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Check prices for these dates

Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

1. Highpoint Hotel

Highpoint Hotel
3.0 star property
University Heights, 0.1 mi from Sioux Empire Medical Museum
9.8 out of 10, Exceptional, (423 reviews)
"Great place to stay."
United States
Lee
The price is £97
includes taxes & fees
24 Nov - 25 Nov
Highpoint Hotel
A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

2. Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 1.7 mi from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1,271 reviews)
"Absolutely love staying here.. alway pleasant experience.. we've stayed here at least 10 times"
United States
Nicholas
The price is £138
includes taxes & fees
22 Nov - 23 Nov
Clubhouse Hotel Suites Sioux Falls
A lobby with a large safe, a checkered floor, and a sofa with cushions.

3. Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1,648 reviews)
"Overall great place to stay. Walked to dinner, easy parking, convenient to airport"
United States
Cynthia
The price is £138
includes taxes & fees
24 Nov - 25 Nov
Hotel On Phillips
A patio with wicker chairs and a round table with a fire pit.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.1 mi from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (683 reviews)
"Friendly staff Great Breakfast"
United States
Dalene
The price is £90
includes taxes & fees
23 Nov - 24 Nov
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
A modern lobby with a glass fireplace, seating areas, and indoor plants.

5. Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 1.5 mi from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (294 reviews)
"Great stay super cute location"
United States
Marnie
The price is £130
includes taxes & fees
23 Nov - 24 Nov
Canopy By Hilton Sioux Falls Downtown
A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

6. Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 1.9 mi from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1,001 reviews)
"Very friendly staff, good choices at breakfast and comfortable room."
United States
Mary
The price is £91
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Sioux Falls
A long dining table with chairs, a bar area with bottles, and a brick wall with a chandelier.

7. Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1,004 reviews)
"great location short walk to Falls"
Canada
David
The price is £101
includes taxes & fees
22 Nov - 23 Nov
Hilton Garden Inn Sioux Falls Downtown
A buffet with labeled containers of omelets and other dishes.

8. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
2.5 star property
Mall District, 1.9 mi from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1,002 reviews)
"It's a good place"
United States
Hagel
The price is £82
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

9. Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1,002 reviews)
"Clean room friendly staff"
United States
Charmaine
The price is £89
includes taxes & fees
6 Dec - 7 Dec
Sheraton Sioux Falls Hotel & Convention Center
A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

10. Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.2 mi from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1,000 reviews)
"Very clean hotel with very helpful and friendly staff."
United States
Chad
The price is £108
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Sioux Falls-City Centre by IHG
A restaurant interior with a bar area, seating, and a decorative ceiling.

11. Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls
3.0 star property
Downtown Sioux Falls, 1.3 mi from Sioux Empire Medical Museum
8.4 out of 10, Very good, (1,428 reviews)
"Great stay!"
United States
Hayley
The price is £72
includes taxes & fees
22 Nov - 23 Nov
Country Inn & Suites by Radisson, Sioux Falls
A hotel room with two beds, a desk with a computer, a television, and a couch.

12. The Center Inn

The Center Inn
2.5 star property
All Saints, 1.5 mi from Sioux Empire Medical Museum
8.4 out of 10, Very good, (941 reviews)
"Very nice, basic hotel with great location on the Avera hospital campus."
United States
thomas
The price is £85
includes taxes & fees
15 Dec - 16 Dec
The Center Inn
An indoor pool area with a slide, seating, and tropical decor.

13. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 1.8 mi from Sioux Empire Medical Museum
7.8 out of 10, Good, (1,662 reviews)
"Rooms were very clean. Staff was very helpful & nice. The bed was nice! Will stay again!"
United States
Julaine
The price is £53
includes taxes & fees
22 Nov - 23 Nov
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

14. Valley Inn

Valley Inn
2.5 star property
University Heights, 0.1 mi from Sioux Empire Medical Museum
8.0 out of 10, Very good, (1,000 reviews)
"It was close to the airport and lots of places to eat. The rooms were spacious and comfortable."
United States
Doreen
The price is £79
includes taxes & fees
16 Dec - 17 Dec
Valley Inn
A reception area with a marble counter, a black office chair, and a potted plant.

15. Sioux Falls Inn

Sioux Falls Inn
2.0 star property
Northwest Sioux Falls, 2 mi from Sioux Empire Medical Museum
5.8 out of 10, (10 reviews)
"A lot of remodeling going on throughout the place, so yes. A lot of debris and new furniture waiting ro be put in."
United States
Maria
The price is £37
includes taxes & fees
16 Nov - 17 Nov
Sioux Falls Inn
A reception area with a counter, a food mart sign, and a security camera.

16. Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
1.6 mi from Sioux Empire Medical Museum
5.8 out of 10, (1,003 reviews)
"Great hotel!! Great customer service and my room was cleaned each day! Enjoy breakfast too!"
United States
Jonathan Robert
The price is £47
includes taxes & fees
22 Nov - 23 Nov
Ramada by Wyndham Sioux Falls
A spacious lobby with a central seating area, a reception desk, and a large window providing natural light.

17. Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG
3.0 star property
South Sioux Falls, 3.2 mi from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (558 reviews)
"Good clean rooms with comfortable beds and a good breakfast spread."
United States
Bailey
The price is £89
includes taxes & fees
22 Nov - 23 Nov
Staybridge Suites Sioux Falls Southwest by IHG
A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

18. Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex
2.5 star property
Northwest Sioux Falls, 3.7 mi from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1,242 reviews)
"Great place, with friendly staff."
United States
Kristine
The price is £84
includes taxes & fees
22 Nov - 23 Nov
Comfort Inn & Suites at Sanford Sports Complex
A modern hotel lobby with seating areas, a bar, and a kitchen visible in the background.

19. Hampton Inn & Suites Southwest/Sioux Falls

Hampton Inn & Suites Southwest/Sioux Falls
2.5 star property
South Sioux Falls, 3.4 mi from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1,002 reviews)
"The bed was extremely comfortable, the room very clean and staff were very helpful!"
United States
Elizabeth
The price is £94
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites Southwest/Sioux Falls
An outdoor patio with a round table and wicker chairs, a fire pit, and a brick wall.

20. Fairfield Inn & Suites Sioux Falls Airport

Fairfield Inn & Suites Sioux Falls Airport
3.0 star property
Northwest Sioux Falls, 3.7 mi from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (822 reviews)
"Nice place, safe area. Comfortable beds, cool air, clean rooms. Definitely would stay again"
United States
Penny
The price is £92
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites Sioux Falls Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Sioux Empire Medical Museum

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious bar area with a large TV screen, a fireplace, and a wine rack.
Highpoint Hotel
3.0 star property
9.8
Exceptional
423 reviews
View
A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.
Clubhouse Hotel Suites Sioux Falls
3.0 star property
9.6
Exceptional
1,271 reviews
View
A lobby with a large safe, a checkered floor, and a sofa with cushions.
Hotel On Phillips
2.5 star property
9.6
Exceptional
1,648 reviews
View
A patio with wicker chairs and a round table with a fire pit.
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
9.4
Exceptional
683 reviews
View
A modern lobby with a glass fireplace, seating areas, and indoor plants.
Canopy By Hilton Sioux Falls Downtown
4.0 star property
9.4
Exceptional
294 reviews
View

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

Hotel On Phillips

10/10 Excellent
"Great place to stay!!"
Melinda 1-night trip
Posted 18 hours ago
Hotel On Phillips

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)
Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?
Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Sioux Empire Medical Museum?
Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.
How many hotels are there close to Sioux Empire Medical Museum?
Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.
If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.
What can I see and do near Sioux Empire Medical Museum?
Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.