The Best Hotels Closest to Sanford USD Medical Center in Sioux Falls - 2026 Updated Prices

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Our top choices for Sanford USD Medical Center hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious lobby with modern seating, large windows, and a city view.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

1. Highpoint Hotel

University Heights, 0.2 mi from Sanford USD Medical Center

Randell J

£106

includes taxes & fees

11 Oct - 12 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

2. Hotel On Phillips

Downtown Sioux Falls, 1.1 mi from Sanford USD Medical Center

Frank

£125

includes taxes & fees

4 Oct - 5 Oct

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

3. Clubhouse Hotel Suites Sioux Falls

Mall District, 1.8 mi from Sanford USD Medical Center

Claudine

£121

includes taxes & fees

11 Oct - 12 Oct

A patio with wicker chairs and a round table with a fire pit.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, < 0.1 mi from Sanford USD Medical Center

Ross

£103

includes taxes & fees

4 Oct - 5 Oct

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

5. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 1.5 mi from Sanford USD Medical Center

Marius

£175

includes taxes & fees

4 Oct - 5 Oct

A covered outdoor area with a wooden railing, chairs, and tables.

A kitchen with white cabinets, granite countertops, stainless steel appliances, and a chandelier.

A small pond with a waterfall, surrounded by rocks and plants.

A two-story house with a front porch, a central entrance, and a small garden area.

6. Historic Victorian Inn

Cathedral, 0.9 mi from Sanford USD Medical Center

Jackie

£101

includes taxes & fees

6 Oct - 7 Oct

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A modern lobby with seating areas, a large pillar, and a wall mural.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A spacious hallway with a patterned carpet, large windows, and seating areas.

7. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 1.2 mi from Sanford USD Medical Center

Todd

£111

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

8. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.1 mi from Sanford USD Medical Center

Rachael

£104

includes taxes & fees

11 Oct - 12 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

An indoor swimming pool with clear windows, chairs, and a tiled floor.

9. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 1.8 mi from Sanford USD Medical Center

Joan

£89

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a large bed, a desk with a computer, a chair, a lamp, and three framed pictures on the wall.

10. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 1.2 mi from Sanford USD Medical Center

Hayley

£80

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a computer, a television, and a couch.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A sign for Center Inn with a parking lot and buildings in the background.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

11. The Center Inn

All Saints, 1.4 mi from Sanford USD Medical Center

Marissa

£80

includes taxes & fees

2 Oct - 3 Oct

An indoor pool area with a slide, seating, and tropical decor.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A living room with a fireplace, a television, and a dining area with a table and chairs.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

12. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 1.8 mi from Sanford USD Medical Center

Sami

£53

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

13. Valley Inn

University Heights, < 0.1 mi from Sanford USD Medical Center

Darrel

£69

includes taxes & fees

29 Sept - 30 Sept

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A wooden door with a glass panel, leading to a brick-paved entrance.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A dining room with a wooden table, six chairs, and a chandelier.

14. Historic Twin Tudors Inn

0.8 mi from Sanford USD Medical Center

Anonymous traveller

£218

includes taxes & fees

4 Oct - 5 Oct

15. Sioux Falls Inn

Northwest Sioux Falls, 1.9 mi from Sanford USD Medical Center

Stephanie

£44

includes taxes & fees

29 Sept - 30 Sept

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

Two vending machines in a hallway with a sign that reads "VENDORS".

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

16. WoodSpring Suites Sioux Falls

1.8 mi from Sanford USD Medical Center

Catherine

£67

includes taxes & fees

29 Sept - 30 Sept

A reception area with a counter, a food mart sign, and a security camera.

A hotel room with two beds, a desk, a chair, and a TV.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

A swimming pool with a tiled floor, a poolside table, and chairs.

17. Ramada by Wyndham Sioux Falls

1.7 mi from Sanford USD Medical Center

Tiffany

£49

includes taxes & fees

11 Oct - 12 Oct

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A conference room with a long table, chairs, water bottles, a flat-screen TV, and a window with curtains.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

18. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 3.3 mi from Sanford USD Medical Center

Bailey

£108

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

19. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 3.7 mi from Sanford USD Medical Center

jason

£86

includes taxes & fees

18 Oct - 19 Oct

A deck with outdoor furniture, a fire pit, and a view of a body of water.

A modern Hyatt Place hotel with a glass entrance canopy and a brick facade.

A reception area with a herringbone-patterned wall, a reception desk, and seating area with chairs and a table.

A modern bar area with seating, a counter with a beverage display, and a large window providing a view.

20. Hyatt Place Sioux Falls South

Mall District, 2.4 mi from Sanford USD Medical Center

Catherine

£98

includes taxes & fees

4 Oct - 5 Oct

View all properties

Compare popular hotels close to Sanford USD Medical Center

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 337 reviews	View
Hotel On Phillips	9.6 Exceptional 1,597 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,226 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 674 reviews	View
Canopy By Hilton Sioux Falls Downtown	9.4 Exceptional 271 reviews	View

Top Sanford USD Medical Center Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"Staff were great. Lobby was amazing"

Valley Inn

10/10 Excellent

"It was very comfortable and peaceful."

Highpoint Hotel

10/10 Excellent

"Beautiful room and views"

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

10/10 Excellent

"The rooms were amazing!! It’s like a mini apartment!!! Mini kitchen and very comfortable beds!!! Best sleep I’ve ever had in a hotel!! Would definitely stay here again if I’m in the area!!"

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

8/10 Good

"1st level very noisy by the door. Slammed all night with each person going in and out."

Country Inn & Suites by Radisson, Sioux Falls

8/10 Good

"This was right on the river so we could walk and enjoy the restaurants there and the beauty of the Falls just a short walk from us. We were close to breweries and many downtown shops. The free breakfast was the usual array of grab and go items, with coffee and juice. There were no bad odors in the hotel. I always take an air cleaner and the room may have had a little stuffiness, but I am very sensitive to that sort of thing. We would stay here again!!"

Stunning! Modern with original hardwood!

10/10 Excellent

"A beautiful property with a great host!! A great overall experience!!"

Stylish, comfort-first 2BR/1BA

10/10 Excellent

"Great property blocks from Sanford Hospital and hosts were fantastic when I needed to extend my stay. Great wi-fi, well furnished and super comfortable."

Sanford Hub | Spacious 4BR Across from Sanford

10/10 Excellent

"Great communication with the owner... It's conveniently located across the street from Sanford Children's Hospital if needed... In addition, it's pretty much close to everything... Sioux Falls isn't that big of a place, so it doesn't take extended periods of time to reach your destination...The rooms were a good size. The bathrooms were nice...The front room with the big window pane overlooking the backyard is a great touch for being able to sit there at night. I watched out that window... There was a really bad thunderstorm, and I sat there and looked out the window while the lightning kept striking... It was beautiful. The kitchen's nice, and overall, I'm very pleased with our decision to stay at that VRBO..."

Frequently asked questions

What's the area like around Sanford USD Medical Center?

Sanford USD Medical Center is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 138 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Sanford USD Medical Center?

Adjacent to Sanford USD Medical Center, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels should I expect to find close to Sanford USD Medical Center?

Expedia has 138 hotels and other accommodation options within a mile from Sanford USD Medical Center.

If I need to cancel the hotel reservation for my stay near Sanford USD Medical Center, will I receive a refund?

Yes! Most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Add dates, click "Search", then you can use the "fully refundable" filter to get the best deals near Sanford USD Medical Center.

What can I see and do near Sanford USD Medical Center?

Study the collections at Washington Pavilion of Arts and Science, Old Courthouse Museum or Sioux Empire Medical Museum. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sanford USD Medical Center, Sioux Falls

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sanford USD Medical Center hotels

1. Highpoint Hotel

2. Hotel On Phillips

3. Clubhouse Hotel Suites Sioux Falls

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Canopy By Hilton Sioux Falls Downtown

6. Historic Victorian Inn

7. Hilton Garden Inn Sioux Falls Downtown

8. Holiday Inn Sioux Falls-City Centre by IHG

9. Sheraton Sioux Falls Hotel & Convention Center

10. Country Inn & Suites by Radisson, Sioux Falls

11. The Center Inn

12. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

13. Valley Inn

14. Historic Twin Tudors Inn

15. Sioux Falls Inn

16. WoodSpring Suites Sioux Falls

17. Ramada by Wyndham Sioux Falls

18. Staybridge Suites Sioux Falls Southwest by IHG

19. Comfort Inn & Suites at Sanford Sports Complex

20. Hyatt Place Sioux Falls South

Compare popular hotels close to Sanford USD Medical Center

Top Sanford USD Medical Center Hotel Reviews

Clubhouse Hotel Suites Sioux Falls

Valley Inn

Highpoint Hotel

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Country Inn & Suites by Radisson, Sioux Falls

Stunning! Modern with original hardwood!

Stylish, comfort-first 2BR/1BA

Sanford Hub | Spacious 4BR Across from Sanford

Frequently asked questions