Santa Fe Holidays from £503

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Your Santa Fe Holiday

Our holiday packages to Santa Fe let you customise your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start travelling. Browse the wide range of options on Expedia today and finally put your Santa Fe holiday plans into motion!

Top Santa Fe Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Summit Rainforest & Golf Resort
Central Hotel Panama Casco Viejo
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Hotel Panamonte

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
970
Max Temp Winter
32ºC
Max Temp Summer
29ºC
Top Sights
Alto de Piedra Waterfall, Cascada de Bermejo and Town Square

Top hotels in Santa Fe

Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita, Santa Fe, Veraguas Province
Fully refundableReserve now, pay when you stay
9.4/10 Exceptional! (34 reviews)
Exquisite Casita
"Excellent accommodation: Room, grounds, and common area are beautifully decorated and spotless clean. Staff were friendly & helpful. Only problem was issue with hot water heater the day of our stay."

Reviewed on 1 Apr 2025

Hotel Anachoreo
La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De, Santa Fe, Veraguas
Fully refundableReserve now, pay when you stay
7.8/10 Good! (18 reviews)
Nice stay in Santa Fe
"Our room had some drawbacks, like many gaps between the roof and walls that enable insects to go inside, but we used our own mosquito net and we were safe to sleep quietly. The second night ants invaded our room, we were offered to be moved to another room, but we were ok with the solution to spray ..."

Reviewed on 17 Mar 2025

La Qhia Eco Retreat
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

2 out of 5
Provincia de Veraguas, Panama, Panama
The price is £122 per night from 11 Aug to 12 Aug
£122
11 Aug - 12 Aug
includes taxes & fees
Cabana Vergara Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Frequently asked questions

Why should I book my Santa Fe holiday with Expedia?
Choose Expedia to organise your next break with ease, all in one convenient place. Our insider tip for bagging a terrific deal on a Santa Fe retreat? Bundle your accommodation, flights and/or car hire into a package holiday. Then add a few awesome tours and activities. Most bookings also come with flexible cancellation policies, so there's no need to panic if you have to switch up your travel plans. Round-the-clock assistance with amending and cancelling your trip is available via our Customer Service Portal link.
When is the best time of year to holiday in Santa Fe?
Peak season falls in January, October and November and is an exciting time to visit — if you don't mind the crowds. April, July and August are typically quieter times of the year. Organise your visit to Santa Fe according to what type of adventure you're looking for. October is the coolest month, when daytime temperatures average 24ºC. In March, the warmest period, you'll experience temperatures of around 27ºC during the day.
What is the top hotel for my holiday in Santa Fe?
Rainforest Yasmin Hotel sets the scene for an unforgettable getaway in Santa Fe, offering all the comforts and amenities you need and more.
How do I get a cheap holiday to Santa Fe?
Booking a Santa Fe holiday with Expedia is a simple way to save. We offer more than 400 partner airlines and 321,000 hotel options around the globe. With such a huge range to choose from, you'll have no hassles putting together your perfect trip. Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.
What should I do on my Santa Fe holiday?
With leading attractions like Alto de Piedra Waterfall and Town Square, a holiday in Santa Fe promises plenty of fun things to do and see. Catholic Church of Santa Fe and Cerro Tute are a couple of other sights also worth exploring.
What is the best area to stay in when on holiday in Santa Fe?
There's so much to do in Santa Fe, so spend your nights close to its top sights and spend more time sightseeing. Alto de Piedra Waterfall is one place to put on your to-do list.
Do I need a visa for my Santa Fe holiday?
Official government websites will have all the information you need on visa requirements, application procedures and necessary documentation. Your nationality and the reason for your visit, whether it be for tourism or business, will determine if you'll need a visa for Santa Fe. Also double-check that your passport is up to date and has at least six months validity remaining after the date of your intended return. Do all your travel planning well ahead of time to avoid any nasty last-minute surprises.
What should I wear on my Santa Fe holiday?
Do some research into the sorts of clothing people in Santa Fe wear, and maybe even look up fashion pages on social media for inspiration. Whatever your look, aim to create a versatile wardrobe filled with pieces that suit your destination and show off your unique style. Daytime temperatures during October, Santa Fe's coolest month, average 24ºC. March marks this city's warmest month when the average daily temperature reaches 27ºC. Our suggestion? Take the guesswork out of what to pack and check the local weather forecast.
What does an Expedia Santa Fe holiday include?
Hotels, flights and a shiny set of wheels for all your road trip adventures. Simply mix and match your favourite bundle and get access to great discounts. Once you've made your booking, add on a few tours and experiences and watch your savings grow. When it comes to creating your Santa Fe trip, the choice is all yours! Expedia features different types of properties, with the most popular in Santa Fe being budget hotels and bed & breakfasts. With Expedia, you can expect the freedom and flexibility to personalise your dream escape your way.
Does Expedia offer Book Now, Pay Later Santa Fe holidays?
Expedia has partnered with online lender Klarna to make your next getaway easier on your hip pocket. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more money to play with while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that works with your budget. Browse these flexible payment options:

  • Pay monthly holidays: Klarna offers the ability to pay in multiple instalments that fit all budgets, so you can have that well-deserved holiday sooner.
  • No-deposit holidays: When you see an unbeatable deal but your budget doesn't quite go that far, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to lock in your getaway.

Can I choose my airline with a Santa Fe Expedia holiday?
Definitely. Expedia has more than 400 partner airlines to pick from across the world. With so much choice, finding the perfect carrier to get you to Santa Fe will be easy.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.