
San Sisto Holidays from £330
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Your San Sisto Holiday
An easy way to experience this interesting city is with a customised San Sisto holiday package. Stay in the neighbourhood of San Biagio della Valle, which is good for views, nature and history or go someplace else — our package deals are all about you. Make your trip to San Sisto even more fun by including some sightseeing. Piazza IV Novembre, Rocca Paolina and Basilica San Pietro are some of the major attractions worth exploring. Expedia is here to help you escape your daily routine. Tailor your holiday to San Sisto to suit your style of travel, whatever that may be.
Top San Sisto Flight + Hotel Deals

Pineta Hotel
Reviewed on 26 Sept 2025


Sina Brufani
Reviewed on 19 May 2026

International Hotel & Suite
Reviewed on 23 May 2025

Borgo Lanciano Resort & Spa
Reviewed on 18 May 2017
San Sisto Essential Information
Language | Italian |
|---|---|
Currency | Euros |
Local Welcome | Ciao |
Local Goodbye | Ciao |
Closest Airport | Sant Egidio Airport (PEG) |
Max Temp Winter | 10ºC |
Max Temp Summer | 29ºC |
Top Sights | Cathedral of Saint Lorenzo, Citta della Domenica and Castello di Ramazzano |
Top hotels in San Sisto

Villa di Piazzano - Small Luxury Hotel of the World
"The Hotel and grounds are beautiful and immaculately maintained. The entire staff really stands out. So friendly and welcoming. Those little gestures of respect and kindness are appreciated. Also it’s very convenient that they can speak English. There are several beautiful hotels in the area to experience, ..."
Reviewed on 14 May 2026

TH Assisi - Hotel Cenacolo

Hotel Sangallo Palace
"Staff, breakfast , size of the room with a view all excellent"
Reviewed on 22 May 2026
Popular places to visit

Piazza IV Novembre
Located in the heart of Perugia, this small square is surrounded by some of the town’s most impressive landmarks.

Rocca Paolina
Explore a maze of tunnels and alleys, and visit markets, events and exhibitions in the foundations of a 16th-century fortress.

National Gallery of Umbria
Discover Umbria’s cultural treasures at its most comprehensive art gallery, where centuries-old works of art bring the past to life.
What to do in San Sisto

Perugia: San Lorenzo Cathedral Audioguide Tour
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.












