Title: Hotels in Santee, NE - Best Santee Hotels from £71 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santee](https://expedia.co.uk/Santee-Holiday-Rentals.d553248634983588478.Travel-Guide-HolidayRentals)[Santee Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santee.d553248634983588478.Car-Hire-Guide)[Santee Holidays](https://expedia.co.uk/Santee.d553248634983588478.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santee, NE from £71 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santee Cabin [](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-11&d1=2025-12-11&endDate=2025-12-13&d2=2025-12-13&lodging=CABIN) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-11&d1=2025-12-11&endDate=2025-12-13&d2=2025-12-13&travelerType=family_friendly) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-11&d1=2025-12-11&endDate=2025-12-13&d2=2025-12-13&amenities=PETS) Waterpark [](https://www.expedia.co.uk/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-11&d1=2025-12-11&endDate=2025-12-13&d2=2025-12-13&amenities=WATER_PARK) ## Check prices for these dates Tonight [27 Nov - 28 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2025-11-27&endDate=2025-11-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [28 Nov - 29 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2025-11-28&endDate=2025-11-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Santee hotels and places to stay ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/58d56b10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Lake View, Lakeside | Living area | 32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/ca1ac849.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/fd537863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lewis and Clark Resort Yankton 8.8/10 Excellent (283) "Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica £71 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13®ionId=553248634983588478&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_BF_PROMO_553248634983588478) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels) ## Top Santee Hotel Reviews ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg) ### Lewis and Clark Resort 10/10 Excellent "Cabin was wonderful!! Beautiful grounds and area! Very friendly and helpful staff!! " [](https://expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Lewis & Clark Trail Hideaway, SD side / 2 min to the lake / 10 min to Yankton. ](https://images.trvl-media.com/lodging/104000000/103440000/103430100/103430081/69c2489d_y.jpg) ### Lewis & Clark Trail Hideaway, SD side / 2 min to the lake / 10 min to Yankton. 10/10 Excellent "Had a quick get-away with two of my grown boys and the house had everything we needed. The Blackstone grill is how I love to cook and the Hot-Tub was an added bonus. " [](https://expedia.co.uk/Yankton-Hotels-Lewis-Clark-Trail-Hideaway.h103430081.Hotel-Information) ![Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake](https://images.trvl-media.com/lodging/105000000/104180000/104178500/104178423/a3df54c4_y.jpg) ### Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake 10/10 Excellent "Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again " [](https://expedia.co.uk/Crofton-Hotels-Cozy-Cabin-Near-Lewis-And-Clark-Lake-And-CJs-At-The-Lake.h104178423.Hotel-Information) ![Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD](https://images.trvl-media.com/lodging/117000000/116510000/116501100/116501093/dd2fade7_y.jpg) ### Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD 10/10 Excellent "It was a wonderful property about a 5 minute drive to marina. Lots of wildlife. Property was well stocked and clean. Plenty of room for everyone. The one negative was that there is no television in the living room. So if you want to watch a game or movie as a group, there is no larger space with a tv to do so. Other than that, we enjoyed our stay." [](https://expedia.co.uk/Yankton-Hotels-Beautiful-Log-Cabin.h116501093.Hotel-Information) ![Gavins Point Lakehouse](https://images.trvl-media.com/lodging/117000000/116490000/116488100/116488080/0ef95485_y.jpg) ### Gavins Point Lakehouse 10/10 Excellent "Property was stunning. Views from the home are stunning and the memories we made were u forgettable. Beds and pillows were all comfortable and the kitchen was stocked with the tools to allow you to prepare whatever upur heart desired. Communication was simple and responses were quick. Definitely a 5 star in Yankton - we have stayed in countless Vrbos in Yankton and this just raised the bar. She’s stunning!" [](https://expedia.co.uk/Yankton-Hotels-Gavins-Point-Lakeshore-Home-Inside-Lewis-Clark-State-Park-Yankton.h116488080.Hotel-Information) ![Spacious Lakeview Cabin Minutes from Private Beach](https://images.trvl-media.com/lodging/105000000/104180000/104179200/104179194/w902h683x61y0-0a0c6d21_y.jpg) ### Spacious Lakeview Cabin Minutes from Private Beach 10/10 Excellent "Great location. Plenty of room for 10 adults to relax inside and outside on the deck. Owner very responsive with questions submitted. " [](https://expedia.co.uk/Crofton-Hotels-Spacious-Lakeview-Cabin-Minutes-From-Private-Beach.h104179194.Hotel-Information) ## More cheap stays in Santee ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Lewis and Clark Resort 43496 Shore Drive Yankton SD £71 1 Dec - 2 Dec includes taxes & fees 8.8/10 Excellent! (283 reviews) [](https://expedia.co.uk/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Santee Hunting Cabin!](https://images.trvl-media.com/lodging/122000000/121720000/121714900/121714833/795e9024_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Santee Hunting Cabin! Niobrara NE [Get rates](https://expedia.co.uk/Hotel-Search?startDate=12%2F12%2F2025&endDate=13%2F12%2F2025&selected=121714833&PinnedHotelID=121714833&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.co.uk/Niobrara-Hotels-Santee-Hunting-Cabin.h121714833.Hotel-Information) ![Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area.](https://images.trvl-media.com/lodging/123000000/122120000/122112900/122112850/00d8303f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area. Yankton SD [Get rates](https://expedia.co.uk/Hotel-Search?startDate=12%2F12%2F2025&endDate=13%2F12%2F2025&selected=122112850&PinnedHotelID=122112850&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.co.uk/Yankton-Hotels-Inviting-3-Bedroom-House-Near-Gavins-Point-Dam-And-Lewis-And-Clark-Lake-Area.h122112850.Hotel-Information) ## Frequently asked questions ### What are some of the best holiday rentals that Santee has to offer? > [Gavins Point Lakehouse](https://www.expedia.co.uk/Yankton-Hotels-Gavins-Point-Lakeshore-Home-Inside-Lewis-Clark-State-Park-Yankton.h116488080.Hotel-Information): This holiday home rental outside of Santee is located in the mountains, and has a fireplace, a balcony and air conditioning to put you at ease in your new surroundings. It has 5 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. See all [vacation rentals in Santee](https://www.expedia.co.uk/Santee-Holiday-Rentals.d553248634983588478.Travel-Guide-HolidayRentals). ### If I need to cancel my hotel reservation in Santee, will I receive a refund? > Yes, you'll find most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within 24 hours of your booking. Filter your search by [fully refundable](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983588478&paymentType=FREE_CANCELLATION) to find flexible hotel deals in Santee. ### What is staying in Santee like? > Those travelling to Santee will definitely enjoy the sights to see and things to do. There are 66 hotels and other accommodation options in the surrounding area. Find out more about [Santee](https://www.expedia.co.uk/Santee.dx553248634983588478). ### What is there to see in Santee? > A favourite place to visit is [Lewis and Clark Lake](https://www.expedia.co.uk/Lewis-And-Clark-Lake-United-States-of-America.d553248635976196329.Attraction). You'll also find [Niobrara State Park](https://www.expedia.co.uk/Niobrara-State-Park-Nebraska.d553248621532648826.Attraction) and [Lewis and Clark Lake State Recreation Area](https://www.expedia.co.uk/Lewis-And-Clark-Lake-State-Recreation-Area-Crofton.d635013358791815168.Attraction) in the area. Take a look at what more there is to see and do in Expedia's [Santee guide](https://www.expedia.co.uk/Santee.dx553248634983588478). ### What's the seasonal weather in Santee? > The hottest months are usually July and August, with an average temperature of 22°C, while the coldest months are January and February, with an average of -3°C. 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[Wahoo Holidays](https://www.expedia.co.uk/Wahoo.d181466.Holidays-City-Breaks) - [Visit Yutan](https://www.expedia.co.uk/Yutan.dx3000349817) - [Avis Corsica Rental Cars in Genoa](https://www.expedia.co.uk/Avis-Corsica-Car-Rentals-In-Genoa.d3000446106-c1004.Car-Rental-Guide-Suppliers) - [Car hire Blair](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Blair.d6952.Car-Hire-Guide) - [Car hire Dodge](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Dodge.d553248634983394899.Car-Hire-Guide) - [Dollar Europe Rental Cars in Central Nebraska](https://www.expedia.co.uk/Dollar-Europe-Car-Rentals-In-Central-Nebraska.d6058276-c1090.Car-Rental-Guide-Suppliers) - [Economy Rent a Car Rental Cars in Bartlett](https://www.expedia.co.uk/Economy-Rent-A-Car-Car-Rentals-In-Bartlett.d553248634983494783-c69.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in Leigh](https://www.expedia.co.uk/Enterprise-Car-Rentals-In-Leigh.d553248634983579551-c15.Car-Rental-Guide-Suppliers) - [Flizzr Rental Cars in Lyons](https://www.expedia.co.uk/Flizzr-Car-Rentals-In-Lyons.d553248634983071985-c1098.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Central Nebraska](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Central-Nebraska.d6058276-c40.Car-Rental-Guide-Suppliers) - [Locauto Rental Cars in Bartlett](https://www.expedia.co.uk/Locauto-Car-Rentals-In-Bartlett.d553248634983494783-c1140.Car-Rental-Guide-Suppliers) - [Sixt Rental Cars in Bee](https://www.expedia.co.uk/Sixt-Car-Rentals-In-Bee.d553248634983410346-c35.Car-Rental-Guide-Suppliers) - [Newcastle Holiday Rentals](https://www.expedia.co.uk/Newcastle-Holiday-Rentals.d6352576.Travel-Guide-HolidayRentals) - [Royal Holiday Rentals](https://www.expedia.co.uk/Royal-Holiday-Rentals.d6303196.Travel-Guide-HolidayRentals) - [West Point Holiday Rentals](https://www.expedia.co.uk/West-Point-Holiday-Rentals.d181465.Travel-Guide-HolidayRentals) - [Things to do in Central Nebraska](https://www.expedia.co.uk/Things-To-Do-In-Central-Nebraska.d6058276.Travel-Guide-Activities) - [Book Hotels in Santee on Expedia.com](https://www.expedia.com/Santee-Hotels.d553248634983588478.Travel-Guide-Hotels) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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