Santa Cruz Holidays from £2,084

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

Top Santa Cruz Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Renaissance Panama City Hotel

Renaissance Panama City Hotel

Bella Vista
£2,084
per person
2 Oct - 7 Oct
found 1 day ago
Return direct flight included
London (LHR) to Panama City (PTY)
8.8/10 Excellent! (289 reviews)
-

Reviewed on 30 Aug 2026

Marriott Panama Hotel

Marriott Panama Hotel

£2,120
per person
2 Oct - 7 Oct
found 1 day ago
Return direct flight included
London (LHR) to Panama City (PTY)
9.2/10 Wonderful! (1,009 reviews)
The property was well maintained. Staff was friendly and very helpful especially Jose S at the front desk he was always willing to help us out with anything we needed. We will definitely be back for another trip !!!!

Reviewed on 2 Sept 2026

Top hotels in Santa Cruz

Bocas del Mar Hotel

Bocas del Mar Hotel

Road to Boca Chica Boca Chica Chiriqui
£162
4 Sept - 5 Sept
includes taxes & fees
9.6/10 Exceptional! (237 reviews)
"This was a 10 out of 10. Everyone was so helpful, we were treated like royalty. The room was clean and modern. The pool was brilliant, the food exceptional,the drinks were delicious and the beer was cold. I could not ask for more. Our stay was wonderful!"

Reviewed on 31 Aug 2026

Bocas del Mar Hotel
Las Lajas Beach Resort

Las Lajas Beach Resort

Playa Las Lajas Las Lajas Chiriqui
9.2/10 Wonderful! (138 reviews)
"Great place for a beach stay in Panama. We loved the resort,the staff,the beach. Keep in mind this is a more rustic area,but the value here is terrific. We really enjoyed it. Also food and drinks are very reasonably priced,and very good."

Reviewed on 26 Mar 2025

Get rates
Las Lajas Beach Resort
Seagull Cove Resort

Seagull Cove Resort

Calle Principal Boca Chica Chiriqui
£150
6 Sept - 7 Sept
includes taxes & fees
9.6/10 Exceptional! (101 reviews)
"Beautiful property that is surrounded by the jungle. The cove is gorgeous and we heard monkeys, saw roads and tree frogs and so many different types of birds. Dinner and breakfast were great and there was something for everyone in my family."

Reviewed on 22 Jul 2026

Seagull Cove Resort
See all 45 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.