Title: Santa Fe Holidays 2026 from £661 | Expedia.co.uk [Hotels in Santa Fe](https://expedia.co.uk/Santa-Fe-Hotels.d6224616.Travel-Guide-Hotels)[Holiday Rentals in Santa Fe](https://expedia.co.uk/Santa-Fe-Holiday-Rentals.d6224616.Travel-Guide-HolidayRentals)[Santa Fe Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Fe.d6224616.Car-Hire-Guide) ![](https://images.trvl-media.com/place/6224616/d66c2c6e-894c-41bc-bf7b-56e1db50f42e.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Fe Holidays from £661 ## Book a Hotel + Flight or Car together to unlock savings Photo by Isa - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected #### Your Santa Fe Holiday Our holiday packages to Santa Fe let you customise your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? [Alto de Piedra Waterfall](https://www.expedia.co.uk/Alto-De-Piedra-Waterfall-Santa-Fe.d553248621532965236.Attraction), [Town Square](https://www.expedia.co.uk/Town-Square-Santa-Fe.d6224711.Attraction) and [Cerro Tute](https://www.expedia.co.uk/Cerro-Tute-Santa-Fe.d553248621532965233.Attraction) are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start travelling. Browse the wide range of options on Expedia today and finally put your Santa Fe holiday plans into motion! ## Top Santa Fe Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![Ramada Plaza by Wyndham Panama Punta Pacifica](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/803aefa9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Ramada Plaza by Wyndham Panama Punta Pacifica San Francisco £661 per person 25 Jan - 1 Feb found 1 day ago Return flight included Montego Bay (MBJ) to Panama City (PTY) 9.6/10 Exceptional! (1,086 reviews) The room was clean and the location was great. Reviewed on 25 Dec 2025 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo Save 100% on your flight £2,369 per person 4 Feb - 11 Feb found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) What really stood out was the staff at reception – they were outstanding! So friendly, helpful, and attentive from the moment we arrived. They made us feel truly welcome and took care of every little detail. Dining was a highlight too. We ate at the Bistro restaurant, and the food was delicious – creative and flavorful with some unique Panamanian touches. They even provided a sommelier with expert advice on wine selection, who helped us pick the perfect pairings for our meal. It elevated the whole dinner experience! The breakfast buffet was another winner – so many options, from fresh fruits and pastries to local specialties. Everything was fresh and tasty; we looked forward to it every morning. Reviewed on 25 Dec 2025 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco £1,129 per person 4 Feb - 11 Feb found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Best hotel I ever stayed Reviewed on 22 Dec 2025 ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites £772 per person 3 Feb - 9 Feb found 1 day ago Return flight included Manchester (MAN) to Panama City (PTY) 10/10 Exceptional! (1 review) Room was spotless, front gate staff was really nice, loved the tiny gym on the main floor. Reviewed on 21 Dec 2025 ![American Trade Hotel](https://images.trvl-media.com/lodging/7000000/6420000/6417200/6417143/19e6fda8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### American Trade Hotel Casco Viejo £964 per person 25 Jan - 1 Feb found 1 day ago Return flight included Montego Bay (MBJ) to Panama City (PTY) 9.4/10 Exceptional! (586 reviews) Had a small delay with the room and they gave me an upgrade. Staff was super nice. Hotel had great ambiance Reviewed on 23 Nov 2025 ## Santa Fe Essential Information | Language | Spanish | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Currency | Panamanian balboas | | Local Welcome | ¡Hola! | | Local Goodbye | Adiós | | Population | 970 | | Max Temp Winter | 32ºC | | Max Temp Summer | 29ºC | | Top Sights | [Alto de Piedra Waterfall](https://www.expedia.co.uk/Alto-De-Piedra-Waterfall-Santa-Fe.d553248621532965236.Attraction), [Cascada de Bermejo](https://www.expedia.co.uk/Cascada-De-Bermejo-Santa-Fe.d553248621532965237.Attraction) and [Town Square](https://www.expedia.co.uk/Town-Square-Santa-Fe.d6224711.Attraction) | ## Top hotels in Santa Fe ![La Qhia Eco Retreat](https://images.trvl-media.com/lodging/30000000/29440000/29430100/29430099/efe9a595_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Qhia Eco Retreat Barriada el Cerro A 100 Mts De Santa Fe Veraguas 7.8/10 Good! (18 reviews) Nice stay in Santa Fe Our room had some drawbacks, like many gaps between the roof and walls that enable insects to go inside, but we used our own mosquito net and we were safe to sleep quietly. The second night ants invaded our room, we were offered to be moved to another room, but we were ok with the solution to spray ... Reviewed on 17 Mar 2025 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=08%2F01%2F2026&endDate=09%2F01%2F2026&selected=29430099&PinnedHotelID=29430099&HadPinnedHotel=true®ionId=6224616) [](https://expedia.co.uk/Hotel-Search?startDate=08%2F01%2F2026&endDate=09%2F01%2F2026&selected=29430099&PinnedHotelID=29430099&HadPinnedHotel=true®ionId=6224616) ![Hotel Anachoreo](https://images.trvl-media.com/lodging/28000000/27780000/27775700/27775675/32d16900_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Anachoreo Calle Chinita Santa Fe Veraguas Province Fully refundableReserve now, pay when you stay 9.4/10 Exceptional! (36 reviews) Wonderful location with absolutely breathing taking views! Room was quite large with a seating area. Beds comfortable but could use slightly better pillows. Reviewed on 14 Nov 2025 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=08%2F01%2F2026&endDate=09%2F01%2F2026&selected=27775675&PinnedHotelID=27775675&HadPinnedHotel=true®ionId=6224616) [](https://expedia.co.uk/Hotel-Search?startDate=08%2F01%2F2026&endDate=09%2F01%2F2026&selected=27775675&PinnedHotelID=27775675&HadPinnedHotel=true®ionId=6224616) ![Cabana Vergara Santa Fe](https://images.trvl-media.com/lodging/109000000/108020000/108011300/108011213/w1440h1075x0y422-dda3f8cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cabana Vergara Santa Fe Provincia de Veraguas, Panama Panama £121 27 Dec - 28 Dec includes taxes & fees [](https://expedia.co.uk/Hotel-Search?startDate=27%2F12%2F2025&endDate=28%2F12%2F2025&selected=108011213&PinnedHotelID=108011213&HadPinnedHotel=true®ionId=6224616) [See all 15 properties in Santa Fe](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=26%2F12%2F2025&endDate=27%2F12%2F2025®ionId=6224616) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ### Popular places to visit #### Quebrada Las Trancas Spa Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting. [](https://expedia.co.uk/Quebrada-Las-Trancas-Spa-Santa-Fe.d553248635976022318.Attraction) ## Explore a world of travel with Expedia - Accommodation - Packages - [Calobre Hotels ](https://www.expedia.co.uk/Calobre-Hotels.d553248635921599085.Travel-Guide-Hotels) - [San Fransisco District Hotels ](https://www.expedia.co.uk/Destinations-In-San-Fransisco-District.d553248635975750662.Hotel-Destinations) - [La Tetilla Hotels ](https://www.expedia.co.uk/La-Tetilla-Hotels.d829297219661209600.Travel-Guide-Hotels) - [Remance Hotels ](https://www.expedia.co.uk/Remance-Hotels.d829297107396464640.Travel-Guide-Hotels) - [Visit Calobre ](https://www.expedia.co.uk/Calobre.dx553248635921599085) - [Quebrada Las Trancas Spa ](https://www.expedia.co.uk/Quebrada-Las-Trancas-Spa-Santa-Fe.d553248635976022318.Attraction) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app