Santiago Holidays from £711

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Your Santiago Holiday

Enjoy the urban city of Santiago with a tailor-made Santiago holiday package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago holiday on Expedia.

Top Santiago Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
San Francisco by Wynwood House

San Francisco by Wynwood House

3 out of 5
San Francisco
Price was £900, price is now £711 per person
£711
per person
3 Aug - 9 Aug
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9.2/10 Wonderful! (56 reviews)
Clean and walkable location

Reviewed on 7 Dec 2025

Mini Design By Wynwood House

Mini Design By Wynwood House

3 out of 5
Bella Vista
Price was £959, price is now £745 per person
£745
per person
3 Aug - 9 Aug
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
10/10 Exceptional! (2 reviews)
Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was £1,479, price is now £1,179 per person
£1,179
per person
17 Jul - 24 Jul
found 6 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9.4/10 Exceptional! (193 reviews)
Amazing property. Beautiful rooms. We reserved two rooms because we have a large family. Both rooms were amazing. The front desk clerk was one of the kindest and sweetest people I’ve met in my life. Would definitely return.

Reviewed on 14 Jun 2026

Amarla Boutique Hotel Casco Viejo Adults Only

Amarla Boutique Hotel Casco Viejo Adults Only

3 out of 5
Casco Viejo
Price was £1,847, price is now £1,514 per person
£1,514
per person
20 Jul - 25 Jul
found 1 hour ago
Return direct flight included
London (LON) to Panama City (PTY)
9.6/10 Exceptional! (133 reviews)
Beautiful hotel, super convenient location

Reviewed on 20 Mar 2026

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Casco Viejo
Price was £1,992, price is now £1,670 per person
£1,670
per person
17 Jul - 24 Jul
found 6 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9.8/10 Exceptional! (660 reviews)
Hotel is in what they call old city (area looks colonial). There are many stores in the area for shopping. The hotel itself is nice. The staff was friendly. The pool was beautiful and I had a great time using the on site spa. The rooftop restaurant had good food and live entertainmen. The hotel was well kept.

Reviewed on 9 Jun 2026

Santiago Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
45,400
Max Temp Winter
32ºC
Max Temp Summer
29ºC
Top Sights
Catedral of Santiago Apostol, Omar Torrijos Herrera Stadium and Plaza Banconal

Top hotels in Santiago

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
The price is £62 per night from 1 Jul to 2 Jul
£62
1 Jul - 2 Jul
includes taxes & fees
8.6/10 Excellent! (407 reviews)
"Great place to stay. I would stay there again."

Reviewed on 4 Jun 2026

Hotel Gran David
HOTEL CORPORATIVO PLAZA COROTÚ

HOTEL CORPORATIVO PLAZA COROTÚ

3 out of 5
Carr. Panamericana Santiago Provincia de Veraguas
Get rates
HOTEL CORPORATIVO PLAZA COROTÚ
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

2 out of 5
Carr. Panamericana Santiago Provincia de Veraguas
Get rates
HOTEL PLAZA COROTÚ
See all 16 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Santiago attractions

Escuela Normal Juan Demostenes Arosemena

9.2/5 (9 reviews)
Take a campus tour or just explore the area of Escuela Normal Juan Demostenes Arosemena during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.
See properties

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.