The best area to stay in Puerto Santander is the town centre, particularly around the main square, Parque Santander.
This area is the heart of Puerto Santander, where you'll find most of the town's amenities and local life. It's a compact and walkable district, with shops, eateries, and guesthouses clustered around the central park. The park itself is a landmark, often bustling with local activity, especially in the evenings.
For travellers seeking convenience and a taste of local life, the town centre is an ideal choice. You'll be within easy reach of the main port for river travel and have quick access to local markets and dining options.