Title: TOP Luxury Hotels in Santa Cruz for 2026 - Santa Cruz Upscale Hotels | Expedia.co.uk [Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6047957.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6047957.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6047957.Holidays-City-Breaks) ![Rows of vineyards, Santa Cruz, Chile](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [22 Jan - 23 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2026-01-22&endDate=2026-01-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [23 Jan - 24 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2026-01-23&endDate=2026-01-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Santa Cruz luxury hotels ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, steam room, body treatments, hydrotherapy, body wraps](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/2713a051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed | Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/880b28a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/b6c7442f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Santa Cruz Plaza [](https://www.expedia.co.uk/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information) Santa Cruz 8.8/10 Excellent (338 reviews) "Yes all great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barrett £118 26 Jan - 27 Jan [](https://www.expedia.co.uk/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information) ![Couples treatment room(s), hot springs/mineral springs, massages](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/38e10dec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium, Habitación en Barrica de Vino | Premium bedding, minibar, in-room safe, bed sheets](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/19bebba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/14fb86c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Icono, Habitación en Barrica de Vino | Premium bedding, minibar, in-room safe, bed sheets](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/db4abfe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cava Colchagua [](https://www.expedia.co.uk/San-Fernando-Hotels-Hotel-Cava-Colchagua.h9422950.Hotel-Information) Santa Cruz 8.8/10 Excellent (171 reviews) "Interesting and beautiful place to stay. Barrel rooms are comfortable. Staff are very pleasant and accomodating. Food at the restaurant was fantastic. Shower was not the best." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Anonymous traveller [](https://www.expedia.co.uk/San-Fernando-Hotels-Hotel-Cava-Colchagua.h9422950.Hotel-Information) ![Separate bathtub and shower, deep-soaking bathtub, free toiletries](https://images.trvl-media.com/lodging/9000000/8730000/8726600/8726594/a803556f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/9000000/8730000/8726600/8726594/7cfca4ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Japanese garden](https://images.trvl-media.com/lodging/9000000/8730000/8726600/8726594/0e9147b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/9000000/8730000/8726600/8726594/3cb714bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vik Chile [](https://www.expedia.co.uk/San-Fernando-Hotels-Vik-Chile.h8726594.Hotel-Information) San Vicente 9.2/10 Wonderful (161 reviews) "The rooms are quirky but very comfortable and spotless. The food is outstanding- ingredients from the property’s farm and orchard, exquisite presentation and service. We enjoyed the tours of the winemaking facility and of the farm. Outstanding experience!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pamela £416 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Fernando-Hotels-Vik-Chile.h8726594.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-05&endDate=2026-02-06®ionId=6047957&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Top Santa Cruz Hotel Reviews ![TerraViña](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/08e2ca8e_y.jpg) ### TerraViña 10/10 Excellent "Clean and spacious suite, fantastic staff and service and very picturesque location" [](https://expedia.co.uk/San-Fernando-Hotels-TerraVina.h3775207.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your Santa Cruz holiday? ### What's the best high-end hotel in Santa Cruz? ### When can I expect good weather in Santa Cruz? ### What's there to see and do in Santa Cruz?