Santiago Holidays from £534

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Your Santiago Holiday

Enjoy the urban city of Santiago with a tailor-made Santiago holiday package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago holiday on Expedia.

Top Santiago Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was £721, price is now £534 per person
£534
per person
8 May - 12 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9/10 Wonderful! (5,057 reviews)
The only thing preventing a 5-star review is that towels were removed from my room, and also from a friend’s room in a totally different floor. We arrived tired from the day and couldn’t take a shower for almost an hour and after 5 calls to the front desk. Other than that l, everything was great. Breakfast, amenities, response to requests… will definitely stay there again if I return to Panama!

Reviewed on 12 Mar 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £895, price is now £608 per person
£608
per person
8 May - 12 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
8.4/10 Very Good! (1,441 reviews)
The room are nice and clean the pool is too much noise. It’s a mess

Reviewed on 10 Mar 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £1,588, price is now £1,146 per person
£1,146
per person
4 Jun - 9 Jun
found 17 hours ago
Return direct flight included
Manchester (MAN) to Panama City (PTY)
9/10 Wonderful! (1,010 reviews)
Great location clean safe and walkable!! Wonderful hotel

Reviewed on 10 Mar 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £727, price is now £578 per person
£578
per person
8 May - 12 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
8.4/10 Very Good! (1,855 reviews)
Perfect place to stay before our flight.

Reviewed on 11 Mar 2026

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member

3 out of 5
San Francisco
Price was £711, price is now £576 per person
£576
per person
8 May - 12 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
2.8/10 (3 reviews)

The Annual Holiday Sale

Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save.
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Santiago Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
45,400
Max Temp Winter
32ºC
Max Temp Summer
29ºC
Top Sights
Catedral of Santiago Apostol, Omar Torrijos Herrera Stadium and Plaza Banconal

Top hotels in Santiago

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (379 reviews)
Mi experiencia reciente en el Hotel Gran David en Veraguas ha sido muy positiva, especialmente al notar una evolución muy favorable en comparación con mi estancia de hace tres años. El personal es sumamente amable y atento, lo que te hace sentir bienvenido desde el primer instante, y tanto las instalaciones ...

Reviewed on 5 Mar 2026

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Hotel Gran David
Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Panama Panamá
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Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

2 out of 5
Carr. Panamericana Santiago Provincia de Veraguas
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HOTEL PLAZA COROTÚ
See all 15 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Popular places to visit

Escuela Normal Juan Demostenes Arosemena

Take a campus tour or just explore the area of Escuela Normal Juan Demostenes Arosemena during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Escuela Normal Juan Demostenes Arosemena

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.