Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Property class: 3

Choose dates to view prices

Consider a stay at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center and take advantage of free on-the-go breakfast, laundry facilities and a 24-hour gym. In addition to a business centre, guests can connect to free in-room WiFi.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Pet-friendly
  • Parking included
  • Free Wi-Fi
  • Air-conditioning
The current price is £91
includes taxes & fees
26 Nov - 27 Nov

Room options

Available filters for rooms
Showing 11 of 11 rooms

View all photos for Studio Suite, 1 King Bed, Non Smoking

A hotel room with a bed, a desk, a chair, a TV, and a lamp.

Studio Suite, 1 King Bed, Non Smoking

9.4 out of 10
Exceptional
(32 reviews)
  • 435 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Studio, 2 Queen Beds, Non Smoking

A hotel room with two beds, a desk, a chair, and a TV.

Studio, 2 Queen Beds, Non Smoking

9.4 out of 10
Exceptional
(14 reviews)
  • 435 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 Bedroom, Non Smoking

A hotel room with a bed, a TV, a desk, a lamp, and a window with curtains.

Suite, 1 Bedroom, Non Smoking

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 4
  • 1 King Bed

View all photos for Studio, 1 King Bed, Accessible, Non Smoking

A hotel room with a bed, a desk, a chair, a lamp, a TV, and a window with curtains.

Studio, 1 King Bed, Accessible, Non Smoking

7.4 out of 10
Good
(3 reviews)
  • 435 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Studio, 1 King Bed, Accessible, Bathtub

A hotel room with a bed, a desk, a chair, a lamp, a TV, and a window with curtains.

Studio, 1 King Bed, Accessible, Bathtub

9.6 out of 10
Exceptional
(4 reviews)
  • 430 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Studio, 2 Queen Beds, Accessible, Non Smoking

A hotel room with two beds, a desk with a computer, a chair, a TV, and a large mirror.

Studio, 2 Queen Beds, Accessible, Non Smoking

9.0 out of 10
Wonderful
(6 reviews)
  • 435 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Studio, 2 Queen Beds, Accessible, Bathtub

A hotel room with two beds, a desk with a computer, a chair, a TV, and a large mirror.

Studio, 2 Queen Beds, Accessible, Bathtub

9.0 out of 10
Wonderful
(2 reviews)
  • 435 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Studio, 2 Queen Beds, Accessible, Non Smoking

A hotel room with two beds, a desk with a computer, a chair, a TV, and a large mirror.

Studio, 2 Queen Beds, Accessible, Non Smoking

9.2 out of 10
Wonderful
(5 reviews)
  • 435 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible, Bathtub

A hotel room with a bed, a TV, a wardrobe, a window with a view, and a wall-mounted lamp.

Suite, 1 King Bed, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • 527 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible, Non Smoking

A hotel room with a bed, a TV, a wardrobe, a window with a view, and a wall-mounted lamp.

Suite, 1 King Bed, Accessible, Non Smoking

  • 530 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible, Non Smoking

A hotel room with a bed, a TV, a wardrobe, a window with a view, and a wall-mounted lamp.

Suite, 1 King Bed, Accessible, Non Smoking

  • 530 sq ft
  • Sleeps 4
  • 1 King Bed

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About the area

University Heights, a neighbourhood in Sioux Falls, is home to Home2 Suites By Hilton Sioux Falls/Sanford Medical Center. Sioux Empire Medical Museum and Edith Mortenson Theatre Center are cultural highlights, and some of the area's activities can be experienced at Denny Sanford Premier Center and Minnehaha Country Club. Looking to enjoy an event or a game while in town? See what's happening at Midco Arena or Sioux Falls Stadium. Visit our Sioux Falls travel guide
Map
1120 S Grange Ave, Sioux Falls, SD, 57105

What's nearby

  • The entrance to the Great Plains Zoo with a sign featuring silhouettes of animals and a covered walkway.
    Great Plains Zoo
    3 min drive - 1.4 miles
  • A waterfall cascading over rocky terrain with a bridge in the background.
    Falls Park
    4 min drive - 1.5 miles
  • University of Sioux Falls
    5 min walk - 0.3 miles
  • Augustana College
    11 min walk - 0.6 miles
  • Washington Pavilion of Arts and Science
    3 min drive - 1.1 miles

Getting around

  • Sioux Falls Regional Airport (FSD)
    8 min drive

Restaurants

  • Casey's
    12 min walk
  • Taco John's
    3 min drive
  • Fryn' Pan
    2 min drive
  • Taco Bell
    14 min walk
  • Perch
    18 min walk

About this property

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

  • Hotel near Denny Sanford Premier Center
  • Take advantage of free on-the-go breakfast, laundry facilities and a 24-hour gym at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center. Stay connected with free in-room WiFi, and guests can find other amenities, such as a business centre.
  • You'll also find perks such as:
    • An indoor pool
    • Free self-parking
    • Express check-out, barbecues and a front desk safe
    • A lift, luggage storage and a 24-hour front desk
    • Guest reviews speak highly of the helpful staff
  • Room features
  • All 80 rooms include comforts such as air conditioning, in addition to amenities such as free WiFi.
  • Extra conveniences in all rooms include:
    • Kitchens with fridges, dishwashers and microwaves
    • Cookware/dishes/utensils, coffee/tea makers and limited housekeeping

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9.2 out of 10, Wonderful, 1,519 reviews
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Frequently asked questions

Does Home2 Suites By Hilton Sioux Falls/Sanford Medical Center have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center?

As of 27 Oct 2026, prices found for a 1-night stay for 2 adults at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center on 26 Nov 2026 start from £91, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is Home2 Suites By Hilton Sioux Falls/Sanford Medical Center pet-friendly?

Yes, this property allows cats and dogs (limit 2 total) with a maximum weight of up to 23 kg per pet. There's a fee of USD 50 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center?

Self-parking is free at this property.

What time is check-in at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center?

Check-in start time: 3:00 PM; check-in end time: 11:00 PM. After-hours check-in is not available.

What time is check-out at Home2 Suites By Hilton Sioux Falls/Sanford Medical Center?

Checkout is at noon.

Where is Home2 Suites By Hilton Sioux Falls/Sanford Medical Center located?

Located in University Heights, this hotel is steps from Sanford USD Medical Center and 2.3 mi (3.8 km) from Denny Sanford Premier Center. Sioux Empire Medical Museum and University of Sioux Falls are also within 5 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center Reviews

9.4

Exceptional

9.6

Cleanliness

9.4

Location

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 516 out of 679 reviews
Rating 8 - Good. 116 out of 679 reviews
Rating 6 - Okay. 27 out of 679 reviews
Rating 4 - Poor. 9 out of 679 reviews
Rating 2 - Terrible. 11 out of 679 reviews

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The property was very clean and the staff was great.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms were amazing!! It’s like a mini apartment!!! Mini kitchen and very comfortable beds!!! Best sleep I’ve ever had in a hotel!! Would definitely stay here again if I’m in the area!!
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff, Clean rooms, very pet friendly, couldn't ask for a better place to stay!
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location next to the hospital and the surgical towers. Staff was friendly, rooms were clean and the breakfast was very good.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, very nice staff, great location
Stayed 1 night in Jun 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Staff were friendly. The room was very clean. Great water pressure in the shower. Breakfast could be a little better; the warm foods were on the cooler side, and the layout of the breakfast could be better organized. Definitely one of the better hotels I have stayed at in awhile; will stay again if needed to stay overnight there.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location if needing a hotel next to Sanford hospital. Very clean. Seems understaffed at times, but seems to be the norm lately. Would definitely stay again if in the area.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The breakfast was substantial and tasty.
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Staff was very friendly, rooms were clean. The stay was amazing
Stayed 1 night in Jan 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again.
Stayed 2 nights in Nov 2025
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The breakfast was amazing and my room was lovely and clean. So convenient to the Sanford Hospital.
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was very clean and comfortable. The staff was very helpful.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service
Very convenient location. Clean modern rooms. Comfortable bed. Would stay again.
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The breakfast was really good! It seemed to use healthier ingredients. The rooms were clean and everyone was very helpful.
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Staff was very friendly, room was clean
Stayed 1 night in Nov 2025
Verified review

8/10 Good

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, staff very helpful.
Stayed 5 nights in Oct 2025
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Great hospitality and clean service
Stayed 7 nights in Oct 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location, nice clean property, Starbucks is available if you take a quick walk over the skyway to the hospital. Breakfast was good, wish they offered more fresh fruit or biscuits and gravy, but they had many options for breakfast sandwiches.
Stayed 3 nights in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
The room was spotless and the staff was very efficient and personable
Stayed 1 night in Jan 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Brought my sister-in-law to Sioux Falls for same-day surgery and we spent the night before here. The young woman at the front desk when we checked in and also the next morning was absolutely wonderful and very nice. I’m very impressed with the hotel. Breakfast was OK nothing special but you didn’t walk away hungry either other than that I say it’s a fantastic place to stay.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Destiny was friendly kind and professional. The room was vey clean and comfortable. I lived my stay.
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, property conditions & facilities
The room was clean and the place is quiet. It was a nice visit.
Stayed 2 nights in Nov 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
All of it was clean and well maintained
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, property conditions & facilities
The staff was so wonderful! Destynee was so kind, her smile just lifted my spirits. The room was comfortable and spotless. Would definitely stay here again!
Stayed 1 night in Dec 2025
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Very clean and comfortable
Stayed 1 night in Dec 2025