Santi Cosma e Damiano Holidays from £408

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £335 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

Your Santi Cosma e Damiano Holiday

An easy way to experience this unique city is with a custom-made Santi Cosma e Damiano holiday package. Stay in the neighbourhood of Gianola, which is good for walking, families and watersports or go someplace else — our package deals are all about you. Fill your spare time with visits to Marina di Minturno Beach, Archaeological Area of Minturnae and Ponte Real Ferdinando Il di Borbone, some of the attractions you should see during your trip to Santi Cosma e Damiano. Expedia has what you need to escape your routine. Tailor your holiday to Santi Cosma e Damiano to suit your travel style, whatever that may look like.

Top Santi Cosma e Damiano Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Fiori
Relais de la Poste
Albergo Etico Roma
Hotel Delle Civette
Tree Charme Parliament Boutique Hotel

The Annual Holiday Sale

Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save.

Santi Cosma e Damiano Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Population
750
Max Temp Winter
13ºC
Max Temp Summer
27ºC
Top Sights
Marina di Minturno Beach, Sassolini Beach and Park of Gianola and Monte di Scauri - Info Point

Top hotels in Santi Cosma e Damiano

Edra Palace

Edra Palace

4 out of 5
Via Ausonia angolo via Cerro Cassino FR
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (168 reviews)
The staff was incredibly sweet and accommodating to our kids. Everything was clean and as it should be if a little outdated. The Christmas decorations in the lobby and garden were a real plus for the kids. Our waiter was especially wonderful at dinner and breakfast I wish i remembered his name. Great ...

Reviewed on 29 Nov 2025

Edra Palace
Virgilio Grand Hotel

Virgilio Grand Hotel

4 out of 5
Viale Primo Romita 33 Sperlonga LT
Fully refundableReserve now, pay when you stay
The price is £94 per night from 22 Mar to 23 Mar
£94
22 Mar - 23 Mar
includes taxes & fees
8.4/10 Very Good! (291 reviews)
Staff was very helpful. Breakfast was amazing

Reviewed on 8 Oct 2025

Virgilio Grand Hotel
Villa Irlanda Grand Hotel

Villa Irlanda Grand Hotel

4 out of 5
Via Lungomare Caboto, 6 Gaeta LT
Fully refundableReserve now, pay when you stay
The price is £111 per night from 18 Mar to 19 Mar
£111
18 Mar - 19 Mar
includes taxes & fees
8.8/10 Excellent! (329 reviews)
Beautiful hotel staff very friendly specially Liz at the restaurant. Only bad thing was a snail in the shower. It was unpleasant. And the oranges were on the floor making walking dangerous.

Reviewed on 13 Feb 2026

Villa Irlanda Grand Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.