Title: Hotels in Santa Cruz - Best Santa Cruz Hotels from £28 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d553248635973463921.Travel-Guide-HolidayRentals)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d553248635973463921.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d553248635973463921.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santa Cruz from £28 ### Change your mind Book hotels with free cancellation ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [7 Oct - 8 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [8 Oct - 9 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2025-10-08&endDate=2025-10-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Santa Cruz hotels and places to stay ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635973463921.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635973463921.Travel-Guide-Hotels) ## Top Santa Cruz Hotel Reviews ## More cheap stays in Santa Cruz ![Hotel La Casona](https://images.trvl-media.com/lodging/6000000/5320000/5318500/5318433/1d2d18a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel La Casona Avenida Fitzcarrald 147, Iquitos, Loreto £28 11 Oct - 12 Oct 8.2/10 Very Good! (122 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Hotel-La-Casona.h5318433.Hotel-Information) ![Studio 69](https://images.trvl-media.com/lodging/40000000/39020000/39016900/39016898/a84b49e8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Studio 69 Jr. Pevas 669, Calle Nanay, Iquitos, Loreto £29 11 Oct - 12 Oct 9/10 Wonderful! (63 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Studio-69.h39016898.Hotel-Information) ![Hotel Fenix](https://images.trvl-media.com/lodging/25000000/24240000/24237200/24237156/12990525_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Fenix Pasaje Angel Brusco 172-174, Iquitos, Loreto £30 8 Oct - 9 Oct 9.8/10 Exceptional! (8 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Hotel-Fenix.h24237156.Hotel-Information) ![Hospedaje Las Amazonas](https://images.trvl-media.com/lodging/13000000/12490000/12481500/12481467/0f099181_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hospedaje Las Amazonas Calle Las Amazonas c/c Calle Señor, de los Milagros s/n, San Juan Bautista, Iquitos [Get rates](https://expedia.co.uk/Hotel-Search?startDate=21%2F10%2F2025&endDate=22%2F10%2F2025&selected=12481467&PinnedHotelID=12481467&HadPinnedHotel=true®ionId=553248635973463921) 7.4/10 Good! (7 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Hospedaje-Las-Amazonas.h12481467.Hotel-Information) ![Cumaceba Amazon Lodge](https://images.trvl-media.com/lodging/15000000/15000000/14991900/14991818/7e8e6ebd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cumaceba Amazon Lodge 35 Kilometros de Iquitos, Belén [Get rates](https://expedia.co.uk/Hotel-Search?startDate=21%2F10%2F2025&endDate=22%2F10%2F2025&selected=14991818&PinnedHotelID=14991818&HadPinnedHotel=true®ionId=553248635973463921) [](https://expedia.co.uk/Iquitos-Hotels-Cumaceba-Amazon-Lodge.h14991818.Hotel-Information) ![Country Club Eco - Casa Jardín](https://images.trvl-media.com/lodging/35000000/34090000/34086300/34086221/f1671dd3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Country Club Eco - Casa Jardín Jr Manuel del Aguila 667, Moyobamba, San Martin [Get rates](https://expedia.co.uk/Hotel-Search?startDate=21%2F10%2F2025&endDate=22%2F10%2F2025&selected=34086221&PinnedHotelID=34086221&HadPinnedHotel=true®ionId=553248635973463921) 7.8/10 Good! (7 reviews) [](https://expedia.co.uk/Tarapoto-Hotels-Country-Club-Eco-Casa-Jardin.h34086221.Hotel-Information) ## Frequently asked questions ### If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund? > Yes, you'll find most hotel reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of booking. Filter your search by [fully refundable](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&paymentType=FREE_CANCELLATION) to find flexible hotel deals in Santa Cruz. ### What should I see while I'm in Santa Cruz? > The picturesque setting of [Pacaya-Samiria National Reserve](https://www.expedia.co.uk/Pacaya-Samiria-National-Reserve-Loreto-Region.d6350893.Attraction) and [Huallaga River](https://www.expedia.co.uk/Huallaga-River-Peru.d553248635976196311.Attraction) exemplify the area's natural beauty. Take a look at what more there is to see and do in Expedia's [Santa Cruz guide](https://www.expedia.co.uk/Santa-Cruz.dx553248635973463921). ### What's the seasonal weather like in Santa Cruz? > The hottest months are usually September and October, with an average temperature of 26°C, while the coldest months are July and June, with an average of 25°C. The rainiest months in Santa Cruz are March, April, February and May, with each month seeing an average of 337 mm of rainfall. ## Explore a world of travel with Expedia - Accommodation - [Lagunas Hotels](https://www.expedia.co.uk/Lagunas-Hotels.d553248635973463236.Travel-Guide-Hotels) - [Yurimaguas Hotels](https://www.expedia.co.uk/Yurimaguas-Hotels.d4006.Travel-Guide-Hotels) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)