Title: Hotels in Santa Cruz - Best Santa Cruz Hotels - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d553248635926569460.Travel-Guide-HolidayRentals)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d553248635926569460.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d553248635926569460.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [2 Mar - 3 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635926569460&startDate=2026-03-02&endDate=2026-03-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [3 Mar - 4 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635926569460&startDate=2026-03-03&endDate=2026-03-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635926569460&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635926569460&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz hotels ![Exterior](https://images.trvl-media.com/lodging/104000000/103950000/103947200/103947104/145ce675.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/104000000/103950000/103947200/103947104/7e111ddd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103950000/103947200/103947104/3556a4b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/104000000/103950000/103947200/103947104/8cef2335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa de huéspedes Chañarmuyo [](https://www.expedia.co.uk/Chanarmuyo-Hotels-Casa-De-Huespedes-Chanarmuyo.h103947104.Hotel-Information) Chañarmuyo 10/10 Exceptional (1 review) "Nice little guesthouse in an amazing location between vines and mountains. Really nice dinner and wine tasting to a fair price!" ![Switzerland](https://a.travel-assets.com/egds/marks/flags/ch.svg) Dominik [](https://www.expedia.co.uk/Chanarmuyo-Hotels-Casa-De-Huespedes-Chanarmuyo.h103947104.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-16&endDate=2026-03-17®ionId=553248635926569460&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_553248635926569460) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635926569460.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Hotels.d553248635926569460.Travel-Guide-Hotels) ## Top Santa Cruz Hotel Reviews ## More cheap stays in Santa Cruz ![HOSTEL La Casa de Li En](https://images.trvl-media.com/lodging/101000000/100410000/100402400/100402365/a1d8a486_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOSTEL La Casa de Li En 514 Guillermo Iribarren Chilecito Chilecito la rioja [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=100402365&PinnedHotelID=100402365&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/Chilecito-Hotels-HOSTEL-La-Casa-De-Li-En.h100402365.Hotel-Information) ![RUKA Apart ](https://images.trvl-media.com/lodging/91000000/90910000/90904400/90904369/82b7825f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### RUKA Apart Vidaleras Ramona y Lidia Barrios Chilecito La Rioja [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=90904369&PinnedHotelID=90904369&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/Chilecito-Hotels-RUKA-Apart.h90904369.Hotel-Information) ![Howard Johnson Chilecito Hotel & Casino](https://images.trvl-media.com/lodging/7000000/6710000/6704900/6704827/70325fc6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Howard Johnson Chilecito Hotel & Casino 19 February and Roque Lanus St, Chilecito La Rioja (province) [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=6704827&PinnedHotelID=6704827&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/Chilecito-Hotels-Howard-Johnson-Chilecito-Hotel-Casino.h6704827.Hotel-Information) ![Eco Hostel Valle Fertil - Adults Only](https://images.trvl-media.com/lodging/19000000/18560000/18552200/18552199/dd2329b6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Eco Hostel Valle Fertil - Adults Only Mendoza 971 San Agustin de Valle Fertil San Juan [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=18552199&PinnedHotelID=18552199&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/San-Agustin-De-Valle-Fertil-Hotels-Eco-Hostel-Valle-Fertil-Adults-Only.h18552199.Hotel-Information) ![Hostal Sisabel](https://images.trvl-media.com/lodging/47000000/46330000/46323600/46323544/242acc97_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hostal Sisabel CALLE 12 DE OCTUBRE Tinogasta CATAMARCA [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=46323544&PinnedHotelID=46323544&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/Tinogasta-Hotels-Hostal-Sisabel.h46323544.Hotel-Information) ![Prisma Apart Hotel](https://images.trvl-media.com/lodging/21000000/20020000/20010900/20010876/ed7dc066_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Prisma Apart Hotel Buenos Aires 104 La Rioja [Get rates](https://expedia.co.uk/Hotel-Search?startDate=16%2F03%2F2026&endDate=17%2F03%2F2026&selected=20010876&PinnedHotelID=20010876&HadPinnedHotel=true®ionId=553248635926569460) [](https://expedia.co.uk/La-Rioja-Hotels-Prisma-Apart-Hotel.h20010876.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Santa Cruz? > This area is the heart of Santa Cruz, offering easy access to many of the city's key attractions. It's very walkable, with streets like Calle General Lavalle and Calle San Martín forming the main commercial arteries, lined with shops, cafes, and restaurants. The Plaza Independencia itself is a focal point, often bustling with local activity and providing a pleasant green space. > > > Couples looking for a relaxing and convenient stay will appreciate the city centre. You'll find a good selection of boutique hotels and guesthouses within a short stroll of the main sights, allowing for romantic evenings out and easy exploration on foot. The proximity to local eateries means you can easily enjoy traditional cuisine. > > > For solo travellers, the city centre offers a practical and engaging base. Its central location means you're never far from public transport options or taxi stands, making day trips or evening excursions straightforward. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Cruz hotel booking with Expedia? ### How much is the nightly rate at a Santa Cruz hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - More ways to book - [Aimogasta Hotels ](https://www.expedia.co.uk/Aimogasta-Hotels.d6348247.Travel-Guide-Hotels) - [Chilecito Hotels ](https://www.expedia.co.uk/Chilecito-Hotels.d6301107.Travel-Guide-Hotels) - [Cochangasta Hotels ](https://www.expedia.co.uk/Cochangasta-Hotels.d6348249.Travel-Guide-Hotels) - [La Rioja Province Hotels ](https://www.expedia.co.uk/Destinations-In-La-Rioja-Province.d6232522.Hotel-Destinations) - [Vinchina Department Hotels ](https://www.expedia.co.uk/Destinations-In-Vinchina-Department.d553248635975751237.Hotel-Destinations) - [Famatina Hotels ](https://www.expedia.co.uk/Famatina-Hotels.d3000439690.Travel-Guide-Hotels) - [Guandacol Hotels ](https://www.expedia.co.uk/Guandacol-Hotels.d3000411692.Travel-Guide-Hotels) - [Jagüé Hotels ](https://www.expedia.co.uk/Jague-Hotels.d3000473952.Travel-Guide-Hotels) - [La Rioja Hotels ](https://www.expedia.co.uk/La-Rioja-Hotels.d1629.Travel-Guide-Hotels) - [Nonogasta Hotels ](https://www.expedia.co.uk/Nonogasta-Hotels.d6353290.Travel-Guide-Hotels) - [Sanagasta Hotels ](https://www.expedia.co.uk/Sanagasta-Hotels.d553248634691623494.Travel-Guide-Hotels) - [Villa Union Hotels ](https://www.expedia.co.uk/Villa-Union-Hotels.d6360464.Travel-Guide-Hotels) - [Flights from London (LGW) to La Rioja (IRJ) ](https://www.expedia.co.uk/lp/flights/lgw/irj/london-to-la-rioja) - [Flights from London (LHR) to La Rioja (IRJ) ](https://www.expedia.co.uk/lp/flights/lhr/irj/london-to-la-rioja) - [Flights from Manchester (MAN) to La Rioja (IRJ) ](https://www.expedia.co.uk/lp/flights/man/irj/manchester-to-la-rioja) - [Flights from Stockholm (STO) to La Rioja (IRJ) ](https://www.expedia.co.uk/lp/flights/sto/irj/stockholm-to-la-rioja) - [Visit Chilecito ](https://www.expedia.co.uk/Chilecito.dx6301107) - [Visit La Rioja Province ](https://www.expedia.co.uk/La-Rioja-Province.dx6232522) - [La Rioja Holidays ](https://www.expedia.co.uk/La-Rioja.d1629.Holidays-City-Breaks) - [Visit Sanagasta ](https://www.expedia.co.uk/Sanagasta.dx553248634691623494) - [Villa Union Holidays ](https://www.expedia.co.uk/Villa-Union.d6360464.Holidays-City-Breaks) - [Car hire near La Rioja Province ](https://www.expedia.co.uk/Destinations-In-La-Rioja-Province.d6232522.Car-Hire-Destinations) - [Book Hotels in Santa Cruz on Expedia.com.ar ](https://www.expedia.com.ar/Santa-Cruz-Hoteles.d553248635926569460.Guia-de-Hoteles) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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