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Santo Tomas Holidays from £856

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Top Santo Tomas flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • Front of property
    18 Aug - 23 Aug

    Decapolis Hotel Panama City + Flight

    San Francisco
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,708 reviews)
    "Todo bien"
    Reviewed July 16, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,131
    £856
    per traveller
    found 1 day ago
    Decapolis Hotel Panama City
  • Front of property
    18 Aug - 23 Aug

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    5 nights
    4.0 star property
    9.2/10 - Wonderful (1,000 reviews)
    "We only stayed for one night but had a great overall experience. Staff were very helpful and courteous. The hotel amenities were high quality and our room was very clean. The only "con" to report is that the hotel could use a little TLC in some areas."
    Reviewed July 12, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,605
    £978
    per traveller
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • Front of property
    18 Aug - 23 Aug

    Megapolis Hotel Panamá + Flight

    San Francisco
    5 nights
    4.5 star property
    8.4/10 - Very good (1,602 reviews)
    "Desde que se realizó le check-in muy rapido, todo el personal muy amable, excelente experiencia, la habitación muy limpia, el desayuno muy variado y todo delicioso"
    Reviewed July 17, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,352
    £891
    per traveller
    found 1 day ago
    Megapolis Hotel Panamá
  • Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
    18 Aug - 23 Aug

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen
    5 nights
    4.0 star property
    8.4/10 - Very good (1,804 reviews)
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,180
    £872
    per traveller
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • 2 outdoor pools, pool umbrellas, pool loungers
    18 Aug - 23 Aug

    Summit Rainforest Golf Resort & All Inclusive + Flight

    Panama City
    5 nights
    4.0 star property
    8.4/10 - Very good (1,001 reviews)
    "Spacious and clean rooms. Great food and drinks with multiple options. Each and every staff member, regardless of their rank, was very friendly and professional. Accommodated us the best they could every time."
    Reviewed July 15, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,212
    £995
    per traveller
    found 1 day ago
    Summit Rainforest Golf Resort & All Inclusive

Santo Tomas Hotel Deals

Apartment, Garden View, Poolside | Private kitchen | Dining tables

Little Italy B&B

Little Italy B&B
3.0 star property
8.4 mi from Santo Tomas
9.4 out of 10, Exceptional, (53 reviews)
"We loved the breakfast which included fresh fruit. Erick and his wife Jessica couldn’t have been more accommodating. We highly recommend this B&B to anyone coming to the area."
The price is £33
includes taxes & fees
22 Jul - 23 Jul
Little Italy B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Santo Tomas
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.