Santiago Holidays from £658

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    Save up to £750 when you book a flight and hotel together*

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    Packages with flights are ATOL protected

Your Santiago Holiday

Enjoy the urban city of Santiago with a tailor-made Santiago holiday package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago holiday on Expedia.

Top Santiago Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Save 100% on your flight
Price was £1,110, price is now £658 per person
£658
per person
11 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.4/10 Very good! (1,816 reviews)
excellent choice near the airport with a good price clean pool, good food

Reviewed on 2 Aug 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £1,884, price is now £780 per person
£780
per person
11 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9.2/10 Wonderful! (1,006 reviews)
Excelente lugar, buen servicio, buena ubicación para caminar por todo Casco Viejo.

Reviewed on 3 Aug 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was £1,829, price is now £937 per person
£937
per person
11 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.4/10 Very good! (1,600 reviews)

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was £1,096, price is now £721 per person
£721
per person
11 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.6/10 Excellent! (1,707 reviews)

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was £1,113, price is now £765 per person
£765
per person
11 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9.6/10 Exceptional! (382 reviews)
Everything was great and as expected.

Reviewed on 3 Aug 2026

Santiago Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
45,400
Max Temp Winter
32ºC
Max Temp Summer
29ºC
Top Sights
Catedral of Santiago Apostol, Omar Torrijos Herrera Stadium and Plaza Banconal

Top hotels in Santiago

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
The price is £47 per night from 9 Aug to 10 Aug
£47
9 Aug - 10 Aug
includes taxes & fees
8.6/10 Excellent! (417 reviews)
"Clean and comfortable. Good stay"

Reviewed on 3 Aug 2026

Hotel Gran David
HOTEL CORPORATIVO PLAZA COROTÚ

HOTEL CORPORATIVO PLAZA COROTÚ

3 out of 5
Carr. Panamericana Santiago Provincia de Veraguas
Get rates
HOTEL CORPORATIVO PLAZA COROTÚ
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Panama Panamá
Get rates
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.
See all 16 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Santiago attractions

Escuela Normal Juan Demostenes Arosemena

9.2/10 (9 reviews)
Take a campus tour or just explore the area of Escuela Normal Juan Demostenes Arosemena during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.
See properties

Frequently asked questions

How much does a Santiago travel package cost?
From as low as £658. Yes, you read that correctly. Our Santiago packages are the easiest way to stretch your budget. Bundle your favourite hotels, flights and rental car and get out and see this destination your way.
If I'm not able to travel, can I cancel my Santiago travel package?
You can cancel your Santiago booking if your plans have changed. Whether you'll be charged a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.
How do I get a cheap travel package to Santiago?
Combine your flights and hotels, add on extras such as tours, and save with a Santiago travel package. You won't just pick up big discounts on your escape — you'll have plenty of choice at your fingertips too. When you book with Expedia, you'll have your pick of over 550 airlines and 1,000,000 properties globally. Your dream holiday begins right here, right now!
Does Expedia offer Book Now, Pay Later Santiago holidays?
Expedia has teamed up with online lender Klarna to make your next trip easier on your budget. Paying by instalment means you can spread the costs of your next adventure, leaving you with more money to spend while you're away. Klarna has several payment plans to pick from, so you're sure to find one that suits your budget. Browse these flexible payment options:

  • Pay monthly holidays: Klarna offers manageable monthly payment plans that work for all budget sizes, so you can have that well-earned holiday sooner.
  • Pay in instalments holidays: Like the idea of paying off your holiday in multiple transactions? Then check out this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: When you spot an awesome deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock in your getaway.

Where should I stay in Santiago?
It makes sense to stay near the action. Many people like to book hotels around popular sights, such as Parque Acuatico Italia Guadalupe Panama, Parque Nacional Cerro Hoya and Plaza Banconal.
What are the top hotels in Santiago?
Hotel Santa Catalina Panama and Hotel Mykonos Panama are among the most sought-after properties in Santiago. Why not look up the facilities and rates at each and then make a decision?
How far in advance should I book my Santiago holiday?
The earlier, the better. Air carriers generally release flight tickets nearly 12 months in advance, and this is an excellent opportunity to pick up some rock-bottom prices. Just been told you should take all your holiday days next week? No sweat. Expedia are never short of fantastic deals to help you have the getaway of your dreams, at a price you can afford.
What does an Expedia Santiago travel package include?
Car rentals, hotels and flights — we connect you to all the best deals. All you'll have to do is select your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to create an awesome Santiago holiday.
What should I know before booking a Santiago travel package?
Booking all the parts of your trip together is an excellent way to save. Combine your airfares, rental cars and hotels into one little package. But you're not restricted to hotels. Expedia has all sorts of properties, including holiday rentals such as beachfront villas and city residences. The list goes on!
Can I choose my airline with a Santiago Expedia travel package?
Yes, you sure can. We have more than 550 partner airlines around the world, so fly with the carrier that best fits your budget needs.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.