudors Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information) 0.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (3 reviews) "Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller £223 includes taxes & fees 12 Feb - 13 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/f71c8bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/cbdbc3ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/51fb710c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/58000000/57890000/57889400/57889349/bfd7245a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Sioux Falls Arpt & Suites [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Sioux-Falls-Airport-Hotel-Suites.h57889349.Hotel-Information) Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum 7.2/10 Good (53 reviews) "Very friendly at check in. Great service at bar." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Sioux-Falls-Airport-Hotel-Suites.h57889349.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/f8bdcdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/a1ad628e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/76cea52f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/4ba92d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information) 1.6 mi from Sioux Empire Medical Museum 5.6/10 (1,001 reviews) "Good room for the price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £43 includes taxes & fees 17 Feb - 18 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/4accd249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/7e85057e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/89ab6f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/03970b6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Sioux Falls South [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information) Mall District, 2.3 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (1,003 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nick £96 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/b4415201.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/0ab0f218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/4f3ca8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/e8087923.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Sioux-Falls.h7726793.Hotel-Information) Mall District, 2.5 mi from Sioux Empire Medical Museum 9.2/10 Wonderful (1,561 reviews) "The room was very clean, the staff was very friendly and professional, and the breakfast had a very nice variety of items." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theresa £69 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Sioux-Falls.h7726793.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/49f47bbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/571db4b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/821e93d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/546d8b44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Sioux Falls by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information) Mall District, 2 mi from Sioux Empire Medical Museum 9.2/10 Wonderful (1,001 reviews) "Nice clean facility in a super convenient location. Great breakfast selection. Super friendly staff. I’ll be staying there again for sure." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) KERRY £93 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-25&endDate=2026-02-26®ionId=553248621532648850&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to Sioux Empire Medical Museum | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | ----------------- | --------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Double Room, 2 Queen Beds \| In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Highpoint Hotel | 3.0 star property | 9.6Exceptional9 reviews | View | | | | | | | ![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel On Phillips | 2.5 star property | 9.6Exceptional1,358 reviews | View | | | | | | | ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Home2 Suites By Hilton Sioux Falls/Sanford Medical Center | 3.0 star property | 9.4Exceptional604 reviews | View | | | | | | | ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Clubhouse Hotel Suites Sioux Falls | 3.0 star property | 9.6Exceptional1,017 reviews | View | | | | | | | ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/282817a7.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Canopy By Hilton Sioux Falls Downtown | 4.0 star property | 9.4Exceptional178 reviews | View | | | | | | ## Top Sioux Empire Medical Museum Hotel Reviews ![Clubhouse Hotel Suites Sioux Falls](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e13e753_y.jpg) ### Clubhouse Hotel Suites Sioux Falls 10/10 Excellent "We asked for " [](https://expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) ![4-bedroom vacation home: Sleeps 13. Foosball, 65" TV, Golf, 4 Season Room](https://images.trvl-media.com/lodging/76000000/75860000/75857500/75857412/bc1597b2_y.jpg) ### 4-bedroom vacation home: Sleeps 13\. Foosball, 65" TV, Golf, 4 Season Room 10/10 Excellent "Pleasant home! It was very quiet and enjoyable." [](https://expedia.co.uk/Sioux-Falls-Hotels-The-Lounge-7-Foosball.h75857412.Hotel-Information) ![Holiday Inn Sioux Falls-City Centre by IHG](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/34cad0f4_y.jpg) ### Holiday Inn Sioux Falls-City Centre by IHG 10/10 Excellent "Yes " [](https://expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information) ![Sheraton Sioux Falls Hotel & Convention Center](https://images.trvl-media.com/lodging/1000000/120000/119000/118966/c06c9122_y.jpg) ### Sheraton Sioux Falls Hotel & Convention Center 10/10 Excellent "Room was clean and inviting. The support bars in the bathroom were very helpful as I am handicapped so it worked out great. Having a laundromat on the 5th floor was very convenient even though we didn't use it. The gentleman checking us in and out was nice, professional, and funny, would definitely stay there again." [](https://expedia.co.uk/Sioux-Falls-Hotels-Sheraton-Sioux-Falls-Convention-Center.h118966.Hotel-Information) ![AeroStay Hotel](https://images.trvl-media.com/lodging/12000000/11270000/11268300/11268258/32d35456_y.jpg) ### AeroStay Hotel 10/10 Excellent "Location and updated room." [](https://expedia.co.uk/Sioux-Falls-Hotels-AeroStay-Hotel.h11268258.Hotel-Information) ![Hampton Inn Sioux Falls](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/ceab3d5c_y.jpg) ### Hampton Inn Sioux Falls 10/10 Excellent "Rooms were quiet and comfortable. " [](https://expedia.co.uk/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Sioux Falls](https://images.trvl-media.com/lodging/8000000/7730000/7726800/7726793/b4415201_y.jpg) ### La Quinta Inn & Suites by Wyndham Sioux Falls 10/10 Excellent "The staff on duty in the front office was super helpful and kind. " [](https://expedia.co.uk/Sioux-Falls-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Sioux-Falls.h7726793.Hotel-Information) ![Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/d8a57168_y.jpg) ### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr 10/10 Excellent "Everyone at this hotel is great, including the wait staff in the restaurant. Ive stayed here several times and its always excellent." [](https://expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) ![AmericInn by Wyndham Sioux Falls](https://images.trvl-media.com/lodging/6000000/5780000/5776700/5776640/4273223a_y.jpg) ### AmericInn by Wyndham Sioux Falls 10/10 Excellent "Clean rooms, helpful staff" [](https://expedia.co.uk/Sioux-Falls-Hotels-AmericInn-By-Wyndham-Sioux-Falls.h5776640.Hotel-Information) ## Hotels near other Sioux Empire Medical Museum attractions ### Great Plains Zoo 4.3/5 (74 reviews) Why not meet the animals who live at Great Plains Zoo during your holiday in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091003) ### University of Sioux Falls 4.1/5 (170 reviews) Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090979) ### Augustana College 4.0/5 (188 reviews) Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6150272) ### Center for Western Studies You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648851) ### Delbridge Museum of Natural History You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090987) ### Washington Pavilion of Arts and Science 4.7/5 (63 reviews) You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090975) ### Pettigrew Home and Museum You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648852) ### USS South Dakota Battleship Memorial Find out about the history of Sioux Falls with a stop at USS South Dakota Battleship Memorial. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091005) ## Frequently asked questions ### What's the area like around Sioux Empire Medical Museum? ### What's the best place to stay close to Sioux Empire Medical Museum? ### How many hotels are there close to Sioux Empire Medical Museum? ### If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund? ### What can I see and do near Sioux Empire Medical Museum?