Title: Santo Domingo Holidays 2026 from £576 | Expedia.co.uk [Hotels in Santo Domingo](https://expedia.co.uk/Santo-Domingo-Hotels.d829297286067531776.Travel-Guide-Hotels)[Holiday Rentals in Santo Domingo](https://expedia.co.uk/Santo-Domingo-Holiday-Rentals.d829297286067531776.Travel-Guide-HolidayRentals)[Santo Domingo Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santo-Domingo.d829297286067531776.Car-Hire-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Santo Domingo Holidays from £576 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top Santo Domingo Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites £576 per person 6 Apr - 11 Apr found 11 hours ago Return flight included Port of Spain (POS) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on 28 Jan 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo Save 100% on your flight £1,207 per person 13 May - 20 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Room was amazing, beautiful hotel in the center of town. Service also very good and attentive. Amazing breakfast. Reviewed on 24 Feb 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco £1,152 per person 13 May - 20 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) No complaints excellent Reviewed on 26 Feb 2026 ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista £905 per person 13 May - 20 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Excellent service all the way. Reviewed on 1 Mar 2026 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo £1,012 per person 6 Apr - 11 Apr found 11 hours ago Return flight included Port of Spain (POS) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on 29 Nov 2025 ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=PKG_SPRING_PROMO_829297286067531776) ## Top hotels in Santo Domingo ![Hotel Bambito By Faranda Boutique, a member of Radisson Individuals](https://images.trvl-media.com/lodging/2000000/1700000/1691400/1691326/e018a7d8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Bambito By Faranda Boutique, a member of Radisson Individuals Volcan, Via Cerro Punta Volcan Chiriqui Fully refundableReserve now, pay when you stay £88 2 Mar - 3 Mar includes taxes & fees [](https://expedia.co.uk/Hotel-Search?startDate=02%2F03%2F2026&endDate=03%2F03%2F2026&selected=1691326&PinnedHotelID=1691326&HadPinnedHotel=true®ionId=829297286067531776) ![Los Brezos Boutique Hotel](https://images.trvl-media.com/lodging/70000000/69410000/69404700/69404636/0830ff2c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Los Brezos Boutique Hotel Calle Tercera Norte Volcan Chiriquí Fully refundableReserve now, pay when you stay 9.4/10 Exceptional! (29 reviews) Excellent choice for your stay in Volcan. I stayed for 2 nights as solo traveler. Great staff and management. Everyone was helpful and friendly. Volcan is a great base for exploring Cerro Punto region for a day or 2\. I highly recommend this hotel. Reviewed on 11 Feb 2026 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=15%2F03%2F2026&endDate=16%2F03%2F2026&selected=69404636&PinnedHotelID=69404636&HadPinnedHotel=true®ionId=829297286067531776) [](https://expedia.co.uk/Hotel-Search?startDate=15%2F03%2F2026&endDate=16%2F03%2F2026&selected=69404636&PinnedHotelID=69404636&HadPinnedHotel=true®ionId=829297286067531776) ![Las Olas Resort](https://images.trvl-media.com/lodging/1000000/970000/967300/967264/470cca90_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Las Olas Resort Avenida Don Antonio Anguizola Guarumal Chiriqui Fully refundableReserve now, pay when you stay £81 8 Mar - 9 Mar includes taxes & fees 7.4/10 Good! (335 reviews) Staff was over the top nice and helpful Reviewed on 1 Mar 2026 [](https://expedia.co.uk/Hotel-Search?startDate=08%2F03%2F2026&endDate=09%2F03%2F2026&selected=967264&PinnedHotelID=967264&HadPinnedHotel=true®ionId=829297286067531776) [See all 49 properties in Santo Domingo](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=02%2F03%2F2026&endDate=03%2F03%2F2026®ionId=829297286067531776) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app