Title: The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices | Expedia.co.uk [Sioux Empire Medical Museum Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sioux-Empire-Medical-Museum.d553248621532648850.Car-Hire-Guide)[Sioux Empire Medical Museum Holidays](https://expedia.co.uk/Sioux-Empire-Medical-Museum-University-Heights.d553248621532648850.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [28 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [29 Mar - 30 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248621532648850&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Sioux Empire Medical Museum hotels ![Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/821a6546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/82416cbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/41b578f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Highpoint Hotel [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 9.8/10 Exceptional (28 reviews) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jammie £94 includes taxes & fees 20 Apr - 21 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/f0fde50d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/7ff68e14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking | Living area | LCD TV](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/w3837h2557x3y3-a3ae36e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton Sioux Falls/Sanford Medical Center [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (614 reviews) "The breakfast was amazing and my room was lovely and clean. So convenient to the Sanford Hospital. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie £89 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Home2-Suites-By-Hilton-Sioux-FallsSanford-Medical-Center.h9011875.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/93b8eb51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/31b10812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, River View (Blarney Stone King) | 1 bedroom, premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/19a1b775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel On Phillips [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information) Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum 9.6/10 Exceptional (1,375 reviews) "Everything was so clean so quiet and we really enjoyed the stay and we will go stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina Kennebeck £136 includes taxes & fees 2 Apr - 3 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hotel-On-Phillips.h36447711.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/e9a40e2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/e6f72405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4e8d1af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clubhouse Hotel Suites Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) Mall District, 1.7 mi from Sioux Empire Medical Museum 9.6/10 Exceptional (1,035 reviews) "Great place to stay?" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jazmine £121 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/282817a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/4a36c889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/a6a97a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/9d38e9aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy By Hilton Sioux Falls Downtown [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information) Downtown Sioux Falls, 1.5 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (196 reviews) "Amazing place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marius £160 includes taxes & fees 13 Apr - 14 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Canopy-By-Hilton-Sioux-Falls-Downtown.h104094801.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/5eaeb99e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two Queens Study Sofabed Nonsmoking | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/ff09a66b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/1421b1c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/80000/74500/74429/9a77764f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information) Mall District, 1.9 mi from Sioux Empire Medical Museum 9.2/10 Wonderful (1,000 reviews) "Clean room, friendly staff, and an excellent pet area outside. Will stay again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott £92 includes taxes & fees 3 Apr - 4 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hampton-Inn-Sioux-Falls.h74429.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3837h2557x3y3-da1cbf43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/w3836h2560x4y0-5db521c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/f7df70ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6410000/6404700/6404700/8fd379c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Sioux Falls Downtown [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information) Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum 8.8/10 Excellent (910 reviews) "Nice hotel! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £101 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hilton-Garden-Inn-Sioux-Falls-Downtown.h6404700.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/e471ae53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/c2b6d037.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/2fcb2d1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45040000/45035200/45035119/07efade6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Victorian Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information) Cathedral, 0.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (57 reviews) "Everything thing was wonderful. We 100% recommend the Historic Victorian Inn. If we find ourselves staying overnight in Sioux Falls again, this will be the place where we will stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vaughn £132 includes taxes & fees 21 Apr - 22 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Victorian-Inn.h45035119.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/c76521c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite, 1 King Bed | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/6ecf1dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/a50b7486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4722/1920c746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Sioux Falls-City Centre by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information) Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum 8.6/10 Excellent (1,001 reviews) "Nice place to stay good restaurants and bars within the facility courteous service and good quality food also. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul £83 includes taxes & fees 2 Apr - 3 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Sioux-Falls-City-Centre.h4722.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/9ba9d9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/59d8aa71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/96cc4a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/40000/34300/34225/553fc343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information) Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum 8.6/10 Excellent (1,196 reviews) "It was a great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trinity £84 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Country-Inn-Suites-By-Radisson.h34225.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/4e8f652b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/93743ca6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/835a882c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible Bathtub, Non Smoking (Communications, Mobility) | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/130000/127000/126929/edd7efef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information) Mall District, 1.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (1,000 reviews) "All parts of our stay was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bruce £100 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Holiday-Inn-Express-Suites-Sioux-Falls-At-Empire-Mall.h126929.Hotel-Information) ![Suite 2 Queens, Recliner, Pullout Sofa | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/ea709935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/2f94c1d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/03926f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handi 1 queen, MF, Recliner | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59830000/59829700/59829643/3c5850aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Center Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information) All Saints, 1.5 mi from Sioux Empire Medical Museum 8.4/10 Very good (740 reviews) "the rooms were clean and the staff very friendly. it's a great place to stay if you want a room close to the hospital or surgical center as you can walk to either." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy £80 includes taxes & fees 3 Apr - 4 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-The-Center-Inn.h59829643.Hotel-Information) ![Basic Studio, 1 King Bed | Desk, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/38fc7edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/05067e34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/92752fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/24e9ff66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valley Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) University Heights, 0.1 mi from Sioux Empire Medical Museum 7.8/10 Good (1,001 reviews) "Clean room Friendliness Great location for us " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rhonda or doug £74 includes taxes & fees 8 Apr - 9 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) ![3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/fe163ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/7248bace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/8735dc1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking (1 King Bed and 2 Queen Beds) | In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/34fff544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum 7.8/10 Good (1,554 reviews) "Clean rooms, nice pool area, nice staff!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristian £56 includes taxes & fees 30 Mar - 31 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) ![50-inch flat-screen TV with cable channels, fireplace, Netflix](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/cc5b60f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/c8a90a6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/77757565.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining room](https://images.trvl-media.com/lodging/101000000/100460000/100456000/100455928/5fb9fa52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Twin Tudors Inn [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information) 0.9 mi from Sioux Empire Medical Museum 8.8/10 Excellent (3 reviews) "Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller £217 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Historic-Twin-Tudors-Inn-Mc-Kennan-Park.h100455928.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058974/81a95a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058974/c9b97756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058974/51faf8ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058974/c0e8f25a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### WoodSpring Suites Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-WoodSpring-Suites-Sioux-Falls.h2058974.Hotel-Information) 1.7 mi from Sioux Empire Medical Museum 5.4/10 (63 reviews) "Clean room, Friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Satoya £50 includes taxes & fees 30 Mar - 31 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-WoodSpring-Suites-Sioux-Falls.h2058974.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/f8bdcdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/4ba92d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Non Smoking (3 Queen Beds) | Premium bedding, blackout curtains, iron/ironing board, cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/3c7f8030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40700/40621/76cea52f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Sioux Falls [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information) 1.6 mi from Sioux Empire Medical Museum 5.6/10 (1,001 reviews) "Good room for the price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £47 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls.h40621.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/49f47bbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/546d8b44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/821e93d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/571db4b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Sioux Falls by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information) Mall District, 2 mi from Sioux Empire Medical Museum 9.2/10 Wonderful (1,001 reviews) "It was a very busy weekend with a ton of youth wrestlers. The staff was very helpful and made our stay very pleasant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra £85 includes taxes & fees 2 Apr - 3 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/4accd249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/89ab6f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/03970b6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/54000000/53992100/53992029/7e85057e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Sioux Falls South [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information) Mall District, 2.3 mi from Sioux Empire Medical Museum 9.4/10 Exceptional (1,001 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aynsley £98 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Hyatt-Place-Sioux-Falls-South.h53992029.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5410000/5406600/5406549/f4dbdf12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5410000/5406600/5406549/6e63e696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5410000/5406600/5406549/c5e29385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5410000/5406600/5406549/2d652eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Sioux Falls by IHG [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Candlewood-Suites-Sioux-Falls.h5406549.Hotel-Information) Mall District, 2.1 mi from Sioux Empire Medical Museum 9.2/10 Wonderful (702 reviews) "Great stay everything was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denise £88 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Sioux-Falls-Hotels-Candlewood-Suites-Sioux-Falls.h5406549.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-11&endDate=2026-04-12®ionId=553248621532648850&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to Sioux Empire Medical Museum | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | ----------------- | --------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Double Room, 2 Queen Beds \| In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Highpoint Hotel | 3.0 star property | 9.8Exceptional28 reviews | View | | | | | | | ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9020000/9011900/9011875/10270e0f.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Home2 Suites By Hilton Sioux Falls/Sanford Medical Center | 3.0 star property | 9.4Exceptional614 reviews | View | | | | | | | ![Interior detail](https://images.trvl-media.com/lodging/37000000/36450000/36447800/36447711/edd573eb.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel On Phillips | 2.5 star property | 9.6Exceptional1,375 reviews | View | | | | | | | ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Clubhouse Hotel Suites Sioux Falls | 3.0 star property | 9.6Exceptional1,035 reviews | View | | | | | | | ![Meeting facility](https://images.trvl-media.com/lodging/105000000/104100000/104094900/104094801/282817a7.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Canopy By Hilton Sioux Falls Downtown | 4.0 star property | 9.4Exceptional196 reviews | View | | | | | | ## Top Sioux Empire Medical Museum Hotel Reviews ![AmericInn by Wyndham Sioux Falls](https://images.trvl-media.com/lodging/6000000/5780000/5776700/5776640/4273223a_y.jpg) ### AmericInn by Wyndham Sioux Falls 10/10 Excellent "Nice suitable breakfast, the staff was very friendly, and the hot tub was very nice and the beds are very comfy" [](https://expedia.co.uk/Sioux-Falls-Hotels-AmericInn-By-Wyndham-Sioux-Falls.h5776640.Hotel-Information) ![Clubhouse Hotel Suites Sioux Falls](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100190/4f6166ff_y.jpg) ### Clubhouse Hotel Suites Sioux Falls 10/10 Excellent "Bed are not the most comfortable, but everything else is great!" [](https://expedia.co.uk/Sioux-Falls-Hotels-Clubhouse-Hotel-Suites-Sioux-Falls.h1100190.Hotel-Information) ![Baymont by Wyndham Sioux Falls](https://images.trvl-media.com/lodging/1000000/60000/50200/50114/ff2f8bab_y.jpg) ### Baymont by Wyndham Sioux Falls 10/10 Excellent "I did not have breakfast." [](https://expedia.co.uk/Sioux-Falls-Hotels-Baymont-By-Wyndham-Sioux-Falls.h50114.Hotel-Information) ![Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr](https://images.trvl-media.com/lodging/1000000/20000/14200/14107/fe163ebb_y.jpg) ### Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr 10/10 Excellent "Very much so! Had a wonderful time" [](https://expedia.co.uk/Sioux-Falls-Hotels-Ramada-By-Wyndham-Sioux-Falls-Airport-Waterpark-Event-Ctr.h14107.Hotel-Information) ![Highpoint Hotel](https://images.trvl-media.com/lodging/121000000/120710000/120706800/120706759/24bd8fd6_y.jpg) ### Highpoint Hotel 10/10 Excellent "Super clean room. " [](https://expedia.co.uk/Sioux-Falls-Hotels-Highpoint-Hotel.h120706759.Hotel-Information) ![My Place Hotel - Sioux Falls, SD](https://images.trvl-media.com/lodging/10000000/9370000/9365400/9365384/w3000h1897x0y3-d71c5ae9_y.jpg) ### My Place Hotel - Sioux Falls, SD 8/10 Good "Property was in an industrial area which my wife referred to as "sketchy". I didn't think it was too bad, but also agreed that we'd drive to the restaurant we were going to instead of walking the distance of just under a mile. I do like the rooms at My Place properties...just well appointed & clean, which I appreciate. If I stay here in the future, I'd ask for a room opposite of the southwest corner where our room was. Traffic was LOUD & was loud all night long!! " [](https://expedia.co.uk/Sioux-Falls-Hotels-My-Place-Hotel-Sioux-Falls.h9365384.Hotel-Information) ![Days Inn by Wyndham Sioux Falls Empire](https://images.trvl-media.com/lodging/1000000/10000/8300/8283/97d1e7e7_y.jpg) ### Days Inn by Wyndham Sioux Falls Empire 6/10 Okay "Breakfast was minimal Night staff was friendly and helpful Day staff ignored us Bathroom. Bath tub was falling apart shower head wouldn’t open. Drain wouldn’t drain properly " [](https://expedia.co.uk/Sioux-Falls-Hotels-Days-Inn-By-Wyndham-Sioux-Falls-Empire.h8283.Hotel-Information) ![Valley Inn](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886239/38fc7edf_y.jpg) ### Valley Inn 10/10 Excellent "Our stay was ideal. Friendly staff, quiet room, and cable tv." [](https://expedia.co.uk/Sioux-Falls-Hotels-Valley-Inn.h3886239.Hotel-Information) ![Staybridge Suites Sioux Falls by IHG](https://images.trvl-media.com/lodging/2000000/1260000/1252800/1252731/49f47bbd_y.jpg) ### Staybridge Suites Sioux Falls by IHG 10/10 Excellent "Everything was as we had hoped it would be. I highly recommend and we will be staying here again in the future!" [](https://expedia.co.uk/Sioux-Falls-Hotels-Staybridge-Suites-Sioux-Falls.h1252731.Hotel-Information) ## Hotels near other Sioux Empire Medical Museum attractions ### Great Plains Zoo 4.3/5 (74 reviews) Why not meet the animals who live at Great Plains Zoo during your holiday in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091003) ### University of Sioux Falls 4.1/5 (170 reviews) Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090979) ### Augustana College 4.0/5 (188 reviews) Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6150272) ### Center for Western Studies You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648851) ### Delbridge Museum of Natural History You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090987) ### Washington Pavilion of Arts and Science 4.7/5 (63 reviews) You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6090975) ### Pettigrew Home and Museum You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648852) ### USS South Dakota Battleship Memorial Find out about the history of Sioux Falls with a stop at USS South Dakota Battleship Memorial. Attend a sporting event or discover the area's beautiful waterfalls. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091005) ## Frequently asked questions ### What's the area like around Sioux Empire Medical Museum? ### What's the best place to stay close to Sioux Empire Medical Museum? ### How many hotels are there close to Sioux Empire Medical Museum? ### If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund? ### What can I see and do near Sioux Empire Medical Museum?