A vineyard with rows of grapevines.

Find luxury hotels in Santa Cruz

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Tonight
5 Oct - 6 Oct
Tomorrow
6 Oct - 7 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Santa Cruz luxury hotels

A bedroom with a bed, a decorative cabinet, and a modern abstract painting on the wall.
Winery
Restaurant
Restaurant

1. Vik Chile

Vik Chile
San Vicente
  • Relax amid wine country elegance at this San Vicente luxury hotel with 2 restaurants and a winery on-site.
£581
18 Oct - 19 Oct
Vik Chile
View all properties

Top Santa Cruz Hotel Reviews

TerraViña

TerraViña

10/10 Excellent
"The staff were very friendly and knowledgeable of the local restaurants and wineries. The room has a balcony which was fabulous. Properly was well maintained and beautiful. Definitely would come back to this property."
andy 2-night trip
Posted 2 months ago
TerraViña

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
During your visit, you might want to enjoy the tours which Santa Cruz is known for.
What's the best high-end hotel in Santa Cruz?
Vibo Wine Lodge is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travellers looking for an elegant place to stay.
When can I expect good weather in Santa Cruz?
Planning for the weather is an important factor for making your trip to Santa Cruz a success, especially when you're splurging. The hottest months are usually January and February, with an average temperature of 21°C, while the coldest months are July and August, with an average of 10°C. Average annual precipitation for Santa Cruz is 743 mm.
What's there to see and do in Santa Cruz?
Experience all that Santa Cruz has to offer when you visit Casino Colchagua, Colchagua Campo y Vino and Lapostolle Clos Apalta Winery. If you have some spare time during your trip, you might want to check out Millahue Valley and Museo de Colchagua.