Title: TOP Luxury Hotels in Santa Cruz for 2025 - Santa Cruz Upscale Hotels | Expedia.co.uk [Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6047957.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6047957.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6047957.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/2/cc9d4f6227cc14a14b1c75c0de60343b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Vivian Rennó # Find luxury hotels in Santa Cruz ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [18 Sept - 19 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-18&endDate=2025-09-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [19 Sept - 20 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-19&endDate=2025-09-20&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-19&endDate=2025-09-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Luxury Hotels ## Our top choices for Santa Cruz luxury hotels ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/08e2ca8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/c669d7a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/7a4b1beb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Living room | TV](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/f87c655e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TerraViña Santa Cruz 9.2/10 Wonderful (198) "We were greeted by Rosita who was the most lovely hostess ever. She had our rooms ready early and adjusted to our requests. She ALSO made a Dr appointment for one of our party at a great local clinic. AND she let me park my car there for a few days while we made our trip to ski in Chillan. Rosita went over and above our expected hospitality. And her English was amazing. We WILL be back. " £99 19 Sept - 20 Sept [](https://www.expedia.co.uk/San-Fernando-Hotels-TerraVina.h3775207.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-02&endDate=2025-10-03®ionId=6047957&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Santa Cruz Hotel Reviews ![TerraViña](//images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/08e2ca8e_y.jpg) ### TerraViña 10/10 Excellent "We were greeted by Rosita who was the most lovely hostess ever. She had our rooms ready early and adjusted to our requests. She ALSO made a Dr appointment for one of our party at a great local clinic. AND she let me park my car there for a few days while we made our trip to ski in Chillan. Rosita went over and above our expected hospitality. And her English was amazing. We WILL be back. " [](https://expedia.co.uk/San-Fernando-Hotels-TerraVina.h3775207.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your Santa Cruz holiday? > During your visit, you might want to enjoy the tours which Santa Cruz is known for. ### What's the best high-end hotel in Santa Cruz? > [Vibo Wine Lodge](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vibo-Wine-Lodge.h112245785.Hotel-Information) is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Another upscale choice for your stay is [Barrica Lodge](https://www.expedia.co.uk/Santa-Cruz-Hotels-Barrica-Lodge.h118203695.Hotel-Information). ### When can I expect good weather in Santa Cruz? > Planning for the weather is an important factor for making your trip to Santa Cruz a success, especially when you're splurging. The hottest months are usually January and February, with an average temperature of 21°C, while the coldest months are July and August, with an average of 10°C. Average annual precipitation for Santa Cruz is 743 mm. ### What's there to see and do in Santa Cruz? > Experience all that Santa Cruz has to offer when you visit Casino Colchagua, Colchagua Campo y Vino and Lapostolle Clos Apalta Winery. If you have some spare time during your trip, you might want to check out Millahue Valley and Museo de Colchagua.