San Sisto Holidays from £289

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Your San Sisto Holiday

An easy way to experience this interesting city is with a customised San Sisto holiday package. Stay in the neighbourhood of San Biagio della Valle, which is good for views, nature and history or go someplace else — our package deals are all about you. Make your trip to San Sisto even more fun by including some sightseeing. Piazza IV Novembre, Rocca Paolina and Basilica San Pietro are some of the major attractions worth exploring. Expedia is here to help you escape your daily routine. Tailor your holiday to San Sisto to suit your style of travel, whatever that may be.

Top San Sisto Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel

4 out of 5
Save 100% on your flight
per person
15 Sept - 20 Sept
found 1 day ago
Return flight included
London (STN) to Ancona (AOI)
8.4/10 Very Good! (326 reviews)
Struttura di recente costruzione dotata di tutti i confort, personale super gentile e soprattutto ottimo ristorante. Solitamente non ceno negli hotel ma in questo caso lo consiglio per la fantastica selezione di piatti, tutti buonissimi, dei vini e per la simpatia unica della manager

Reviewed on 23 Jun 2025

Natural Village Resort

Natural Village Resort

4 out of 5
per person
10 Sept - 17 Sept
found 1 day ago
Return flight included
London (LGW) to Ancona (AOI)
8.4/10 Very Good! (109 reviews)
It was so peaceful, entire facility from the private beach to the pool and family friendly property were top notch.

Reviewed on 3 Jul 2025

Raffaello Hotel

Raffaello Hotel

4 out of 5
Save 100% on your flight
per person
10 Sept - 17 Sept
found 1 day ago
Return flight included
London (LGW) to Ancona (AOI)
8.8/10 Excellent! (99 reviews)
The front desk was extremely helpful and kind

Reviewed on 12 Nov 2023

Relais La Corte Di Bettona

Relais La Corte Di Bettona

4 out of 5
Save 100% on your flight
per person
20 Sept - 27 Sept
found 15 hours ago
Return flight included
London (LON) to Ancona (AOI)
8.4/10 Very Good! (123 reviews)
The views were incredible! The historical values and sense of being made every moment special. The location on the mountain top made you feel safe, protected and relaxed. The staff was gracefully accommodating and tended to our every want and need! This was my second stay here and it won't be my last...we LOVE it here!

Reviewed on 9 May 2024

Hotel Priori Secret Garden

Hotel Priori Secret Garden

4 out of 5
Old Town Perugia
per person
25 Oct - 28 Oct
found 1 day ago
Return flight included
London (LON) to Ancona (AOI)
9.6/10 Exceptional! (152 reviews)
In the heart of the action, yet removed enough to sleep like a baby, we had a fabulous stay at Priori Secret Garden. Looking forward to going back next year.

Reviewed on 20 Jul 2025

San Sisto Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Closest Airport
Sant Egidio Airport (PEG)
Max Temp Winter
10ºC
Max Temp Summer
29ºC
Top Sights
Cathedral of Saint Lorenzo, Citta della Domenica and Castello di Ramazzano

Top hotels in San Sisto

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Localita Piazzano, C.P. 6, Cortona, AR
The price is £441 per night from 17 Aug to 18 Aug
£441
17 Aug - 18 Aug
includes taxes & fees
9.6/10 Exceptional! (217 reviews)
"AMAZING! Gorgeous! I would recommend to everyone!"

Reviewed on 29 Jul 2025

Villa di Piazzano - Small Luxury Hotel of the World
Hotel Sangallo Palace

Hotel Sangallo Palace

4 out of 5
Via L Masi 9, Perugia, PG
Fully refundableReserve now, pay when you stay
The price is £121 per night from 8 Aug to 9 Aug
£121
8 Aug - 9 Aug
includes taxes & fees
8.8/10 Excellent! (573 reviews)
"What a lovely hotel. Rooms really comfortable and balcony a surprise extra"

Reviewed on 2 Aug 2025

Hotel Sangallo Palace
Giotto Hotel & Spa

Giotto Hotel & Spa

4 out of 5
Via Fontebella 41, Assisi, PG
Fully refundableReserve now, pay when you stay
The price is £76 per night from 10 Aug to 11 Aug
£76
10 Aug - 11 Aug
includes taxes & fees
8.8/10 Excellent! (712 reviews)
"Very courteous and helpful staff, absolutely beautiful views!!"

Reviewed on 5 Aug 2025

Giotto Hotel & Spa
See all 3,409 properties in San Sisto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Popular places to visit

Piazza IV Novembre featuring heritage architecture and a city as well as a small group of people

Piazza IV Novembre

Located in the heart of Perugia, this small square is surrounded by some of the town’s most impressive landmarks.

Piazza IV Novembre
Rocca Paolina showing heritage architecture

Rocca Paolina

Explore a maze of tunnels and alleys, and visit markets, events and exhibitions in the foundations of a 16th-century fortress.

Rocca Paolina
National Gallery of Umbria showing heritage architecture and signage

National Gallery of Umbria

Discover Umbria’s cultural treasures at its most comprehensive art gallery, where centuries-old works of art bring the past to life.

National Gallery of Umbria

What to do in San Sisto

Truffle hunting or Olive harvest - seasonal

Truffle hunting or Olive harvest - seasonal

£78
per adult
Truffle hunting or Olive harvest - seasonal
Perugia: Entry Ticket and Guided Tour of Perugia Underground

Perugia: Entry Ticket and Guided Tour of Perugia Underground

£10
per adult
90% of travellers recommend
Perugia: Entry Ticket and Guided Tour of Perugia Underground
Perugia: Old Town Walking Tour, Piazza IV Novembre

Perugia: Old Town Walking Tour, Piazza IV Novembre

£26
per adult
Perugia: Old Town Walking Tour, Piazza IV Novembre
See all activities in San Sisto

Frequently asked questions

How much does a San Sisto travel package cost?
Tailor make your San Sisto package from only £289. Pick from any combination of flights, hotels and rental cars to pull together the escape of your dreams. Be sure to add on some activities and experiences!
If I'm not able to travel, can I cancel my San Sisto travel package?
Yes, you can. We get that even the best-laid plans can go awry, so we're happy to help if you have to make changes to your San Sisto travel package. You may be able to change or cancel your itinerary for free if you've booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for further information. Also, check your itinerary for the nitty-gritty on change fees.
How do I get a cheap travel package to San Sisto?
Browse and book everything in the one place with our San Sisto travel packages. We have deals on flights, hotels and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 air carriers and 1,000,000 properties worldwide to select from, you have countless opportunities to mix and match all you want.
Does Expedia offer Book Now, Pay Later San Sisto holidays?
Your bank balance shouldn't prevent you from going on holiday, so Expedia has worked out a solution to help. Thanks to our partnership with online lender Klarna, it's easier than ever to book a dream getaway without exhausting your savings. Klarna offers flexible payment options during the checkout process that take the worry out of budgeting for your trip. Consider one of these flexible payment options:

  • Pay monthly holidays: Jet off on that dream holiday sooner with Klarna's manageable monthly instalment plans. If making small repayments each month sounds right for you, pick this option at checkout.
  • Pay in instalments holidays: If you want to pay off your escape in multiple transactions, holidays paid in instalments might be the right option for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: When you want to jump on an amazing deal but don't have the full amount yet, Klarna's low deposit holiday plan will help you lock in your escape.

Where should I stay in San Sisto?
With so much to discover in San Sisto, we suggest you secure a room in a hotel near its attractions. Piazza IV Novembre, Rocca Paolina and Fontana Maggiore are some top ones to put on your itinerary.
What are the top hotels in San Sisto?
If it's your first time in San Sisto, make a reservation at Chocohotel or Sina Brufani. Both hotels have good amenities and are popular options with lots of travellers.
How far in advance should I book my San Sisto holiday?
While prices change frequently, we generally recommend booking your holiday as early as possible. Many international airfares can be compared on Expedia up to a year in advance. If you're booking late, you might still get lucky. Low prices to San Sisto sometimes appear just weeks before departure.
What does an Expedia San Sisto travel package include?
Hotels, flights and a shiny set of wheels for all your fun road trip adventures. Simply mix and match your preferred bundle and get access to great discounts. Once you've made your booking, add on a few tours and experiences and watch your savings pile up. When it comes to crafting your San Sisto break, you're the one in control!
What should I know before booking a San Sisto travel package?
A travel package can be tailored to your budget and is a fantastic way to make your money go further. How much you include is your call. Rental cars, hotels and flights — come up with a combination that suits your style.
Can I choose my airline with a San Sisto Expedia travel package?
You can, and with more than 550 airlines to choose from around the world, you're not short on choice. Take a look at the available options and see which airline suits your needs and budget.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.