Not a good value
A number of people describe this hotel as quaint and charming, while a few call it dark and somewhat dingy. We were more in the latter camp. Our room was OK, but nothing special. A/C involved a window unit that was blasting a bit too much when on. The bathroom was about what I'd expect in an $80-100 hotel, small and somewhat rundown with very basic tub and shower. The bed was fine and the furnishings were adequate, but the room felt a bit small. The hotel offers a free glass of wine from 5-6 PM. That's a nice idea, but we had to wait 10 minutes for the bartender to show up. Then the wine was of such poor quality that it wasn't even drinkable. They serve Sycamore Lane wine as their house wine at $8 a glass. Retail prices on this wine are ~$5 a bottle (I looked it up), and I'm sure they pay substantially less in volume. So that's a pretty nice profit margin on the house wine (outside of the free hour).
Overall, this did not feel like a good value at $350/night. Unfortunately, I think this says as much about the hotel scene in San Francisco as this particular hotel.