Title: Hotels in Santa Cruz - Best Santa Cruz Hotels from £26 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d553248635973463921.Travel-Guide-HolidayRentals)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d553248635973463921.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d553248635973463921.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [7 Apr - 8 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [8 Apr - 9 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Apr - 19 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=553248635973463921&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635973463921.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635973463921.Travel-Guide-Hotels) ## Top Santa Cruz Hotel Reviews ## More cheap stays in Santa Cruz ![Studio 69](https://images.trvl-media.com/lodging/40000000/39020000/39016900/39016898/4af31b61_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Studio 69 Jr. Pevas 669 Iquitos Loreto £26 17 Apr - 18 Apr 9/10 Wonderful! (72 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Studio-69.h39016898.Hotel-Information) ![Hotel Fenix](https://images.trvl-media.com/lodging/25000000/24240000/24237200/24237156/700a8d33_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Fenix Pasaje Angel Brusco 172-174 Iquitos Loreto £30 16 Apr - 17 Apr 10/10 Exceptional! (12 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Hotel-Fenix.h24237156.Hotel-Information) ![La Posada Del Cauchero Hotel & Suites](https://images.trvl-media.com/lodging/113000000/112490000/112483000/112482972/1bd57c81_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Posada Del Cauchero Hotel & Suites 449 Antonio Raimondi Iquitos Loreto £33 9 May - 10 May 7/10 Good! (4 reviews) [](https://expedia.co.uk/Iquitos-Hotels-La-Posada-Del-Cauchero-Hotel-Suites.h112482972.Hotel-Information) ![Hotel La Casona](https://images.trvl-media.com/lodging/6000000/5320000/5318500/5318433/5702283d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel La Casona Avenida Fitzcarrald 147 Iquitos Loreto £34 9 Apr - 10 Apr 8.4/10 Very Good! (133 reviews) [](https://expedia.co.uk/Iquitos-Hotels-Hotel-La-Casona.h5318433.Hotel-Information) ![Cumaceba Amazon Lodge](https://images.trvl-media.com/lodging/15000000/15000000/14991900/14991818/9b1ca81f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cumaceba Amazon Lodge 35 Kilometros de Iquitos Belén £226 12 Apr - 13 Apr [](https://expedia.co.uk/Iquitos-Hotels-Cumaceba-Amazon-Lodge.h14991818.Hotel-Information) ![Alojamiento Casa Luna](https://images.trvl-media.com/lodging/118000000/117890000/117880200/117880171/247db752_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Alojamiento Casa Luna 727 Jirón Rufino Echenique Iquitos Loreto [Get rates](https://expedia.co.uk/Hotel-Search?startDate=22%2F04%2F2026&endDate=23%2F04%2F2026&selected=117880171&PinnedHotelID=117880171&HadPinnedHotel=true®ionId=553248635973463921) [](https://expedia.co.uk/Iquitos-Hotels-Alojamiento-Casa-Luna.h117880171.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Santa Cruz? > This central area is the heart of Santa Cruz, offering a convenient and accessible base for exploring. It's characterised by its historic architecture, pedestrian-friendly streets, and a pleasant overall feel. The Plaza de Armas itself is a focal point, surrounded by significant buildings like the Cathedral Basilica of Santa Cruz and the Casa de la Cultura. You'll find a concentration of shops, restaurants, and cafes within a few blocks of the plaza. > > > For couples, staying in this central district provides easy access to evening strolls, dining experiences, and cultural sites. Many hotels here offer a blend of traditional charm and modern comforts, making it simple to enjoy the city's offerings without extensive travel. The proximity to various eateries means a relaxed evening is always on the cards. > > > Solo travellers will also find the city centre an excellent option. Its central location means most attractions are within walking distance or a short taxi ride, and there's always something happening around the main square. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Cruz hotel booking with Expedia? ### How much is the nightly rate at a Santa Cruz hotel? ## Explore a world of travel with Expedia - Accommodation - [Lagunas Hotels ](https://www.expedia.co.uk/Lagunas-Hotels.d553248635973463236.Travel-Guide-Hotels) - [Yurimaguas Hotels ](https://www.expedia.co.uk/Yurimaguas-Hotels.d4006.Travel-Guide-Hotels) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app