The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious lobby with modern seating, large windows, and a city view.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious living room with a fireplace, large windows, and modern furniture.

1. Highpoint Hotel

University Heights, 0.1 mi from Sioux Empire Medical Museum

Randell J

£106

includes taxes & fees

11 Oct - 12 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

2. Hotel On Phillips

Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum

Frank

£125

includes taxes & fees

4 Oct - 5 Oct

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A spacious lobby with a central seating area, a staircase, and a fireplace.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

3. Clubhouse Hotel Suites Sioux Falls

Mall District, 1.7 mi from Sioux Empire Medical Museum

Claudine

£121

includes taxes & fees

11 Oct - 12 Oct

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.1 mi from Sioux Empire Medical Museum

Ross

£103

includes taxes & fees

4 Oct - 5 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel lobby with a bar area, seating, and a television.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

5. Hampton Inn Sioux Falls

Mall District, 1.9 mi from Sioux Empire Medical Museum

Derrick

£93

includes taxes & fees

4 Oct - 5 Oct

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 1.5 mi from Sioux Empire Medical Museum

Marius

£175

includes taxes & fees

4 Oct - 5 Oct

A covered outdoor area with a wooden railing, chairs, and tables.

A small pond with a waterfall, surrounded by rocks and plants.

A two-story house with a front porch, a central entrance, and a small garden area.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

7. Historic Victorian Inn

Cathedral, 0.9 mi from Sioux Empire Medical Museum

Jackie

£101

includes taxes & fees

6 Oct - 7 Oct

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A spacious hallway with a patterned carpet, large windows, and seating areas.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A modern lobby with seating areas, a large pillar, and a wall mural.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum

Todd

£111

includes taxes & fees

25 Oct - 26 Oct

A buffet with labeled containers of omelets and other dishes.

A snack and beverage display with various brands and products.

A reception area with a glass door entrance, a reception desk, and a computer station.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 1.9 mi from Sioux Empire Medical Museum

John

£88

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

10. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum

Rachael

£104

includes taxes & fees

11 Oct - 12 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

A hotel room with a bed, a sofa, a TV, and a desk.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum

Joan

£89

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum

Hayley

£80

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a computer, a television, and a couch.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A sign for Center Inn with a parking lot and buildings in the background.

13. The Center Inn

All Saints, 1.5 mi from Sioux Empire Medical Museum

Marissa

£80

includes taxes & fees

2 Oct - 3 Oct

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

14. Valley Inn

University Heights, 0.1 mi from Sioux Empire Medical Museum

Darrel

£69

includes taxes & fees

29 Sept - 30 Sept

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A dining room with a wooden table, six chairs, and a chandelier.

A two-story house with a steeply pitched roof, a front porch, and a brick entrance.

15. Historic Twin Tudors Inn

0.9 mi from Sioux Empire Medical Museum

Anonymous traveller

£218

includes taxes & fees

4 Oct - 5 Oct

16. Sioux Falls Inn

Northwest Sioux Falls, 2 mi from Sioux Empire Medical Museum

Stephanie

£44

includes taxes & fees

29 Sept - 30 Sept

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

17. WoodSpring Suites Sioux Falls

1.7 mi from Sioux Empire Medical Museum

Catherine

£67

includes taxes & fees

29 Sept - 30 Sept

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A conference room with a long table, chairs, water bottles, a flat-screen TV, and a window with curtains.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

18. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 3.2 mi from Sioux Empire Medical Museum

Bailey

£108

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

A hotel room with a bed, a sofa, a desk, and a chair.

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a clear view of the building's facade.

19. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 3.7 mi from Sioux Empire Medical Museum

jason

£86

includes taxes & fees

18 Oct - 19 Oct

A deck with outdoor furniture, a fire pit, and a view of a body of water.

A modern Hyatt Place hotel with a glass entrance canopy and a brick facade.

A modern hotel lobby with a dining area, seating arrangements, and a kitchen in the background.

A reception area with a herringbone-patterned wall, a reception desk, and seating area with chairs and a table.

20. Hyatt Place Sioux Falls South

Mall District, 2.3 mi from Sioux Empire Medical Museum

Catherine

£98

includes taxes & fees

4 Oct - 5 Oct

View all properties

Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 337 reviews	View
Hotel On Phillips	9.6 Exceptional 1,597 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,226 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 674 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,005 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Valley Inn

8/10 Good

"Very nice room, algjough while not a big there was no microwave. Still a vey nj e place to stay"

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Staff were great. Lobby was amazing"

Highpoint Hotel

10/10 Excellent

"Beautiful room and views"

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

10/10 Excellent

"The rooms were amazing!! It’s like a mini apartment!!! Mini kitchen and very comfortable beds!!! Best sleep I’ve ever had in a hotel!! Would definitely stay here again if I’m in the area!!"

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"1st level very noisy by the door. Slammed all night with each person going in and out."

Upper West Villa-by Sanford,MidcoAqu.&CountryClub

10/10 Excellent

"Nice place"

Stylish & Modern •Sleeps 10• Cornhole+PingPong • Minutes to Most!

10/10 Excellent

"Very cute and trendy house. Older on the outside but updated on the inside. Nice TV’s for watching football, ping ping, foos ball and a fun electronic game table with tons of games. Perfect for three couples. One bathroom on main floor and one in the basement. Very clean."

Stylish, comfort-first 2BR/1BA

10/10 Excellent

"Great property blocks from Sanford Hospital and hosts were fantastic when I needed to extend my stay. Great wi-fi, well furnished and super comfortable."

Skots Villa Upper East. Centrally located near Sanford Medical Center & Midco.

10/10 Excellent

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Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Hotel On Phillips

3. Clubhouse Hotel Suites Sioux Falls

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Historic Victorian Inn

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

10. Holiday Inn Sioux Falls-City Centre by IHG

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. The Center Inn

14. Valley Inn

15. Historic Twin Tudors Inn

16. Sioux Falls Inn

17. WoodSpring Suites Sioux Falls

18. Staybridge Suites Sioux Falls Southwest by IHG

19. Comfort Inn & Suites at Sanford Sports Complex

20. Hyatt Place Sioux Falls South

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Valley Inn

Clubhouse Hotel Suites Sioux Falls

Highpoint Hotel

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Upper West Villa-by Sanford,MidcoAqu.&CountryClub

Stylish & Modern •Sleeps 10• Cornhole+PingPong • Minutes to Most!

Stylish, comfort-first 2BR/1BA

Skots Villa Upper East. Centrally located near Sanford Medical Center & Midco.

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions