Title: Hotels in Santee, NE - Best Santee Hotels from £74 - Fully Refundable Options - Expedia.co.uk

[Holiday Rentals in Santee](https://expedia.co.uk/Santee-Holiday-Rentals.d553248634983588478.Travel-Guide-HolidayRentals)[Santee Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santee.d553248634983588478.Car-Hire-Guide)[Santee Holidays](https://expedia.co.uk/Santee.d553248634983588478.Holidays-City-Breaks)

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## Go beyond your typical stay in Santee

Cabin

[](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America&regionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-01-27&d1=2026-01-27&endDate=2026-01-29&d2=2026-01-29&lodging=CABIN)

Family friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America&regionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-01-27&d1=2026-01-27&endDate=2026-01-29&d2=2026-01-29&travelerType=family_friendly)

Pet friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America&regionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-01-27&d1=2026-01-27&endDate=2026-01-29&d2=2026-01-29&amenities=PETS)

Waterpark

[](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America&regionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-01-27&d1=2026-01-27&endDate=2026-01-29&d2=2026-01-29&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[13 Jan - 14 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2026-01-13&endDate=2026-01-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[14 Jan - 15 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2026-01-14&endDate=2026-01-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santee hotels

![Family House, 4 Bedrooms, Lake View, Lakeside | Living area | 32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d9482fb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/bfa0d3b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family House, 4 Bedrooms, Lake View, Lakeside | Private kitchen | Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/7c824038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d845bf74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lewis and Clark Resort

[](https://www.expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information)

Yankton

8.8/10

Excellent

(286 reviews)

"Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jessica

£74

includes taxes & fees

18 Jan - 19 Jan

[](https://www.expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-27&endDate=2026-01-28&regionId=553248634983588478&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Top Santee Hotel Reviews

![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg)

### Lewis and Clark Resort

10/10 Excellent

"Clean, full kitchen "

[](https://expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information)

![Spacious Lakeview Cabin Minutes from Private Beach](https://images.trvl-media.com/lodging/105000000/104180000/104179200/104179194/w902h683x61y0-0a0c6d21_y.jpg)

### Spacious Lakeview Cabin Minutes from Private Beach

10/10 Excellent

"The host was great and the stay was better!"

[](https://expedia.co.uk/Crofton-Hotels-Spacious-Lakeview-Cabin-Minutes-From-Private-Beach.h104179194.Hotel-Information)

![Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake](https://images.trvl-media.com/lodging/105000000/104180000/104178500/104178423/a3df54c4_y.jpg)

### Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

10/10 Excellent

"Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again "

[](https://expedia.co.uk/Crofton-Hotels-Cozy-Cabin-Near-Lewis-And-Clark-Lake-And-CJs-At-The-Lake.h104178423.Hotel-Information)

![Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD](https://images.trvl-media.com/lodging/117000000/116510000/116501100/116501093/dd2fade7_y.jpg)

### Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD

10/10 Excellent

"It was a wonderful property about a 5 minute drive to marina. Lots of wildlife. Property was well stocked and clean. Plenty of room for everyone. The one negative was that there is no television in the living room. So if you want to watch a game or movie as a group, there is no larger space with a tv to do so. Other than that, we enjoyed our stay."

[](https://expedia.co.uk/Yankton-Hotels-Beautiful-Log-Cabin.h116501093.Hotel-Information)

![Gavins Point Lakehouse](https://images.trvl-media.com/lodging/117000000/116490000/116488100/116488080/0ef95485_y.jpg)

### Gavins Point Lakehouse

10/10 Excellent

"Property was stunning. Views from the home are stunning and the memories we made were u forgettable. Beds and pillows were all comfortable and the kitchen was stocked with the tools to allow you to prepare whatever upur heart desired. Communication was simple and responses were quick. Definitely a 5 star in Yankton - we have stayed in countless Vrbos in Yankton and this just raised the bar. She’s stunning!"

[](https://expedia.co.uk/Yankton-Hotels-Gavins-Point-Lakeshore-Home-Inside-Lewis-Clark-State-Park-Yankton.h116488080.Hotel-Information)

## More cheap stays in Santee

![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Lewis and Clark Resort

43496 Shore Drive Yankton SD

£74

18 Jan - 19 Jan

includes taxes & fees

8.8/10 Excellent! (286 reviews)

[](https://expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information)

![Santee Hunting Cabin!](https://images.trvl-media.com/lodging/122000000/121720000/121714900/121714833/795e9024_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Santee Hunting Cabin!

 Niobrara NE

[Get rates](https://expedia.co.uk/Hotel-Search?startDate=27%2F01%2F2026&endDate=28%2F01%2F2026&selected=121714833&PinnedHotelID=121714833&HadPinnedHotel=true&regionId=553248634983588478)

[](https://expedia.co.uk/Niobrara-Hotels-Santee-Hunting-Cabin.h121714833.Hotel-Information)

![Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area.](https://images.trvl-media.com/lodging/123000000/122120000/122112900/122112850/00d8303f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area.

 Yankton SD

[Get rates](https://expedia.co.uk/Hotel-Search?startDate=27%2F01%2F2026&endDate=28%2F01%2F2026&selected=122112850&PinnedHotelID=122112850&HadPinnedHotel=true&regionId=553248634983588478)

[](https://expedia.co.uk/Yankton-Hotels-Inviting-3-Bedroom-House-Near-Gavins-Point-Dam-And-Lewis-And-Clark-Lake-Area.h122112850.Hotel-Information)

## Frequently asked questions

### What are some of the best holiday rentals that Santee has to offer?

### If I need to cancel my hotel reservation in Santee, will I receive a refund?

### What is staying in Santee like?

### What is there to see in Santee?

### What's the seasonal weather in Santee?

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