San Antonio Holidays from £655

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Your San Antonio Holiday

From its rich history to its cultural experiences and beyond, there's a whole lot to love about San Antonio. Discover the wonders of this exciting city with a San Antonio holiday package that's tailor-made for you. Metromall Panama is just one of the must-see attractions to add to your sightseeing agenda during a trip to San Antonio. A few clicks is all it takes to craft the ideal San Antonio holiday on Expedia.

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was £911, price is now £655 per person
£655
per person
19 Mar - 24 Mar
found 1 day ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
9/10 Wonderful! (4,515 reviews)
El hotel es bellísimo, tiene restaurantes,cafetería 24 horas, piscina .El servicio es excelente.El desayuno es de primera.Disfrute muchísimo mi estancia aquí.

Reviewed on 11 Feb 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,197, price is now £833 per person
£833
per person
19 Mar - 24 Mar
found 1 day ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
Nice hotel. Friendly staff

Reviewed on 9 Feb 2026

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was £2,314, price is now £1,736 per person
£1,736
per person
20 Mar - 27 Mar
found 15 hours ago
Return direct flight included
London (LHR) to Panama City (PTY)
7.4/10 Good! (1,002 reviews)
It was a wonderful stay with wonderful people

Reviewed on 7 Feb 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £886, price is now £680 per person
£680
per person
19 Mar - 24 Mar
found 1 day ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
8.6/10 Excellent! (1,884 reviews)
Built beautifully. Not upkept well. Lamps next to bed needed.

Reviewed on 8 Feb 2026

Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
Price was £1,034, price is now £833 per person
£833
per person
20 Mar - 27 Mar
found 15 hours ago
Return direct flight included
London (LHR) to Panama City (PTY)
7.4/10 Good! (577 reviews)
The staff was excellent. The rooms comfortable and very clean. Also the location was ideal. It was within walking distance to all the sites in Casco Viejo.

Reviewed on 2 Feb 2026

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
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Rufina Alfaro

1 out of top 10 points of interest in this area

Rufina Alfaro might not have many top sights, but Metromall Panama and Los Pueblos Commercial Center are two attractions nearby that you can check out.

Find hotels in Rufina Alfaro

Top hotels in San Antonio

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
Fully refundableReserve now, pay when you stay
The price is £85 per night from 6 Mar to 7 Mar
£85
6 Mar - 7 Mar
includes taxes & fees
8.8/10 Excellent! (1,007 reviews)
Staff and facilities excellent.

Reviewed on 6 Feb 2026

Courtyard by Marriott Panama Metromall
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £106 per night from 10 Mar to 11 Mar
£106
10 Mar - 11 Mar
includes taxes & fees
9/10 Wonderful! (4,935 reviews)
Everything was great, the food, room amenities and location

Reviewed on 8 Feb 2026

Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £87 per night from 23 Feb to 24 Feb
£87
23 Feb - 24 Feb
includes taxes & fees
7.6/10 Good! (1,010 reviews)
All fantastic. We return year after year

Reviewed on 2 Feb 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
See all 1,528 properties in San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
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Family Friendly Holidays

Frequently asked questions

How much does a San Antonio travel package cost?
We make it easy to travel somewhere new, with San Antonio packages starting from as little as £655. You'll have the flexibility to combine your favourite hotels, airlines and car rental. For the ultimate escape, why not add a couple of activities and tours to your itinerary?
If I'm not able to travel, can I cancel my San Antonio travel package?
Yes you can, and we'll help you every step of the way. You may be able to cancel or amend your San Antonio travel package at no cost within 24 hours of booking. However, you may be charged a fee by your airline, hotel or car rental company for older bookings. If life throws you a curveball, browse our Customer Service Portal for further information.
How do I get a cheap travel package to San Antonio?
Just think of all the amazing things you could do in San Antonio with extra cash in your wallet. Watch your savings stack up when you bundle your airfare and hotel bookings into a San Antonio travel package. You have loads of choice when you book with Expedia too. In fact, you can pick from more than 550 airlines and 1,000,000 hotel options throughout the world. Whether you're heading off with the entire family or adventuring alone, planning a trip to San Antonio is better with a package.
Does Expedia offer Book Now, Pay Later San Antonio holidays?
Expedia has partnered with online lender Klarna to make booking your next trip a bit easier on the wallet. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to pick from, so you're sure to find something that falls within your budget. Browse these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams come true sooner with Klarna's easy monthly instalment plans. If paying just a small amount each month works for you, pick this option at checkout.
  • Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the total upfront) makes it easier to click that "book now" button, consider a low deposit holiday payment plan with Klarna.

Where should I stay in San Antonio?
There's loads to explore in San Antonio, so stay near its best sights and allow yourself more time sightseeing. Metromall Panama is one spot to put on your must-see list.
What are the top hotels in San Antonio?
Courtyard by Marriott Panama Metromall and Los Panas Hostel are two of the most sought-after properties in San Antonio. Why not look up the rates and amenities at each and then make a decision?
How far in advance should I book my San Antonio holiday?
Travellers are usually able to browse international flights on Expedia within 12 months of the departure date. Booking at the last minute? With a stroke of luck, it's still possible to purchase a cheap ticket just weeks before your journey.
What does an Expedia San Antonio travel package include?
It depends on what type of trip you're planning. San Antonio travel deals can include car rentals, flights and hotels. You can mix and match to find the package that suits your needs. You can also add on activities and experiences after you've booked to pick up even bigger discounts.
What should I know before booking a San Antonio travel package?
When you book your flights, hotels and car rentals together, you'll enjoy incredible discounts. Whether you're organising an island getaway in a villa or would rather stay in a convenient hotel in the city, Expedia will help make it happen.
Can I choose my airline with a San Antonio Expedia travel package?
With a travel package, the choice is in your hands. Whether you'd like to fly to San Antonio in coach or first class, simply select from the available airline options. Expedia has access to over 550 partner airlines all over the world.

Things to do

Slingshot Tour Panama

Slingshot Tour Panama

£88
per adult
90% of travellers recommend
Slingshot Tour Panama
Panama Canal Half Transit Experience

Panama Canal Partial Transit

£110
per adult
84% of travellers recommend
Panama Canal Partial Transit
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

£58
per adult
100% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in San Miguelito

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.