Title: San Sisto Holidays 2026 from £416 | Expedia.co.uk [San Sisto Travel Guide](https://expedia.co.uk/San-Sisto.dx3000377291)[Hotels in San Sisto](https://expedia.co.uk/San-Sisto-Hotels.d3000377291.Travel-Guide-Hotels)[Holiday Rentals in San Sisto](https://expedia.co.uk/San-Sisto-Holiday-Rentals.d3000377291.Travel-Guide-HolidayRentals)[San Sisto Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Sisto.d3000377291.Car-Hire-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # San Sisto Holidays from £416 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected #### Your San Sisto Holiday An easy way to experience this interesting city is with a customised San Sisto holiday package. Stay in the neighbourhood of San Biagio della Valle, which is good for views, nature and history or go someplace else — our package deals are all about you. Make your trip to San Sisto even more fun by including some sightseeing. [Piazza IV Novembre](https://www.expedia.co.uk/Piazza-IV-Novembre-Old-Town-Perugia.d6073770.Attraction), [Rocca Paolina](https://www.expedia.co.uk/Rocca-Paolina-Old-Town-Perugia.d6073792.Attraction) and [Basilica San Pietro](https://www.expedia.co.uk/Basilica-San-Pietro-Old-Town-Perugia.d6077838.Attraction) are some of the major attractions worth exploring. Expedia is here to help you escape your daily routine. Tailor your holiday to San Sisto to suit your style of travel, whatever that may be. ## Top San Sisto Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![TH Assisi - Hotel Cenacolo](https://images.trvl-media.com/lodging/4000000/3490000/3485400/3485400/60a89c43_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### TH Assisi - Hotel Cenacolo £416 per person 28 Mar - 4 Apr found 1 day ago Return flight included London (LON) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG) 9.2/10 Wonderful! (605 reviews) TH Assisi. The check-in process was very”Italian” . I had to remind them that my reservation includes breakfast, a bottle of wine and a free upgrade. I was refused the upgrade by the very not nice female manager claiming that “there are no Superior rooms available due to an event”. When I showed her that I could right there and then make a reservation on Expedia for superior room for the whole 5 days of our stay, she still insisted that each of these room was assigned at least one of the days in question and she cannot change that. While the rooms are somewhat soundproofed, the doors are not at all and so you hear lots of door banging and other noises from the corridor. While the room is clean , modern and the mattress very comfortable, this 4 stars hotel does not offer body lotion, nor a hand held shower. There is no coffee/tea in the room - there is a bar in the lobby where you can PURCHASE but at least the curtains keeps the room dark at night. WiFi @ room was weak/intermediate. Breakfast was underwhelming. Not a piece of vegetable, only TASTELESS white or whole wheat sliced bread and two kinds of cold cut and cheese. The workers, in general and specifically in breakfast seems very motivated, and nice , but the problem might be that they were never instructed properly and so things run out occasionally. Reviewed on 20 Jan 2026 ![Fonteverde Lifestyle & Thermal Retreat](https://images.trvl-media.com/lodging/1000000/910000/909000/908918/f6fb188e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Fonteverde Lifestyle & Thermal Retreat £756 per person 1 May - 4 May found 1 day ago Return flight included London (LHR) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG) 9.4/10 Exceptional! (184 reviews) Best resort I’ve ever stayed in! So clean, bathroom is refreshing, the many thermal pools, the views, I’ll be going back every year. Reviewed on 25 Oct 2025 ![Precise Tale Poggio Alla Sala](https://images.trvl-media.com/lodging/91000000/90890000/90888700/90888666/8fbdd5cc_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Precise Tale Poggio Alla Sala £975 per person 30 Mar - 3 Apr found 1 day ago Return flight included London (LHR) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG) 9.4/10 Exceptional! (123 reviews) Loved everything about this property! The spa is a lovely experience. Next time will stay longer Reviewed on 8 Oct 2025 ![Villa di Piazzano - Small Luxury Hotel of the World](https://images.trvl-media.com/lodging/1000000/980000/972000/971985/473f66a9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Villa di Piazzano - Small Luxury Hotel of the World Save 100% on your flight £1,999 per person 2 Apr - 8 Apr found 7 hours ago Return flight included Edinburgh (EDI) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG) 9.8/10 Exceptional! (228 reviews) Room was wonderful, bathroom spacious and well appointed. Staff amazing and so friendly Reviewed on 6 Nov 2025 ![Relais La Corte Di Bettona](https://images.trvl-media.com/lodging/2000000/1280000/1276100/1276010/1520f7f9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Relais La Corte Di Bettona £466 per person 3 Apr - 6 Apr found 1 day ago Return flight included London (LON) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG) 8.4/10 Very Good! (128 reviews) The views were incredible! The historical values and sense of being made every moment special. The location on the mountain top made you feel safe, protected and relaxed. The staff was gracefully accommodating and tended to our every want and need! This was my second stay here and it won't be my last...we LOVE it here! Reviewed on 9 May 2024 ## San Sisto Essential Information | Language | Italian | | --------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | Euros | | Local Welcome | Ciao | | Local Goodbye | Ciao | | Closest Airport | Sant Egidio Airport (PEG) | | Max Temp Winter | 10ºC | | Max Temp Summer | 29ºC | | Top Sights | [Cathedral of Saint Lorenzo](https://www.expedia.co.uk/Cathedral-Of-Saint-Lorenzo-Old-Town-Perugia.d6077846.Attraction), [Citta della Domenica](https://www.expedia.co.uk/Citta-Della-Domenica-Perugia.d553248621532500659.Attraction) and [Castello di Ramazzano](https://www.expedia.co.uk/Castello-Di-Ramazzano-Perugia.d553248621532500519.Attraction) | ## Top hotels in San Sisto ![TH Assisi - Hotel Cenacolo](https://images.trvl-media.com/lodging/4000000/3490000/3485400/3485400/60a89c43_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### TH Assisi - Hotel Cenacolo Viale Patrono d'Italia 70 Assisi PG Fully refundableReserve now, pay when you stay £77 18 Feb - 19 Feb includes taxes & fees 9/10 Wonderful! (627 reviews) Convenient location - close to the train station and bus stop. Reviewed on 27 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=18%2F02%2F2026&endDate=19%2F02%2F2026&selected=3485400&PinnedHotelID=3485400&HadPinnedHotel=true®ionId=3000377291) ![Giotto Hotel & Spa](https://images.trvl-media.com/lodging/3000000/2550000/2544400/2544317/c322aa7a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Giotto Hotel & Spa Via Fontebella 41 Assisi PG Fully refundableReserve now, pay when you stay £81 10 Feb - 11 Feb includes taxes & fees 8.8/10 Excellent! (763 reviews) Beautiful hotel with lovely staff Reviewed on 17 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=10%2F02%2F2026&endDate=11%2F02%2F2026&selected=2544317&PinnedHotelID=2544317&HadPinnedHotel=true®ionId=3000377291) ![Sina Brufani](https://images.trvl-media.com/lodging/1000000/30000/27300/27255/d1aec88a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sina Brufani Piazza Italia, 12 Perugia PG £145 21 Feb - 22 Feb includes taxes & fees 9.2/10 Wonderful! (623 reviews) Good Reviewed on 9 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=21%2F02%2F2026&endDate=22%2F02%2F2026&selected=27255&PinnedHotelID=27255&HadPinnedHotel=true®ionId=3000377291) [See all 3,295 properties in San Sisto](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=10%2F02%2F2026&endDate=11%2F02%2F2026®ionId=3000377291) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ### Popular places to visit ![Piazza IV Novembre featuring heritage architecture and a city as well as a small group of people](https://images.trvl-media.com/place/6073770/669c7920-c2b1-448d-9d04-9f55e1a88733.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Piazza IV Novembre Located in the heart of Perugia, this small square is surrounded by some of the town’s most impressive landmarks. [](https://expedia.co.uk/Piazza-IV-Novembre-Old-Town-Perugia.d6073770.Attraction) ![National Gallery of Umbria showing heritage architecture and signage](https://images.trvl-media.com/place/6077890/4f97d384-2820-43e2-9cc0-3c5012386678.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### National Gallery of Umbria Discover Umbria’s cultural treasures at its most comprehensive art gallery, where centuries-old works of art bring the past to life. [](https://expedia.co.uk/National-Gallery-Of-Umbria-Old-Town-Perugia.d6077890.Attraction) ![Rocca Paolina showing heritage architecture](https://images.trvl-media.com/place/6073792/c68828bf-3744-4046-a425-1438278e264a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Rocca Paolina Explore a maze of tunnels and alleys, and visit markets, events and exhibitions in the foundations of a 16th-century fortress. [](https://expedia.co.uk/Rocca-Paolina-Old-Town-Perugia.d6073792.Attraction) ### What to do in San Sisto ![Perugia: Chapter Museum Entry Ticket](https://mediaim.expedia.com/localexpert/48827216/b6c3a433-f3ea-4486-8939-4d2bf83cba47.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Perugia: Chapter Museum entry ticket £7 per adult [](https://expedia.co.uk/things-to-do/perugia-chapter-museum-entry-ticket.a48827216.activity-details) ![Picture 3 for Activity Perugia: San Lorenzo Cathedral Audioguide Tour](https://mediaim.expedia.com/localexpert/48846732/67356f97-7201-4f6b-9b6f-922373854131.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Perugia: San Lorenzo Cathedral Audioguide Tour £3 per adult [](https://expedia.co.uk/things-to-do/perugia-san-lorenzo-cathedral-audioguide-tour.a48846732.activity-details) ![Perugia: Old Town Walking Tour, Piazza IV Novembre](https://mediaim.expedia.com/localexpert/44633641/00be2add-8f9a-4821-bf24-fede78faf06f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Perugia: Old Town Walking Tour, Piazza IV Novembre £26 per adult [](https://expedia.co.uk/things-to-do/perugia-old-town-walking-tour.a44633641.activity-details) [See all activities in San Sisto](https://expedia.co.uk/things-to-do/search?rid=3000377291) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app