Santa Fe Holidays from £613

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Your Santa Fe Holiday

Our holiday packages to Santa Fe let you customise your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start travelling. Browse the wide range of options on Expedia today and finally put your Santa Fe holiday plans into motion!

Top Santa Fe Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
£613
per person
2 Oct - 8 Oct
found 1 day ago
Return direct flight included
Georgetown (GEO) to Panama City (PTY)
8.6/10 Excellent! (1,718 reviews)
My overall stay was ok. The hotel is beautiful on the outside and decent on the inside. The furniture was a bit dated, the bathtoom tub had some kind of adhesive residue, kinda like the sticky remains of a shower mat, and one of the face basin towel handle kept falling off. One of the side chairs were one sit away from breaking (it was really old). The lights in the closet couldn't turn off. The mattress were a bit too low. The breakfast buffet was ok for the most part, however if you don't eat meat, then your options would be fruits, eggs, bread, cereal and vegetable sushi rolls. And the occasional cold salmon slices. The staff their are helpful and nice. It's located in the city and is next to the megapolis outlet malls. It was was easy to get around to and from the hotel.

Reviewed on 11 Aug 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
Save 100% on your flight
£695
per person
2 Oct - 8 Oct
found 1 day ago
Return direct flight included
Georgetown (GEO) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at breakfast, may disturb your sleep.

Reviewed on 10 Aug 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
Save 100% on your flight
£741
per person
2 Oct - 8 Oct
found 1 day ago
Return direct flight included
Georgetown (GEO) to Panama City (PTY)
8.4/10 Very good! (1,621 reviews)
Good hotel price and service. The only thing I didn't like was i had the do not disturb sign up and I received room service anyway. I had the sign up for a reason

Reviewed on 11 Aug 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

£620
per person
2 Oct - 8 Oct
found 1 day ago
Return direct flight included
Georgetown (GEO) to Panama City (PTY)
8.4/10 Very good! (1,814 reviews)
Good value for money close to the airport, clean room, simple but good breakfast (starting at 6:30 am), nice pool with tropical vibe (open till 10 pm)

Reviewed on 11 Aug 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
£741
per person
2 Oct - 8 Oct
found 1 day ago
Return direct flight included
Georgetown (GEO) to Panama City (PTY)
9.6/10 Exceptional! (398 reviews)
Great staff, clean rooms, excellent value

Reviewed on 11 Aug 2026

Things to do in and around Santa Fe

Santa Fe, Veraguas, is a haven for outdoor enthusiasts, offering stunning scenery and adventure-filled activities. Visitors can indulge in luxurious resorts and rejuvenating spa treatments. Key attractions include sightseeing opportunities, engaging live music, and a vibrant atmosphere perfect for exploring the town. Whether hiking through lush landscapes or enjoying local festivities, Santa Fe promises a memorable experience for all types of travellers.

Shopping

In Santa Fe, you can enjoy shopping at the local Mercado, a vibrant public market. If you're up for a drive, visit Cerámica La Peña and the Artisan Market, both located 46.7km away, offering unique crafts and local goods amidst a lively atmosphere.

Recreation

Experience rejuvenation at Los Pozos Termales, a serene retreat 43.5km from Santa Fe, where soothing thermal waters will melt your stress away. For sports enthusiasts, the Omar Torrijos Herrera Stadium, located 46.7km away, offers a vibrant atmosphere to enjoy local sporting events and activities.

Adventure

Parque Acuatico Italia Guadalupe Panama is a thrilling waterpark located 45.1km from Santa Fe. Enjoy a fun-filled day with family and friends, featuring exciting water slides, pools, and various attractions that guarantee an exhilarating experience for all ages.

Nightlife

Santa Fe boasts a vibrant nightlife with charming venues like the lively Café Santa Fe, perfect for mingling over cocktails. For a more laid-back vibe, visit La Casa de la Cultura, where local music and dance create an enchanting atmosphere, making for a memorable evening.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in Santa Fe

Santa Fe, Veraguas, offers an idyllic setting for outdoor enthusiasts and adventure seekers. Explore stunning waterfalls, charming piazzas, and historic churches that provide a perfect backdrop for romance and adventure. Whether you're hiking the scenic trails or enjoying the local culture, Santa Fe's attractions promise a memorable experience. Don't miss out on the delightful activities available to fully appreciate this remarkable destination.

  • Quebrada Las Trancas Spa: Experience a rejuvenating retreat at this natural spa, where adventure meets tranquillity. Nestled in lush surroundings, it offers a unique blend of relaxation and outdoor exploration, allowing you to unwind and connect with nature.
  • Alto de Piedra Waterfall: This stunning waterfall is perfect for outdoor enthusiasts and romantics alike. Surrounded by vibrant flora, it provides a picturesque setting for hiking, swimming, or simply soaking in the beauty of the cascading waters.
  • Town Square: Immerse yourself in the local culture at the Town Square, a lively hub filled with charming shops, cafes, and vibrant street life. It’s the ideal place to experience the essence of Santa Fe and engage with the friendly locals.

Best time to go to Santa Fe

The best time to visit Santa Fe can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Fe falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Santa Fe falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January77.9°F (25.5°C)No RainSunnySlightly HighSlightly Low
February79.7°F (26.5°C)No RainSunnySlightly HighSlightly High
March81.1°F (27.3°C)No RainSunnySlightly HighAverage
April81.5°F (27.5°C)Light RainMostly SunnyAverageAverage
May79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
June78.1°F (25.6°C)Frequent RainMostly CloudySlightly LowSlightly Low
July77.7°F (25.4°C)Frequent RainMostly CloudyAverageAverage
August77.5°F (25.3°C)Frequent RainMostly CloudyAverageAverage
September77.2°F (25.1°C)Frequent RainMostly CloudyAverageAverage
October76.5°F (24.7°C)Frequent RainMostly CloudySlightly LowAverage
November75.9°F (24.4°C)Frequent RainMostly CloudyAverageSlightly High
December76.5°F (24.7°C)Light RainMostly SunnyAverageSlightly High

Tips to save on your trip to Santa Fe

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling to Santa Fe during the low season (January and May to June) for more affordable options.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
970
Max Temp Winter
32ºC
Max Temp Summer
29ºC
Top Sights
Alto de Piedra Waterfall, Cascada de Bermejo and Town Square

Top hotels in Santa Fe

Hotel Anachoreo

Hotel Anachoreo

Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
£69
12 Aug - 13 Aug
includes taxes & fees
9.6/10 Exceptional! (45 reviews)
"Great property location and beautiful views, room and bath areas great. Breakfast was solid. Hot water was very inconsistent, usually cold. WiFi great"

Reviewed on 24 Jul 2026

Hotel Anachoreo
La Qhia Eco Retreat

La Qhia Eco Retreat

Barriada el Cerro A 100 Mts De Santa Fe Veraguas
Get rates
La Qhia Eco Retreat
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

Provincia de Veraguas, Panama Panama
£121
14 Aug - 15 Aug
includes taxes & fees
Cabana Vergara Santa Fe
See all 13 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays
Golf Holidays
Golf Holidays
Luxury Holidays
Luxury Holidays
gay friendly holidays
LGBTQ+ Holidays
LGBTQ+ Holidays
Romantic Holidays
Romantic Holidays
Ski Holidays
Ski Holidays
Pet Friendly Holidays
Pet Friendly Holidays
Holiday in Month
Where to go when
Where to go when

Stay near popular Santa Fe attractions

Alto de Piedra Waterfall

7.6/10 (7 reviews)
Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.
See properties

Quebrada Las Trancas Spa

8.0/10 (2 reviews)
Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting.
See properties

Town Square

7.6/10 (11 reviews)
You can find out about the history of Santa Fe when you stop by Town Square. Amble around the area's riverfront or visit its churches.
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Orchid House

5.6/10 (5 reviews)
Explore the great outdoors at Orchid House, a lovely green space in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.
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Catholic Church of Santa Fe

8.4/10 (5 reviews)
After visiting Catholic Church of Santa Fe, make a plan to see the other sights and activities in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.
See properties

Mercado

8.0/10 (1 review)
Find out about the history of Santa Fe when you take a trip to Mercado. Stroll along the riverfront or visit the churches while you're in the area.
See properties

Frequently asked questions

Why should I book my Santa Fe holiday with Expedia?
Choose Expedia to organise your next break with ease, all in one convenient place. Our insider tip for bagging a terrific deal on a Santa Fe retreat? Bundle your accommodation, flights and/or car hire into a package holiday. Then add a few awesome tours and activities. Most bookings also come with flexible cancellation policies, so there's no need to panic if you have to switch up your travel plans. Round-the-clock assistance with amending and cancelling your trip is available via our Customer Service Portal link.
When is the best time of year to holiday in Santa Fe?
Peak season falls in January, October and November and is an exciting time to visit — if you don't mind the crowds. April, July and August are typically quieter times of the year. Organise your visit to Santa Fe according to what type of adventure you're looking for. October is the coolest month, when daytime temperatures average 24ºC. In March, the warmest period, you'll experience temperatures of around 27ºC during the day.
What is the top hotel for my holiday in Santa Fe?
Rainforest Yasmin Hotel sets the scene for an unforgettable getaway in Santa Fe, offering all the comforts and amenities you need and more.
How do I get a cheap holiday to Santa Fe?
Booking a Santa Fe holiday with Expedia is a simple way to save. We offer more than 400 partner airlines and 321,000 hotel options around the globe. With such a huge range to choose from, you'll have no hassles putting together your perfect trip. Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.
What should I do on my Santa Fe holiday?
With leading attractions like Alto de Piedra Waterfall and Town Square, a holiday in Santa Fe promises plenty of fun things to do and see. Catholic Church of Santa Fe and Cerro Tute are a couple of other sights also worth exploring.
What is the best area to stay in when on holiday in Santa Fe?
There's so much to do in Santa Fe, so spend your nights close to its top sights and spend more time sightseeing. Alto de Piedra Waterfall is one place to put on your to-do list.
Do I need a visa for my Santa Fe holiday?
Official government websites will have all the information you need on visa requirements, application procedures and necessary documentation. Your nationality and the reason for your visit, whether it be for tourism or business, will determine if you'll need a visa for Santa Fe. Also double-check that your passport is up to date and has at least six months validity remaining after the date of your intended return. Do all your travel planning well ahead of time to avoid any nasty last-minute surprises.
What should I wear on my Santa Fe holiday?
Do some research into the sorts of clothing people in Santa Fe wear, and maybe even look up fashion pages on social media for inspiration. Whatever your look, aim to create a versatile wardrobe filled with pieces that suit your destination and show off your unique style. Daytime temperatures during October, Santa Fe's coolest month, average 24ºC. March marks this city's warmest month when the average daily temperature reaches 27ºC. Our suggestion? Take the guesswork out of what to pack and check the local weather forecast.
What does an Expedia Santa Fe holiday include?
Hotels, flights and a shiny set of wheels for all your road trip adventures. Simply mix and match your favourite bundle and get access to great discounts. Once you've made your booking, add on a few tours and experiences and watch your savings grow. When it comes to creating your Santa Fe trip, the choice is all yours! Expedia features different types of properties, with the most popular in Santa Fe being budget hotels and bed & breakfasts. With Expedia, you can expect the freedom and flexibility to personalise your dream escape your way.
Does Expedia offer Book Now, Pay Later Santa Fe holidays?
Expedia has partnered with online lender Klarna to make your next getaway easier on your hip pocket. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more money to play with while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that works with your budget. Browse these flexible payment options:
  • Pay monthly holidays: Klarna offers the ability to pay in multiple instalments that fit all budgets, so you can have that well-deserved holiday sooner.
  • No-deposit holidays: When you see an unbeatable deal but your budget doesn't quite go that far, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to lock in your getaway.
Can I choose my airline with a Santa Fe Expedia holiday?
Definitely. Expedia has more than 400 partner airlines to pick from across the world. With so much choice, finding the perfect carrier to get you to Santa Fe will be easy.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.