San Antonio Holidays from £724

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your San Antonio Holiday

From its rich history to its cultural experiences and beyond, there's a whole lot to love about San Antonio. Discover the wonders of this exciting city with a San Antonio holiday package that's tailor-made for you. Metromall Panama is just one of the must-see attractions to add to your sightseeing agenda during a trip to San Antonio. A few clicks is all it takes to craft the ideal San Antonio holiday on Expedia.

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £940, price is now £724 per person
£724
per person
28 Jul - 31 Jul
found 6 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.4/10 Very Good! (1,523 reviews)
I love the breakfast spread and the staff were very nice..i didn’t like the smell of the room but it was some air freshener they place on the vents once i removed it everything was fine…the pool area was clean and the staff was very attentive. I will definitely be returning.

Reviewed on 15 May 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £1,090, price is now £781 per person
£781
per person
28 Jul - 31 Jul
found 6 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Very nice and clean hotel in the centralized area. It is very safe to walk all over the place.

Reviewed on 11 May 2026

Hilton Panama

Hilton Panama

5 out of 5
Bella Vista
Price was £942, price is now £766 per person
£766
per person
28 Jul - 31 Jul
found 6 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9/10 Wonderful! (1,008 reviews)
First class hotel in downtown with excellent view from pool and restaurant area on high floor (really pleasant at night). Many dining options and not far from Panama Canal and old city.

Reviewed on 30 Apr 2026

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Casco Viejo
Price was £976, price is now £806 per person
£806
per person
28 Jul - 31 Jul
found 6 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9.8/10 Exceptional! (648 reviews)
Beautiful hotel, the rooms are lovely the beds are so comfortable, in a great location and the staff were so kind and polite and helpful. The speakeasy is fabulous and so fun. The only thing was the food at the pool bar was not very good but the drinks were great, and the food and service at the roof top bar Ammi, not so great. Otherwise highly recommend staying at Sofitel in Casco Viejo!

Reviewed on 12 May 2026

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was £1,015, price is now £848 per person
£848
per person
28 Jul - 31 Jul
found 6 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
7.6/10 Good! (1,001 reviews)
Very friendly staff and great food.

Reviewed on 14 May 2026

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
Default Image

Cerro Viento

Shopping and restaurants are notable features of Cerro Viento. You might consider stopping by Metromall Panama while you're exploring the neighbourhood.

Find hotels in Cerro Viento

Top hotels in San Antonio

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
Fully refundableReserve now, pay when you stay
The price is £80 per night from 31 May to 1 Jun
£80
31 May - 1 Jun
includes taxes & fees
9/10 Wonderful! (1,001 reviews)
It was in a nice location close to the mall . Breakfast was great.

Reviewed on 14 May 2026

Courtyard by Marriott Panama Metromall
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £107 per night from 1 Jun to 2 Jun
£107
1 Jun - 2 Jun
includes taxes & fees
9/10 Wonderful! (5,428 reviews)
the food there is really good

Reviewed on 14 May 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is £109 per night from 30 May to 31 May
£109
30 May - 31 May
includes taxes & fees
8.6/10 Excellent! (2,539 reviews)
It was close to the airport and clean. The staff were pleasant and the hotel was clean. There was also a nice bar and a shuttle to and from the airport.

Reviewed on 15 May 2026

Crowne Plaza Panama Airport by IHG
See all 1,727 properties in San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a San Antonio travel package cost?
We make it easy to travel somewhere new, with San Antonio packages starting from as little as £724. You'll have the flexibility to combine your favourite hotels, airlines and car rental. For the ultimate escape, why not add a couple of activities and tours to your itinerary?
If I'm not able to travel, can I cancel my San Antonio travel package?
Yes you can, and we'll help you every step of the way. You may be able to cancel or amend your San Antonio travel package at no cost within 24 hours of booking. However, you may be charged a fee by your airline, hotel or car rental company for older bookings. If life throws you a curveball, browse our Customer Service Portal for further information.
How do I get a cheap travel package to San Antonio?
Just think of all the amazing things you could do in San Antonio with extra cash in your wallet. Watch your savings stack up when you bundle your airfare and hotel bookings into a San Antonio travel package. You have loads of choice when you book with Expedia too. In fact, you can pick from more than 550 airlines and 1,000,000 hotel options throughout the world. Whether you're heading off with the entire family or adventuring alone, planning a trip to San Antonio is better with a package.
Does Expedia offer Book Now, Pay Later San Antonio holidays?
Expedia has partnered with online lender Klarna to make booking your next trip a bit easier on the wallet. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to pick from, so you're sure to find something that falls within your budget. Browse these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams come true sooner with Klarna's easy monthly instalment plans. If paying just a small amount each month works for you, pick this option at checkout.
  • Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the total upfront) makes it easier to click that "book now" button, consider a low deposit holiday payment plan with Klarna.

Where should I stay in San Antonio?
There's loads to explore in San Antonio, so stay near its best sights and allow yourself more time sightseeing. Metromall Panama is one spot to put on your must-see list.
What are the top hotels in San Antonio?
Courtyard by Marriott Panama Metromall and Los Panas Hostel are two of the most sought-after properties in San Antonio. Why not look up the rates and amenities at each and then make a decision?
How far in advance should I book my San Antonio holiday?
Travellers are usually able to browse international flights on Expedia within 12 months of the departure date. Booking at the last minute? With a stroke of luck, it's still possible to purchase a cheap ticket just weeks before your journey.
What does an Expedia San Antonio travel package include?
It depends on what type of trip you're planning. San Antonio travel deals can include car rentals, flights and hotels. You can mix and match to find the package that suits your needs. You can also add on activities and experiences after you've booked to pick up even bigger discounts.
What should I know before booking a San Antonio travel package?
When you book your flights, hotels and car rentals together, you'll enjoy incredible discounts. Whether you're organising an island getaway in a villa or would rather stay in a convenient hotel in the city, Expedia will help make it happen.
Can I choose my airline with a San Antonio Expedia travel package?
With a travel package, the choice is in your hands. Whether you'd like to fly to San Antonio in coach or first class, simply select from the available airline options. Expedia has access to over 550 partner airlines all over the world.

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

£111
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

£36
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

£24
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
See all activities in San Miguelito

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.